COXINEX 450MG/300MG CAPSULE

COXINEX 450MG/300MG CAPSULE belongs to the rifamycin group of antibiotics and is used to treat numerous bacterial infections.This includes leprosy, tuberculosis and Legionnaire's disease. This medicine is administered either by mouth or intravenously. It works by interfering and preventing the production of RNA by bacteria.

This medicine is helpful in the management of active tuberculosis in combination with other agents; eliminate meningococci from asymptomatic carriers; and prophylaxis of Haemophilus influenzae type b infection. Also, it is used in combination with other anti-infectives in the treatment of staphylococcal infections.

Common side effects of this drug include diarrhoea, nausea, vomiting and loss of appetite. It often turns the colour of sweat, urine and tears red or orange. Liver problems or allergic reactions may also occur as side effects. Even though its safety during pregnancy is not known, COXINEX 450MG/300MG CAPSULE is part of the recommended treatment of tuberculosis during pregnancy.

People with hypersensitivity to COXINEX 450MG/300MG CAPSULE and jaundice are not recommended this medicine. It should be used with caution in people with a history of alcoholism and hepatic and renal impairment. Elderly, malnourished patients, children below 2 years of age, pregnant or breastfeeding women need to take this medicine in lower doses.

This medicine is best taken on an empty stomach 1 hour before or 2 hours after a meal. Your dosage will be as prescribed by your doctor where your age, weight and medical condition will be taken into consideration.

Take per recommended schedule. Complete full course of therapy; do not skip doses. Take on an empty stomach (1 hour before or 2 hours after meals). Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake).

It will discolor urine, stool, saliva, tears, sweat, and other body fluids red-brown. Stains on clothing or contact lenses are permanent. Report persistent vomiting; fever, chill, or flu-like symptoms; unusual bruising or bleeding; or other persistent adverse effects.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

• Tuberculosis

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

• Hypersensitivity

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

• Skin Rash

• Nausea

• Vomiting

• Anorexia

• Diarrhoea

• Cramps

• Pancreatitis

• Flushing

• Edema (Swelling)

• Headache

• Drowsiness

• Dizziness

• Confusion

• Numbness

• Pruritus

• Urticaria

• Thrombocytopenia

• Weakness

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

• Is It safe with alcohol?

  Interaction with alcohol is unknown. Please consult your doctor.

• Are there any pregnancy warnings?

  This medicine may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Inform prescriber if you are or intend to be pregnant or if you are using oral contraceptives (rifampin may effect the effectiveness of certain oral contraceptives)

• Are there any breast-feeding warnings?

  Cavidin 450mg tablet is probably safe to use during breastfeeding. Please consult your doctor.

• Is it safe to drive while on this medicine?

  There is no data available. Please consult doctor before consuming the drug.

• Does this affect kidney function?

  Caution to be advised in patients with impaired renal function.

• Does this affect liver function?

  Dose reductions may be necessary to reduce hepatotoxicity.

• How long is the duration of effect?

  The effect of this medicine remain active for up to 24 hours.

• What is the onset of action?

  The effect of this medicine is initiated within 2 - 4 hours after its administration.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

Below is the list of medicines, which have the same composition, strength and form as COXINEX 450MG/300MG CAPSULE , and hence can be used as its substitute.

• Rifalin I 450 Mg/300 Mg Tablet

  Lincoln Pharmaceuticals Ltd

• Mycocox 450 Mg/300 Mg Tablet

  Cadila Pharmaceuticals Ltd

• R-Cinex Capsule

  Lupin Ltd

• Akt-2 Tablet

  Lupin Ltd

• Macox Plus Tablet

  Macleods Pharmaceuticals Pvt Ltd

• Rizide 450 mg/300 mg Tablet

  Prayas Pharmaceuticals

• Wokex 450 Mg/300 Mg Tablet

  Wockhardt Ltd

• ARZADE 450MG/300MG CAPSULE

  Albert David Ltd

• Coxwin Zh 450 Mg/300 Mg Tablet

  Marc Laboratories Pvt Ltd

• Rifawk 450 mg/300 mg Tablet

  Wockhardt Ltd

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

• Are there any missed dose instructions?

  If you miss a dose of Rifampicin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

COXINEX 450MG/300MG CAPSULE inhibits bacterial RNA polymerase which is the enzyme responsible for the transcription of DNA. Rifampicin binds and prevents RNA synthesis by blocking elongation and synthesis of bacterial proteins. It blocks the bond between nucleotides in the RNA backbone.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

test

• Interaction with Lab Test

  Positive Coombs' reaction [direct], rifampin inhibits standard assay's ability to measure serum folate and B12; transient increase in LFTs and decreased biliary excretion of contrast media.

• Interaction with Medicine

  • CYP3A3/4 enzyme substrate; CYP1A2, 2C9, 2C18, 2C19, 2D6, 3A3/4, and 3A5-7 enzyme inducer.
  • Coadministration with INH or halothane may result in additive hepatotoxicity; probenecid and co-trimoxazole may increase rifampin levels while antacids may decrease its absorption.

• Interaction with Disease

  Use with caution and modify dosage in patients with liver impairment; observe for hyperbilirubinemia; discontinue therapy if this in conjunction with clinical symptoms or any signs of significant hepatocellular damage develop; since rifampin has enzyme-inducing properties, porphyria exacerbation is possible; use with caution in patients with porphyria; do not use for meningococcal disease, only for short-term treatment of asymptomatic carrier states.

• Interaction with Food

  Rifampin is best taken on an empty stomach since food decreases the extent of absorption.

• Ques : What is COXINEX 450MG/300MG CAPSULE used for?

  Ans : COXINEX 450MG/300MG CAPSULE is used to treat numerous bacterial infections. This includes leprosy, tuberculosis and Legionnaires disease.

• Ques : What is the onset of action of COXINEX 450MG/300MG CAPSULE?

  Ans : COXINEX 450MG/300MG CAPSULE takes approximately 2 to 4 hours to show its effect.

• Ques : What is the duration of the effect of COXINEX 450MG/300MG CAPSULE?

  Ans : The effect of COXINEX 450MG/300MG CAPSULE lasts between 9 to 12 hours.

• Ques : Where is COXINEX 450MG/300MG CAPSULE approved?

  Ans : COXINEX 450MG/300MG CAPSULE is approved in India, Japan, Micronesia, and the USA.

• Ques : Should COXINEX 450MG/300MG CAPSULE be taken with a meal or without a meal?

  Ans : COXINEX 450MG/300MG CAPSULE should be taken with a meal for better effectiveness.

• Ques : Does COXINEX 450MG/300MG CAPSULE lead to drug-resistance?

  Ans : COXINEX 450MG/300MG CAPSULE should be used only when the microbial infection is confirmed as irrational usage of COXINEX 450MG/300MG CAPSULE may cause drug-resistance.

• Rifampicin-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 30 May 2022].Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/rifampicin

• Rifampicin-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 30 May 2022].Available from:

  https://go.drugbank.com/drugs/DB01045