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Overview

Geftib 250mg Tablet

Manufacturer: Glenmark Pharmaceuticals Ltd
Medicine composition: Gefitinib
Prescription vs.OTC: Prescription by Doctor required

Geftib 250mg Tablet helps to relieve the extreme pain and discomfort suffered by patients of breast or lung cancers. It slows down the production of cancer cells, thereby inhibiting the spread of the malignant tissues. It can be administered orally with or without food.

The dosage depends upon the medical history of the patient, health conditions and the response to the therapy.

The drug is contraindicated in patients who have suffered or are suffering from glaucoma, cardiac disorders, lungs or liver disorders or renal malfunctioning. Take proper medical help in case you are pregnant, planning a pregnancy any time soon or breastfeeding. You must also inform the doctor of any other prescription drugs that you may be taking, such as hormonal pills as oral contraceptives, or any dietary supplements as Geftib 250mg Tablet may interact with the other drugs and cause a number of health complications. You must avoid alcohol consumption, smoking, tobacco or caffeine during the course of the treatment to avoid any further health complications. There may be a number of side effects such as headaches, blurred vision, some nausea, and some allergic rashes on the skin. However there can be some adverse reactions as well. It is advised that even the slightest discomfort should be reported to the doctor immediately, in order to avoid complications.

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Oncologist before using this medicine.

In addition to its intended effect, Geftib 250mg Tablet may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
Rash
Weakness
Loss of appetite
Dry skin
Stomatitis (Inflammation of the mouth).
Is It safe with alcohol?
Interaction with alcohol is unknown. Please consult your doctor.
Are there any pregnancy warnings?
Emfib 250mg tablet is unsafe to use during pregnancy.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
Are there any breast-feeding warnings?
Emfib 250mg tablet is probably unsafe to use during breastfeeding. Please consult your doctor.
Is it safe to drive while on this medicine?
Patients may experience undesirable effects like asthenia and should avoid driving vehicles or using machines.
Does this affect kidney function?
There is no interaction between renal impairment and consuming this drug. So dose alteration is not needed.
Does this affect liver function?
There is no data available. Please consult doctor before consuming the drug.
Below is the list of medicines, which have the same composition, strength and form as Geftib 250mg Tablet , and hence can be used as its substitute.
Ark Life Sciences Pvt Ltd
Cadila Pharmaceuticals Ltd
Natco Pharma Ltd
Zydus Cadila
Neon Laboratories Ltd
Emcure Pharmaceuticals Ltd
Natco Pharma Ltd
Ind Swift Laboratories Ltd
Celon Laboratories Ltd
Sun Pharmaceutical Industries Ltd
Sun Pharmaceutical Industries Ltd
Zuventus Healthcare Ltd
Hetero Drugs Ltd
Alkem Laboratories Ltd
Panacea Biotec Ltd
Biochem Pharmaceutical Industries
Torrent Pharmaceuticals Ltd
Gland Pharma Limited
Parenteral Drugs India Ltd
Dr Reddy s Laboratories Ltd
Pfizer Ltd
RPG Life Sciences Ltd
Geftib 250mg Tablet is an anticancer agent which binds to the ATP binding site of the enzyme tyrosine kinase, an epidermal growth factor receptor (EGFR). This inhibits tyrosine kinase and prevents activation of Ras signal transduction cascade, preventing growth of malignant cells.
What are you using Geftib 250mg Tablet for?
Other
breast and lung cancer
How much was the improvement?
Poor
Average
Excellent
How long did it take before seeing improvement?
Within a day
More than 2 days
How frequently did you take this medicine?
Once a day
How did you take this medicine?
With Food
What were the side effects of this medicine?
Loss of appetite
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

My mother age 68 years has been diagnosed for Metastatic poorly differentiated adenocarcinoma as per report dtd 12-Mar-2018. The Mri dorsal spine dtd 13-feb-2018 shows collapse of d3, d7 vertebral body. Lesions on D3, D7, D12 spinal area. PET CT report 23-feb-2018 is also available. She is under the treatment of Doc. from Dharamshila hospital. According to them all treatment is going to be palliative, no cure is available. Accordingly, she was advised 10 RT and 6 chemotherapy. RT has been completed. EGFR, ALK, ROS1 by fish, PDL1 by ihc reports have come and EGFR mutation is positive. The doctor has advised Xovoltib 40 mg (afatinib dimaleate)/ Geftib 250 mg (gefitinib). No CT is to be done. After RT she has difficulty in swallowing food. Earlier she was taking Dexona 4 mg/Forcan as advised by once radiologist Dr. , after RT was done. She Has intermittent fever around 100. Has started reported pain and stiffness in back for the past few days. Right now, she has pain in her upper back and shoulder, though not very acute. She has difficulty in holding up things, but is currently active and mobile. Food habits are moderate to light, there is no change in that. No significant weight loss is observed as of now. She is a patient of High BP, has glaucoma and cataract also. She has developed slight incontinence now, and bowel movements have become very irregular. If any more information is required please let me know. I shall be extremely grateful for your support and advise in this matter.

MBBS, M.S. General Surgery, M.R.C.S. England, M.Ch. Surgical Oncology, DNB Surgical Oncology, FEBS Surgical Oncology, DNB General Surgery, MNAMS, FMAS, FIAGES, FAIS, FICS, FEBS Breast Surgery, FACS, Fellowship IFHNOS & MSKCC USA, Fellowship in breast and oncplastic Surgery
Oncologist, Mumbai
I presume she is lung cancer patient, although you have not mentioned the same (as you wrote she is EGFR positive, ALK4 and ROS1 and PDL1 are done in lung) Geftinib is an EGFR inhibitor given in lung cancer EGFR +ve, with good response rates. It does cause diarrhoea and rash in a few patients though. If she has other symptoms, treat her symptomatically. We try to prolong their life by giving palliative treatment, which may be months to few years in exceptional cases. But cure is not a target.
1 person found this helpful

Hi, After taking 2 months of gefitinib 250 mg tablet. What will be next treatment?

C.S.C, D.C.H, M.B.B.S
General Physician, Alappuzha
After taking 2 months of gefitinib 250 mg tablet, the next treatment is based on the condition for which treatment is started and the progress

My mom has non small cell cancer of advance stage. Her lungs was filled with fluid. Gefitinib 250 is started from two days. Her age is 67 and have severe disk problem. Is there any hope.

MBBS, M.S. General Surgery, M.R.C.S. England, M.Ch. Surgical Oncology, DNB Surgical Oncology, FEBS Surgical Oncology, DNB General Surgery, MNAMS, FMAS, FIAGES, FAIS, FICS, FEBS Breast Surgery, FACS, Fellowship IFHNOS & MSKCC USA, Fellowship in breast and oncplastic Surgery
Oncologist, Mumbai
Geftinib (Osimertinib is newer drug preferred) is usually started in Non Small cell cancer (Adeno carcinoma) if Patient is EGFR +ve, it usually responds well to the drug initially. The usual side effects are rash on the palms and soles and loose motions in some patients. The drug is continued till the disease is responding, stable or progressing only minimally (which may be a few months to a few years) If the disease shows rapid progression, 2nd line chemotherapy may be considered depending upon the General condition and age of the patient. If lungs are filled with fluid, she may need insertion of intercostal drainage tube with pleurodesis if necessary. Also is the back pain due to slip disk or bone metastasis. If bone metastasis then she may benefit from Bisphosphonates and / or palliative RT depending on the findings. Also immunotherapy drugs like nivolumab are showing promising results, but cost of almost 2lacs per month is a limiting factor. If you want to share the detailed case history and reports, feel free to contact me directly.
1 person found this helpful

My father has been diagnosed with Non-Small Cell Lung Cancer, Stage 4 with primary tumour in his Left Upper Lung and metastasis in Liver and Bone. The biopsy report has confirmed it to be adenocarcinoma. The cancer was detected while he was admitted at a hospital in Mumbai and was undergoing treatment for Acute Paraplegia which happened on 02 Nov 16, due to arteries-Venous Fistula at D-10 level resulting in oedema/ ischemia of the spine from D-5 to Conus. After two failed attempts of embolization, towards treatment of the AVF, surgical clipping of the fistula was undertaken on 10 Nov 16. As part of post-operative rehabilitation therapy for his paraplegia, he was given 65 session of Hyper-basic Oxygen Therapy at 2.4 ata pressure for about two and a half month and about two hour of Physiotherapy for the same duration. My father was recovering well and had started walking with the help of support (walker). MRI of the spine taken in mid Jan & Mid June 2017 indicates that the spinal cord oedema had improved significantly, although atrophy of the spine cord is still present. He complained of wheezing and breathing difficulty and towards ascertaining the cause a X-ray was taken on 23 Feb 17 which showed massive pleural effusion in his left lungs. A series of tests followed with the ultimate result as NSCLC Stage 3B. He was started with CCRT treatment which concluded on 05 May 17. During the treatment he was given daily dose of radiation therapy using IGRT (60 Gy/ 30 #/6 weeks) and weekly chemotherapy with paclitaxel (150 mg) & Carboplatin (300 mg) for 6 weeks. Despite the treatment, the cancer is advancing and has now spread to Liver and Bones as brought out in his latest PET CT report. Lung tissue which was obtained during CT guided biopsy conducted in the month of Mar 17, before the CCRT treatment was started, has tested positive for EGFR mutation – “E746_A750del is detected in EXON 19 of EGFR gene”. The medicine oncologist has however said that the gene profiling of the primary tumour tissue is not sufficient for starting Targeted Therapy and gene profiling of a tissue obtained from any of the metastatic site is necessary for the same. Three procedures have been undertaken to obtain tissue sample from the metastases site, twice from the liver and once from the pleural deposits, and all the three times the cancerous tissue could not be obtained. Due to non-availability of conformed cancerous tissue from the metastases site, a firm treatment plan has yet not been made for my father. In the meantime, the doctor has recently started my father on Erlotinib 150 mg OD as there has been considerable delay in his next phase of treatment due to non availability of metastases cancerous tissue. Could you please help me by answering the following:- 1.Can you suggest anything towards treatment of my father? 2.Is gene profiling of tissue from a metastases site absolutely necessary for starting targeted therapy for my father? 3.I read online that Erlotinib or Afatinib can be used as Targeted Therapy for patient with EGFR Lung cancer mutation. Is this true? If yes, will a daily tablet of these drugs be sufficient for his next phase of treatment, or a concurrent conventional chemotherapy is also required? 4.Can 65 session of Hyper-basic Oxygen Therapy at 2.4 ata given at a stretch of about 80 days, with a daily dose of 02 hour be a cause of his cancer? I have read it online that the oxygen free radical produced during HBOT treatment can cause cancer.

MS, DNB (Surgical Oncology)
Oncologist, Jodhpur
Hi lybrate-user, You summarize the case very well. I understanding of your case says, he has Ca lung adenoca, treated with dCTRT, that progressed and now disseminated disease, which is not curable by any means. The goal of the treatment in such cases would be palliative only, which means to increase longevity without causing much side effects of the drugs and reduce his problem. Now going towards your questions, 1&2. At this juncture, Gene profiling is not necessary for me but to start the EGFR targeted medicines, which includes Erlotinib/Gefitinib or Afatinib. Usually patients with such mutation as in your case responded but unfortunately not for the indefinite period but averagely 6 to 10 months. On progression, you have to get the gene profiling to see the change in the mutational status. You can refer to NCCN guidelines or American cancer society information. 3. Your father should receive, targertd therapy only, no chemotherapy for sure. It is proven better than chemotherapy in terms of Quality of life and progression free survival (average duration to progress on Treatment) 4. Regarding etiology or causation of lung cancer, HBOT not implicated for such cancers. And more so any carcinogen if cause cancer, it has a reasonable time to show its effects, like you must have seen chronic (long term) smokers will develop lung cancer. HBOT cause local hypervascularization and produce free radicles, so many studies tried see its role as a carcinogen, but tilll date it is not proven carcinogen as per ICAR. Hoping it solves your query. It is nice to see a son is keen and read in-depth about his father's illness. Good luck for further treatment.
2 people found this helpful

Popular Health Tips

Lung Cancer - Causes, Symptoms And Treatments Of It!

DM - Pulmonary Med & Critical Care Med, MD - Pulmonary Medicine, MBBS
Pulmonologist, Delhi
Lung Cancer - Causes, Symptoms And Treatments Of It!

 

Lung cancer is the uncontrolled growth of abnormal cells in one or both lungs. These abnormal cells do not carry out the functions of normal lung cells and do not develop into healthy lung tissue. As they grow, the abnormal cells can form tumors and interfere with the functioning of the lung, which provides oxygen to the body via the blood.

Lung cancer is the most common cause of death due to cancer in both men and women throughout the world. According to the U.S. National Cancer Institute, approximately one out of every 14 men and women in the U.S. is diagnosed with cancer of the lung at some point in their lifetime. Lung cancer is predominantly a disease of the elderly; almost 70% of people diagnosed with lung cancer are over 65 years of age, while less than 3% of lung cancers occur in people under 45 years of age.

What Causes Lung Cancer?

The development of lung cancer is strongly associated with cigarette smoking, approximately 90% of lung cancers are attributable to use of tobacco. Pipe and cigar smoking can also cause lung cancer, but the risk is not as high as with cigarette smoking. Tobacco smoke contains more than 4,000 chemical compounds, many of which are cancer causing (carcinogens). Passive smoking, i.e. the inhalation of tobacco smoke by non-smokers who live or work with smokers, is also an established risk factor for the development of lung cancer.

Genetic susceptibility (i.e. family history) may play a role in the development of lung cancer. Other causes of lung cancer include air pollution (from vehicles, industry, and power generation) and inhalation of asbestos fibres (usually in the workplace).

Lung Cancer Symptoms:

Early symptoms and signs of lung cancer:

There may be no symptoms at the onset of the disease. When present, common symptoms of lung cancer may include:

  1. Coughing: This includes a persistent cough that doesn't go away or changes to a chronic smoker's cough, such as more coughing or pain.
  2. Coughing up blood: Coughing up blood or rust-colored sputum (spit or phlegm) should always be discussed with your doctor.
  3. Breathing Difficulties: Shortness of breathwheezing or noisy breathing(called stridor) may all be signs of lung cancer.
  4. Loss of Appetite: Many cancers cause changes in appetite, which may lead to unintended weight loss.
  5. Fatigue: It is common to feel weak or excessively tired.
  6. Recurring infections: Recurring infections, like bronchitis or pneumonia, may be one of the signs of lung cancer.

Signs of advanced stages of lung cancer: Advanced stages of lung cancer are often characterized by the spread of cancer to distant sites in the body. This may affect the bones, liver or brain. As other parts of the body are affected, new lung cancer symptoms may develop, including:

  1. Bone pain
  2. Swelling of the face, arms or neck
  3. Headachesdizziness or limbs that become weak or numb
  4. Jaundice
  5. Lumps in the neck or collar-bone region

Treatment: Treatment for cancer involves a combination of surgery to remove cancer cells, chemotherapy and radiation therapy to kill cancer cells. Lung cancer is incurable unless complete surgical removal of the tumour cells can be achieved. Surgery is the most effective treatment for lung cancer, but only a few percentage of lung cancers are suitable for surgery i.e. Stage I and II NSCLC and cancer that has not spread beyond the lung.

Radiation therapy may be used for both NSCLC and SCLC and is a good option for people who are not suitable for surgery or who refuse surgery. Chemotherapy is used for both NSCLC and SCLC. Chemotherapy drugs may be given alone or in combination with surgery or radiation therapy. Chemotherapy is the treatment of first choice for SCLC since it has usually spread extensively in the body by the time it has been diagnosed.

Also used in the treatment of lung cancer are targeted therapies. These are drugs (gefitinib and erlotinib) or antibodies (cetuximabbevacizumab) that block the growth and spread of cancer by interfering with specific molecules involved in tumor growth and progression. They are used in some patients with NSCLC that does not respond to standard chemotherapy.

Lung Cancer: Causes, Symptoms and Treatments

MD - Pulmonary, DTCD
Pulmonologist, Faridabad
Lung Cancer: Causes, Symptoms and Treatments

Lung cancer is the uncontrolled growth of abnormal cells in one or both lungs. These abnormal cells do not carry out the functions of normal lung cells and do not develop into healthy lung tissue. As they grow, the abnormal cells can form tumors and interfere with the functioning of the lung, which provides oxygen to the body via the blood.

Lung cancer is the most common cause of death due to cancer in both men and women throughout the world. According to the U.S. National Cancer Institute, approximately one out of every 14 men and women in the U.S. is diagnosed with cancer of the lung at some point in their lifetime. Lung cancer is predominantly a disease of the elderly; almost 70% of people diagnosed with lung cancer are over 65 years of age, while less than 3% of lung cancers occur in people under 45 years of age.

What Causes Lung Cancer?

The development of lung cancer is strongly associated with cigarette smoking, approximately 90% of lung cancers are attributable to use of tobacco. Pipe and cigar smoking can also cause lung cancer, but the risk is not as high as with cigarette smoking. Tobacco smoke contains more than 4,000 chemical compounds, many of which are cancer causing (carcinogens). Passive smoking, i.e. the inhalation of tobacco smoke by non-smokers who live or work with smokers, is also an established risk factor for the development of lung cancer.

Genetic susceptibility (i.e. family history) may play a role in the development of lung cancer. Other causes of lung cancer include air pollution (from vehicles, industry, and power generation) and inhalation of asbestos fibres (usually in the workplace).

Lung Cancer Symptoms:

Early symptoms and signs of lung cancer:

There may be no symptoms at the onset of the disease. When present, common symptoms of lung cancer may include:

  1. Coughing: This includes a persistent cough that doesn't go away or changes to a chronic smoker's cough, such as more coughing or pain.
  2. Coughing up blood: Coughing up blood or rust-colored sputum (spit or phlegm) should always be discussed with your doctor.
  3. Breathing Difficulties: Shortness of breath, wheezing or noisy breathing (called stridor) may all be signs of lung cancer.
  4. Loss of Appetite: Many cancers cause changes in appetite, which may lead to unintended weight loss.
  5. Fatigue: It is common to feel weak or excessively tired.
  6. Recurring infections: Recurring infections, like bronchitis or pneumonia, may be one of the signs of lung cancer.

Signs of advanced stages of lung cancer: Advanced stages of lung cancer are often characterized by the spread of cancer to distant sites in the body. This may affect the bones, liver or brain. As other parts of the body are affected, new lung cancer symptoms may develop, including:

  1. Bone pain
  2. Swelling of the face, arms or neck
  3. Headaches, dizziness or limbs that become weak or numb
  4. Jaundice
  5. Lumps in the neck or collar-bone region

Treatment: Treatment for cancer involves a combination of surgery to remove cancer cells, chemotherapy and radiation therapy to kill cancer cells. Lung cancer is incurable unless complete surgical removal of the tumour cells can be achieved. Surgery is the most effective treatment for lung cancer, but only a few percentage of lung cancers are suitable for surgery i.e. Stage I and II NSCLC and cancer that has not spread beyond the lung.

Radiation therapy may be used for both NSCLC and SCLC and is a good option for people who are not suitable for surgery or who refuse surgery. Chemotherapy is used for both NSCLC and SCLC. Chemotherapy drugs may be given alone or in combination with surgery or radiation therapy. Chemotherapy is the treatment of first choice for SCLC since it has usually spread extensively in the body by the time it has been diagnosed.

Also used in the treatment of lung cancer are targeted therapies. These are drugs (gefitinib and erlotinib) or antibodies (cetuximab, bevacizumab) that block the growth and spread of cancer by interfering with specific molecules involved in tumor growth and progression. They are used in some patients with NSCLC that does not respond to standard chemotherapy.

3102 people found this helpful

Table of Content

About Geftib 250mg Tablet
When is Geftib 250mg Tablet prescribed?
What are the side effects of Geftib 250mg Tablet ?
Key highlights of Geftib 250mg Tablet
What are the substitutes for Geftib 250mg Tablet ?