Alzheimer's disease is a neurological problem that is characterised by a cognitive decline and memory loss. It is a type of neurodegenerative dementia. The symptoms of alzheimer's disease include not being able to absorb and retain new information, lack of reasoning and judging, not being able to take on complex tasks, impaired visuospatial abilities, problems in reading, writing and speech, among many others. If a person has at least two of these symptoms in a debilitating manner, then the diagnosis can be made in favour of alzheimer's disease. The main causes of alzheimer's are shrinkage of the brain size and death of the brain cells. The immune system is also said to trigger this neurodegenerative disease. Let us find out what medical science has found so far.

1. Connections: many a times, in alzheimer's disease, the memory and behaviour of the person changes because the brain is unable to make proper neural connections which can lead to memory loss of how a person behaved and the elements that formed the basis of the patient's cognition. Apparently, the immune system behaves in the same way within the brain and blocks the connection. This happens because there is constant communication between the brain and immune system along neurological lines, which is where the disease first emanates.

2. Inflammation: the brain is prone to inflammation or swelling that is not the normal kind. This inflammation happens as a result of the activation of the infection fighting neurotransmitters and the chemical changes that happen in the brain when an infection strikes. The inflammation usually happens in the plaques or clumps which the brain tries to protect. These clumps are made up of a protein called amyloid. The immune system is responsible for creating this inflammation in the brain of the patient.

3. Pattern recognition receptors: many of these receptors work in different manners and cooperate with each other to create a response in the brain. These prrs can be found in the brain plaques, and they develop the signs of danger which further fuels the inflammation in the brain as a matter of protection.

4. Activation of cells linked with the immune system: when the prrs begin to respond, it basically activates the immune system and the cells of the same. This is the basic reaction that causes the changes in brain which then leads to the attachment of the protein to the tissue that is diseased, in which case alzheimer's disease starts. The inflammation that we had spoken about earlier basically happens in the nervous tissue.

It is important to recognise and act on the initial signs of alzheimer's disease before it progresses beyond one's control.

Can the Immune System Trigger Alzheimer's Disease

What is Parkinson s disease?
Parkinson s disease is a progressive and degenerative disorder of the Central Nervous System that mostly affects older people. It is a chronic disease and the symptoms develop over a period of time. The characteristic symptoms of Parkinson s are rigidity, shaking, bradykinesia (slowness in movement) and shuffled gait. Anxiety and depression also seem to be common in advanced stages of Parkinson s disease. In addition to the motor symptoms, the cognitive function of the brain is also compromised.

Degeneration of the nerve cells in the substantia nigra of the brain results in the reduction in production of dopamine which is a neurotransmitter in the brain. Neurotransmitters relay impulses from one nerve to the other. This is what is mainly responsible for the motor symptoms in Parkinson s. Although, Parkinson s is not a curable disease, it can be controlled and the progress of the disease can be kept in check with certain medications.

What causes Parkinson s disease?
The cause of Parkinson s is mostly idiopathic, i.e. the cause is unknown and is not specific. However, there have been cases which show that it can be attributed to factors such as genetic and environmental factors.
What are the symptoms of Parkinson s?

The symptoms of Parkinson s can be classified as Motor symptoms and Non-motor symptoms:

Motor Symptoms 

Bradykinesia: Slow movement
Tremor of limbs
Rigidity or stiffness of trunk and limbs
Impaired balance and difficulty in coordination or postural instability
Non-motor Symptoms 

Depression
Anxiety and fear
Loss of energy and fatigue
Constipation
Excessive salivation
Weight gain or weight loss
Cognitive problems such as difficulty in remembering, confusion, dementia
Parkinson s disease is not curable, but when detected early, medicines are prescribed to give symptomatic relief. Dopamine substitutes are prescribed to the patient to relieve the motor symptoms.

Parkinson's Disease - Understanding The Motor & Non-motor Symptoms!

Dementia refers to the progressive loss of memory in a human being. It does not refer to any particular disease. It is rather a cumulative representation of symptoms which signify that the person is losing his or her memory. Dementia occurs in seven stages. Read on to read more about them:

In the first stage, there is no cognitive decline and the person is mentally sound. There is no memory loss as well.
In the second stage, there is a very mild cognitive decline leading to normal forgetfulness that is often associated with progressing age.
In the third stage, there is a mild cognitive decline. The person has an increased forgetfulness and may find it difficult to concentrate on things.
In the fourth stage, there is moderate cognitive decline and the person starts forgetting even the most recent events. They cannot even travel alone or manage their own finances.
In the fifth stage, there is moderately severe cognitive decline. The person going through this stage often requires help even with their daily activities. People tend to forget even the most common things like phone and email passwords.
In the sixth stage, there is severe cognitive decline. This stage is also called middle dementia and there is prominent memory loss. People cannot even count from 1 to 10. Their speech becomes slurry. They also start having delusions.
In the seventh stage, there is very severe cognitive decline. This stage is also called late dementia. The psychomotor skills are also lost at this stage and the person may not even be able to walk properly.
Some of the early signs of dementia are listed below:

In the initial days of dementia, the person usually tends to get confused when it comes to choosing the right words. This makes them take much longer time to conclude their speech.
There might also be a change in the mood of the person.
Depression is also one of the early signs.

The person will have a tendency to forget even the most recent events that took place in his or her life. This means that they might remember what happened ten years before but they might not remember what they did in the morning.
Early signs also include failure to sense directions. People often tend to forget their addresses and the landmarks and thus become lost when they travel alone.
Confusion is also one of the common signs and this is directly correlated to the loss of memory because when a person cannot remember familiar faces, it leads to a lot of confusion within his own mind.
So, if you suspect that someone in your house is suffering from dementia, then you must look out for these early signs and seek medical help immediately. Early treatment can keep the condition from worsening.

Dementia - Stages and Early Signs!

Diagnosing dementia can be more difficult than you can imagine. Medically, the patient needs to have at least two areas of mental functionality impaired to an extent where it interferes with their everyday life. However, diagnosis is just the beginning as treating dementia can be even more challenging. Here is a look at some of the treatment options available for dementia patients.

 Treatment for Dementia
There is often no cure for most forms of dementia. Treatment relies on the management of the condition, to ensure that the progression can be impeded. With proper treatment, patients can live a relatively normal life for a number of years.

Cholinesterase inhibitors- These medications are used for the treatment of Alzheimer s disease. They are chemical agents that boost the memory and judgment of the patient. The same is also an effective medication for those suffering from Parkinson s disease and Lewy body dementia.
Therapy- Making small changes to some aspects of life of the patient can often yield good results. For instance, clearing the clutter and noise in the house can be an effective way of helping dementia patients deal with their condition. Similarly, creating a safe environment at home with little chance of severe accidents, will ensure the safety of the patient.
Stress in caregivers of dementia patients
Dementia patients need to be cared for, ideally by a close family member such as a spouse. However, these caregivers undergo a lot of stress while providing support to the patient. For instance, Alzheimer s patients often do not recognize their caregiver who may also be their spouse. Here are some burdens that caregivers have to deal with.

Anger- The sense of fury towards the patient can be strong after years of providing care. They may also be frustrated with the fact that the affected person is unable to perform simple everyday jobs, such as brushing their teeth or tying their shoelaces.
Anxiety- A sense of hopelessness regarding the future is common. It is also the fear of what new challenges the next day might bring.
Depression- Seeing their loved one s mental state deteriorating with each passing day can be difficult to handle and pushes some caregivers into depression.
With such continuous emotional and physical stress, caregivers often fall sick themselves. This is why it is necessary to maintain a bright outlook and remember that a dementia patient can only get well if they have the full support of the caregiver. In case you have a concern or query you can always consult an expert & get answers to your questions!

Treating Dementia - Things You Should Know!

Alzheimer's disease is a dynamic disease that causes loss of memory and other vital mental functions. To start with, someone with Alzheimer's disease may witness light confusion in the beginning and trouble recalling. In the long run, individuals with the disease may even overlook important individuals in their lives and experience emotional identity changes.

Dementia: Alzheimer s disease is the most widely recognised reason for dementia   a gathering of brain issues that causes the loss of intellectual and social abilities. In Alzheimer's disease, the brain cells deteriorate and die, bringing on an enduring decrease in memory and mental capacity.
Brain Cells: Despite the fact that the reasons for Alzheimer's is not yet completely comprehended, its impact on the brain is clear. Alzheimer's disease harms the brain cells. A mind influenced by Alzheimer's has fewer cells and fewer associations among surviving cells than a solid mind.
Brain Shrinkage: As more brain cells start to die, Alzheimer's prompts critical brain shrinkage. At the point when specialists inspect Alzheimer's brain tissue under the magnifying instrument, they see two sorts of irregularities that are considered to cause Alzheimer s. These are:
Plaque: These clusters of a protein called beta-amyloid may harm and crush brain cells in a few ways, meddling with cell-to-cell functioning. In spite of the fact that a definitive reason for brain cell passing in Alzheimer's is not known, the accumulation of beta-amyloid on the outside of brain cells is a prime reason.
Tangles: Brain cells rely upon an inner support and transport framework to carry the supplements and other fundamental materials through their long extensions. This framework requires the typical structure and working of a protein called tau. In Alzheimer's, strings of tau protein turn into strange tangles inside the brain cells. This may also cause the decrease of brain cells. 
Here are some more causes that can lead to this disease:

Age: Age is a most critical cause in the development of Alzheimer's disease. The probability of building up the condition increases after you reach sixty-five years of age.
Family history: The qualities you acquire from your parents can add to your danger of building up Alzheimer's infection. This may also contribute to the environmental factors which can cause this condition. In some families, a single gene creates Alzheimer s disease and the dangers of the condition being passed on are much higher.
Head injuries: Individuals who have had serious head damage have been observed to be at higher risk of building up Alzheimer's disease.
Cardiovascular diseases: Research demonstrates that few lifestyle components and conditions connected with cardiovascular disease can build the danger of Alzheimer's disease. These include smoking, obesity, diabetes, hypertension and high cholesterol.


Alzheimer's Disease - Reasons That Can Lead To It!

The skin is an elastic organ (yes, it is an organ!), but only to a certain extent. It has a limit to which it can accommodate the underlying tissues. With the increase in bulk, for example, puberty, pregnancy, muscle mass building or surgical implants, the skin is made to stretch beyond its limits. What happens is this stretch causes the skin to stretch too, and these stretch marks or striae become an unpleasant thing that needs to be hidden. 

Dressing needs to be changed so that they are not showing. Dermatologists see a big demand for getting rid of these marks too. There have been conventional, time-tested methods which help in getting rid of these. However, with newer advancements in dermatology, the platelet rich plasma is being widely used for getting rid of these stretch marks.

Why stretch marks? 

In any of the scenarios above, the stretch marks appear because there is a lack of underlying supportive tissue when it is stretched out. There is a lack of collagen and connective tissue, causing stretch marks. These are most evident in fat collecting areas like breasts, abdomen, thighs, upper arms, etc.

What is platelet-rich plasma or PRP? 

The blood is composed of a liquid portion known as plasma, which contains three main types of cells i.e. white blood cells, red blood cells, and platelets. The white blood cells are the ones responsible for fighting infections. The red cells give blood its color and also are responsible for carrying nutrients to the various organs. The platelets are tiny fragments of cells which help in blood clotting. Platelets are also rich in what are called totipotent cells, which can grow into any type of cells. When the body is affected, due to injury, infection, trauma, etc., these get concentrated in the affected area and are produced in large numbers to help in the recovery of the particular affected area.

Technique: 

The area to be treated is isolated and prepared. Blood is centrifuged to remove other cells and obtain platelet rich plasma. This RPR is injected into the underlying layers of the skin. This induces the release of growth factors into the connective tissue space. Collagen is produced over a period of time, which causes the skin to become taut and lose the stretch marks. The injection can be repeated if required on the topmost layer. It can also be mixed with thrombin to form a gel, which is then used similarly. Using it both in the underlying and superficial layers helps in completely getting rid of the marks.

Studies have shown a reduction in both the depth and size of the stretch marks and some might require two to three repeat injections.


Stretch Marks - How PRP Therapy Can Help You?

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