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Pioglitazone

Prescription vs.OTC: Prescription by Doctor required
Last Updated: December 14, 2018

Pioglitazone is a drug used to control high blood sugar levels in patients with type 2 diabetes. It is an anti diabetic drug. It makes the blood cells more sensitive to the action of insulin thus lowering the blood sugar levels in the body. It is used in combination with a proper diet and exercise program to maximize its effects. It also helps in preventing kidney damage, nerve problems and sexual problems. Controlling blood sugar level also helps reduce the risk of a heart attack or stroke.

Pioglitazone is a drug used to control high blood sugar level in patients with type 2 diabetes. It is an anti diabetic drug. It makes the blood cells more sensitive to the action of insulin thus lowering the blood sugar level. It is used alongside a proper diet and exercise program to maximize its effects. It also helps in preventing kidney damage, nerve problems and sexual problems. Controlling blood sugar level also helps reduce the risk of heart attack or stroke.

Pioglitazone is a prescribed drug and should always be taken under the guidance of a medical expert. It is available in three doses: 15mg, 30 mg and 45mg orally consumed tablets. The course duration for this medication is normally3 to 6 months after which the doctor examines its effects on the patient.

There are a few conditions under which you shouldn’t take Pioglitazone: if you are allergic to any ingredients of this medicine, if you have suffered from a heart attack in the past or if you have any liver disease. It is also important to mention to your doctor if you are currently using any prescribed drugs or dietary supplements. Pioglitazone might also cause changes in the menstrual cycle and increase the risk of becoming pregnant. Hence, it is advisable to use reliable birth control while using this medication. During pregnancy, use this drug only when it’s extremely necessary. Pioglitazone might also cause certain side effects.

Some common side effects of this medication are: cold, headache or sore throat. These side effects last for a few days before going away on their own. However sometimes severe side effects occur in which case one should immediately consult the doctor. These side effects are allergic reactions, blurred vision, symptoms of liver problems (like dark urine, stomach trouble or vomiting), or symptoms of low blood sugar. These side effects appear rarely, but if they do, you should immediately consult the doctor.

Pioglitazone should be stored at a temperature between 15 to 25 degrees C. It should be kept moisture free and away from direct sunlight. Keep it out of the reach of children or pets.

type diabetes

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Diabetologist before using this medicine.

Type II Diabetes Mellitus

Pioglitazone is used to control blood sugar levels in adults with Type II Diabetes Mellitus. The medicine is generally taken in conjunction with controlled diet and regular exercise.
Pioglitazone is not recommended if you have a known history of allergy to the medicine. It is not recommended for use in people who are sensitive to any medicine belonging to the parent class Sulphonamide derivatives. It is a very broad group and hence caution is advised.
In addition to its intended effect, Pioglitazone may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.

Hypoglycemia

Major Common

Dizziness

Moderate Less Common

Headache

Moderate Less Common

Nausea

Moderate Less Common

Asthenia

Moderate Rare

Flu like symptoms

Moderate Common

Allergic skin reaction

Moderate Rare

Elevated liver enzymes

Major Common

Anemia

Major Rare

Jaundice

Major Rare

Weight gain

Moderate Common

How long is the duration of effect?

The effect of this medicine lasts for an average of 24 hours.

What is the onset of action?

The effect of this medicine can be observed within an hour of oral administration. However, it takes 2-4 hours for the medicine to reach its peak effect.

Are there any pregnancy warnings?

This medicine is not recommended for use in pregnant women. There is a possibility of an adverse effect on the fetus and there is a lack of conclusive evidence from clinical studies. It is advisable to consult your doctor.

Is it habit forming?

No habit forming tendencies were reported

Are there any breast-feeding warnings?

This medicine is suspected of passing into breast milk and having a harmful effect on the baby. Alternative therapy should be considered in such cases after consulting the doctor.

Are there any missed dose instructions?

The missed dose can be taken as soon as you remember. If it is time for the next dosage then the missed dose can be skipped.

Are there any overdose instructions?

It is recommended to discontinue the medication and contact your doctor immediately if an overdose is suspected. Symptoms like dizziness, confusion, increased heartbeat, tremor and sweating after taking the medication should be reported immediately.

India

United States

Japan

Below is the list of medicines, which contains Pioglitazone as ingredient
Mitoch Pharma Pvt Ltd
Alembic Pharmaceuticals Ltd
Micro Labs Ltd
Alembic Ltd
Elder Pharmaceuticals Ltd
Aprica Pharmaceuticals Pvt Ltd
Mitoch Pharma Pvt Ltd
Mova Pharmaceutical Pvt Ltd
Medley Pharmaceuticals
Dr. Reddys Laboratories Ltd
Wockhardt Ltd
Alkem Laboratories Ltd
Abbott India Ltd
Systopic Laboratories Ltd-Mem
Abbott Healthcare Pvt. Ltd
Pioglitazone activates peroxisome proliferator activator receptor causing an increase in the production of components that breaks down lipids and glucose in the body. It also increases insulin response without effecting its secretion.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

Interaction with Disease

Heart disease

Major
Pioglitazone should be administered with extreme caution if you suffer from any disease of heart and blood vessels.

Kidney disease

Major
Pioglitazone should be administered with extreme caution in you suffer from any disease of the kidneys. You should consult your doctor to make suitable adjustment in dosage quantity and/or time-interval between two dosages.

Liver disease

Major
Pioglitazone should be administered with extreme caution in you suffer from any disease of the liver. You should consult your doctor to make a suitable adjustment in dosage quantity and/or time-interval between two dosages.

Hypoglycemia

Moderate
Pioglitazone should be administered with caution in if you are prone to having episodes of low blood sugar. This population includes diabetics who are also malnourished or those receiving Beta-blocker drugs such as Metoprolol and Propranolol.

Hemolytic Anemia/G6PD Deficiency

Moderate
Pioglitazone is not recommended for use in people suffering from Hemolytic Anemia. Reporting this condition to the doctor is a must. In such cases, alternate medication not belonging to Sulfonylureas should be considered.

Interaction with Alcohol

Ethanol

Moderate
Consumption of alcohol in large quantities is not recommended when you are taking Pioglitazone for controlling blood sugar levels. It is recommended to reduce the alcohol intake so that the adverse effects can be avoided. Symptoms of both reduced or elevated blood sugar levels should be reported to the doctor immediately.

Interaction with Lab Test

Elevated ALT

Minor
You should consult the doctor about the usage of Pioglitazone if a liver test is to be taken in immediate future. This is necessary as the likelihood of getting a false result is very high in such cases.

Interaction with Food

Food

Information not available.

Interaction with Medicine

Gatifloxacin

Major
Pioglitazone is not recommended for use along with Gatifloxacin. You should report the use of either of the medicines to the doctor. Symptoms of high blood sugar, as well as low blood sugar, should be reported immediately. You should not stop the usage of any medicine without talking to the doctor.

Miconazole

Major
Pioglitazone should not be used with the oral form of Miconazole. Report the usage of either of the medication to the doctor. Suitable dose adjustment and safety monitoring are required in these cases. Symptoms like headache, dizziness, tremor, sweating after taking these medicines should be reported immediately.

Fluconazole

Moderate
Pioglitazone should not be used with Fluconazole. Report the usage of either of the medication to the doctor. Suitable dose adjustment and safety monitoring are required in these cases. Symptoms like headache, dizziness, tremor, sweating after taking these medicines should be reported immediately.

Rifampin

Moderate
Pioglitazone should not be used with Rifampin. Report the usage of either of the medication to the doctor. Suitable dose adjustment and safety monitoring are required in these cases. Symptoms like increased thirst, hunger, and urination after taking these medicines should be reported immediately.

Colesevelam

Moderate
Report the usage of either of these medications to the doctor. Pioglitazone and Colesevelam should be taken with suitable time gap to avoid the interaction from happening. Normally, there should be a gap of 4 hours between the administration of these two medicines.

Diclofenac

Moderate
Pioglitazone should not be co-administered with Diclofenac or other NSAIDs. Appropriate dosage adjustment and more frequent monitoring of blood sugar levels are necessary in such cases. Do not stop the usage of any drug without consulting your doctor.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

I have type 2 diabetes since 10 yes. I take Galvusmet 1000/50 twice, Pioglitazone 15 mg. Once, 5 mg tablet once for cholesterol and blood pressure. My hb1ac is 7.cholesterol and BP is excellent. I get high sugar only after lunch 175 to 225. Is my treatment Ok? Is pioglitazone dangerous?

MD - Medicine, Diploma in Diabetes Management
Diabetologist, Surat
I have type 2 diabetes since 10 yes. I take Galvusmet 1000/50 twice, Pioglitazone 15 mg. Once, 5 mg tablet once for c...
Dear lybrate-user, Your HbA1C level shows idea control but 175-225 post meal is still not acceptable. Your current treatment could be modified to meet the target values.

Sir I hve diabetes I take now morn pioglitazone 15+metformin 500 nd night time I take 500 mg metformin. Fasting sugar avrg 105 to 120. Night time after 2 hr of food is 160. pioglitazone is safe to take log time.

MBBS, Diploma In Diabetology
Diabetologist, Mumbai
Sir I hve diabetes I take now morn pioglitazone 15+metformin 500 nd night time I take 500 mg metformin. Fasting sugar...
Since you are overweight, instead of pioglitazone we can start other medication which may help in weight loss.

I am having diabetes mellitus type 2. I m taking metformin 1 gm twice daily and pioglitazone. Still my sugars are not in control. What to do?

MSc
Dietitian/Nutritionist, Hyderabad
I am having diabetes mellitus type 2. I m taking metformin 1 gm twice daily and pioglitazone. Still my sugars are not...
There are several means to gain control over your diabetes. Few of them as below: 1. Eating at regular intervals 2. Avoiding foods high in processed and invisible sugar 3. Good sleep hygiene 4. Consistent workouts to be able to give you specific g...
1 person found this helpful

I am 65, have been taking half tablet of Glitaris M7. 5 after dinner for more than 3 years. Recently, I came to know that this tablet contains Pioglitazone and it has long-term adverse side effects. What is the substitute to this?

MBBS
General Physician, Mumbai
I am 65, have been taking half tablet of Glitaris M7. 5 after dinner for more than 3 years. Recently, I came to know ...
When Benefits outweigh the risks we have to prescribe few medicine And In a known case of diabetic we need to control sugar levels with medication , aerobic exercise and following a diabetic diet.
1 person found this helpful

I have been taking Glitaris M7. 5 (Pioglitazone 7.5 mg) as anti diabetic since more than 10 years. My endocrinologist insists that I should continue with it. I understand that Pioglitazone improves body's ability to use insulin to lower blood sugar. However, I read that Glimepiride also helps tissues respond better to insulin. It means both have similar functions (advantages). My question is, as Pioglitazone has more side effects than similar medicines (ref. Literature), should I switch over to Glimepiride as a substitute to Pioglitazone?

MBBS Bachelor of Medicine and Bachelor of Surgery, nMRCGP, Post Graduate Diploma in Diabetology
Diabetologist,
I have been taking Glitaris M7. 5 (Pioglitazone 7.5 mg) as anti diabetic since more than 10 years. My endocrinologist...
Dear Lybrate user, I understand that you have been doing quite a bit of research on the medications, but I just want to make one correction. You are right about pioglitazone, but not the glimepiride whose main function is to stimulate insulin prod...
1 person found this helpful

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Table of Content
About Pioglitazone
When is Pioglitazone prescribed?
What are the contraindications of Pioglitazone ?
What are the side effects of Pioglitazone ?
Key highlights of Pioglitazone
What are the dosage instructions?
Where is the Pioglitazone approved?
Medicines containing Pioglitazone
How does medicine works?
What are the interactions for Pioglitazone ?