Abstract

Background: it is essential to have an understanding of life expectancy and risk factors among patients with sickle cell disease (sickle cell anemia, hemoglobin diseases, and thalassemias). These are required to counsel the patients, target treatment, and plan the right clinical trials.

 

Methods: a research followed 3764 people ranging from birth to 66 years of age and suffering from scd. The procedure was done to understand the life expectancy and calculate the average age at death. Moreover, the study understood the reasons for the death in all 209 adults. It used the proportional-hazards regression analysis to know the risks for an untimely death in adults with sickle cell anemia.

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Results: when the results for young kids and adults with sickle cell anemia were observed, it was found that the average age at death was 48 for women and 42 for men. Moreover, suffering from hemoglobin c disease had an average mortality age of 60 for men and 68 years for women.

 

In people with sickle cell disease, 18% of deaths took place in patients with mainly renal organ failures. 33% of the tested patients were medically free of organ failures but episodes of pain crisis took their life. Out of these patients, 78% experienced chronic pain, chest syndrome, or both, while 22% suffered a stroke that took their lives.

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Clinical modeling showed that people with sickle cell anemia faced acute chest syndrome, seizures, kidney failure, a white-cell count of over 15, 000 per cubic mm, and a low hemoglobin level were related to a risk of early death.

 

Conclusions: results suggested that 50% of patients with sickle cell anemia lived beyond the age of 50. A huge share of those who lost their lives suffered no noticeable chronic organ failure. However, most of them died due to acute episodes of pain or stroke. Early death was seen highest among patients who had symptomatic disease. High levels of fetal hemoglobin suggested improved chances of survival and are assumably a credible source to foresee the risks and other factors related to adult life expectancy.


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Life Expectancy And Risk Factors Involved In Sickle Cell Disease

Blood donation is a procedure carried out for the noble cause of helping patients and saving lives. As the healthy donor's blood is transfused into the patient, it gives them a new life. That said, the donor has to fulfill a few criteria to be eligible to donate blood.

Eligibility

While any healthy adult of any gender can donate blood, it is advised for males to donate once every three months and for females to donate once every four months. Some of the other criteria are-


	
	Age
	


Any person in the age group of 18 to 65 years can donate blood depending on other factors.


	
	Weight
	


A donor should be at least weigh 45 kilograms in order to be eligible.


	
	Pulse
	


The temperature and pulse of the donor should be normal during the time of blood donation.


	
	Hemoglobin
	


Hemoglobin in the blood should be at least 12.5 grams otherwise the donor stands ineligible.


	
	Childbirth
	


A female donor should have delivered at least 1 year ago and stopped lactation.


	
	Blood pressure
	


Ensuring that the systolic and diastolic pressures are within normal limits is a must.


	
	Malaria
	


One should not have malarial symptoms and not have been treated for the same in the last 3 months.


	
	Tattoo
	


A person should not have had a tattoo in the past 12 months.


	
	Immunization and vaccination
	


A donor should not have had shots for cholera, typhoid, diphtheria, tetanus, or plague in the last 15 days.


	
	Cancer
	


A person should be checked for cancer and should not have any signs of cancer in the body.


	
	Infection
	


There should not be hepatitis b, c, tuberculosis, leprosy, or hiv infection in the body.


	
	Diseases
	


A person should not have epilepsy, bleeding disorders, sickle cell, or thalassemia.


	
	Drugs
	


One cannot donate blood if injected intravenously ever. It may cause risk to the recipient.


	
	Heart issues
	


A person willing to donate cannot have any heart disease.


	
	Diabetes
	


People on oral drugs or dieting to control diabetes can donate blood while patients with insulin injections cannot.

 

Strictly prohibited


	
	Ones who have been tested hiv positive.
	
	
	People suffering from cardiac problems, hypertension, cancer, epilepsy, or kidney ailments.
	
	
	Donors who have consumed alcohol in the past 24 hours.
	
	
	Ones with a major dental procedure done in the last one month.
	
	
	Women with miscarriages in the past 6 months.
	



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Know Eligibility Rules For Donating Blood

Urinary tract infections (uti) can occur anywhere in the urinary system   the bladder, kidneys, urethra, and ureter. Most of these infections affect the lower part of the urinary system   urethra and the bladder.

An infection ;confined to the bladder can be frustrating and painful. You may experience pain during urination, and pus or blood in the urine. However, the condition becomes worse if the infection spreads to the upper part of the urinary system, particularly to the kidneys, triggering nausea, ;vomiting, and severe pain in the back.

If uti is left untreated, it can potentially lead to kidney damage   a condition known as pyelonephritis.

How does untreated uti affect the kidneys?

Untreated urinary tract infections can cause the kidneys to swell up and damage them permanently. The infections initially begin in the lower tract of your urinary system. Then the bacteria slowly enter your body through the urethra and begin multiplying and spreading up to the bladder. The bacteria eventually travel to your kidneys through the ureters.

Some people are at higher risk for kidney damage due to urinary tract infections. This includes  


	
	Pregnant women
	
	
	Elderly people
	
	
	People with kidney problems
	
	
	Someone with a weak immune system
	


Signs to watch out for

An untreated infection in the bladder that has spread to the kidneys is associated with symptoms, such as the following  


	
	Chills and ;fever
	
	
	Vomiting and nausea
	
	
	Pain in either side of your lower back
	


You should visit a doctor right away if you notice the above uti symptoms. The condition requires immediate medical intervention in order to prevent damage to your kidneys.

Symptoms of painful utis can be managed by combining medications and lifestyle remedies. Consult a specialist to diagnose the condition early and seek appropriate treatment to avoid complications.

Untreated Urinary Tract Infections And Kidney Damage: Know The Connection

All types of viral hepatitis diseases are contagious and they can be transmitted from one person to another easily. Although, the modes of transmission may vary.

 

Experts recommend some preventive steps for every type of infection to lower your risk of acquiring or spreading hepatitis infection.

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Here are some preventive measures that may help in preventing the infection:

 

Vaccines

Vaccines for hepatitis a and hepatitis b are the best ways to prevent these viruses. Vaccines are not for all types of hepatitis infections. However, hepatitis a vaccination can help prevent the infection caused by the hepatitis a virus. The hepatitis a vaccine is generally administered in 2 doses. Similarly, there are vaccines available for hepatitis b as well. It is administered within 6 months duration. The same vaccine is helpful to prevent hepatitis d as well. There are no vaccines for hepatitis c and hepatitis e currently.

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Reducing exposure

Hepatitis diseases can be transmitted through bodily fluids, water, and food containing the infection. One can lower the risk of contamination by minimizing contact with these agents. Practicing proper and good hygiene is a way to avoid getting hepatitis through these mediums.

 

You can decrease your risk of coming in touch with fluids containing these viruses by avoiding:

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	Sharing used needles and razors
	
	
	Using someone else s toothbrush
	
	
	Touching spilled blood
	
	
	Not using condoms and dental dams during sexual contact
	


 

Handwashing

One must trust in personal hygiene to lower the risk of spreading or acquiring the hepatitis virus. Here are some preventive steps you can follow by washing hands:

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	Washing your hands thoroughly after accessing the restroom
	
	
	When you get in touch with an infected person's blood, or stool
	
	
	After daycare routine for caretakers
	
	
	After a diaper change, and before serving food.
	


 

Avoiding contaminated consumption:

Contaminated or infected food and water may become the primary causes of hepatitis infection. One should take these precautions to avoid any contaminated consumption of food or water:

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	Avoid eating raw shellfish
	
	
	Beware of fruits that have been washed in contaminated water
	
	
	Avoiding unhygienic street vendors
	
	
	Use bottled water for brushing or oral cleaning in areas where clean water is not available
	
	
	Bringing the water to a 1-minute boil is a must in doubtful areas
	
	
	Heated food to be eaten right away
	


Hepatitis: Some Ways To Prevent Yourself

Hepatitis- related to an inflammatory condition of the liver. It occurs mainly due to infection caused by viruses but there are other possible causes as well. Hepatitis can be temporary or viral. Temporary hepatitis, which is acute in nature, gets resolved on its own. Viral hepatitis can be of five types, a, b, c, d, and e.

Symptoms of hepatitis

Hepatitis, in its initial phase, is called the acute phase. The following symptoms along with mild flu are visible:

Loss of appetite
Fatigue
Joint pains
Pain in the abdomen
Nausea
Weight loss
Jaundice
Though this phase is not really dangerous for some patients, it can result in liver failure leading to death.

How is hepatitis diagnosed?

Physical examination
Laboratory tests
Imaging tests


Treatment for hepatitis

Treatment options for different types of hepatitis are:

Hepatitis a: this doesn t require treatment as it is short-term in nature. In case the symptoms cause a lot of discomforts, then bed rest is recommended. The vaccine is available to prevent this infection.

Hepatitis b: acute hepatitis b doesn t require treatment either. Its chronic form can be treated with antiviral medications. This can be prevented with vaccination.

Hepatitis c: this type of hepatitis, both in its acute and chronic forms, is treated through antiviral medications.

Hepatitis d: according to a study in 2013, a drug known as alpha interferon is used to treat this type of hepatitis. Unfortunately, this only comes to the rescue of 25-30% of people.

Hepatitis e: this acute form of hepatitis gets resolved on its own. Adequate rest, drinking a sufficient amount of water, and taking enough nutrients in their food are some of the ways to get healed from this disease.


 

Hepatitis: Signs, Diagnosis, And Treatment

Hepatitis is a condition that affects the liver by causing inflammation which is a common outcome resulting from a viral infection. While different types of hepatitis diseases are caused by different causes, there are some reasons like medications, toxins, alcohol, and drugs that are typically known.

 

Types

The five common types of viral hepatitis are hepatitis a, b, c, d, and e.

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	Hepatitis a
	


Hepatitis a is the result of an infection caused by the hepatitis a virus. This type of hepatitis is an acute disease.

 


	
	Hepatitis b
	


The hepatitis b virus causes hepatitis b. This is often a chronic disease that lasts longer.

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	Hepatitis c
	


Hepatitis c comes from the hepatitis c virus. It is one of the most common bloodborne infections in the world. It is a long-lasting condition.

 


	
	Hepatitis d
	


This is a not so commonly found form of hepatitis that only occurs in hepatitis b infected people. This virus not only causes liver inflammation but also cannot be contracted without an existing hbv infection.

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	Hepatitis e
	


Hepatitis e is waterborne. Hepatitis e virus infection is responsible for it. It is generally acute but can be severely chronic for pregnant women.


 

Causes of viral hepatitis

It is true that different types of viral hepatitis infections are caused by distinct modes of transmission. Here are the causes of a hepatitis infection:

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	Hepatitis a- when a person is exposed to the hepatitis a virus through food or water.
	


 


	
	Hepatitis b- when an individual comes in contact with hepatitis b virus through the transmission of bodily fluids like blood, semen, etc.
	


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	Hepatitis c- when someone gets infected with the hepatitis c virus through the contamination of bodily fluids.
	


 


	
	Hepatitis d- when a person is exposed to hepatitis d virus-infected blood, it causes this disease.
	


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	Hepatitis e- when a person comes in contact with the hepatitis e virus through water or food.
	


 

Causes of non-viral hepatitis

Although hepatitis is commonly caused due to an infection, other factors can also be reasons to cause hepatitis.

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Alcohol

Excessive alcohol can lead to liver damage, causing inflammation. It can also be called alcoholic hepatitis. The alcohol impacts the liver cells directly. Moreover, it can also cause cirrhosis or even permanent liver failure.

 

Autoimmune system response

In rare cases, the immune system of a person attacks the liver itself. It leads to inflammation that can be mild to severe according to the infection. Moreover, it s more common in females than in males.

How Is Hepatitis Caused And Some Common Types?

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