This medication is an anti-hypertensive drug composed of Sacubitril and Valsartan. It is used for treatment and prevention of chronic heart failure and other heart conditions. The tablet works by inhibiting a prodrug neprilysin which reduces the strain on the failing heart.
Consult your doctor if you experience any side-effects such as low blood pressure, swelling in ankles and feet, feeling short of breath, fainting, dizziness and high blood potassium levels. Some other rare side effects include muscle weakness, painful urination, little or no urination, tingly feeling, slow heart rate, weak pulse, cough and renal impairment.
You should not use this medicine if you are allergic to it or if you have ever had a severe allergic reaction to any blood pressure medication. Patients suffering from diabetes, liver disease or a kidney disease should exercise caution.
Is It safe with alcohol?Interaction with alcohol is unknown. Please consult your doctor.
Are there any pregnancy warnings?Pregnant women must consult doctor before consuming this medication.
Are there any breast-feeding warnings?Breastfeeding women should not use this medication. Please consult your doctor.
Is it safe to drive while on this medicine?Occasionally dizziness or weariness may occur.
Does this affect kidney function?There is no interaction between renal impairment and consuming this drug. So dose alteration is not needed.
Does this affect liver function?There is no data available. Please consult doctor before consuming the drug.
Are there any missed dose instructions?Missed dose should be taken as soon as possible. Skip your missed dose if it is the time for your next scheduled dose.
Are there any overdose instructions?Consult your doctor in case of overdose.
This medicine blocks the enzyme neprilysin, which leads to the degeneration of atrial and brain natriuretic peptide. When these peptides remain excessively active the blood pressure is reduced, as the blood volume is lowered.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Alcohol
AlcoholConsumption of alcohol is not advisable.
Interaction with Food
FoodIf you are allergic to any food, please consult with the physician.
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Valsartan- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 09 May 2019]. Available from:https://druginfo.nlm.nih.gov/drugportal/name/valsartan
Valsartan- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 09 May 2019]. Available from:https://www.drugbank.ca/drugs/DB00177
Sacubitril- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 09 May 2019]. Available from:https://druginfo.nlm.nih.gov/drugportal/name/sacubitril
Sacubitril- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 09 May 2019]. Available from:https://www.drugbank.ca/drugs/DB09292
ENTRESTO- sacubitril and valsartan tablet, film coated- Daily Med [Internet]. dailymed.nlm.nih.gov. 2018 [Cited 09 May 2019]. Available from:https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=000dc81d-ab91-450c-8eae-8eb74e72296f
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