HIV: QUICK FACTSIntroductionThe human immunodeficiency virus (HIV) is a subgroup of retrovirus (lentivirus) that causes HIV infection. After a period of time, this infection leads to what is called acquired immunodeficiency syndrome (AIDS).

Epidemiology

According to the Centers for Disease Control and Prevention (CDC), from 2010-2015, the estimated rate of HIV infection in all 50 US states decreased from 14.2 per 100,000 population in 2010 to 12.3 per 100,000 population in 2015. In 2015, 39,513 individuals were diagnosed with HIV infection. From 2010 to 2014, the annual number of new HIV infections decreased by 9%.

Virology HIV-1 and HIV-2 are retroviruses in the Retroviridae family, Lentivirus genus. They are enveloped, diploid, single-stranded RNA viruses with a DNA intermediate.Upon entry into the target cell, the viral RNA genome is converted into double-stranded DNA by an enzyme, reverse transcriptase that is transported along with the viral genome in the virus particle. The resulting viral DNA is then imported into the cell nucleus and integrated into the cellular DNA by a virally encoded enzyme, integrase. HIV contains three retroviral genes, namely gag, pol, and env.

Gag gene: Encodes group-specific antigen; the inner structural proteins
Pol gene: Encodes polymerase; it also contains integrase and protease
Env gene: Encodes the viral envelope, the outer structural proteins responsible for cell-type specificity. Glycoprotein 120, the viral envelope protein, binds to the host CD4+molecule
Pathophysiology

HIV infects vital cells in the human immune system, such as helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells and leads to cellular immune deficiency. This results in the development of opportunistic infections and neoplastic processes.

Mode of Transmission
Sexual intercourse: Unprotected sexual intercourse; especially receptive anal intercourse and different sexual partnersContact with or transfer of blood, pre-ejaculate, semen, and vaginal fluids infected with the virus.Spread from an infected mother to her infant through breast milk. An HIV-positive mother can transmit HIV to her baby both during pregnancy and childbirth due to exposure to her blood or vaginal fluid.

Signs and Symptoms There are 3 categories of infection 

Category A: Asymptomatic HIV infection without a history of symptoms or AIDS-defining conditions
Category B: HIV infection with symptoms that are directly attributable to HIV infection
Category C: HIV infection with AIDS-defining opportunistic infections
Investigation

A high-sensitivity enzyme-linked immunosorbent assay (ELISA) should be used for screening.

Management

Start with antiretroviral therapy (ART) in all HIV-infected adults ready to start therapy. 
CD4 count is no longer a criterion for starting the therapy.
Use of nucleoside reverse transcriptase inhibitors and protease inhibitors.
For refractory cases, during the failing treatment regimen and before switching therapy, use rapid confirmation, perform resistance testing and reevaluate.

HIV - Quick Facts Need To Know!

Vitiligo is a medical condition, which causes the loss of skin color due to loss of pigmentation. This usually occurs in blotches and looks very unsightly. Vitiligo is very unpredictable and can affect any part of your body. In some cases it also affects the inside of the mouth, eyes, and hair. Vitiligo is more noticeable on people with darker skin tone.

Symptoms of Vitiligo:

Premature graying or whitening of the hair in your eyebrows, eyelashes, scalp, and beard. This usually occurs before the age of 35.
Skin discoloration can also occur from other parts of the body such as hands, feet, abdomen, neck and other areas.
Change or loss of the color of the retina (inner layer on the eyeball).
Discolored patches on and around the navel, rectum and genitals.
What causes vitiligo?

A medical disorder where your immune system destroys and attacks the melanin forming pigments in your skin. This is known as an autoimmune disorder and by far is the most common cause behind vitiligo. An event such as sudden or prolonged stress, sunburn, or being exposed to industrial chemicals. A history of family members or relatives having vitiligo in the past.

Ayurvedic Treatments for Vitiligo:

Mustard and Turmeric Oil: A paste made with mustard and turmeric oil can be applied on the affected area. This is also good for the skin and reduces vitiligo. Do this at least 2 times a day to reduce the patches considerably.
Duckweed: This is a type of water plant and is very rich in a mineral called lignin. It is considered a natural treatment for skin disorders and vitiligo. It will also help to restore your natural skin color.
Sun screen: If you already have vitiligo, exposure in the sun can make it worse, so applying a sunscreen with SPF 30 or above (or an appropriate level of sunscreen protection) can protect your skin from further damage.
Papaya: This fruit is great for restoring and reviving melanin (responsible for skin pigmentation). Drinking papaya juice or rubbing papaya on the affected area can reduce vitiligo to some extent.

Vitiligo - 4 Ayurvedic Preparations for Treating it 

Ringworm of the scalp usually affects children. This is a common type of a fungal infection of the scalp and has nothing to do with the worms as the name suggests. This is treated with antifungal medications and though the antifungal shampo-is not to-effective, it might be advised along with medication.

Causes of scalp ringworm:

 Most of the times a ringworm infection is transfered from person to person through sharing towels and touching. The fungi and its spores can remain alive on brushes, combs, sheets, furniture and unwashed towels for long. Some people are only carriers of fungi, meaning that they carry the fungi and its spores in their hair and skin but do not have any infection and symptoms. But they might pass the fungi to others who may develop the symptoms.
 It spreads from pets like cats and dogs who are very prone to fungal infection of the skin. They easily pass their infection to children and other family members. Farm animals are also a source of fungal infection and if the farm gate is touched from where the infected cattle passes, it is enough to cause infection.
 Also at times there is no reason and fungi infection can just happen out of the blue. Like for example, the fungi spores can get transmitted through air, they might get into the air by an infected person and land on someone else's head. This can develop into fungi and can cause infection.

Symptoms of scalp ringworm:

 The infection looks more like dandruff, a severe form of dandruff in different parts of the scalp. This is often mistaken to be psoriasis.
 In some infection there is loss of hair leading to bald patches. These patches become scaly and inflamed. The patches might have broken off small hair.
 Several painful pustules and boils occur on the scalp
 In severe infection there is boggy swelling on some part of the scalp, which is known as kerion. This might be tender and oozing and if not treated can lead to hair loss and permanent scarring.
 In severe infections like with pustules and kerion, one might develop high fever and the glands of the neck might swell. 

Treatment of scalp ringworm:
The treatment of the fungal infection of the scalp involves the following:

 Antifungal medicines: these are usually taken in the form of tablets and following are advised:
 Griseofulvin: this is often the first choice and a course of 8-12 weeks is required. The tablet can be crushed and taken with water.
 Terbinafine: the course for this is four weeks and is important to complete the course in order to get rid of the infection.

Fungal Infection on Scalp: How to Treat It?

For nearly 30 years, HIV (human immunodeficiency virus) and AIDS (acquired immunodeficiency syndrome) have been shrouded in myths and misconceptions. In some cases, these mistaken ideas have prompted the very behavior that cause more people to become HIV positive. Here are the top five myths about HIV, along with the facts to dispute them.

Myth No. 1: I can get HIV by being around people who are HIV-positive.

The evidence shows that HIV is non communicable and does not spread through touch, tears, sweat or saliva. You cannot catch HIV by:

    Breathing the same air as someone who is HIV-positive
    Touching a toilet seat or doorknob handle after an HIV-positive person
    Drinking from a water fountain
    Hugging, kissing, or shaking hands with someone who is HIV-positive
    Sharing eating utensils with an HIV-positive person
    Using exercise equipment at a gym

You can get it from infected blood, semen, vaginal fluid, or mother's milk.

Myth No. 2: I can get HIV from mosquitoes.

Because HIV is spread through blood, people have worried that biting or bloodsucking insects might spread HIV. Several studies, however, show no evidence to support this, even in areas with lots of mosquitoes and cases of HIV. When insects bite, they do not inject the blood of the person or animal they have last bitten. Also, HIV lives for only a short time inside an insect.

Myth No. 3: I'm HIV positive, my life is over.

In the early years of the disease epidemic, the death rate from AIDS was extremely high. But today, antiretroviral drugs allow HIV positive people and even those with AIDS to live much longer, normal and productive lives.

Myth No. 4: My partner and I are both HIV positive there's no reason for us to practice safer sex.

Practising safer sex, wearing condoms or using dental dams can protect you both from becoming exposed to other (potentially drug resistant) strains of HIV.

Myth No. 5: You can't get HIV from oral sex.

It's true that oral sex is less risky than some other types of sex. But you can get HIV by having oral sex with either a man or a woman who is HIV positive. Always use a latex barrier during oral sex.

Top 5 Myths & Misconceptions About HIV & AIDS!

Washing your skin with water is something that you probably do daily, but you may not know at what temperature the water should be. Using water at the correct temperature is advantageous for the skin. Water at extreme temperatures is harmful for the skin as your skin is not designed that way.

The temperature of the water should also depend on the purpose for which it is being used. Here are some tips on how to set the temperature of the water depending on the purpose: 

1. Showering: while showering, if you are using hot water, then it may strip your skin of its essential oils and make it vulnerable to dryness. This may cause various skin complications, such as cracked and rough skin. Hence, use lukewarm water while you shower.

2. Washing your hair: using hot water to wash your hair may lead to hair damage as it rids your hair of all the essential oils and makes it limp and dull. Lukewarm to normal water is recommended while washing your hair as it will allow the hair to retain its natural oils.

3. Brushing: the right temperature of water while brushing your teeth should optimally be lukewarm. Too cold or hot water can lead to teeth sensitivity and cause oral problems.

4. Washing your face: before you apply a cleansing agent on your face, use warm water to wet the face as it helps to open up your pores. After the cleansing agent is applied, then use cold water to wash your face. Cold water helps in closing the pores after the impurities are removed from the skin.

5. Shaving: if you are going to shave, then opt for warm water as it opens the pores up and thus makes it easier for the blade to glide through the skin. This also reduces the risk of razor burns on your skin.

6. Washing your feet: wash your feet with lukewarm water as it facilitates dead cell removal and also helps in getting rid of warts.

Hot vs Cold: Which Water Temperature is Best for Your Skin

5 Ways to protect your skin this summer

Staying out in the sun too long can cause you to suffer from a host of skin problems such as age spots, wrinkles and even increase your risk of developing skin cancer. During the summer months, you need to take extra care of yourself as the sun is at its peak at that time. Here's what you can do in this summer to ensure that your skin remains protected:

1. Avoid the rays of the sun between 10 am and 2 pm

The strength of the UV rays depends on a number of factors such as reflective surfaces, height, and time of day. The sun's UV rays are at their strongest between 10 am and 2 pm. If you're outdoors, seek a cool area to protect yourself from the damaging rays of the sun. You could stand under a tree or use an umbrella to shield yourself from its ultraviolet rays.

2. Don't use tanning beds

Several studies reveal that tanning beds can cause skin cancer. According to these studies, individuals under 30 who use tanning beds increase their risk of melanoma (the most deadly of all skin cancers) by about 75%.

3. Increase your fluid intake

One of the ways in which you can beat the sun and protect your skin is by increasing your fluid intake during this time. On an average, one should have about 3 liters of fluids every day, which is about 1.5-2 liters of water and 1 liter of fluid from solid foods. From summer foods like watermelon and berries to beverages like fruit juice, milk, etc and liquid-based meals - all these avenues should be considered.

4. Have a proper cleansing regimen

To help your skin look fresh even during the summer months, you should exfoliate regularly. When you do this, all the dead skin cells are removed, giving your face a youthful and fresh appeal.

5. Use a sunscreen all the time

To protect yourself from the damaging ultraviolet rays of the sun, you should never forget to apply sunscreen when going out. Ideally, a sunscreen that has an SPF of 30 should be applied thoroughly to your skin 30 minutes before leaving your house. More importantly, it should be applied again every 2 hours.



5 Ways to protect your skin this summer

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