Knee replacement can be extremely painful. Previously, opioids or narcotics were administered for pain relief. But excessive addition of opioids is not exactly effective for controlling pain. 

Multimodal pain management has become an important part of the perioperative care of patients undergoing total joint replacement. The principle of multimodal therapy is to use interventions that target several different steps of the pain pathway, allowing more effective pain control with fewer side effects. Many different protocols have shown clinical benefit. The goal of this review is to provide a concise overview of the principles and results of multimodal pain management regimens as a practical guide for the management of joint arthroplasty patients.

Multimodal denotes administering two or more than two types of medications that work with different mechanisms. The following are the techniques used:

Pre-operative Femoral Nerve Block: Prior to the surgery, a catheter is placed beside the femoral nerve for blocking it. This nerve is located in the upper thigh. Medication is delivered through the catheter for the nerve to be numbed for 24 hours. Thus, pain signals to the brain are blocked. This method reduces the use of narcotics and the consequent side effects.

Patient Controlled Analgesia (PCA): This method is also known as  Pain Pump . An intravenous pump is used to administer pain relief medications, such as oxymorphone or morphine, after the surgery. The control button of the machine could be pressed, by the patient for 6 to 10 times per hour. The machine is used for two post-operative days.

Oral Medications: The oral medications include Non-Steroidal Anti-Inflammatory drugs or NSAID; such as Celebrex which is similar to aspirin, structurally. Alternatively, acetaminophen, such as Tylenol or its equivalent composition, can also be used.

Acetaminophen: It acts on the Central Prostaglandin Synthesis and relieves the patient of pain through multiple mechanisms.

Epidural Analgesia: It produces lower pain scores and involves less time for achieving physical therapy goals. However, this is subject to side effects such as dizziness, urinary retention and itchiness.

Gabapentinoids: These medications include membrane stabilizers such as Gabapentin and Pregabalin.

The objective of multimodal treatments is to provide quick relief to the patient and immediately so. Earlier the rehabilitation, more successful will be the knee replacement surgery.

Multimodal Pain Relief After Total Knee Replacement

Why does PAIN occur? Understand the Mechanism of Pain

Pain is an unpleasant and distressing physical sensation caused by disease or injury, which induces hurt and anxiety in those suffering from it.
There are many different manifestations of pain, ranging from short term (acute pain) to long term (chronic pain). Other classifications include pain in the internal organs (visceral pain), injured tissue (inflammatory pain), nerves (neuropathic pain), etc.

The reason for the occurrence of pain depends on the cause and kind of pain being experienced. In most cases, pain acts as a warning sign that the body has been afflicted by a disorder of some sort, which may have arisen due to internal sickness or external wounding. Acute pains are generally cured on their own through rest or simple medication. Chronic pains, on the other hand, are more complicated in nature and the treatment requires more elaborate diagnosis.

The mechanism of pain

Pain is an extremely personal and subjective experience and affects each individual to varying degrees. The pain signals, which can arise in any part of the body, travel through the spinal cord to the brain along thousands of specialized nerves and nerve fibres. In the brain, it is processed in the centres associated with anxiety, emotions, memory, appetite, etc. Signals and pain inputs are then returned from the brain to the spinal cord, which may heighten or diminish pain.

In some cases, pain may also be induced by damage to the brain and spinal cord, which happens after a stroke.
A constant barrage of pain signals may cause the cells at the end of nerve fibres to become over-sensitized. This is known as 'wind-up' and is one of the most common causes of chronic pain that occurs even though the root of the problem has been identified and treated.

The causes and effects of pain differ from case to case depending on the signals received by the brain and its interpretation. It affects the individual's day to day activities and if persistent, can also have a harmful impact on mental health and psychosis. Pain is always handled, diagnosed and treated differently in all patients by drawing out the best possible solution to the problem.





Why does PAIN occur? Understand the Mechanism of Pain

Calcium is known for its role in maintaining the bone health, from keeping your teeth stronger to normal functioning of the cells.  But there are various factors, which lead to a deficiency of calcium in the human body and paves the way for several complications.

Here are the top three signs that indicate you are suffering from calcium deficiency.

Difficulty in sleeping: Sleep is essential for your bone health and calcium is directly associated with your sleep cycle. The level of calcium in your bones rises and falls when you are asleep and it reaches its peak when you are in deep slumber. This indicates that when you are unable to sleep properly, it is a warning sign of calcium deficiency. There are various researches that have confirmed, that by increasing the level of calcium, it is possible to restore the normal sleep cycle of an individual. This is also related to the role that calcium plays in the production of a sleep hormone called melatonin. When the calcium content in the body is really low, this hormone is not produced, thus, making it difficult for a person to sleep.
Difficulty in losing extra pounds: Yet another frustrating aspect of any individual s life is the inability to shed off excess pounds. This issue is also linked with the lack of calcium supply in the body. The calcium that s stored in the cells assists in the processing and storage of fat. So the fat cells with high calcium content burn faster, making you lose weight. Thus, if you have trouble losing weight in spite of having a well-regulated diet and regular workout, it s a sign that you are suffering from low calcium.
Paresthesia: Though this ailment is not much heard of, it could be a sign of calcium deficiency. Paresthesia is a nervous disorder, which causes tingling sensation, tremors, numbness and loss of sensitivity. It could also lead to poor concentration, amnesia, confusion, hearing impairment, twitches and other physical as well as neurological impairment. This is because low calcium in the blood is connected with the health of your nerves.
The deficiency of calcium can manifest itself in different intensity, ranging from the non-existent to minimal to severe levels. Chronic calcium deficiency can lead to life-threatening diseases like rickets, osteopenia, and even osteoporosis. Therefore, you shouldn t ignore these signs and consult an expert without delay.

Calcium Deficiency - 3 Signs You are Suffering from it

A meniscus tear is a common injury associated with the knee. The meniscus acts a defensive shield, providing a much-needed cushion to the knees, keeping it stable and injury free. Each knee joints contain two menisci located between the tibia and the femur. In this article, we will discuss important details related to meniscus tear to help you understand the injury better.

Facts related to a Meniscus Tear

A meniscus tear can affect all and sundry. However, sports persons (especially those associated with soccer, tennis, football, and basketball) and aged people are more susceptible to the condition.
As per Boston Children's Hospital, of late there has been a steady rise among children suffering from the meniscus tear.
Osteoarthritis may act as a catalyst, accelerating the chances of a meniscus tear.
In most of the times, a meniscus tear occurs when you exert immense pressure on the knee joints such as lifting a heavy object or suddenly standing up from a squatting position. With age, the meniscus is known to suffer from a natural wear and tear resulting in the injury.
As already mentioned, there are two menisci present in each knee joints. The one present inside the knee joint is called Medial Meniscus. Lateral Meniscus is the one present on the outer part of the joint.
Depending on the extent and severity of the injury, a meniscus tear may be
A minor tear: This is a small injury accompanied by mild pain and swelling which may last for not more than 2-3 weeks.
A moderate tear: The injury results in pain that are concentrated mainly around the center or the sides of the knee. The swelling goes from bad to worse over the next 2-3 days, with the person facing discomfort while bending their knee. The knee also stiffens. You may be relieved of the symptoms within a week or two but overusing the knee or twisting it may cause a relapse.
A severe tear: True to its name, your knee is the worst affected in this case. The cartilage tear may be such that the torn pieces get lodged in between the joint spaces causing the knee to lock, pop or even catch. A person experiences unbearable pain and discomfort along with stiffness and swelling (can be immediately following the injury or within 2-3 days). In the case of a severe meniscus tear, a person may not be able to straighten the knee at all (without treatment and medical intervention)
Treatment for a meniscus tear may be surgical or nonsurgical.
The nonsurgical treatment involves the application of cold compress on the affected area. The person needs to take ample rest exerting minimum pressure on the affected knee. Physiotherapy and strengthening exercise can go a long way in improving the condition. To reduce the pain and swelling, the doctor may prescribe painkillers and NSAIDs (Nonsteroidal Anti-Inflammatory Drugs). Keep the knee elevated. The use of elastic wraps may be helpful.

In extreme cases, surgery may help to treat the injury and the associated symptoms.

Facts About a Meniscus Tear!

Meniscus refers to the soft ligament in your knee joint, which cushions your bones and protects it from wear and tear. It is vital for the fulfilment of regular activities and the health of your bones. Thus, a damage to the meniscus can be extremely painful. Meniscuses are exposed to injuries and shocks in case of rigorous activities and this is a fairly common syndrome faced by athletes and sports person. It can cause a substantial amount of hurt and generally impairs movement to a large extent. It potentially gets worse as the inflammation sets in and the swelling grows. The risk of a meniscus tear increases with age. The treatment for a torn meniscus depends upon the degree of tear. While minor tears repair on their own, for graver injuries, the following therapies may prove effective.

Symptoms of a torn meniscus
1. You might be able to experience a popping sensation in your knee joint
2. Stiffness and swelling
3. You will experience pain, especially while you are trying to twist your knee
4. You might not be able to straighten your knee completely

The treatment for a torn meniscus depends upon the degree of tear. While minor tears repair on their own, for graver injuries, the following therapies may prove effective:
1. Light exercises: For slightly serious meniscus tears, there are certain knee exercises which are recommended to abort any further damage as well as to repair the wound. Limiting the activities which might exert pressure on the knees, getting adequate rest, using ice packs and wearing neoprene sleeves always aid in recovery.
2. Anti-inflammatory medications: Often, meniscus tears are cured with the help of anti-inflammatory drugs like Ibuprofen. They not only reduce pain but also enable the mending of the injured tissue. However, one needs to be aware of a few side effects which often become natural repercussions of such drugs. Possibility of ulcers and bleeding get increased by leaps and bounds on the intake of such drugs.
3. Surgery: For all other forms of meniscus tears, if healing is not obtained through non-surgical methods, the only option available is that of surgery. Such a situation arises when the pain becomes unbearable and the meniscus tear does not respond favorably to superficial treatments. These surgeries are less complicated than replacement surgeries. They usually do not involve any life threatening hazard and cautious and efficiently conducted surgeries release all pains and handicaps.

Torn Meniscus Knee Treatment - Exercise, Anti Inflammatory & Surgery

Knee pain is one of the most common and painful ailments that can limit mobility. Injuries can result in cartilage or meniscal tears or sprains too. Obesity is another reason because of which knee pain is on the rise. Also, regular wear and tear of ligaments and tendons around the knees due to old age is another cause. These days, with reduced physical activities and sedentary lifestyles, the rate at which knees are wearing out has also become accelerated. Whatever the reason, a correct diagnosis followed by prompt treatment can help. Over the years, physiotherapy has been playing an important role in treating knee injuries. Whether to supplement the various drugs to reduce pain and inflammation or to avoid surgery, physiotherapy has helped many and its popularity is growing every day. Here are some ways that physiotherapy can help reduce pain.

Improve flexibility of tendons: The knee cap is an area where there are lot of tendons and ligaments, coordinating to enable movement. Careful exercising can ensure that the flexibility of tendons and ligaments is improved, thereby making your knee movement easier and less painful.
Improves blood supply: As we all know, proper movement requires good blood supply. Exercising with special focus on the knee ensures that blood supply is improved, and thereby the supporting ligaments and tendons function optimally.
Enhances the knee cap function: The knee cap is that portion which joins your thigh bone to your calf bones. This is prone to slip out of place, especially with arthritis and injuries. This can be painful and limit movement to a great degree. Focused exercises aimed at improving knee cap function will ensure that the knee cap has a wider range of function, and does not slip out of its socket easily.
Reduce rigidity: Once you start physiotherapy, you will feel your knees getting more flexible. The rigidity that had set in as a result of injuries and/or old age will also reduce over a period of time.
Slow down the wear and tear: When you start physiotherapy after knee damage, continuing the exercise routine, of course with expert guidance, can reduce the pace at which further damage might happen. A word of caution though. Be sure to consult an experienced physiotherapist before you begin. Exercising in a bad manner can do equal or more harm than the original injury or old age itself.

Knee Pain and Physiotherapy

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