Medical science constantly challenges the boundaries by finding not only the cures to the most dangerous diseases, but finds a way to prevent them even before they occur. With years of research, practice and data available for analysis, scientists are using advanced technology in combination with years of research to create a predicting mechanism for often fatal diseases like cancer.

Breast cancer screening has always been done with mammography. The fact is that this method is only 75% accurate, laden with false positives and misses a whole set of women totally- and that too when cancer has already developed. Part of the problem comes from the dense breast tissue which one in three women have. This tissue masks the lumps, which makes it difficult for mammograms to accurately screen cancer.

Some breakthrough scientific methods are changing this by drawing on years of research to predict this deadly disease, years before it can manifest itself.

A genetic test to predict cancer 10-11 years ahead of time
This test was performed to see how environmental factors could influence cancer, along with habits like smoking, abusing alcohol or hormones, genetic changes that occur and are put a large percentage of the women at a high risk of developing this disease.

A simple blood test is used for the genetic analysis of hereditary cancer. Researchers found a biological marker, methylation of the ATM gene, which has a very high ability to predict the risk of developing cancer, several years before diagnosis. 'Methylation' concluded that when one biological indicator is exposed to carcinogenic substances, or other abusive substances like tobacco and alcohol, it may trigger the development of cancer. On the flip side, this test will take time to reach the commercial market and even then cannot give an exact timeline as to when someone may develop the disease.

A simple blood test to predict breast cancer 5 years before it develops
This is the kind of medical miracle the world is looking for. Last year in April, researches in Denmark identified a simple blood test that can predict breast cancer five years before it actually develops with an accuracy of a whopping 80%.

It works by "measuring all of the compounds in the blood to build a 'metabolic profile' of an individual, in order to detect changes in the way chemicals are processed, during a pre-cancerous stage," says Laura Donnelly, health editor at The Telegraph, which covered this development. Danish researchers observed 57,000 participants over 20 years, gathering blood samples along the way, specifically comparing a set of 800 women who remained healthy or developed breast cancer within 7 years of their first blood sample. The researchers found they were able to predict, with 80 percent accuracy, which patients would be affected by the disease, just by looking at the metabolic profiles they built from the participants' blood samples. The results have been published in Metabolomics.


Are you living with the uncertainty of a lump in your breast? It's time you take the first step and consult a specialist here.

Can Breast Cancer Be Predicted Before It Develops?

The incidence of pain and lumps in the breast is on the rise. Breast cancer has grown in incidence over the years. More women are getting diagnosed with it, and the age at which they are being diagnosed has reduced too. Therefore, preventative checks and screenings have gone up significantly. The number of women diagnosed with small lumps has gone up drastically. The good thing is that since these are diagnosed in the early stages, the treatment is simpler and the prognosis far better than women who get diagnosed much later in life.

In a majority of cases, once a lump is identified the most preferred treatment is removal. This is known as lumpectomy. However, before a final decision is made to remove the lump, there are certain tests that are run by the doctor to confirm the diagnosis and extent of spread.

A thorough breast exam to identify if this is an isolated lump or if there are more lumps in either breast. The exact shape and size of the lump also need to be identified so that treatment can be planned accordingly.
Imaging to see if the lymph nodes have been involved. In most cases, there could be spread to the lymph nodes in the armpits which also need to be removed if required. If the lump is too big or too many in number, then a mastectomy may be required instead of a lumpectomy. This requires removal of the entire breast tissue on one or both sides (rarely) along with involved lymph nodes.
Pre-surgery: Once the diagnosis is confirmed, then the doctor will plan treatment. Prior to the surgery,

Talk to your doctor about your other medical conditions and medications and allergies, if any
Gynecologic history is very important to be discussed in detail
Blood thinners have to be stopped prior to the surgery
Post-surgery care needs to be planned, including a caretaker for a few days and postop care
During surgery:

Lumpectomy or mastectomy is often done under general anaesthesia
This requires hospitalization and carries the risks associated with anaesthesia
The outlined breast tissue or complete breast and surrounding lymph nodes will be removed. The area will be closed using sutures and bandaged
Post-surgery:

The wound needs to heal, and so postop care is very important
For the first few days, painkillers and antibiotics are used to control pain and infection
As a follow-up, some women may require radiation therapy to contain the suspicious tissue that may be left behind after lumpectomy
If extensive breast tissue was removed, some women may prefer to have reconstructive surgery done
Remember that lumpectomy is not a definitive procedure, and there could be cases that require a repeat operation
Advantages:

Less invasive compared to a mastectomy
The appearance of the breast is minimally affected, and symmetry is maintained
Disadvantages:

May not ensure complete removal
May require additional radiation therapy
May require repeat surgery

Surgical Treatment For Pain And Lumps In Breasts Of Women!

According to a major study that provides a connection between height and cancer, it is stated that taller people are more prone to developing cancer. Research has found that the risk of developing any kind of cancer in women rises by 18% for an increase of every 10 cm in height. In men, the risk rises by 11%, even though height is not as major a factor as are obesity, smoking and a bad, unhealthy diet.

Several reasons have been put forward for the above statement. One of the reasons is that the number of body cells in taller people is more than people with average height. This leads to an increase in the number of cells which could potentially turn malignant.

While individually analysing the impact of height on different cancer forms, it was found that the highest increase in risk was in skin cancer (30% for every 10 cm increase in height), while a 20% increase was noted in taller women developing breast cancer.

Development of cancer in regions including the colon and rectum is known as colorectal cancer. Long legs have been surprisingly associated with this form of cancer. In comparison with shorter people, it was reported that taller people had a higher risk percentage of developing colorectal cancer. Two hypotheses regarding the formation of colorectal cancer have been developed. One hypothesis is that taller people have longer colons, which in turn result in more surface area where colon cancer can develop. The other hypothesis is that taller people experience increased levels of growth hormones. These particularly affect the length of their legs. The growth hormone called 'insulin-like growth factor 1' is increased during puberty and is considered to be a risk factor for colorectal cancers occurring at later stages.

Being Taller Increases Your Risk of Cancer!

Cancer is the abnormal, uncontrolled growth of cells in a particular body part. With continued growth, pieces of this tissue travel through the blood to different body parts and continue to grow in the new area. This is known as metastases. Breast cancer is one of the most common forms of cancer and affects about 1 in 8 women in the USA. Read on to know more details of breast cancer   breast anatomy, causes, symptoms, risk factors, detection, prevention, and of course treatment.

Anatomy: The main function of the breast is lactation through its milk-producing tissue that are connected to the nipple by narrow ducts. In addition, there is surrounding connective tissue, fibrous material, fat, nerves, blood vessels and lymphatic channels which complete the structure. This is essential to know as most breast cancers develop as small calcifications (hardened particles) in the ducts or as small lumps in the breast tissue which then continues to grow into cancer. The spread can happen through lymphatic or blood flow to other organs.

Warning signs/symptoms: The following are some symptoms that need to be watched out for if you have a predisposition to breast cancer.

    A lump in either of the breasts or armpits
    Change in size, shape, or contour of either breast
    Redness of your breast or nipple
    Discharge of clear or bloody fluid
    Thickening of breast tissue or skin that lasts through a period
    Altered look or feel of the skin on the breast or the nipple (dimpled, inflamed, scaly, or puckered)
    One area on the breast that looks very different from the other areas
    Hardened area under the breast skin

Either one or a combination of these should be an indication to get a detailed checkup done. Early diagnosis results in controlling the disease with minimal treatment and reduced complications.

Causes and risk factors: The exact cause for breast cancer is yet to be pinned down. However, risk factors are clearly identified, and women with risk factors need to watch out for warning signs.

    Family history: Of all the risk factors, the family history is the most important. Breast cancer runs in families, and if there is a first-degree relative with the breast cancer, the chances of developing it are almost double. Two genes BRCA1 and BRCA2 are the carriers of the disease, and this testing can be done in women to identify if they are at risk.
    Family history of other cancers: Even if there is no breast cancer, if there are other cancers that run in the family, watch out.
    Age: Women over 50 are at higher risk of developing breast cancer.
    Race: Caucasian and Jewish women are at higher risk of breast cancer than African-American women.
    Hormones: Greater exposure to the female hormone estrogen increases the chances of developing breast cancer. Women who use birth control pills for contraception and hormone replacement after menopause are at a higher risk of developing breast cancer.
    Gynecologic milestones: Women who have abnormal menstrual milestones need to watch out. These include those who attain menarche before 12 years of age, get pregnant after 30, attain menopause after 55, and have menstrual cycles shorter than 26 days or longer than 29 days.
    Obesity and alcohol abuse are also likely to increase a woman s chances of developing breast cancer.

Stages: Starting from stage 0, higher stages indicate advanced disease.

    Stage 0: The growth which has begun in the milk-producing tissue or the ducts has remained there (in situ) and not spread to any other area, including the rest of the breast.
    Stage I: The tissue slowly becomes invasive and has begun to affect the surrounding healthy tissue. It could have spread to the fatty breast tissue and some breast tissue may be found in the nearby lymph nodes.
    Stage II: The cancer at this stage grows considerably or spreads to other parts. There are chances that cancer may grow and also spread.
    Stage III: It may have spread to the bones or other organs but small amounts are present in up to 9 to 10 of the lymph nodes in the armpits and collar bones which makes it is difficult to fight.
    Stage IV: The cancer is widespread to far-flung areas like the liver, lungs, bones, and even the brain.

Screening: This is one of the most effective ways to identify the disease in its early stages. This will help in controlling cancer from spreading with minimal treatment.

    Self-examination: A thorough self-examination to look for changes in terms of shape, size, colour, contour, and firmness should be learned by all women. Watch for any discharge, sores, rashes, or swelling in the breasts, surrounding skin, and nipple. Examine them while standing and when lying down.
    In most women, annual screening mammograms are advised after the age of 40. However, in women who have a strong family history or genetic makeup, it is advisable to have screening mammograms starting at age 20 every 3 years and then annually from the age of 40.
    Women in high-risk categories should have screening mammograms every year and typically start at an earlier age.
    Ultrasound screening can also be given in addition to mammograms.
    Breast MRI is another way to screen for breast cancer if the risk is greater.

Breast Cancer Prevention: Now that there is so much awareness about causes and risk factors, there are definitely ways to prevent or delay the onset of the disease.

    Exercise and a healthy diet with reduced amount of alcohol are definitely effective in minimising the chances of developing cancer.
    Tamoxifen is used in women who are at high risk for breast cancer.
    Evista (raloxifene) which is used to treat osteoporosis after menopause. It is also widely used in preventing breast cancer.
    In high-risk women, breasts are surgically removed to prevent the development of cancer (preventive mastectomy).

Treatment: As with all cancers, treatment would depend on the stage at which it is identified and include a combination of chemotherapy, radiation, and surgery. As noted earlier, if you are at risk, look out for warning signs as early diagnosis is the key to maximum recovery.

Breast Cancer - Know More to Say 'No' More!

International Childhood Cancer Day is celebrated annually on 15 February to raise awareness and to express support for children and adolescents with cancer, survivors and their families.

Why is Cancer the biggest Threat to the YOUNG in India?

There are fewer Indians who have successfully battled Cancer and have emerged successful. Yuvraj Singh, the legendary cricketer, who was diagnosed with a rare cancer at 29, survived due to an early detection. Cancer cases in India are not as many as they are in the developed world. However, due to late detection the survival rate in the country is far worse. Particularly, we are losing our youth to Cancer. Most tobacco (pan masala) related cancers and child cancers go undetected until very late.

Few cancers like cervical cancer and breast cancer which affect women of any age, are curable, however, due to lack of awareness and timely screening, many Indian women succumb to these cancers. The most common sites for cancer among men are lung, prostate, colon, rectum, stomach and liver while that among women are breast, colon, rectum, lung, cervix and stomach.

In proportion to our population, we lack the right infrastructure nationwide. esp in the northern and north eastern region, there is a dearth of good cancer facilities, where radiation, care or treatment can be given. Not even one third of cancer patients are alive beyond 5 years after their diagnosis in India, and about 71% of cancer deaths occur in patients in their prime productive years   between the ages of 30 to 69 years.

 Most Indians believe that cancer is generally incurable and that it should be kept secret from neighbors and family.  -  Dr Paul Goss, MD, Harvard University.

All these factors have contributed to a very high mortality rate. No wonder Cancer is dreaded in the country. Investment, infrastructure, lifestyles as well as mindsets need to change if we were to contain the Cancer mortality rate. While you need to watch out for early signs of cancer, here are the lifestyle changes every individual esp. all youth must adopt to avoid cancer.

Avoid Tobacco - both smoking and chewing.

Reduce alcohol intake - Save your organs from deteriorating.

Limit UV ray exposure from the sun - Keeps your skin safe.

Maintain a healthy diet - Include foods rich in Vitamins, minerals and fiber which nourish your body and build immunity.

Increase your level of fitness - Maintain a good bodyweight. Additional flab invites a host of troubles, that includes variety of cancers.

Seeking regular medical checkup or screening - This is the only way to prevent and get detected early on.

International Childhood Cancer Day - Why Cancer Is A Threat For Young?

Cancer has been regarded as one of the most deadly diseases. It is a non-communicable chronic disorder, caused by uncontrolled growth of cells in the human body. Every year over 7 million people succumb to this disease globally and over 12 million people are diagnosed with cancer. Indian Council of Medical Research (ICMR), estimated that India will observe over 8 lakh deaths and over 17 lakh new cancer cases annually by the year 2020. The survival expectancy of a cancer patient depends upon the stage of diagnosis.

There are some forms of cancer which show any noticeable symptoms only in the final stage while there are certain other subtle symptoms which if paid attention to might save a life.
Some common signs of cancer:

Unexplained weight loss: This is one of the earliest noticeable symptoms of cancer and is particularly common in patients of lung and breast cancer. Weight loss has been observed in over 40% of cancer patients at the time of diagnosis. Losing over 10% of body weight in a span of 6 months or less could be a cause of concern.
Wheezing: This is associated with lung cancer, which is also the most common form of cancer. When the airway in the lungs is pressed or narrowed by a tumor, it creates a wheezing sound while breathing.
Frequent infections: Frequent infections and fever may indicate that something is not right with the internal organs of the body. This could be because of cancerous conditions such as leukemia or lymphoma. 
Loss of appetite: Cancer impacts the metabolic process of the body, hence often leads to a loss of appetite. This is particularly a symptom of colon, stomach, ovaries and pancreatic cancer. 
Blood in stool/urine: Traces of blood while passing stool or urine could be a symptom of cancer. Though, this could be attributed to many other infections and conditions as well.
Chronic cough: Flu and cough along with symptoms like chest pain, hoarseness, weight loss and fatigue could be because of lung cancer.
Night sweats: Though night sweat could be attributed to many more reasons, it is also one of the many early warning signs of cancer.

Early Warning Signs Of Cancer That We Often Ignore!

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