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Mitotax 300 MG Injection Health Feed

Asked for male, 57 years old from Mumbai
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My father has been diagnosed with Non-Small Cell Lung Cancer, Stage 4 with primary tumour in his Left Upper Lung and metastasis in Liver and Bone. The biopsy report has confirmed it to be adenocarcinoma. The cancer was detected while he was admitted at a hospital in Mumbai and was undergoing treatment for Acute Paraplegia which happened on 02 Nov 16, due to arteries-Venous Fistula at D-10 level resulting in oedema/ ischemia of the spine from D-5 to Conus. After two failed attempts of embolization, towards treatment of the AVF, surgical clipping of the fistula was undertaken on 10 Nov 16. As part of post-operative rehabilitation therapy for his paraplegia, he was given 65 session of Hyper-basic Oxygen Therapy at 2.4 ata pressure for about two and a half month and about two hour of Physiotherapy for the same duration. My father was recovering well and had started walking with the help of support (walker). MRI of the spine taken in mid Jan & Mid June 2017 indicates that the spinal cord oedema had improved significantly, although atrophy of the spine cord is still present. He complained of wheezing and breathing difficulty and towards ascertaining the cause a X-ray was taken on 23 Feb 17 which showed massive pleural effusion in his left lungs. A series of tests followed with the ultimate result as NSCLC Stage 3B. He was started with CCRT treatment which concluded on 05 May 17. During the treatment he was given daily dose of radiation therapy using IGRT (60 Gy/ 30 #/6 weeks) and weekly chemotherapy with paclitaxel (150 mg) & Carboplatin (300 mg) for 6 weeks. Despite the treatment, the cancer is advancing and has now spread to Liver and Bones as brought out in his latest PET CT report. Lung tissue which was obtained during CT guided biopsy conducted in the month of Mar 17, before the CCRT treatment was started, has tested positive for EGFR mutation – “E746_A750del is detected in EXON 19 of EGFR gene”. The medicine oncologist has however said that the gene profiling of the primary tumour tissue is not sufficient for starting Targeted Therapy and gene profiling of a tissue obtained from any of the metastatic site is necessary for the same. Three procedures have been undertaken to obtain tissue sample from the metastases site, twice from the liver and once from the pleural deposits, and all the three times the cancerous tissue could not be obtained. Due to non-availability of conformed cancerous tissue from the metastases site, a firm treatment plan has yet not been made for my father. In the meantime, the doctor has recently started my father on Erlotinib 150 mg OD as there has been considerable delay in his next phase of treatment due to non availability of metastases cancerous tissue. Could you please help me by answering the following:- 1.Can you suggest anything towards treatment of my father? 2.Is gene profiling of tissue from a metastases site absolutely necessary for starting targeted therapy for my father? 3.I read online that Erlotinib or Afatinib can be used as Targeted Therapy for patient with EGFR Lung cancer mutation. Is this true? If yes, will a daily tablet of these drugs be sufficient for his next phase of treatment, or a concurrent conventional chemotherapy is also required? 4.Can 65 session of Hyper-basic Oxygen Therapy at 2.4 ata given at a stretch of about 80 days, with a daily dose of 02 hour be a cause of his cancer? I have read it online that the oxygen free radical produced during HBOT treatment can cause cancer.

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MS, DNB (Surgical Oncology)

Oncologist•Jodhpur
Hi lybrate-user, You summarize the case very well. I understanding of your case says, he has Ca lung adenoca, treated with dCTRT, that progressed and now disseminated disease, which is not curable by any means. The goal of the treatment in such cases would be palliative only, which means to increase longevity without causing much side effects of the drugs and reduce his problem. Now going towards your questions, 1&2. At this juncture, Gene profiling is not necessary for me but to start the EGFR ...more
Asked for male, 35 years old from South Goa
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My father (age 56 years & weight 70 Kg) has been diagnosed with Non-Small Cell Lung Cancer, Stage 4 with primary tumour in his Left Upper Lobe and metastasis in Liver and Bone. The biopsy report has confirmed it to be adenocarcinoma. The cancer was detected while he was admitted at a hospital in Mumbai and was undergoing treatment for Acute Paraplegia which happened on 02 Nov 16, due to arteries-Venous Fistula at D-10 level resulting in oedema/ ischemia of the spine from D-5 to Conus. After two failed attempts of embolization, towards treatment of the AVF, surgical clipping of the fistula was undertaken on 10 Nov 16. As part of post-operative rehabilitation therapy for his paraplegia, he was given 65 session of Hyper-basic Oxygen Therapy at 2.4 ata pressure for about two and a half month and about two hour of Physiotherapy for the same duration. My father was recovering well and had started walking with the help of support (walker). MRI of the spine taken in mid Jan & Mid June 2017 indicates that the spinal cord oedema had improved significantly, although atrophy of the spine cord is still present. He complained of wheezing and breathing difficulty and towards ascertaining the cause a X-ray was taken on 23 Feb 17 which showed massive pleural effusion in his left lungs. A series of tests followed with the ultimate result as NSCLC Stage 3B. It was categorised as Stage 3B as the pleural effusion was para-malignant and no metastases was noted in any other body parts. He was started with CCRT treatment which concluded on 05 May 17. During the treatment he was given daily dose of radiation therapy to his primary tumour site in his left upper lobe using IGRT (60 Gy/ 30 #/6 weeks) and weekly chemotherapy with paclitaxel (150 mg) & Carboplatin (300 mg) for 6 weeks. Despite the treatment, the cancer is advancing and has now spread to Liver and Bones as brought out in his latest PET CT report. Lung tissue which was obtained during CT guided biopsy conducted in the month of Mar 17, before the CCRT treatment was started, has tested positive for EGFR mutation – “E746_A750del is detected in EXON 19 of EGFR gene”. His doctor has started my father on Erlotinib 150 mg OD since 26 Jun 17. My father has developed Post Obstructive Pneumonia in his left lung and there is consolidation in his entire left lung. This is evident from a recent X-ray. He is having difficulty in breathing, takes short & fast breath, sweats a lot, feels cold, has irritation in his throat and gets tired very fast. He also has issue eating solid food and had greatly cut down his diet. He was started on Oral antibiotic for a week, but did not respond to it. He is admitted in the hospital and is being injected with antibiotics through IVs and injections. His condition remains to be same with no much improvement. His SPO2 level is also low at 90-92%. My father also has severe lower back pain and has also been diagnosed with progressive paraparesis. Because of the back pain he is not able to lie down on his back. A recent screening of the entire spine has confirmed that there is no evident compression of the spinal cord but clearly shows a number of metastasis in the vertebrae (Clivus, Dv2, Lv2, Lv4 & Tail Bone). There are plans to start him on Radiation Therapy for his spine. Is this:- 1.The right therapy for him? 2.What other option do we have for treating his spinal mets? 3.Can Radiation to treat his mets in the vertebra, damage his spine and cause further paraparesis? 4.Could you please suggest anything towards treatment of my father?

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DM - Oncology, MD - Internal Medicine

Oncologist•Noida
If there is localized backache than radiation treatment may be the right choice for the time being. Though it won't cure lung cancer. It may help in resolving the local pain. Patient is on erlotinib since 26-6-17. The medicine should have shown some benefit by now. Continue it for another one month. It may be stopped for the time /days spinal radiation is given by your treating doctor. Add bisphosphonates taking care of creatinine and calcium levels. Ask for appropriate amount of analgesics. Giv...more
Asked for female, 30 years old from Delhi
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Dear Doctors. Had a two IVF done, One went to ectopic (Doc Said) and other went to miscarriage with B-HCG level 3900 (4th week pregnancy ). During the IVF, I have noticed that my Glucose level was fluctuating (Mostly between 150 to 200) but strange thing was, It’s always high in evening times. My Doc implanted the Embryo, when my HBA1C was 7 and the following medicine was prescribed after embryo transfer (ET) Tab Estrabet 2 mg. Cap Strone 400 mg GEL Utreva GEL 8% w/w Cap KQ-100 Cap Consevel Tab Wysolone 10 mg Tab Zinetac 150 mg Ing AqSusten 25 mg Inj Busarlin 0.5 Unit Injec Endokine Before ET, Doctor need to create some lining in Uterus and for that She suggested the below medicines Cap Consevel Cap KQ-100 Cap PureZest 400 mg Inj Busarlin oestrogel Latest Report for Thyroid and Sugar T3: 114 T4: 8.80 TSH: 2.632 HBA1C: 9.1 I have also contacted with Diabetologist doing the IVF process and he suggested us the below medicines Before ET: Metformin HydroChloride 1000 mg, 2 Tablets after lunch and dinner but I felt vomit and loose motion Then Doctor asked me stop taking tablet and start taking insulin injection (10 Unit after dinner)After embryo transfer, start taking insulin injection (10 Unit after dinner)Once the pregnancy had confirmed with B-HCG 400, then he asked me to take insulin before each meal (Nova Rapid :- 5 – 8 units) I have a question, How the pregnancy got affected with sugar and how we can control it. I have seen many woman’s turn to diabetic during the pregnancy. Is there any side-effect of the injections and medicines that I am taking which may turn into legitamte diabetic. I don’t feel any symptoms of being diabetic. I would strongly suggest that this case would be handled by those doctors who handled this kind of case before. I have also tried to visit the apollo Doc (name can’t be taken) but he started turning me to move into apollo hospital. Losing the patient and money every years with disappointing.

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MBBS Bachelor of Medicine and Bachelor o...read more

Diabetologist•Thane
GDM or hyperglycemia in pregnancy need to be controlled by
Diet, medicines and Insulin Your HBA1C is bit high. As you said you unable to tolerate Metformin which is routinely used in GDM. So the last resort is always Insulin. GDM can affect foetus or mother of not controlled. We use Mixtard Insulin too. Current regimen seems OK to me.
Asked for male, 25 years old from Pune
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MBBS, MD Internal Medicine, PhD (Endocri...read more

Endocrinologist•Vellore
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Dear Mr. lybrate-user,
I note that for a height of 158 cm (5'2") your weight of 82 kg is too much. The ideal weight for your height would be 55-60 kg. If you go on a very strict 1500 calorie diabetic diet and walk for 5-6 km per day your weight will start coming down and along with this your insulin requirements will come down
professor m s seshadri.
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MBBS, MS - Orthopaedics

Orthopedist•Delhi
Total knee replacement surgery is, safe if done by specialist in a properly equipped center. Nova specialty hospital is one such hospital in delhi I am associated with. Apollo hospital has taken over it. The risk of surgery is no more than the risk of crossing road.
Any way,
sleep on a hard bed with soft bedding on it.
Rule out diabetes & vit. D deficiency or any other metabolic disorder.
Paracetamol 250mg od & sos x 5days
you will need other supportive medicines also.
Do...more
Asked for male, 39 years old from Firozabad
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M.D. Consultant Pathologist, CCEBDM Diab...read more

Sexologist•Sri Ganganagar
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Please go for insulin. Start with lantus 10 you late night. Inj. Nova rapid 5 units each just before each meal. Monitor by glucometer or by lab. Every 3-4 days. Change the dosage accordingly. You can ask on phone also.
Diabetic diet and exercises play great role.
For diabetes you can ask any question.
209 people found this helpful
Asked for male, 53 years old from Kolkata
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M.D. Consultant Pathologist, CCEBDM Diab...read more

General Physician•Sri Ganganagar
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Methi seeds will not help her in ckd. Please control by nova rapid and lantus insulin. For details contact with me on line by paid audio consultation.
248 people found this helpful
Asked for female, 42 years old from Ahmedabad
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MBBS, MD - Physical Medicine & Rehabilit...read more

Pain Management Specialist•Jaipur
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Hello Ms. lybrate-user
Insulin doesn't create allergies. You must be having allergy problems before also, but they may have increased by now, due to diabetes. Get CBC, ESR done. We need to see your investigations and discuss your problem in detail. I can't write medicines here without proper diagnosis. Kindly consult me in private for complete treatment.
Thank u.
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