Alzheimer's disease is a neurological problem that is characterised by a cognitive decline and memory loss. It is a type of neurodegenerative dementia. The symptoms of alzheimer's disease include not being able to absorb and retain new information, lack of reasoning and judging, not being able to take on complex tasks, impaired visuospatial abilities, problems in reading, writing and speech, among many others. If a person has at least two of these symptoms in a debilitating manner, then the diagnosis can be made in favour of alzheimer's disease. The main causes of alzheimer's are shrinkage of the brain size and death of the brain cells. The immune system is also said to trigger this neurodegenerative disease. Let us find out what medical science has found so far.

1. Connections: many a times, in alzheimer's disease, the memory and behaviour of the person changes because the brain is unable to make proper neural connections which can lead to memory loss of how a person behaved and the elements that formed the basis of the patient's cognition. Apparently, the immune system behaves in the same way within the brain and blocks the connection. This happens because there is constant communication between the brain and immune system along neurological lines, which is where the disease first emanates.

2. Inflammation: the brain is prone to inflammation or swelling that is not the normal kind. This inflammation happens as a result of the activation of the infection fighting neurotransmitters and the chemical changes that happen in the brain when an infection strikes. The inflammation usually happens in the plaques or clumps which the brain tries to protect. These clumps are made up of a protein called amyloid. The immune system is responsible for creating this inflammation in the brain of the patient.

3. Pattern recognition receptors: many of these receptors work in different manners and cooperate with each other to create a response in the brain. These prrs can be found in the brain plaques, and they develop the signs of danger which further fuels the inflammation in the brain as a matter of protection.

4. Activation of cells linked with the immune system: when the prrs begin to respond, it basically activates the immune system and the cells of the same. This is the basic reaction that causes the changes in brain which then leads to the attachment of the protein to the tissue that is diseased, in which case alzheimer's disease starts. The inflammation that we had spoken about earlier basically happens in the nervous tissue.

It is important to recognise and act on the initial signs of alzheimer's disease before it progresses beyond one's control.

Can the Immune System Trigger Alzheimer's Disease

Sleep disorder is a serious problem which a large number of people are facing due to multiple reasons. Almost every other person complains of having some sort of sleep disorder, irrespective of his/her age. Sleep disorders may come across as something which can be overlooked, but this shouldn t be the case, as when the problem aggravates it can take quite a scary turn. You need to be aware of the different kinds of sleep disorders which affect a vast number of people, on a daily basis. Given below are some of the most common ones which affect the majority of the crowd.

1. Insomnia
Insomnia, a worldwide epidemic, is the most common type of sleep disorder today. A number of factors can cause insomnia and affect even the healthiest being. From stress, anxiety or depression, substance and alcohol abuse to certain types of medication, a lot of factors can cause this issue. People who have insomnia have difficulty in sleeping and then maintaining that sleep. A cognitive behavioral therapy can help people suffering from this disorder. Often medications are also prescribed.

2. Sleep Apnea
If you have a partial or complete blockage of the throat then, you might be suffering from sleep apnea. This disorder is the second most prevailing sleep disorder in the world today. People who suffer from this disorder hardly realize it until someone informs them about having the trouble. Some of the common symptoms of Sleep apnea are morning headaches, daytime sleepiness, and excessively loud snoring as well. People suffering from apnea may also face trouble breathing multiple times per night. Continuous Positive Airway Pressure machine is a common treatment for this disorder.

3. RLS or Restless Leg Syndrome
The real reason behind RLS is still not known by experts, however, most believe the real cause of the disorder is hereditary. Some medications can also be a cause of restless leg syndrome. In this disorder, an urge to move your legs and hands precedes the need to sleep. RLS usually occurs when the patient is resting. In order to treat the restless leg syndrome, one must reduce the consumption of alcohol and caffeine along with doing regular exercises. For more severe cases, often medications are prescribed. RLS is observed more in women than in men.

4. Narcolepsy
People with narcolepsy often complain about falling asleep during odd times and feeling weak quite often. An abnormality in the brain is usually the reason behind this sleep disorder. Patients of narcolepsy often develop cataplexy which is a condition where patients feel faintish as an emotional reaction to any situation. People suffering from narcolepsy are given medications as a treatment.


4 Most Common Sleep Disorders

In recent times, the advancement of medical science has substantially contributed in comprehending the Alzheimer s disease. Unfortunately, the number of individuals suffering from the disease is expected to rise in the next ten years which pose a threat to the allocation of health care resources and public health. Alzheimer s disease is thought to be a complex disease which influences a person s behavior as well as cognition through numerous mechanisms.

Can surgery be deemed as a treatment for Alzheimer s disease?
The surgery is a multicenter clinical trial which is making a new direction in clinical research. It is devised to halt or slow down the problems caused by the disease which gradually erases a lifetime of memories in elderly patients. Though there is no cure for Alzheimer s disease, it has been found that low-voltage electric charges delivered right at the brain. Only the symptomatic therapies for Alzheimer s disease are provided which do not have any effect on the evolution of the disease. The standard medical treatments for Alzheimer s disease include cholinesterase inhibitors along with a partial N-methyl D-aspartate antagonist. In most cases of mild to moderate symptoms of this disease, a combination of treatments is used according to the clinical history, age and condition of the patient.

Mental activity supporting cognition
Many patients having normal cognition or mild impairment have a fear that they may develop AD. Many experts are of the opinion that mentally challenging activities including brain teasers and crossword puzzles can be helpful in reducing the risks in such patients. Clinical trials are under the way for determining whether or not these types of activities have any substantial effect on halting the progression of AD.

Treating AD in its moderate to the severe stage
Numerous studies have shown that blockade of NMDA receptors by memantine can be used safely in combination with ChEls. This combination has been shown to delay the institutionalization in patients with Alzheimer s disease.

Treating secondary symptoms
A variety of behavioral as well as pharmacologic interventions can help in overcoming the clinical manifestations of the disease. These include anxiety, psychotic behavior, depression and agitation among others. The effectiveness of this disease can range from modest to excellent. No particular agent or dose of it can be unanimously accepted to be the sole treatment option for the wide range of clinical issues. Moreover, in the recent time, the FDA has not accepted any psychotropic agent for treating AD.

Along with these treatment options, there are behavioral interventions that can range from patient-centred approaches to caregiver training for helping manage the cognitive and behavioral manifestations of Alzheimer s disease. Last but not the least, it is very crucial to point out the significance of treatment in the early stages of AD in order to cure it better.

Alzheimer's Disease - Can Surgery Help You Treat It?

A tumor is an uncontrolled and abnormal growth of cells. A brain tumor is thus an abnormal growth and multiplication of cells in the brain. The cell growth can also be in areas adjacent to the brain. The brain tumor may

Have its origin in the brain (Primary brain tumor), or
Its origin may be in some other parts or organs of the body, which gradually spreads to the brain (Secondary/metastatic brain tumor).
Not all brain tumors are harmful and life threatening.

Brain tumors that exist as noncancerous cell growths are known as Benign brain tumors. Benign brain tumors seldom pose any threat to life.

Brain tumors that are cancerous and, thus, harmful, are known as Malignant brain tumors.

Do not neglect any brain tumors (malignant or not). It is better to be safe than to be sorry.

Types of Primary brain tumors:

Based on its cell of origin, primary brain tumors (benign as well as malignant) may be of the following types:

Meningiomas: Brain tumors that originate from the meninges (the membranes that cover the brain and the spinal cord). Meningiomas are seldom malignant.
Acoustic Neuromas: A noncancerous cell growth that has its origin in the vestibulocochlear nerve (the eighth cranial nerve). This nerve connects the brain with the inner ear.
Gliomas: Here, the tumor has its origin in the brain and the spinal cord (glial cells). This type of brain tumors, in most cases (~80%), are malignant.
Primitive Neuroectodermal Tumors (PNETs): Extremely rare, PNETs are malignant tumors that develop in the embryonic cells in the brain.
Medulloblastomas: Medulloblastomas is a malignant brain tumor that mostly affects children. It originates in the cerebellum (lower part of the brain).
Craniopharyngiomas: A benign brain tumor that has its origin near the pituitary gland (base of the brain). Craniopharyngiomas are common in children.
Probability of a secondary brain tumor are more in people who have had;

Kidney cancer
Breast cancer
Lung cancer
Colon cancer
Melanoma
Symptoms:

The symptoms of brain tumor include:

Chronic and regular headaches.
A change in the headache pattern.
Seizures.
A person may experience vision problems (Peripheral vision may be affected, double or blurred vision).
There may be difficulty in hearing.
Nausea and vomiting.
Behavioral and speech problems.
An arm or a leg may lose sensation.
A person has difficulty with balance.
Diagnosis and Treatment:
Though brain tumor can affect anyone and everyone, its chances are higher in

People who are more exposed to ionizing radiation. People having undergone a radiation therapy are equally vulnerable.
Children as well as older people.
People having a family history of brain tumors.
The diagnosis includes;

An imaging test like the MRI, CT scan and PET (Positron Emission Tomography).
Biopsy, whereby samples of the abnormal tissue is collected and examined.
Neurological examination.
Treatment:

Surgery is an effective treatment for brain tumors.
One can also opt for:

Radiations, whereby the abnormal tumor cells are destroyed using protons and x-rays (high-energy beams).
Chemotherapy: In this treatment, the tumor cells are destroyed using strong drugs (taken orally or intravenously).
Radiosurgery.
Targeted drug therapy: This treatment blocks the abnormalities that are characteristically present only in the cancer cells.

Brain Tumors: Types, Symptoms, Diagnosis, and Treatment

Autism is a developmental disorder that is usually diagnosed within the first three years of a child s life. Speech disorders and an inability to communicate with others are characteristic symptoms of autism. Speech therapy can be very beneficial for such children. Thus, it is often a major part of a treatment plan for autism. Some of the benefits of speech therapy for autistic children include:

Better articulation: Autistic children often find it hard to make certain sounds. Hence, they tend to babble or make harsh sounds or grunt instead of talking. A speech therapist can help the child learn to articulate sounds in a better way. For this, the therapist will help the child exercise the facial muscles and lips. This can make it easier for them to be understood by others.
Treating echolalia: Echolalia refers to a child s behaviour where he or she answers a question by repeating part of it. This may be because they find it difficult to express their own thoughts and feelings. Echolalia is very common amongst autistic children. Speech therapy is the only way to treat this condition. If left untreated, it could make the child withdraw into himself.
Better vocabulary: Autistic children often memorize words without understanding them. A speech therapist can help the child put words into context and thus help reduce their dependence on gestures. This can also make autistic children more confident. In addition to expanding their vocabulary, a therapist can also teach children the proper time and place for communication. For example, when to say good morning and good evening.
Initiate communication: When children are not confident of expressing themselves, they wait to be called on before saying anything. By helping them articulate sounds better and expanding their vocabulary, a speech therapist can help children gain the confidence needed to initiate conversations. With therapy, autistic children can also follow simple instructions and begin to answer questions independently. This will make them more independent.
Speech therapy does not follow the same techniques for all children. For therapy to be effective, the therapist must work in close collaboration with the child s parents and caregivers to set the right goals and monitor the child s progress. Some of the techniques that may be used include the use of electronic talkers, typing or signing, picture boards, facial exercise and massages, using rhyme to help construct sentences and using sounds to help the child expand speech sounds. If the child is non-verbal, the therapist may also introduce alternatives to verbal communication.

Can Speech Therapy Help Autistic Children?

Living with epilepsy can be highly challenging. This is a medical condition that can be controlled with medications in most cases, but it might not be useful for all patients due to severe side effects. It is estimated that up to 30% people who have epilepsy face this issue, and in such cases, surgery might be considered as an option.

This condition typically results in seizures which is a result of sudden electrical activity in the brain. So, certain complicated epilepsy operations on the brain can help patients with their seizures and contain their symptoms.

The goal of epilepsy surgeries involves removing part of the brain that causes these seizures and disrupting parts of the nervous system in the brain that contribute to the same. The procedure also involves the installation of a device that helps control the side effects of epilepsy.

When is surgery not an option for epilepsy?
Doctors would accurately identify the part of the brain that is causing seizures as the first step. These parts are known in medical terms as the  seizure  focus. This area should not be related critical functions of the brain like movement, sensation, and language involved   else surgery would not be possible.

Surgery is not viable when seizures are severe and impair bodily movement or if the patient has serious medical conditions (like cancer or heart diseases).

Common Surgery Options Available

Lesionectomy: This is one of the most commonly used procedures. This form of surgery involves the surgeon removing brain lesions from the brain or areas of injury due to malformed blood vessels or tumors. These injuries can often cause seizures and epilepsy and can be treated effectively with lesionectomy.
Lobe resection: This is another form of treatment which is possible only if the epilepsy is located in one of the four parts of the brain   the temporal lobe. It is quite common in younger people and can easily be treated by expert neurosurgeons by removing the brain tissues that are causing epilepsy.
Multiple Subpial Transections: While the above methods involve cutting out brain tissues, sometimes such surgeries just might not be possible due to other complications. If the parts of the brain cannot be cut out, surgeons tend to adopt Multiple Subpial Transections. This procedure can help control seizures without requiring cutting out parts of the brain. Small intersections are made in the brain to disrupt the impulses from affected brain cells that cause seizures, and they do not affect normal brain activity. It helps leave all abilities intact in patients and aids in treatment very effectively.
So, if you are just fed up with dealing with the seizures, consult your doctor who will be able to advise on the course of action depending on the history and medical condition.

Epilepsy - Is Surgery An Option?

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