World sickle cell day is observed annually on the 19th of june to raise awareness of sickle cell-related diseases. It is observed to increase people's knowledge and the understanding required to face the challenges posed by the disease.


 

What is sickle cell disorder (scd)?

Sickle cell disorders or sickle cell diseases are genetic blood disorders that cause an abnormality in the red blood cells. The rbcs turn into sickle-shaped cells that stick together and block the blood flow in the body.


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Types

There are four major classifications of sickle cell diseases-


	
	Hemoglobin ss disease
	
	
	Hemoglobin sc disease
	
	
	Hemoglobin sb+ thalassemia
	
	
	Hemoglobin sb 0 thalassemia
	



 

Symptoms

One can start noticing symptoms of sickle cell in a patient at around 6 years of age. However, they can differ from person to person. Some of the most typical symptoms are-

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	Anemia
	


A shortage of red blood cells occurs due to the excessive early dying in 10-20 days. It leads to an oxygen shortage in the body.


	
	Excessive pain
	


Blockage of blood flow due to the change in shape leads to periodic cycles of pain in the body.


	
	Swelling in the body
	


As the blood circulation becomes irregular, swelling becomes a regular phenomenon.


	
	Infections
	


Sickle cell can be damaging to the spleen. It increases the risk of ailments in the body that can be prevented only by antibiotics.


	
	Delayed puberty
	


Oxygen and nutrients carried by the blood are required for growth. As a reason, irregular blood flow can lead to slow growth or delay in puberty.


	
	Vision issues
	


Infected blood vessels carrying blood to the eyes can cause damage to the retina. It can lead to visual problems.


 

Traits and treatment

As sickle cell is genetic, it is suggested to take a test that can detect any trait of the disease. It can prevent any life-threatening risks to the newborn. However, we don't have a complete cure for sickle cell disorders. There are preventive measures that reduce the adversity of the disease to an extent. Procedures like blood transfusions help greatly in minimizing the effects of the disorder.

World Sickle Cell Day: Know All About Sickle Cell Disease

Your body needs some cholesterol to produce hormones and vitamins that help in digestion. Two types of lipoproteins   ldl cholesterol and hdl cholesterol   are responsible for carrying cholesterol to and from the cells in your body.

Hdl or high-density cholesterol is good cholesterol. It carries bad cholesterol away from the arteries and other body parts back to the liver to be processed by the liver.

Ldl or low-density cholesterol, also known as the bad cholesterol, contributes to fatty build-ups within the arteries. This results in narrowing of the arteries and increases your risk of cardiovascular diseases like pad, heart attack, or even stroke.

Although there are medications to bring down ldl cholesterol levels, your doctor may recommend using therapeutic lifestyle changes to see how well your cholesterol levels can be managed without medications.

How to reduce  bad  cholesterol naturally

You can lower ldl cholesterol levels naturally with the following measures  

Diet and weight loss

Being obese or overweight not only increases the odds of developing high ldl levels but also contributes to cardiac diseases and chronic conditions. Studies suggest that losing even a little weight may help reduce ldl levels.

Your diet plays an important role in losing excess fat and maintaining ideal body weight. Eating the right kind of food   such as those that contain a good amount of monosaturated fats, phytosterols and soluble fibre   can help lower harmful ldl cholesterol and increase the levels of hdl cholesterol in the blood. Focus on eating whole grains, fruits and leafy vegetables, legumes, nuts and seeds, and fatty fish.

Exercise more often

Exercising regularly, in moderate amounts, can bring down your cholesterol levels and promote weight loss. Any form of cardiovascular activity, such as cycling, running, swimming and jogging benefits your heart health. You may also turn to other forms of exercise   weight training or yoga   as they also work to decrease the levels of bad cholesterol.

Quit smoking

Smoking causes a number of chemical changes in your body. Cigarette smoke increases bad cholesterol (ldl) and triglycerides levels. This leads to the accumulation of waxy plaque, which clogs the arteries. At the same time, smoking reduces the level of good cholesterol   the one that prevents the formation of plaque in your blood. Quit smoking and turn to a healthier lifestyle to see a difference in the levels of your ldl cholesterol.

Limit alcohol consumption

According to studies, heavy alcohol consumption or drinking more than what is considered moderate significantly increases bad cholesterol, which again raises triglyceride levels and ldl cholesterol.

Lifestyle changes are the natural and first line of treatment for people with high cholesterol levels. However, if your doctor suspects these levels could put you at risk of other medical conditions, he/she might recommend medications to manage bad cholesterol.

Reduce LDL Cholesterol With These Easy Steps

Hepatitis- related to an inflammatory condition of the liver. It occurs mainly due to infection caused by viruses but there are other possible causes as well. Hepatitis can be temporary or viral. Temporary hepatitis, which is acute in nature, gets resolved on its own. Viral hepatitis can be of five types, a, b, c, d, and e.

Symptoms of hepatitis

Hepatitis, in its initial phase, is called the acute phase. The following symptoms along with mild flu are visible:

Loss of appetite
Fatigue
Joint pains
Pain in the abdomen
Nausea
Weight loss
Jaundice
Though this phase is not really dangerous for some patients, it can result in liver failure leading to death.

How is hepatitis diagnosed?

Physical examination
Laboratory tests
Imaging tests


Treatment for hepatitis

Treatment options for different types of hepatitis are:

Hepatitis a: this doesn t require treatment as it is short-term in nature. In case the symptoms cause a lot of discomforts, then bed rest is recommended. The vaccine is available to prevent this infection.

Hepatitis b: acute hepatitis b doesn t require treatment either. Its chronic form can be treated with antiviral medications. This can be prevented with vaccination.

Hepatitis c: this type of hepatitis, both in its acute and chronic forms, is treated through antiviral medications.

Hepatitis d: according to a study in 2013, a drug known as alpha interferon is used to treat this type of hepatitis. Unfortunately, this only comes to the rescue of 25-30% of people.

Hepatitis e: this acute form of hepatitis gets resolved on its own. Adequate rest, drinking a sufficient amount of water, and taking enough nutrients in their food are some of the ways to get healed from this disease.


 

Hepatitis: Signs, Diagnosis, And Treatment

Preeclampsia is a condition that affects women during pregnancy. It is characterized by increased blood pressure and high levels of protein in the urine. Women with preeclampsia also experience swelling in the feet, legs, and arms.

Researchers suspect that excessive body fat or poor nutrition are the primary contributors to preeclampsia and eclampsia.

If left undetected, preeclampsia can lead to a more severe complication, known as eclampsia. Eclampsia can put you and your baby at risk, and can even lead to death (in rare cases).

How do preeclampsia and eclampsia affect the mother?

Preeclampsia and eclampsia can cause a host of complications for the mother, such as the following  

Hellp syndrome   hellp syndrome refers to three different conditions   low platelet count, elevated liver enzymes, and haemolysis. This generally occurs late in pregnancy and affects the processing of rbc, functioning of the liver, and blood clotting.

Seizures

Heart and renal failure

Water in the lungs

Bleeding from the liver

Reversible blindness

Effects of preeclampsia and eclampsia on the baby

Preeclampsia can lead to problems with the placenta in the initial stage of pregnancy. This may pose risks, including the following to the baby  

Lack of nutrients and oxygen, which may prevent the foetus to grow properly

Preterm birth

Stillbirth   this happens when the placenta is separated from the uterine wall

Infant death

Stillbirths are more common when the mother has suffered from a severe form of preeclampsia, like hellp syndrome.

Preeclampsia and eclampsia are linked to a myriad of health issues and life-long challenges for prematurely born babies. These may include cerebral palsy, learning disorders, epilepsy, deafness and blindness.

There is no particular cure for preeclampsia and eclampsia. Treatment, however, depends on how close you are to your due date, and how much the foetus has developed. In the case of mild preeclampsia, your doctor may recommend resting, healthy eating   that limits salt intake   and regular prenatal checkups.

Effects Of Preeclampsia And Eclampsia On You And The Baby

People suffering from sickle cell disease (scd) usually start showing symptoms very early. They can appear to show up even during the first year of life. Symptoms of a sickle cell vary from one person to another and can be mild to serious depending on the condition.

 

Sickle cell disease is a health condition that worsens with time. Despite the absence of any full-proof solution, some treatments prevent further complications. These treatments can help patients receive aid for a lifetime. Simply said, sickle cell diseases can be managed medically.

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Treatment

Treatment in a sickle cell patient depends on the severity of the symptoms. Preventing complications and relieving pain is the primary aim of the diagnosis. They can range from medications to blood transfusions.

 

Concerns

Some of the concerns that need to be taken care of during the treatment of scd are-

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	Prevent painful scenarios
	


A painful episode or sickle cell crisis can be avoided by consuming sufficient fluids, wearing warm clothing, and staying away from sudden temperature changes.

 


	
	Avoid infections
	


Children with sickle cell anemia are made safe from infections by using penicillin. Adults with anemia might need to take penicillin all their lives. Doctors should ensure that all vaccinations in children and adults are periodically done to avoid any infections. However, during the covid-19 pandemic sickle cell patients should take extra care.

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Medications

While there can be numerous ways to manage sickle cell treatment, medications help in a significant way. Some of the prescribed medicines are-


	
	Hydroxyurea- it reduces the frequency of sickle crises. Pregnant women should stay away from this according to experts.
	
	
	Crizanlizumab- this drug injected into the patient can help reduce the sickle crises in adults and children over the age of 16.
	
	
	Voxelotor- it is an oral drug used in children over 12. It lowers the risk of anemia by improving blood flow.
	
	
	Pain-relievers- narcotics to prevent excessive pain can also be used during the treatment.
	


 

Surgical procedures


	
	Blood transfusion
	


It is used to prevent stroke and other related complications in patients. This can increase the number of red blood cells in the body that can help reduce the symptoms.

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	Stem cell transplant
	


It is also called a bone marrow transplant and is used to replace affected bone marrow with a healthy one. This procedure is carried out between matched donor and recipient. Although it is a known cure for sickle cell disease, various risks involved make it a less used practice.

 

Can Sickle Cell Be Cured?

Blood donation is a process that is carried out when a person voluntarily offers for blood to be extracted from his body. There are countless myths about blood donation that need to be squashed and awareness is the only way of doing it.

While blood donation brings multiple health benefits to both the donor and recipient, some facts are known to only a few. These facts will not only open doors to endless possibilities, but will make people feel confident about it.

Facts

Here are some lesser-known facts about blood donation- every person should know-

 


	
	Approximately 112.5 million units of blood are collected from blood donation globally.
	
	
	Around 30 million units are transfused annually.
	
	
	Any person in sound health, at least 18 years old, and weighing at least 45 kilograms can donate blood every 56 days.
	
	
	Your one unit of donated blood can save up to 3 lives.
	
	
	A, b, ab, and o are the primary blood groups. While ab is a universal recipient, o negative is a universal donor.
	
	
	The blood donation process normally takes less than 10-12 minutes.
	
	
	Donating blood does not make you physically weak or decrease your strength.
	
	
	Only 1% of india's population donates blood each year, leading to an annual deficit of two million units.
	
	
	All donated blood units are tested for diseases like hepatitis b, hepatitis c, hiv, and syphilis before transfusion.
	
	
	Red cells, plasma, cryoprecipitate, and platelets are the various types of transfusable elements derived from the blood. The procedure takes place using a method called apheresis.
	
	
	Red blood cells carry oxygen to the organs.
	
	
	Red blood cells survive for about four months in the system of circulation.
	
	
	Platelets encourage blood clotting and provide leukemia patients and other cancer patients with better treatment.
	
	
	Plasma is a pale yellow combination of proteins, salts, and water.
	
	
	Plasma is 55 percent of the volume of blood and 90 percent water.
	
	
	White cells are the chief defense of the body against infections.
	
	
	There is no alternative for blood donation as blood cannot be manufactured.
	
	
	You cannot contract aids or other infectious diseases due to blood donation.
	


Lesser Known Facts About Blood Donation

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