Orencia 250Mg Injection is an injectible medicine. It is also called an immunodepressent that inhibits the functions of the immunity system of the body in the form of an antibody modified by man. This drug is mainly used to treat rheumatoid arthritis. It helps to detain the advancement of the disease and controls the damage caused by rheumatoid arthritis. It also helps to reduce the uncomfortable and painful symptoms of the disease. It helps to reduce the muscular and structural damage, stop the destruction tissues, and reduce the inflammation of the cartilage that weakens the bones. It helps to stop the disease from progressing to the joints surrounding the affected area.
Common side effects include persistent headache along with dizziness, hypertension or hypotension, nausea and vomiting, skin rashes or an infection in the upper respiratory tract along with breathing difficulties.
Orencia 250Mg Injection is a prescription drug that is not recommended for pregnant women or breastfeeding women as there are potential health risks that may be caused in foetus or infants. There may be certain serious drug interactions causing unnecessary complexities. You must inform the doctor if you are taking any kind of hormonal birth control pills, dietary supplements or any other kind of prescription drugs.
Juvenile rheumatoid arthritis also known as juvenile idiopathic arthritis is a commonly occurring arthritis in children under the age of 15. Some common problems that are faced by patients with this disease include stiffness, joint pain, and swelling. While the symptoms might persist for a few months for some patients, for others it might continue for the rest of their lives. Patients might face serious complications such as inflammation of the eye, problems related to growth etc. The treatment of this condition focuses on preventing the bones from getting damaged, pain control and improving the function of the body.
What are some of the common symptoms of juvenile arthritis?
What are the causes of Juvenile Rheumatoid Arthritis?
Juvenile Rheumatoid Arthritis occurs when the immune system of the body attacks its own tissues and cells. It is still unclear as to why it happens, although, researchers believe that the environment and heredity have a role to play. Certain geneticmutations might make a childmore vulnerable and susceptible to microbes that can trigger this condition.
What are the complications involved?
There could be several complications that might arise due to this condition. It is, therefore, wise to keep a close watch on the child. Seeking immediate medical attention can go a long way in mitigating the risk of these complications.
How to diagnose juvenile arthritis?
It is not very easy to diagnose juvenile arthritis. Doctors often prescribe blood tests to get an idea of erythrocyte sedimentation rate, rheumatoid factor, C-reactive protein, anti-nuclear antibody, cyclic citrullinated peptide etc. A doctor might also prescribe imaging tests such as X-rays, MRI etc to detect congenital defects, fractures, tumors etc.
What are the treatment options available?
Some of the medications that are prescribed for this condition include NSAID such as ibuprofen and naproxen, DMARD such as Trexall and Azulfidine, TNF blockers such as Humira and Enbrel, immune suppressants such as Kineret, Rituxin and Orencia. In addition to this doctors would also prescribe corticosteroids and therapies.
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Rheumatoid arthritis is a chronic inflammatory arthritis with a prevalence of 0.5-1% in India. It is characterized by joint pain and swelling associated with morning stiffness lasting for more than 30 minutes. It generally has a slow onset - over weeks to months, though the onset can be acute also. Most common joints involved are small joints of hands and feet. Larger joints like knee and shoulder can also be involved. The incidence of RA increases with age. It is twice more common in females than in males. Early treatment is necessary to bring down the inflammation, avoid joint deformities and prevent other complications (lung, heart, vasculitis).
Predisposition to RA is multifactorial. It has a genetic component (family history of RA increases the risk). Environmental factors like smoking also play a role.
Initial symptoms start with fatigue, malaise, generalised bodyaches, low-grade fever. The onset is generally slow and eventually patient develops joint pain and swelling. Though the joint involvement is symmetrical in most cases, asymmetric onset is common (involving joints predominantly on one side).
Diagnosis is made by a physician after detailed history, clinical examination and supportive lab tests. Rheumatoid factor and anti-CCP antibody are positive in 75-80% patients with RA. They have raised inflammatory markers (ESR, CRP) during active inflammation.
RA treatment options are wide and quite effective. It starts with patient education regarding nature of the disease and the risk of complications. The need of early aggressive therapy should be emphasized. The patient should put in efforts for physiotherapy which play a very important role in muscle strength and joint mobility. Pharmacotherapy options are wide and include disease-modifying antirheumatic drugs (DMARDS). These can be conventional DMARDS like methotrexate (usually the first line drug), sulfasalazine, hydroxychloroquine, leflunomide. Failure to adequately respond to these drugs should lead your Rheumatologist to consider Biologic DMARDS (TNF antagonists, Rituximab, Abatacept, Tocilizumab). Your Rheumatologist is the best person to guide you about dose, indications, monitoring and side effects of the drugs used in RA. Treatment duration depends on patient's response but is generally long (5-10 years or lifelong).
COMPLICATIONS BEYOND JOINTS:
RA patients can have rheumatoid nodules in skin, lungs, heart and other sites. These patients are at risk of accelerated bone loss, so calcium and vitamin D intake should be optimized. Eye complications include dryness, redness (scleritis and episcleritis) and certain eye threatening complications. Lung involvement can be seen in various forms (fluid in lungs, nodules, interstitial lung disease).
These patients are at high risk of atherosclerosis (heart and blood vessel disease). They also have a tendency to have frequent infections.
NEED OF THE HOUR:
All patients with joint pains should be seen early by Rheumatologist for diagnosis and treatment. With so many treatment options, no patient should suffer from joint deformities and other complications associated with long standing, untreated RA. LEAD A HEALTHY LIFE! If you wish to discuss about any specific problem, you can consult a rheumatologist.