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Last Updated: Mar 20, 2020
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Polyarteritis Nodosa - Symptoms, Causes And Treatment

About Symptoms Causes Diagnosis Treatment Complications Is polyarteritis nodosa hereditary?

What is Polyarteritis nodosa?

Polyarteritis nodosa (PAN)occurs when the arteritis swells due to some damage. Primarily the effect is on the small and medium arteries but it can also become serious when it occurs in the blood vessels caused due to malfunction of the immune system. If you suffer from any such complication then you must visit the doctor before the symptoms become chronic.

What are the signs and symptoms of polyarteritis nodosa?

Polyarteritis Nodosa can also cause a severe effect on your central nervous system thus affecting all your organs. The symptoms include:

  • Fever
  • muscle and joint pain
  • abdominal pain
  • excessive fatigue
  • sudden weight loss
  • decrease of appetite

What is the cause of polyarteritis nodosa?

The cause of PAN (Polyarteritis nodosa) is not known completely but it is classified as an autoimmune disorder and one of the reasons for occurrence for PAN is when natural defense system attacks healthy tissues by mistake. Sometimes PAN is It also associated with hepatitis B and hepatitis c infection.

Polyarteritis Nodosa can affect the nervous system of your body and 70 percent of people may get affected due to this. PAN can also lead to seizure and neurological issues if not treated on time.

It also includes a reduction in alertness and cognitive dysfunction of the body. In this skin lesions also become common during PAN and mainly affects the skin of hands and legs, which can be very painful.

How Is Polyarteritis Nodosa Diagnosed?

There is no specific test for diagnosing Polyarteritis Nodosa. Doctor will include symptoms, will talk about the detailed history of the disease, physical examination, laboratory tests, and image studies.

Laboratory testing includes blood test, urinalysis and it also helps diagnosis of PAN.

  • Imaging: If the doctor suspects PAN an X-ray and an angiogram is done while injecting a contrast agent which helps in diagnosis. Narrowing of blood vessels can be detected by angiogram. CTA or MRA are also used for looking the changes in the blood vessel.
  • Biopsy: in this biopsy of affected tissue is done and it is surgically removed. After which analysis of tissue is done and also sample taken from affected blood vessel or organ confirms the diagnosis completely. Most of the biopsies for PAN are taken from skin, nerve or muscle tissue.

Is polyarteritis nodosa fatal?

Polyarteritis nodosa can be fatal sometimes if it remains untreated and it can even cause death due to kidney failure, heart or gastrointestinal complications. But if PAN is detected at an early stage then it can be treated.

What is the treatment for polyarteritis nodosa?

The most common treatment for Polyarteritis nodosa is the combination of drugs that are being prescribed, include: Corticosteroid, antiviral medications, immune suppressants.

These medications help reduce the symptoms of PAN by reducing inflammation as they replace certain hormones in the body.

A corticosteroid helps to keep your arteries safe by keeping the immune system away so that they cannot keep damaging the arteries but they must be taken in combination with immunosuppressive medications.

Comparable medicines like methotrexate, azathioprine or mycophenolate that let the steroid dosage to be reduced too are put into use. If the condition is particularly severe Cyclophosphamide is put into use.

What are the complications associated with polyarteritis nodosa?

There are a number of complications associated with polyarteritis nodosa which are inclusive of the following:

  • Heart attacks may result from polyarteritis nodosa.
  • Perforation and necrosis of the intestines may also result from polyarteritis nodosa.
  • Kidney failure is yet another common complication.
  • Strokes may also occur due to the disease.

Is polyarteritis nodosa hereditary?

A genetic predisposition of Polyarteritis nodosa is still not known. In the majority of cases, the etiology is unknown.

Does polyarteritis nodosa go away?

There is no cure for polyarteritis nodosa but it can be diagnosed and the symptoms can be managed. Treatment is available to present the progression of the disease and from damaging any kind of organ failure.

Popular Questions & Answers

I am 37 yrs old male. I have Polyarteritis nodosa from last 3 months. Please help me.

B.H.M.S., Senior Homeopath Consultant
Homeopath, Delhi
Please take con. Mac. - 0/2 three times a day for one month. Revert back after one month with feedback.
1 person found this helpful

I am 22, and I am having pain in testicles, pain so much heavy and lasts about 1-2 hrs, I observe that, this happen when I meet my girlfriend, please help me with this.

MBBS, MS - General Surgery, MCH- Urology
Urologist, Kolkata
This is happening due to congestion of the epididymis which is the route of semen from testis to penis. It happens when you get excited but don't ejaculate. So mustarbation will help to reduce such pain.

I am losing my hair from two years and I have experienced so many medicine after consultation with doctors but all treatments failed I request your advice.

Trichologist
Dermatologist, Mumbai
Hair loss is of various kinds.It can be simple hair fall or thinning of hair,Alopecia,Trichorhexis nodosa etc.It is very important to understand the problem first and then treat it. Hair is made up of minerals,protein and iron.These all forms the ...

I have pain in my testicle part on both. Im worried about. Is there anything to worry. Please suggest me.

Bachelor of Ayurveda, Medicine and Surgery (BAMS), MBA (Healthcare)
Ayurveda, Dehradun
Hi Pain in the testicles can be caused by minor injuries to the area. However, if you’re experiencing pain in the testicle, other most possible conditionss pain in testicles are; 1.Torsion of Testes; This condition is considered a medical emergenc...
1 person found this helpful

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