This tablet is an anti-hypertensive medication and primarily consist of sacubitril and valsartan. It helps in the treatment and prevention from chronic heart failure and other heart conditions. The medication inhibits a prodrug neprilysin and reduces the strain on the failing heart.
Consult your doctor if you experience any side-effects due to this medicine. Some common side effects are low blood pressure, swelling in ankles and feet, feeling short of breath, fainting, dizziness and high blood potassium levels. Other side effects include muscle weakness, painful urination, slow heart rate, weak pulse, cough and renal impairment.
You should not use this medicine if you are allergic to it or ever had a severe allergic reaction to any blood pressure medication. Avoid taking the tablet if you have kidney disease, liver disease and diabetes.
Is It safe with alcohol?Interaction with alcohol is unknown. Please consult your doctor.
Are there any pregnancy warnings?This medicine should be avoided by pregnant women unless suggested by the doctor. The effect of this medicine on fetus is not clearly established. Hence, Doctor consultation is recommended before consumption.
Are there any breast-feeding warnings?This medicine is probably unsafe to use during breastfeeding. Please consult your doctor.
Is it safe to drive while on this medicine?Occasionally dizziness may occur.
Does this affect kidney function?There is no interaction between renal impairment and consuming this drug. So dose alteration is not needed.
Does this affect liver function?There is no data available. Please consult doctor before consuming the drug.
Are there any missed dose instructions?It is suggested to take the missed dose as soon as possible.
Are there any overdose instructions?Immediate medical attention is needed in case of overdose.
The tablet blocks the enzyme neprilysin, which leads to the degeneration of atrial and brain natriuretic peptide. When these peptides remain excessively active the blood pressure is reduced, as the blood volume is lowered. Valsartan is an ARB. It brings about inhibition of combination to angiotensin II to AT1 selectively. This occurs within many tissues such adrenal glands and smooth vascular muscles.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Medicine
MedicineDo not take this medicine in combination with insulin, dexamethasone, angiotensin-converting enzyme inhibitors, non-steroidal anti-inflammatory medicines and spironolactone.
Interaction with Disease
DiseaseAvoid using this medication if you suffer from kidney or liver disease and hypo-tension.
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Valsartan- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 09 May 2019]. Available from:https://druginfo.nlm.nih.gov/drugportal/name/valsartan
Valsartan- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 09 May 2019]. Available from:https://www.drugbank.ca/drugs/DB00177
Sacubitril- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 09 May 2019]. Available from:https://druginfo.nlm.nih.gov/drugportal/name/sacubitril
Sacubitril- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 09 May 2019]. Available from:https://www.drugbank.ca/drugs/DB09292
ENTRESTO- sacubitril and valsartan tablet, film coated- Daily Med [Internet]. dailymed.nlm.nih.gov. 2018 [Cited 09 May 2019]. Available from:https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=000dc81d-ab91-450c-8eae-8eb74e72296f
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