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Depsol Plus 2 Mg/25 Mg Tablet

Manufacturer: Intas Pharmaceuticals Ltd
Medicine composition: Diazepam, Imipramine
Prescription vs.OTC: Prescription by Doctor required

Depsol Plus 2 Mg/25 Mg Tablet is an anticonvulsant and belongs to a group of drugs called benzodiazepine. It is used to treat anxiety disorders, alcohol withdrawal symptoms and muscle spasms. It is sometimes used in combination with other medications to treat seizures. It also provides sedation before medical procedures. It works by increasing the effect of the neurotransmitter gamma-Aminobutyric acid which calms the brain and nerves. It can be taken by mouth, inserted into the rectum, injected into muscle, or injected into a vein.

Common side effects include trouble with coordination and sleepiness. Serious side effects rarely occur. They include suicidal thoughts, an increased risk of seizures and a decreased breathing rate. Occasional agitation or excitement may occur. Long term use of this medicine can result in dependence, tolerance and withdrawal symptoms on dose reduction. Abruptly discontinuing the medicine after long-term use can be potentially dangerous. After stopping, cognitive problems may persist for six months or longer. It is not recommended during pregnancy or breastfeeding.

You should not use this medicine if you are allergic to diazepam or similar drugs, or if you have a muscle weakness disorder, severe liver disease, a severe breathing problem, sleep apnea, alcoholism, or addiction to drugs similar to diazepam. Before taking the medicine, inform your doctor if you have glaucoma, epilepsy or other seizure disorder, a history of mental illness, depression, or suicidal thoughts.

Depsol Plus 2 Mg/25 Mg Tablet should only be used for only a short period of time. It may increase the risk of habit forming tendency if taken for a long duration or at larger doses. Do not abruptly stop taking this medicine as it may cause withdrawal symptoms like convulsions, tremor, behavioural disorder and anxiety. When given into a vein, effects begin in one to five minutes and last up to an hour. While using this medicine, you may need to take frequent blood tests at your doctor’s clinic.

Depsol Plus 2 Mg/25 Mg Tablet is used in the treatment of anxiety disorders. Uneasiness, difficulty in sleeping, sweating of hands and feet are some of the symptoms of anxiety disorder.
Depsol Plus 2 Mg/25 Mg Tablet is used in the treatment of symptoms of alcohol withdrawal like hallucinations, anxiety, and seizures.
Relieve muscle spasm
Depsol Plus 2 Mg/25 Mg Tablet is used to relieve skeletal muscle spasm which occurs due to an inflammation of the muscle or joints.
Adjunct prior to endoscopic procedures
Depsol Plus 2 Mg/25 Mg Tablet is used in to relieve the symptoms of anxiety or stress in the patients undergoing endoscopic procedures.
Preoperative sedation
Depsol Plus 2 Mg/25 Mg Tablet is used to relieve the symptoms of anxiety and tension in the patients undergoing surgical procedures.
Seizure disorder
Depsol Plus 2 Mg/25 Mg Tablet is used in the treatment of seizure disorders.
Not recommended in the patients with allergy to Depsol Plus 2 Mg/25 Mg Tablet.
Not recommended in the patients with known case of myasthenia gravis.
Narrow-angle glaucoma
Not recommended in the patients with known case of narrow-angle glaucoma.
In addition to its intended effect, Depsol Plus 2 Mg/25 Mg Tablet may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
Unsteady walk Major Common
Agitation and anxiety Major Rare
Decrease in frequency of urination Major Rare
Skin rash Major Rare
Irritability Moderate Rare
Loss of appetite Major Rare
Diarrhea Minor Rare
Dry mouth Minor Rare
Double vision Minor Rare
Indigestion Minor Rare
Duration of effect
The effect of this medicine lasts for an average duration of 3 to 4 days.
Onset of action
The peak effect of this medicine can be observed in 30 to 90 minutes for an oral dose.
Pregnancy warnings
This medicine is not recommended for pregnant women.
Is it habit forming?
Habit forming tendency has been reported
Breast-feeding warnings
This medicine is not recommended in breastfeeding women.
Missed Dose instructions
If you miss a dose of Depsol Plus 2 Mg/25 Mg Tablet, take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.
Overdose instructions
Seek emergency medical treatment or contact the doctor in case of an overdose.
United States
Whenever you take more than one medicine, or mix it with certain foods or beverages, you're at risk of a drug interaction.
Interaction with Disease
Glaucoma Major
Depsol Plus 2 Mg/25 Mg Tablet is known to increase the fluid pressure inside the eye. It is contraindicated in acute narrow-angle glaucoma which is an eye disorder.
Seizures Major
The sudden stop of Depsol Plus 2 Mg/25 Mg Tablet may cause withdrawal effects and can precipitate seizures. The dose should be reduced gradually. Do not stop taking this medicine without consulting the doctor.
Interaction with Alcohol
Alcohol Major
Consumption of alcohol with this medicine is not recommended as it increases the risk of side effects like dizziness, difficulty in concentration. Do not perform activities that require mental alertness like driving or operating machinery.
Interaction with Lab Test
Information not available.
Interaction with Food
Grape fruit juice Moderate
Grapefruit juice should be consumed with Depsol Plus 2 Mg/25 Mg Tablet. Alternatively, you can consume orange juice which does not affect the medicine.
Interaction with Medicine
Cetirizine Moderate
Use of Depsol Plus 2 Mg/25 Mg Tablet with cetirizine or levocetirizine should be avoided if possible. Do not operate heavy machinery if you are using these medicines. Appropriate dose adjustments or replacement of the medicine should be made under the doctor's supervision.
Metoclopramide Moderate
Use of Depsol Plus 2 Mg/25 Mg Tablet with metoclopramide should be avoided if possible. Do not operate heavy machinery if you are using these medicines. Appropriate dose adjustments or replacement of the medicine should be made under the doctor's supervision.
Opoids Major
Opioids like morphine, codeine, tramadol, hydrocodone or any cough preparations containing these medicines should be avoided when you are on Depsol Plus 2 Mg/25 Mg Tablet or other benzodiazepines. Appropriate dose adjustments are to be made if coadministration is needed and monitoring of sedation, breathlessness, and hypotension is necessary.
Azole antifungal agents Moderate
Azole antifungal agents like ketoconazole and itraconazole should be avoided when you are Depsol Plus 2 Mg/25 Mg Tablet due to the risk of increased concentrations of the medicine in the body which may cause increased sedation and changes in ECG. Inform the doctor if you are receiving these medicines when you are prescribed with Depsol Plus 2 Mg/25 Mg Tablet. If coadministration is needed then alternative medicines like lorazepam and oxazepam could be considered.
Antihypertensives Moderate
You may experience hypotensive effects like dizziness, lightheadedness if these medicines are used together. Regular monitoring of blood pressure is necessary. Appropriate dose adjustments or replacement of the medicine should be made under the doctor's supervision.
What are you using Depsol Plus 2 Mg/25 Mg Tablet for?
Relieve muscle spasm
How much was the improvement?
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

I am 35 yrs. having nervous problem. To strength the nerve pls give tablet. Depsol plus strengthen the nerve? OR it only for sleeping tab. Pls answer.

General Physician, Jalgaon
I am 35 yrs. having nervous problem. To strength the nerve pls give tablet. Depsol plus strengthen the nerve? OR it o...
Depsol plus is for depression and anxiety to strengthen our nervous system please sleep early and wake up early do regular exercise yoga and pranayam daily do meditation regularly. Must avoid excess thinking avoid negative thoughts keep your mind relaxed keep your self busy take saraswatarishta 15 ml twice daily with water badam pak 1tsf 2 times with milk all for 3 months minimum.
1 person found this helpful

I am taking quetiapin formulate 25mg at night for treating depression from 8 months. But finally I do not feel better should I continue or switch over to another medicine. Previously I had taken depsol plus I.e.imiprimine plus diozipam 25 mg for 20 years at night. Now insomnia and sleep disturbance persisting. Please suggest the right medicine

(MRCPSYCH-UK), MD - Psychiatry, MBBS
Psychiatrist, Hyderabad
You have been taking a medication for 25 years. either it has a placibo effect or you would have developed dependance on depsol plus. One should take medicines for a specific illness only and not just for a symptom. You may not require any m,edication. Just use some natural methods to help you with your sleep. Have patience try the sleep techniques for few weeks.

Sir I am OCD patients and taking medicine as per doctor advise XET CR Plus 12.5 mg twice a day and Depsol Plus 25 mg half morning and half evening and sos since last 10 years and for BP taking Telma H daily. Doctor advise take xet cr plus and depsol plus daily and not confirm when it will stop and advise in USA people taking XET XR Plus daily till life and told me if your life running smooth with one tablet then what is the issue. I agree becoz when I try to stop then face big problem of anxiety and etc. Please advise the above medicine will taken by my till entire life and their is no side effect. As per doctor no negative effect. Please guide me. I am very much upset due to this problem and tears coming when depression coming too much with thought of Kahi Cardiac arrest na aa Jaye, Ya Heart attack Na ho jaye but 18 years gone out nothing has happen but when this thought coming then I will take depsol plus and zappiz 0.5 mg then found rest. When this thought coming, I cannot sit and too much anxiety will face if depsol plus and zappiz was not available then what will happen I do not know, is their any solution to avoid this problem once for all.

Psychiatrist, Bangalore
Dear Rakesh, OCD is a lifelong disorder and needs treatment for life long. Are you ready to live totally apathetic after cutting off the brain parts causing OCD (solution once for all)? Instead, why not you take tablets and live with good quality life? There are no drugs without any side effect. But you are getting more benefit out of tablets than side effect. If Depsol plus and Zapiz is not available, there will be better drugs than these two. Science will develop. Already in these 18 years, Xet CR/ER plus has come up.
2 people found this helpful

I have Obsessive compulsive disorder and anxiety problem and taking medicine since long like XET CR plus 12.5 mg twice and depsol plus half tab in after noon and half tab in night. My doctor said ,when these tablet do well to you then what is the issue to not take. Is it correct. He told me in USA number of people taking xet cr and it is common disease so do not worry and take medicine and live your life with enjoy.

MD - Psychiatry
I have Obsessive compulsive disorder and anxiety problem and taking medicine since long like XET CR plus 12.5 mg twic...
Hi lybrate-user, You have to take the medication at least for 18 months and further the doctor would decide on whether to continue. In my opinion if your OCD and anxiety is stabilised it sufficient you take XET cr alone but do consult and opine your doctor for the same. Every doctor has a reason to prescribe which every patient should ask for. There would be side effect but in terms of risk benefit you should continue. Good luck!

Popular Health Tips

Supplements for Sleeplessness

Alternative Medicine Specialist,
Nutrition and dietary supplements for insomnia:

A carbohydrate snacks of cereal and crackers with milk before bed may help because food rich in carbohydrates and low in protein and fat may boost the production of serotonin and melatonin, brain chemicals thought to promote sleep.

L-tryptophan: it is thought to bring on sleep by raising serotonin.

Melatonin: 1-3 mg of the melatonin is recommended for sleep, but as little as 0.3mg has been used successfully.

Valerian: it act as a mild sedative and improve both the ability to fall asleep and the quality of sleep.

Kava kava: it is effective for insomnia. Kava kava and diazepam induce similar changes in brain wave activity.

Other herbs that a professional herbalist may use to treat insomnia include:
Passion flower, hops, jamaica dogwood, lemon balm, lavender flower, german chamomile, mother wort, gotukola, and skullcap.
Massage therapy with essential oil, particularly lavender may result in improved sleep quality, more stable mood, increased mental capacity and reduced anxiety.
6 people found this helpful

MD-PhD, FIPS, Fellow of Academy of General Education (FAGE), DPM, MBBS
Psychiatrist, Ludhiana
Cocaine Detoxification

Medical Detoxification is a process that systematically and safely withdraws people from addicting drugs, usually under the care of a physician. Drinking alcohol or using drugs can cause physical dependence over time and stopping them can result in withdrawal symptoms in people with this dependence. The detoxification process is designed to treat the immediate bodily effects of stopping drug use and to remove toxins left in the body as a result of the chemicals found in drugs and/or alcohol.

While at the present time, no proven pharmacologic therapy for cocaine addiction exists, several kinds of medications have been used in the detoxification of cocaine. Withdrawal from chronic cocaine use produces anxiety, depression and intense cravings for the drug. Several types of medications address these issues in different ways.

Antidepressant drugs such as desipramine or a combination of phentermine and fenfluramine have been used to reduce cocaine withdrawal symptoms such as anxiety and depression. Benzodiazepines, tranquilizers such as Diazepam, have been used to reverse anxiety induced by cocaine withdrawal. Amantadine, a drug used to treat Parkinson's Disease, may be an effective treatment for cocaine-dependent patients with severe cocaine withdrawal symptoms and may reduce cocaine craving. Bromocriptine, a drug that works on the brain's dopamine system, has been used to decrease the craving for cocaine during detoxification and to reduce mood disturbance.

Propanolol, a beta-blocker drug used to treat high blood pressure, may be useful for severe cocaine withdrawal symptoms, as it slows down the effects of adrenaline, thereby calming the body's "fight or flight" response to stressful situations. This type of drug has been used to treat general anxiety and anxiety associated with alcohol withdrawal. Propranolol's lessening of symptoms such as palpitations and sweating has helped reduce cocaine craving. Its use, however, is not risk free in patients who have taken cocaine and can be associated with decreased blood flow to the heart and other changes that predispose patients to arrhythmia and a severe increase in blood pressure that can lead to a stroke. Delayed toxic effects are possible. Any use of beta-blockers in this setting requires careful monitoring and caution

Cerebral Palsy In Kids - Treatments That Can Help!

Diploma in Child Health (DCH), MRCPCH, MRCP (UK), MD - Paediatrics, MBBS
Pediatrician, Delhi
Cerebral Palsy In Kids - Treatments That Can Help!

Cerebral Palsy is a disorder related to the posture, movement or muscle tone, mostly due to immature development of the brain in a baby. This condition usually crops up, when the baby is already in the womb. The symptoms may surface when the baby is in its infancy or even later. Irregularities in the reflexes, posture, walking style, etc should ring a bell for the parents. Kids suffering from cerebral palsy may also suffer from muscle imbalance of the eye muscles, leading to problems focusing on an object. The range of motions becomes limited as well. There could be conditions such as deafness, epilepsy, impaired brain function and blindness associated with this disease. 

Whom to consult for cerebral palsy in kids? 
A kid suffering from Cerebral Palsy might have to work with a medical team for a very long time. Parents might need the help of a paediatrician, orthopaedic surgeon, paediatric neurologist, physical therapist, speech-language pathologist, mental health specialist, developmental therapist, recreation therapist and special education teacher. 

Treatments that are available for Cerebral Palsy in kids Medication: 

Medications: Medications are often used to improve the functional abilities of a kid. Certain spasticity related complications, treatment of pain, and other symptoms of Cerebral Palsy can be treated with medications. It is important to discuss with the doctor, the side-effects involved in taking the medication. There are two types of medications- for isolated spasticity and for generalized spasticity. In case of Isolated spasticity, doctors recommend Botox injections every 4-6 months to stabilize one muscle group. If the whole body is affected due to cerebral palsy, doctors recommend medications such as baclofen, diazepam and dantrolene to relax the contracted and stiff muscles. 

Therapies: While there are many therapy treatment, three types of therapies are the most important for treating a child suffering from cerebral palsy. They are physical therapy, occupational therapy and speech& language therapy. Physical therapy is necessary for the flexibility, mobility and motor development of the child. Occupational therapy helps a kid imbibe alternative strategies to participate in daily activities. From teaching a child to walk with a cane to help them operate a wheelchair, physical therapy makes a child self-sufficient as much as possible. Speech and language therapy helps child’s ability to communicate either verbally or with sign-language. 

Surgery: Surgery may be necessary to loosen the muscles, correct abnormalities of the bone etc. An orthopaedic surgery is necessary in cases where a kid was born with several deformities. The correction can decrease pain and increase mobility. In severe cases when the normal treatments do not help, doctors cut the tendon of spastic muscle. It helps to relieve the pain and relax the muscle.

In case you have a concern or query you can always consult an expert & get answers to your questions!

2638 people found this helpful

Meniere's Disease - What Is The Right Way To Manage It?

ENT Specialist, Ghaziabad
Meniere's Disease - What Is The Right Way To Manage It?

Meniere’s disease is a condition of the middle ear, the exact cause of which is not known. If often affects one ear and affects adults who are aged over 40. It is diagnosed by few characteristic symptoms:

There could be periods of dizziness, where the patient falls, known as “drop attacks.” These attacks are followed by long periods with no symptoms whatsoever. It is unpredictable and so a patient can never really be prepared for an attack. While it is not easy to diagnose the condition, doctors do a detailed history to confirm the diagnosis. Hearing test, CT scan, and MRI may be used to confirm the diagnosis.

Management: There is no definitive treatment for this condition. However, various options have been proposed, and many people have found them to be helpful. Some commonly used measures including diet and cognitive therapy are listed below:

  • Medications: There is no medication to attack the root cause. Medicines are used often to control dizziness, which is the most irritating symptom of this condition. Meclizine and diazepam are often used. In some people, gentamicin or corticosteroid injections are used. However, long-term use of gentamicin can cause hearing loss.
  • Salt restriction: Reducing salt intake indirectly reduces the fluid retention in the body, which helps manage the blood pressure and vertigo
  • Dietary changes: When a detailed history is taken, there are patterns which indicate that increased caffeine, chocolate, or alcohol worsen the symptoms. These are reduced with an intent to reduce the symptoms
  • Pulse treatment: A pulse of air is pushed through to the inner ear, which helps in symptom relief. This device fits into the outer ear, and when the pulse of air is pushed through, it improves fluid circulation within the middle ear, which is believed to be a cause for the condition.
  • Surgery: As a last resort, some surgical options are used:
    • A shunt is placed in the middle ear to drain out the excess fluid and maintain balance.
    • Labyrinthectomy may also be done to reduce symptoms, which may also involve removal of the eighth cranial nerve, which is believed to be the cause.
    • Hearing aids can be used if the hearing loss is severe.
    • Alternative medicines including acupressure and acupuncture are proven to reduce symptoms in some people.
    • Herbs like gingko biloba and ginger root have also been used, not with proven effect though.
  • Prevention: When possible, avoid
    • Driving
    • Operating heavy machinery
    • Swimming
    • Use of ladders
    • Being on terraces without somebody supervising

In case you have a concern or query you can always consult an expert & get answers to your questions!

3305 people found this helpful

Pain Management for Chronic Back Pain

Fellowship in Interventional Pain management , Diploma in Anesthesia, DA, MBBS
Pain Management Specialist, Jaipur
Pain Management for Chronic Back Pain

Back pain may occur due to various reasons. Chronic back pain is the one that remains for 12 weeks or more than that even after the cause of the pain has been treated. There are several ways of treating chronic back pain. Its treatment depends upon the nature of injury or the actual underlying cause of the pain.

The treatment for back pain has been listed below:

  1. Short-term methods: Initially, people use short-term remedies for tackling back pain. Over-the-counter painkillers and home remedies are used to cure the patient. This might show useful results within six weeks.
  2. Continue movement: Although traditionally, patients with back pain were advised to take complete bed rest. However, doctors today are of the opinion that patients should not take complete bed rest. The patient should try to move around a bit. It may be hurting first, but slowly it will heal the pain. One can take up brisk walking for best results.
  3. Painkillers: Patients are first prescribed to take paracetamol. However, some people take non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen for faster relief. There are stronger painkillers like codeine. But one must keep in mind that painkillers are not good for health. They have side effects. Long-term use of painkillers can cause damage to the kidneys. If these are not effective, the doctor might switch to muscle relaxant like diazepam.
  4. Hot and cold compress: Patients are advised to take hot or cold compress to get relief. A hot bath or compress with hot water can be useful. Otherwise, using ice pack can also produce effective results. Often, alternate hot and cold compress are advised to get rid of the pain.
  5. Change your sleeping style: The pain can be reduced to a great extent by changing one's sleeping pattern. Use pillows to change the sleep pattern.
  6. Exercise: The patient might have developed back pain due to faulty posture or obesity. In order to get rid of the pain, one must address these issues first. Shred the extra pounds b exercising the correct way to get cured of the pain.
  7. Acupuncture: It is a kind of treatment in which fine needles are put at different points of the body. This helps in reducing the pain.
  8. Oil massage: There are various kinds of massage techniques available. These improve the circulation of blood. This in turn, rejuvenates the muscles and bones by providing sufficient oxygen supply.
  9. Antidepressants: These are prescribed when painkillers don't show effective results. Tricyclic antidepressants (TCAs), such as amitriptyline are given to the patient. However, these are given in small doses.
  10. Stay calm and positive: It is important to have a positive frame of mind to get rid of the pain. One has to be patient and not lose hope while the treatment is on. If you wish to discuss any specific problem, you can consult a pain management specialist.
4101 people found this helpful

Table of Content

About Depsol Plus 2 Mg/25 Mg Tablet
When is Depsol Plus 2 Mg/25 Mg Tablet prescribed?
What are the contraindications of Depsol Plus 2 Mg/25 Mg Tablet?
What are the side effects of Depsol Plus 2 Mg/25 Mg Tablet?
Key highlights of Depsol Plus 2 Mg/25 Mg Tablet
What are the dosage instructions?
Where is the Depsol Plus 2 Mg/25 Mg Tablet approved?
What are the interactions for Depsol Plus 2 Mg/25 Mg Tablet?