Vitiligo is a skin disorder where white patches of depigmentation develop on the skin and keep enlarging. This disorder is long term and continuous in nature. The patches appear due to the death of melanocytes within the skin. Melanocytes are skin pigment producing cells, which produce melanin. Vitiligo can affect the skin of several areas, including the eyes, hair and the portion inside the mouth.

Causes
The causes of this disease are as follows:
1. Autoimmune disorders in which the immune system of a patient becomes over reactive and the melanocytes are destroyed.
2. This disease may also occur due to genetic oxidative stress imbalance.
3. Stressful events may also lead to vitiligo.
4. Harm or damage to the skin from sunburns or cuts also leads to vitiligo.
5. Exposure of the skin to several harmful chemicals may be a cause.
6. Neural disorders are also responsible for vitiligo.
7. Vitiligo may also happen from viral causes or may be hereditary and passed on from family members.

Symptoms
Vitiligo has only one major symptom. White, flat spots and patches develop on the surface of the skin. The earliest of these white patches appear on the parts of the body which are exposed to the sun continuously.
It starts off as a simple spot in the beginning and gradually, the spot starts getting pale and finally turns white. The patches have irregular shapes, and in some cases the edges get inflamed and are red in color. Itchiness is experienced in the affected areas. Symmetrical patches signify slow development of vitiligo.

The two major types of vitiligo are:
1. Non segmental vitiligo, which affects the back of the hand, the arms, knees, elbows, feet, mouth.
2. Segmental vitiligo, which is more stable than non segmental vitiligo, but spreads faster. It usually affects areas of the skin, which are attached to nerves.

Treatment
The different methods of treatment for vitiligo are:
1. Phototherapy with UVB and UVA light: Exposing the affected area of the skin to UVB lamps is a popular cure for vitiligo. This treatment can be performed easily at home. UVA treatment incorporates taking of a drug which makes the skin more sensitive to ultraviolet light and then the skin is exposed to high doses of UVA light.
2. Skin Camouflage: Cosmetic creams and makeup can be used to camouflage affected areas of the skin. These topical creams are waterproof.
3. Depigmentation: Depigmentation is used to treat widespread areas affected by vitiligo. The skin color of the unaffected areas is reduced in order to match the affected areas. It is done using topical ointments.
Vitiligo is a skin disease, the major causes of which are still to be discovered. Proper care and treatment should be taken for skin areas affected by vitiligo.

Vitiligo: Causes, Symptoms and Treatments

Herpes simplex virus is a viral infection of the genitals. This disorder can also occur in the mouth, characterized by the formation of fever, blisters and cold sores. The disorder occurs when the body is infected by the Herpes Simplex Virus.

Causes:

Herpes is caused by a contagious virus called the  Herpes Simplex Virus . This virus spreads through direct contact with an infected person. A child may also contract the disease from an already infected adult. This infection may also spread via media such as sharing utensils, kissing or sharing toiletries. Sexual contact with an infected person is one of the primary ways to contract genital herpes. The risk factors for this disorder are  

Multiple sex partners.

Gender: Women are more prone to developing Genital Herpes.

Weak immune system.

If you are affected by a sexually transmitted infection.

Symptoms:

In case of genital herpes, sores form on the genitals. Symptoms include difficulty in passing urine, headaches, fever, fatigue and a lack of appetite. Pain in the eyes and watery discharge from the eyes will be common symptoms if the infection spreads to the eyes.

Treatment:

There is no cure for this disorder. The aim of the treatment is to manage the symptoms and prevent it from spreading. The sores need not necessarily be medically catered to. Certain medications such as  acyclovir  and  valacyclovir  are prescribed to reduce the severity of the symptoms.

Once infected with the virus, it might remain in the body in a dormant state till a long time, in some cases, even a lifetime. However, symptoms might not show up. Factors such as stress and excessive sun exposure can lead to reactivation of the virus. Over time, the intensity of the symptoms tend to come down as the body adapts itself to the disease.

Sores Forming On Your Genitalia - A Sign Of Herpes Simplex Virus

This contagious and highly itchy skin condition comes with symptoms like thin and irregular burrow like tracks containing blisters. These may be found on the affected areas of the skin. Mostly, these growths are found in the folds of one's skin and can occur for children and adults alike. The most common areas where these blisters, sores and bumps may be found include the genital areas, buttocks, the inner side of the elbows, soles of the feet, around the breasts, the waistline, the insides of the wrists and other areas. Let us have a look at the various causes of this condition.

1. Mite: an eight legged mite is the most common cause of this skin disease. The female mites are known to burrow deep in the folds of the skin, where they leave their eggs to hatch and spread. These mites usually make a tunnel like burrow in which the eggs get deposited. The mite larvae then reach the surface the skin and cause a lot of itching once they begin to mature. This itching is mainly an allergic reaction to the larvae as well as the eggs and waste.

2. Physical contact with infected parties: this condition is mostly caused when there is contact with an infected person or animal. This happens due to the fact that contact with an infected party can lead to a deposit of the mites on to the skin, leading to the process of burrowing, egg laying and maturing of the larvae. There has to be close and prolonged contact with an infected person or animal for this to happen. Yet, it has been observed that the mites prefer to live on the host. They do not live for too long on someone inherits the disease with contact.

3. Scratching: there are lots of complications that can lead to the breakout or worsening of the situation. Scratching the skin can often break the same which can lead to secondary bacterial skin infections. Superficial infections like impetigo can also lead to an accumulation of these mites, which can further spread the condition.

4. High risk groups: there are many people who are more at risk of contracting this skin disease. Patients with chronic health conditions like hiv and leukaemia can contract a severe form of scabies known as crusted scabies or norwegian scabies. Also, people who have spent long periods in hospitals and nursing facilities due to prolonged illness and treatment can contract this contagious ailment. Further, it has been found that older people living in nursing homes also often come down with this condition. The crusty and scaly patches caused by this disease can cover the entire body and may be very difficult to treat.

Different Causes of Scabies

You must be aware that while emotional intimacy is highly required for a healthy relationship, physical intimacy is equally important. And, to keep things exciting and satisfying for both the partners trying out several sex positions could be the key.

If you are looking for ways to stimulate your woman to achieve orgasm and ensure pleasurable intercourse moments, mission in-her-possible, a variant of the popular missionary position, can be a good option to try. Understand the intricacies involved with this position by reading further.

What it has to offer to the women?
Women who face difficulties in having an orgasm very often can find this particular sex positions, especially known for its stimulation, is an ideal position to try. Offering the perfect clitoris and G-spot stimulation in its every thrust, it can be one of the best sex positions that can give a woman that perfect long elusive taste of pleasure when a man presses his pelvis against her clitoris. With one leg placing up in the air and one leg placing on the bed, it lets women feel the pleasure of sex and stimulation like never before.

Why will men love it too?
Men who often feel self-conscious and worried about not being able to make their partners achieve an orgasm or stimulate properly, this position can take away all their worries. Though it may demand a bit of endurance from the men's side as they have to lean forward, relying upon the resting leg of women for further guidance and support, and also a certain penis size, still, considering the results, trying this position is worth all the efforts.

Some quick facts about the position

Numbered as 13, mission in-her-possible is for specifically experienced couples. Yes, considering the difficulty levels of it, sexologists recommend it to those who have previous experience in trying various sex positions. 
It doesn t require much of stretching, despite appearing to be so. While the level of pleasure, acquired from this position, can be low for men but as far as women are concerned, pleasure level it provides is high. 
The position may not be very suitable for men with a small penis and for the women who experience pain during intercourse. Men with a penis size of 7 inches or more may be perfectly suitable for this position. 
The requirement of both stamina and flexibility for this position is medium and the pleasure quotient is high.
Remember, whenever trying this particular sex position, both the man and the woman must feel comfortable with each other. Trying  mission in-her-possible' indeed helps in improving the chances of women having an orgasm, but it is only possible when the interest of trying it develops in both the partners, participating in the sexual act.

Sex Position: Mission In-Her Possible!

It is important for you to know about inflammatory bowel disease or IBD, it is a group of intestinal disorders, which leads to prolonged inflammation of your digestive tract. The digestive tract is made of the mouth, stomach, oesophagus, small intestine and large intestine. It performs the task of breaking down food, removing unusable materials and waste products, and for breaking down nutrients from food. Inflammation along with the digestive tract causes disruption in this process. IBD is a fatal condition which can be life threatening in some cases.

Major types of inflammatory bowel disease
The term inflammatory bowel disease is an umbrella term under which many diseases are included. The two major and most common diseases under IBD are ulcerative colitis and Crohn s disease. Crohn s disease (a chronic inflammatory disease of the intestines, especially the colon and ileum, associated with ulcers and fistulae) can lead to inflammation in any part of your digestive tract. It commonly affects the small intestine s tail end. In case of ulcerative colitis, inflammation takes place in the large intestine.

Causes of IBD
Although the exact cause of IBD is not known, several factors may lead to this condition. They are as follows:

Genetics: You are more likely to develop IBD if someone in your family has the disease. This is because of the genetic component of IBD.
The immune system: The body s immune system plays a role in IBD. Usually, your immune system defends your body from pathogens. A bacterial or viral infection in the digestive tract may lead to an immune response. The digestive tract becomes inflamed as the body fights against the bacteria or viruses. The inflammation goes away when the infection is gone.
However, in the case of IBD, the digestive tract inflammation may occur without any infection. Your immune system attacks your body s cells. This is called an autoimmune response. IBD can also occur when the infection is cured, but the inflammation remains.

Symptoms
The various symptoms of IBD depend on the severity and location of the inflammation. They are as follows:

Diarrhoea which occurs when the bowel cannot reabsorb water.
Bleeding ulcers which cause blood to show up in your stool.
Stomach pain, bloating and cramping because of bowel obstruction.
Weight loss and anaemia, which leads to delayed development and growth in children.
In patients with Crohn s disease, canker sores may develop in the mouth.
Ulcers and fissures may appear on the anus or genital area.
IBD may also be associated with problems such as eye inflammation, arthritis and skin disorders.
The major complications which may arise from IBD include colon cancer, malnutrition with weight loss, fistulas, intestinal rapture and bowel obstruction. It is important for you to consult a doctor on noticing any of the IBD symptoms.

Inflammatory Bowel Disease - Know the Types!

HIV: QUICK FACTSIntroductionThe human immunodeficiency virus (HIV) is a subgroup of retrovirus (lentivirus) that causes HIV infection. After a period of time, this infection leads to what is called acquired immunodeficiency syndrome (AIDS).

Epidemiology

According to the Centers for Disease Control and Prevention (CDC), from 2010-2015, the estimated rate of HIV infection in all 50 US states decreased from 14.2 per 100,000 population in 2010 to 12.3 per 100,000 population in 2015. In 2015, 39,513 individuals were diagnosed with HIV infection. From 2010 to 2014, the annual number of new HIV infections decreased by 9%.

Virology HIV-1 and HIV-2 are retroviruses in the Retroviridae family, Lentivirus genus. They are enveloped, diploid, single-stranded RNA viruses with a DNA intermediate.Upon entry into the target cell, the viral RNA genome is converted into double-stranded DNA by an enzyme, reverse transcriptase that is transported along with the viral genome in the virus particle. The resulting viral DNA is then imported into the cell nucleus and integrated into the cellular DNA by a virally encoded enzyme, integrase. HIV contains three retroviral genes, namely gag, pol, and env.

Gag gene: Encodes group-specific antigen; the inner structural proteins
Pol gene: Encodes polymerase; it also contains integrase and protease
Env gene: Encodes the viral envelope, the outer structural proteins responsible for cell-type specificity. Glycoprotein 120, the viral envelope protein, binds to the host CD4+molecule
Pathophysiology

HIV infects vital cells in the human immune system, such as helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells and leads to cellular immune deficiency. This results in the development of opportunistic infections and neoplastic processes.

Mode of Transmission
Sexual intercourse: Unprotected sexual intercourse; especially receptive anal intercourse and different sexual partnersContact with or transfer of blood, pre-ejaculate, semen, and vaginal fluids infected with the virus.Spread from an infected mother to her infant through breast milk. An HIV-positive mother can transmit HIV to her baby both during pregnancy and childbirth due to exposure to her blood or vaginal fluid.

Signs and Symptoms There are 3 categories of infection 

Category A: Asymptomatic HIV infection without a history of symptoms or AIDS-defining conditions
Category B: HIV infection with symptoms that are directly attributable to HIV infection
Category C: HIV infection with AIDS-defining opportunistic infections
Investigation

A high-sensitivity enzyme-linked immunosorbent assay (ELISA) should be used for screening.

Management

Start with antiretroviral therapy (ART) in all HIV-infected adults ready to start therapy. 
CD4 count is no longer a criterion for starting the therapy.
Use of nucleoside reverse transcriptase inhibitors and protease inhibitors.
For refractory cases, during the failing treatment regimen and before switching therapy, use rapid confirmation, perform resistance testing and reevaluate.

HIV - Quick Facts Need To Know!

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