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Tacrolimus

Prescription vs.OTC: Prescription by Doctor required
Last Updated: December 14, 2018

Tacrolimus belongs to a group of medicines which are known as immunosuppressants. Thus, the drugs effectively weakens the immune system in order to make it easier for the body to adjust itself with the new organ that has been transplanted. The transplanted organ may be a heart, kidney or even liver.

Tacrolimus can be taken orally either with a meal or without. Although it is best advised that the medicine is taken without food, patients who suffer from nausea and experience stomach problems can take it along with a meal. But in this case, the body absorbs a smaller amount of the drug. However, your choice of taking the medicine should be constant. Do not take the drug without meal on some occasions and with meal on others. This will greatly affects the amount of medicine the body takes in at a time.

The dosage of the medicine generally depends on the weight of the patient, his health, results of the blood tests done and the body’s response to the treatment. Before you discontinue with Tacrolimus seek your doctor’s advice.

Side effects are a part and parcel of taking medicine. Some side effects are temporary and disappear with time, whereas other can be more severe results in major complications. Tacrolimus results in some minor side effects which include appetite loss, headache, problems with sleep, diarrhea and a tingling sensation in the hands and the feet. A few major side effects include kidney problems, irregular heartbeat, dizziness and severe pain in the stomach. There is also a rare chance that a patient may develop a brain infection, which can result in severe complications. Thus, if you experience symptoms like excessive weakness, problems with concentration and thinking, problems with muscle mobility, seizure and vision issues, seek medical help immediately.

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Allergist/Immunologist before using this medicine.

  • Organ Transplant - Rejection Prophylaxis

    Tacrolimus is used to reduce the immune response of the body in organ transplant patients.
  • Allergy

    Not recommended in patients with known allergy to Tacrolimus.
  • How long is the duration of effect?

    The effect of this medicine lasts for an average duration of 2 to 4 days for an immediate release tablet and 3 to 5 days for an extended release tablet.
  • What is the onset of action?

    The effect of this medication can be observed in 0.5 to 6 hours.
  • Are there any pregnancy warnings?

    This medicine is not recommended for pregnant women unless necessary. The benefits and risks should be discussed with the doctor before taking this medicine.
  • Is it habit forming?

    No habit forming tendencies were reported.
  • Are there any breast-feeding warnings?

    This medicine is known to excreted in breast milk. It is not recommended in breastfeeding women unless necessary. The benefits and risks should be discussed with the doctor before taking this medicine.
  • Missed Dose instructions

    If you miss a dose of Tacrolimus, take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.
  • Overdose instructions

    Seek emergency medical treatment or contact the doctor in case of an overdose.
  • India

  • United States

  • Japan

Below is the list of medicines, which contains Tacrolimus as ingredient

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Tacrolimus works by obstructing the action of Calcineurin, a substance found in the white blood cells known as T-lymphocytes. This averts the T-lymphocytes from producing lymphokines, in case a foreign particle is detected in the body.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

  • Interaction with Disease

    Diabetes Mellitus

    This medicine may cause a condition called post-transplant insulin-dependent diabetes mellitus. Insulin should be administered in these patients. Close monitoring of glucose levels is necessary.
  • Interaction with Alcohol

    Alcohol

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Interaction with Lab Test

    Lab

    Information not available.
  • Interaction with Food

    Food

    Information not available.
  • Interaction with Medicine

    Amlodipine

    The effect of Tacrolimus may increase if taken with antihypertensives like amlodipine. Inform the doctor if you have any symptoms of diarrhea, headache, and weakness. Dose adjustments or an alternate class of antihypertensives should be considered based on the clinical condition.

    Carbamazepine

    The effect of Tacrolimus may increase if taken with carbamazepine. Inform the doctor if you have any symptoms of diarrhea, headache, and weakness. Dose adjustments or an alternate class of medicines should be considered based on the clinical condition.

    Live vaccines

    You may be at the risk of developing infections if these medicines are taken together. Inform the doctor if you had received either of these medicines. Your doctor may postpone therapy based on the condition.

    Neomycin

    These medications may increase the risk of kidney injury if taken together. Inform the doctor if you are receiving any antibiotics or pain killers. Close monitoring of kidney function is necessary. Any symptoms of swelling, weight gain, altered urine frequency should be informed to the doctor.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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Table of Content
About Tacrolimus
What are the uses of Tacrolimus
What are the contraindications of Tacrolimus ?
What are the side effects of Tacrolimus ?
Key highlights of Tacrolimus
What are the dosage instructions?
Where is the Tacrolimus approved?
Medicines containing Tacrolimus
How does this medication work?
What are the interactions of Tacrolimus ?