Gastroesophageal reflux disease (GERD) is also called as acid reflux. It is a long-term digestive disorder that affects the lower esophageal sphincter, the ring of muscle between the esophagus and stomach which causes the stomach contents to come back up into the esophagus resulting in either symptoms or complications. Gastroesophageal reflux disease is mild acid reflux that occurs at least twice a week or moderate-to-severe acid reflux which occurs at least once a week.

Epidemiology

In western populations, GERD affects approximately 10% to 20% of the population and 0.4% newly develop the condition. In developed nations, the prevalence rate of GERD is associated with age; with adults aged 60 to 70 being the most commonly affected.

Signs and Symptoms

Esophageal symptoms include:

Heartburn
Regurgitation of food or sour liquid
Dysphagia
Sensation of a lump in the throat
Extraesophageal symptoms include:

Coughing and/or wheezing
Hoarseness, sore throat, or 
Otitis media
Noncardiac chest pain
Enamel erosion or other dental manifestations
New or worsening asthma
Disrupted sleep
Risk Factors

Obesity
Pregnancy
Hiatus hernia
Scleroderma and systemic sclerosis
The use of medicines such as prednisolone 
Delayed stomach emptying Zollinger-Ellison syndrome which can show an increase in gastric acidity because of gastrin production
A high blood calcium level which can increase gastrin production, leading to increased acidity
Visceroptosis or Gl nard syndrome, in which the stomach has sunk in the abdomen upsetting the motility and acid secretion of the stomach.
Factors that can increase acid reflux involve:

Smoking habit
Eating heavy meals or eating late at night
Eating fatty or fried foods
Drinking certain beverages, such as alcohol or coffee
Medications, such as aspirin
Tight clothes
Increased intra-abdominal pressure
Differential Diagnosis

Heart disease causing chest pain
Laryngopharyngeal reflux OR extraesophageal reflux disease
Infection
Peptic ulcer
Esophageal spasm
Complications

Narrowing of the esophagus (esophageal stricture): Stomach acid causes the formation of a scar tissue which narrows the food pathway.
An open sore in the esophagus (esophageal ulcer): Acid causes an open sore which bleeds, causes pain, and makes swallowing difficult.
Precancerous changes in the esophagus (Barrett's esophagus): Damage from acid can cause changes in the tissue lining the lower esophagus
Anemia
How to arrive at the diagnosis?

Upper gastrointestinal endoscopy/esophagogastroduodenoscopy
Esophageal manometry
Ambulatory 24-hour pH monitoring
Treatment

The goals of treatment are controlling symptoms, healing esophagitis, and prevention of recurrent esophagitis or other complications. Lifestyle modifications include the following:

Losing weight (if overweight)
Eating small and frequent meals instead of large meals
Waiting 3 hours after a meal to lie down
Elevating the head end of the bed by 8 inches
Avoiding bending or stooping positions
Medications

H2 receptor antagonists (ranitidine, cimetidine)
Proton pump inhibitors (omeprazole, pantoprazole)
Prokinetic agents (aluminum hydroxide)
Antacids (magnesium hydroxide)
Surgery

Transthoracic and transabdominal fundoplication
Placement of a device to augment the lower esophageal sphincter

Gastroesophageal Reflux Disease - What Causes It?


Cancer is the most dangerous disease noticeable throughout the world. The most common type of cancer that affects men is prostate cancer. Prostate is a small exocrine gland situated directly below the bladder and in front of the rectum. This is gland is approximately in size of a walnut and plays an important role in production of a milky fluid during orgasm of sex in which the semen travels. During the climax stage of the prostate gland is forced to push the fluid and remove the semen out of the reproductive structures.

Prostate gland is a slow progressive disease which makes many males left unidentified even the presence of prostate cancer even until they die. 6 out of 100 male over the age of 60 are getting prostate cancer. Though prostate cancer can be cured at a better rate when compared to other type of cancer it is always best to stay protected. Prevention is always better than cure. Here are few tips to keep your prostate healthy.

Signs and symptoms of prostate cancer-
During the early stages of prostate cancer there are usually no symptoms. Most men at this stage find out they have prostate cancer after a routine check up or blood test. When symptoms do exist, they are usually one or more of the following:

The patient urinates more often
The patient gets up at night more often to urinate
He may find it hard to start urinating
He may find it hard to keep urinating once he has started
There may be blood in the urine
Urination might be painful
Ejaculation may be painful (less common)
Achieving or maintaining an erection may be difficult (less common).

If the prostate cancer is advanced the following symptoms are also possible:

Bone pain, often in the spine (vertebrae), pelvis, or ribs
The proximal part of the femur can be painful
Leg weakness 
Urinary incontinence 
Fecal incontinence 

Ways to have a healthy prostate  
Diet and weight   the most important factor is the diet to maintain a healthy weight. Avoid fatty food items and take fats from vegetables than from animals. Avoid dairy products and increase the intake of fresh fruits and vegetables.
Exercise   have a regular practise of doing exercise at least for 30mins a day. This really helps you to keep your body fit.
Be precautious   if you have a family history of prostate cancer or if you feel you are at high risk of getting prostate cancer talk with your doctor about it and take preventive drugs as per the doctor s advice.
Red foods   research shows that men who consume red foods like watermelon, tomato and other red fruits are at lower risk of getting prostate cancer as they contain a powerful antioxidant called lycopene
Caffeine   three to four cups of coffee per day reduces your risk of getting prostate cancer.
Stop smoking   if you are at high risk of getting prostate cancer it is best advised to quit smoking and alcohol. 


Prostate Cancer -  Signs and Symptoms

The kidneys are responsible for the elimination of waste from the body. The blood is filtered in the kidneys and all toxic wastes are filtered out and excreted through urine. When this filtration does not happen effectively, a lot of waste can be found in the blood, which affects normal body function.

Kidneys may lose their functioning either due to age, injury, or disease conditions. Whatever the reason, when kidney function is hampered, the body suffers. If there was an injury or congenital problem, it could be unilateral and the non-affected kidney could still do the function. However, if it is infection or old age, normally both kidneys are affected and then replacement should be looked for externally. This is where a kidney transplant comes into the picture.

What is it?

It is a surgery where a healthy, functioning kidney is placed into the body. The donor could be

Living: These donors have to be related or unrelated. Related is often termed someone, who is a family member and is willing to donate one kidney (one kidney is sufficient for normal, healthy individuals) to the diseased person.
Cadaver: If a person is willing to donate kidneys post death, these are used for transplant, within a specified time.
Identifying the right donor and recipient:

Blood type and tissue type should be matched; a good tissue type match improves the chances of success
Overall health of the donor to ensure there is no heart disease, lung disease, or diabetes
The recipient also should be healthy
What to expect during surgery?

Once a donor is identified, in living donors, the surgery to remove the kidney and to transplant it are done simultaneously
The surgery usually takes about 3 to 4 hours
Antibiotics are given prior to the surgery to prevent infection
The blood vessels and ureter are connected back to the kidney after the transplant
Hospital stay can range from 5 days to 2 weeks, depending on the overall health of the patient and the anticipated risk of rejection.
Most transplanted kidneys work effectively almost immediately. A kidney stored from a cadaver may take a little longer compared to a fresh kidney from a living donor
People who have had transplants are put on immunosuppressants on a chronic basis to reduce chances of rejection. The new kidney will always be recognised by the body as a foreign body, and so this is essential.
Kidney transplant success rates are quite high, and more and more people are opting for transplants as opposed to dialysis.

Kidney Transplant - What To Expect From It?

This surgery involves the removal of Gallbladder, which is a pear-shaped organ that lies right beneath the right side of the liver. The main function of the gallbladder is to collect and concentrate bile, which is a digestive juice produced by liver after eating, aiding digestion. The most common disorder of the digestive system is presence of Gallstones, which are the stones made up of a mixture consisting of cholesterol, bile pigment and calcium salts.

These Gallstones don t cause any problems in most cases. But prompt treatment is required if stones block ducts and cause infections and inflammation in the pancreas. This may lead to removal of the gallbladder through a surgery, known as cholecystectomy, which further includes techniques such as laparoscopic (keyhole) cholecystectomy or open surgery.
Although it is a less vital organ, the body can cope up even after removal.

Procedure of surgery:

    The surgery involves removal of gallbladder and gallstones through several incisions in the abdomen. In order to see clearly, the surgeon inflates the abdomen with air or carbon dioxide.
    A lighted scope attached to a video camera is inserted into one incision near the belly button. The video monitor is used as a guide for inserting other surgical instruments into the other incisions to remove the gallbladder.
    Intraoperative cholangiography is the X-ray procedure which shows the anatomy of bile ducts. This is done before the surgeon removes the gallbladder.
    Bile flows from the liver through the common bile duct after the surgery into the small intestine. As the gallbladder has been removed, the gallbladder can no longer store bile between meals but has no effect or little effect on digestion.
    In case of open surgery, the surgeon reaches the gallbladder through a large, single incision in the abdominal wall.

Complications after gallbladder surgery:
This surgery carries some degree of risk like any other surgery. Complications such as internal bleeding, infection, injury to nearby digestive organs, injury to the bile duct and injury to blood vessels.

Types of gallstones:
There are three main types of gallstones. They are
1. Mixed stones: They are made up of cholesterol and salts. They tend to develop in batches.
2. Cholesterol stones: Mainly made of cholesterol, which is crucial to many metabolic processes. They can grow large enough to block the bile ducts.
3. Pigment stones: The colour of bile is greenish-brown, due to some particular pigments.

Medical factors to consider before cholecystectomy:
The most important factor is a consideration of your medical history. This is because the pre-existing conditions influence decisions on surgery and anaesthetic and information about any bad reactions or side effects from any medications would be helpful for surgery.

Self-care after the surgery:
Taking rest is the most important thing after surgery. Avoid things such as heavy lifting and physical exertion. The usual recovery period after the surgery is one week. 

Gallstone Surgery - Things You Should Know About It 

Bladder cancer refers to a  cancer, which arises from the epithelial lining or the urothelium of the urinary bladder. In the most common form of bladder cancer, the normal histology of the urothelium is recapitulated. It is called transitional cell carcinoma. Bladder cancer is a serious form of cancer that leads to many deaths too.

Treatment:
There are several modes of treatment for bladder cancer. They are:

1. Bladder cancer surgery: Surgeries are common for treating bladder cancer. 

2. Transurethral resection of bladder tumor or TURBT: This mode is used for determining the presence of bladder cancer and to find out if it has invaded the bladder wall muscle layer. This treatment mode is generally used in the early stages of bladder cancer.

3. Cystectomy: A cystectomy is undertaken when bladder cancer is very invasive and parts of the bladder or the whole of it has to be removed. There are two types of cystectomy.

Partial cystectomy is used when the cancer invades the bladder muscle layer in a small area. It can be removed without the whole bladder being taken out.
A Radical cystectomy is undertaken in case the cancer affects a large area and is present in multiple areas of the bladder. This surgery removes the bladder entirely and all its nearby lymph nodes.
4. Intravesical therapy: In intravesical therapy, a liquid drug is put directly into the bladder via a catheter instead of injecting it or consuming it orally. The cells lining the bladder are affected without causing any harm to other body parts. This therapy is usually used after TURBT in non-invasive cases of bladder cancer to prevent recurrence.

5. Chemotherapy: Chemotherapy is an effective treatment for bladder cancer. Chemotherapy may be used in two ways:

Intravesical chemotherapy, where the chemo drug is put directly into the bladder and is applicable only for early treatment stages.
Systematic chemotherapy, which involves the injection of chemo drugs into the vein or muscle and can also be administered in the form of pills. The drug reaches all parts of the body via the bloodstream and affects all cancer cells.
6. Radiation therapy: This treatment procedure for bladder cancer involves the use of high energy radiation for killing cancer cells. It is used in early phases of treatment and is the primary remedy for people who cannot have a surgery. It is combined with chemotherapy to make the radiation effective. The most common type of radiation therapy for treating bladder cancer is called external-beam radiation therapy where radiation occurs from an outside source.

Bladder cancer is a severe form of cancer. Proper and ideal treatment is required among the several treatment methods available.

In case you have a concern or query you can always consult an expert & get answers to your questions!

Bladder Cancer and How It Can Be Treated

In recent years there has been a rise in gastrointestinal disease due to lifestyle changes. Conditions like irritable bowel syndrome, gastroesophageal reflux disease, nonalcoholic fatty liver, cancer of colon, liver and pancreas have been affecting the young and the elderly equally.

The advancement of medical science has given rise to a series of laparoscopic surgeries relating to gastrointestinal diseases. These surgeries are minimally invasive compared to open surgeries. Let s have a look at the various forms of gastrointestinal surgeries.

Conditions Cured through Gastrointestinal Surgeries:

Gastrointestinal surgery can be used to prevent and treat the following health disorders.

  Peptic ulcer disease
  Barrett s Esophagus
  Hiatal hernia
  Radiation bowel injury
  Gastrointestinal tumours
  Inflammatory bowel disease
  GERD
  Achalasia
  Malignant disease of the pancreas
  Malignant disease of the biliary tract
  Infectious disease of the colon and rectum

Types of Gastrointestinal Surgeries:

Some examples of gastrointestinal surgeries include  

  Colon Cancer Surgery - It may involve local excision which is done in the early stage of colon cancer. Here the doctor inserts a cutting tool into the colon to remove the cancerous growth. Colectomy is the next stage that is performed only when the cancer has spread to the nearby tissues.

  Oesophagal Cancer Surgery - It includes esophagectomy or removing the oesophagus partially leaving the patient with the ability to swallow.

  Gall Bladder Cancer Surgery - It involves four stages of treatment namely Cholecystectomy, Surgical Biliary Bypass, Endoscopic Stent Placement and Percutaneous Transhepatic Biliary Drainage. Each procedure is performed at different stages depending on the severity of the condition.

  Liver Disease Surgery - Liver disease surgery involves Partial Hepatectomy, Liver Transplant and Ablation used at different stages of cancer.

  Pancreatic Cancer Surgery - The four stages of pancreatic cancer surgery includes Whipple procedure, Total Pancreatectomy, Distal Pancreatectomy and Gastric Bypass.

Apart from these open surgeries, the laparoscopic procedures include -

  Laparoscopic Adrenalectomy
  Laparoscopic Appendectomy
  Laparoscopic Nephrectomy
  Laparoscopic Splenectomy

Benefits of a Gastrointestinal Surgery:

  Minimally invasive due to which scarring is less
  Shorter recovery period
  Reduced chances of infection
  Reduced chances of reoccurrence of the disease

Most of these benefits apply specifically to the gastrointestinal surgeries performed using the laparoscopic technique.

With the rampant increase in gastrointestinal diseases among the masses the wide ranges of gastrointestinal surgeries have made treatment and prevention easier and more accessible.

Gastrointestinal Surgery - All You Should Know About It!

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