Prescription vs.OTC: Prescription by Doctor required

Imipramine is a tricyclic antidepressant (TCA). It belongs to the dibenzazepine group of compounds. Imipramine is used primarily in the treatment of depression. It can also be used in combination for curing enuresis( bedwetting tendency). Using Imipramine for treating depression has been shown to significantly improve mood, sleep, eating disorders and your interest in daily activities and life in general. It functions by boosting the activity of chemicals in the brain.

Probable side effects that may occur are enlargement of the pupils and breasts, black tongue, decreased or increased libido,discoloration of the skin, swelling of various body parts, frequent unrination urges, difficulty with bowel movements, eye sensitivity. Major reactions include abdominal pain, blurred vision, aggression, chest pain, darkening of the urine, fever, dry skin, hearing loss, fatigue, chronic cough, irritability, difficulty in movement, nightmares, sudden weight gain, sweating, slurred speech, tremors, restlessness. In case of the latter category check with your physician immediately.

Before taking Imipramine have a discussion with your doctor and avoid using this medication in case if:

  • You are allergic to Imipramine, or any other medications or foods.
  • You are taking monoamine oxidase (MAO).
  • You are taking any prescriptive or non-prescriptive drugs, herbal medications, vitamins or dietary supplements.
  • You have reacently had a heart attack or have heart diseses.
  • You are taking electroshock therapy.
  • You are about to undergo surgery soon.
  • You smoke. Tobacco products may lower the functionality of Imipramine.
  • You are pregnant, or are planning to become pregnant or are breastffeding a baby.
  • You drink alcohol.
  • You have to be exposed to the sunlight for long hours.

The recommended dosage in adults to fight depression are 100 mg orally every day. For curing enuresis in children about 25 mg every day in the intitial stage. For bedwetters, this medication should be taken at least one hour before your bedtime. In case of a missed dose, take it as soon as possible, otherwise skip it. Do not have a double dose. In case of overdose. Seek medical help right away.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.
  • Depression

    Imipramine is used to relieve symptoms of depression characterized by sadness, loss of interest, irritability, and sleeplessness.
  • Allergy

    Not recommended in patients with known allergy to Imipramine.
  • Monoamine oxidase inhibitors (MAOI)

    Imipramine is not recommended patients receiving monoamine oxidase inhibitors selegiline and isocarboxazid.
  • Myocardial Infarction

    Imipramine is not recommended for use if the patient is recovering from a recent heart attack.
  • Abdominal Pain

  • Blurred Vision

  • Decrease In Frequency Of Urination

  • Dry Mouth

  • Rapid Weight Gain

  • Yellow Colored Eyes Or Skin

  • Unusual Tiredness And Weakness

  • Increased Sensitivity Of The Eyes To Sunlight

  • Skin Rash

  • How long is the duration of effect?

    The effect of this medicine lasts for an average duration of 18 to 54 hours.
  • What is the onset of action?

    The effect of this medicine can be observed after 2 weeks.
  • Are there any pregnancy warnings?

    This medicine should be used by pregnant women only when the benefits outweigh the risk associated with usage. Hence, you are advised to consult your doctor before taking this medicine.
  • Is it habit forming?

    No habit forming tendencies were reported.
  • Are there any breast-feeding warnings?

    This medicine should not be used by women who are breastfeeding. If it is absolutely necessary to take this medicine then you should stop breastfeeding. Consult your doctor before using this medicine.
  • Missed Dose instructions

    Take the missed dose as soon as you remember. However, if it is almost time for the next scheduled dose then the missed dose should be skipped.
  • Overdose instructions

    Contact a doctor immediately if an overdose is suspected. Symptoms of overdose may include a change in pulse rates, severe drowsiness, confusion, vomiting, hallucinations, convulsions, and fainting. Immediate medical intervention may be required if the overdose symptoms are severe.
  • India

  • United States

  • Japan

Below is the list of medicines, which contains Imipramine as ingredient

View More

This medication belongs to the tricyclic antidepressants class of drugs. It works by preventing the reuptake of neurotransmitters namely norepinephrine and serotonin. Imbalance of these chemicals is observed in depression patients.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

  • Interaction with Alcohol


    Consumption of alcohol is not recommended while taking this medicine as it increases the risk of side effects of this medicine like dizziness, blurred vision, sweating, and muscle stiffness. Do not perform activities that require mental alertness like driving vehicle and operation machinery.
  • Interaction with Lab Test


    Information not available.
  • Interaction with Medicine


    Report the use of either of the medicine to the doctor. The risk of adverse effects on the heart is very high while these medicines are administered together. Suitable dose adjustment and clinical safety monitoring may be required in such cases.

    Antidiabetic medicines

    Imipramine may increase the effect of sulfonylureas like Glimepiride. Inform the doctor if you have hypoglycemic symptoms like dizziness, headache, weakness after taking these medicines. An alternative class of medicines or dose adjustments should be made under doctor's supervision.


    Opioids like morphine, codeine, tramadol, hydrocodone or any cough preparations containing these medicines should be avoided when you are receiving Imipramine. Appropriate dose adjustments are to be made if coadministration is needed and monitoring of sedation, breathlessness, and blood pressure is necessary.


    You may experience hypotensive effects like dizziness, lightheadedness if these medicines are used together. Regular monitoring of blood pressure is necessary. Appropriate dose adjustments or replacement of the medicine should be made under the doctor's supervision.
  • Interaction with Disease

    Heart Diseases

    Imipramine should be used with caution in patients suffering from heart disease like heart failure, stroke, heart block etc. A fall in blood pressure, change in pulse, dizziness and other associated complications should be reported to the doctor. It is advised to not take this medicine if the patient has recently suffered a heart attack.


    Imipramine should be administered with extreme caution in patients suffering from Pheochromocytoma, the risk of severe to fatal change in blood pressure is very high. Suitable dose adjustment and clinical monitoring of the symptoms is recommended in such cases.

    Seizure Disorders

    Imipramine should be used with caution in patients having a seizure disorder. Seizures may be caused due to a disease, some other medicine, head injury in the past etc. Using this medicine can cause more frequent and severe episodes of seizures.
  • Interaction with Food


    Information not available.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

Popular Health Tips

Content Details
Written By
PhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child Care
Reviewed By
MBBS, Master in Healthcare Administration, Diploma in Occupational Health
General Physician
Table of Content
About Imipramine
What are the uses of Imipramine
What are the contraindications of Imipramine ?
What are the side effects of Imipramine ?
Key highlights of Imipramine
What are the dosage instructions?
Where is the Imipramine approved?
Medicines containing Imipramine
How does this medication work?
What are the interactions of Imipramine ?