Alzheimer s disease is a neurological, irreversible, progressive brain disorder. It is a chronic neurodegenerative dementia that causes the death of brain cells, causing memory loss and cognitive decline. It affects a person s thinking and behavior. The symptoms develop slowly and get worse as time passes.

Causes:
As it is a kind of dementia, Alzheimer s is caused by the death of brain cells. Over a course of time, brain cells die progressively and at the end, the tissue is left with fewer nerve cells and connections. As a result, the total brain size shrinks. Tiny inclusions called plaques and tangles can be seen in the postmortem. These cannot be seen or tested in a living Alzheimer s affected brain. These plaques are given the name  amyloid plaques  because they are found among the dying cells of the brain when a protein called beta-amyloid builds. The tangles stay in the neurons; they are formed from a protein called tau.

There are several reasons behind all this, some of which are listed below-

Anti-anxiety medications
Hitting on the head too many times
Regularly sleep-deprived
Loneliness
Diabetes in the brain
Old age
Genetic line
Down s syndrome
Cardiovascular diseases
Symptoms:
Alzheimer s disease damages the brain, so the clinical signs and symptoms begin to show very early. The symptoms are-

Memory loss
Agitation and mood swings
Poor judgment
The trouble with money calculations
Difficulty doing familiar tasks
Trouble in planning or solving a problem
Confusion with time and place
Difficulty in communicating
Loss of motivation
Inappropriate behavior
Aggressive personality
Childlike behavior
Preventing Alzheimer s disease:
Alzheimer s disease ultimately results in death. Even if there are treatments, they cannot fully cure it. So it s better to try to prevent it before it happens. Ways to prevent Alzheimer s disease are-

Eating more fruits and vegetables.
Eating berries every day.
Increasing omega-3 fatty acids.
Taking folic acid supplements.
Drinking grape juice or red wine with evening meal.
Doing the Mediterranean style diet.
Controlling the blood pressure.
Having strong social support.
Treatment of Alzheimer s disease:

Treatment of Alzheimer s disease is a long time process.
First of all, doctors perform a physical exam to check the overall neurological health. By this, they check muscle strength, reflexes, walking ability, sense of sight and hearing, coordination and balance.
Then comes the blood test to find the cause of confusion and memory loss by checking the thyroid disorder and vitamin deficiency.
Then they perform the neuropsychological test and check the mental status.
Then there are other tests, like MRI, CT, and PET.
After all this, drugs are given and a safe and supportive environment is created with proper exercise and nutrition.
Alzheimer s disease is undoubtedly the worst kind of disease. Hence, it is highly recommended to contact a doctor as soon as any symptom is noticed.

All About Alzheimer's Disease!

With age, most body organs begin to deteriorate in their function. This happens to the brain also, thereby reducing the overall speed of functioning of most organs. While slowing of bodily movement is visible, the internal organs functioning also slows down, which is not that obvious. Memory loss or dementia is one of the main manifestations of this degeneration of the brain.

Alzheimer s is the most common form of dementia, and the associated symptoms includes reduced reasoning abilities and cognitive defects. Though it is seen only in the elderly, not all elderly people will have Alzheimer s. The overall quality of life of the affected person is reduced with difficulty remembering things that were recently learned. It is a progressive disease and as it gets more severe, a full-time caretaker may be required.

Causes: The brain cells are affected by protein masses known as plaques and tangles. These hamper the way communication between the brain cells happens as well as affect nutrition from reaching all parts of the brain. This leads to shrinking of the brain, eventually leading to memory loss and other problems. There is also a strong genetic linkage, as most people with Alzheimer s have the lipoprotein A gene.

Symptoms: Though memory loss is the most common symptom, there are other symptoms:

Being confused about places, people, and times
Inability to find the right words during conversations
Regular objects are misplaced
Becoming irritable, (in someone who was not so previously)
Mood swings
Personality changes
Inability to organise thoughts
Not able to make the right decisions
Repetitive talks and actions
Forgetfulness (not something the person always does)
Difficulty with numbers (again, not something calculations
Difficulty managing everyday tasks and minor problems
Suspicion of others (like immediate family members and friends)
Risk factors: While age is definitely a risk factor, the fact that not all aged people develop Alzheimer s is to be borne in mind. Other risk factors include the history of stroke, high cholesterol, high blood pressure, diabetes, smoking, obesity, and poor lifestyle choices.

Diagnosis: While there is no definitive way to diagnose Alzheimer s, symptoms along with brain scans and neuropsychological function testing are useful ways to confirm the diagnosis.

Treatment: This is aimed at two things reducing the rate of disease progression and treat (or reverse) symptoms if possible.

Cholinesterase inhibitors improve cellular communication in the brain and also manage depression and agitation. Memantine is used to slow the pace of disease progression.
In people with the disease, small changes are useful to help them with the symptoms. These include keeping essential things like keys and wallet in the same place, keep a daily diary to help them remember things, keep pictures of friends and family within visible distance.

Alzheimer's - An Overview!

Parkinson's disease is a neurodegenerative condition that affects your brain cells which produce dopamine and thus hampering all kinds of motor functioning and other emotional responses. After the disease is diagnosed, medication and therapy can help to provide relief from the symptoms to a large extent but a permanent cure is not possible.

Causes:

The disorder does not have a definite set of causes. A small percentage of the cases have been related to hereditary factors and others have a range of environmental causes associated with them.

1. Genetic factors:

Specific gene mutations and gene variations have been proved to cause Parkinson's, such as SNCA, PARK2, PARK7, PINK1 and LRRK2. These make or recycle proteins which are linked to the disease.

Research shows that men are at a 1.75 times greater risk of developing the condition than women are. Also, age plays a role with most cases occurring after the age of 60.

2. Environmental factors:

Regular exposure to inorganic insecticides, pesticides, herbicides and heavy metals or other toxins may cause the disorder. In rare cases, Parkinson's disease occurs in the aftermath of a severe head injury or immune disorders.

Symptoms:

The symptoms can be classified into two broad categories-

1. Motor symptoms:

The hand tremors when in resting position
The grip loosens
Walking slows down
Facial muscles freeze partially
Speech is slurred
Balance is disturbed
Swallowing is painful
Urination is abnormally frequent
Dementia-like symptoms are seen
There is involuntary twitching of the fingers and toes
Repetition of the same movement in quick succession is nearly impossible
2. Non-motor symptoms:

Dental problems
Vision impairment
Skin disorders
Panic attacks
Excessive secretion of saliva
Extreme weight loss or gain
Sexual problems
Loss of sense of smell
Lowering of the pitch of the voice
Fatigue

Causes and Symptoms of Parkinson's Disease

One of the common ailments in the elderly people is the Parkinson s. A progressive disorder, when left untreated, results in worsening of the symptoms. Hence, it is essential to understand the treatment options available to manage the condition effectively. You may be suggested surgical therapies if medication is not effective enough to treat the symptoms.

Surgical treatment options can be beneficial for patients who are suffering from symptoms, but they do not help with treating the disease. In the past, surgical methods like Thalamotomy and Pallidotomy were used to destroy brain cells that contributed to the symptoms. While these methods are still used, they are very rare and situational.

Deep Brain Stimulation (DBS), an FDA-approved procedure, has become much more popular as it is much safer and does not involve invasive surgery. Instead of destroying brain cells like traditional methods, DBS involves sending electric pulses to the affected brain cells to reduce the symptoms. It is not a treatment procedure, but a means of bringing down the severity of Parkinson s to allow better and more comfortable treatment.

Deep Brain Simulation   Who are the right candidates?
Deep Brain Simulation is commonly used for Parkinson  s disease, but it is not recommended for everyone. It is a preferred method of treatment for people who have had Parkinson s for at least four years but have complications which include long periods of time where medications do not work, or symptoms return, uncontrolled and involuntary movements or the freezing/stiffness in the body.

Deep Brain Simulation is not recommended for those who have Dementia as it can lead to memory problems. The general rule of thumb that neurosurgeons follow is that Deep Brain Simulation can help with symptoms that do not get better with medication. DBS can help reduce medication requirements for patients as well as reduce the side effects that may occur due to medication.

Disorder specialists and neurosurgeons can conduct tests to determine if DBS is going to be effective for a patient before going ahead with such a procedure. An extensive assessment is necessary to understand the symptoms, the effect of Parkinson's drugs and also brain imaging is done. All of the expected benefits are then evaluated for the patients, and if the procedure can help alleviate the symptoms, DBS is given a green signal by neurosurgeons and patients can undergo the procedure.

How Does Deep Brain Simulation Work?
Deep Brain Simulation is a very complex procedure. Brain cells communicate with the rest of the body through electric signal, and these become irregular and do not work properly when affected by Parkinson's. DBS smoothens the functioning of these brain cells and reduces symptoms through electric pulses through the implantation of a medical device known as neurostimulator which is also referred as brain pacemaker.

But, as with any treatment procedure, DBS has potential risks and side effects, hence discuss with neurosurgeon thoroughly to access the suitability.

Adopting Deep Brain Stimulation For Parkinson's disease

Parkinson s disease adversely affects the way you move, as it is a neurodegenerative disorder. This happens when there are problems with certain nerve cells in the brain. These nerve cells produce an important chemical called Dopamine, which in turn sends signals to the region of our brain that takes care of the movement. This chemical help muscles to function smoothly and allow in carrying out one s daily activities. When somebody is suffering from Parkinson s disease, the nerve cells break down, thus hampering movements of limbs.

What Causes This Disease?

Over the years, a lot of research has taken place to find out the exact reasons due to which people get affected by Parkinson s disease but till now neither scientists nor doctors have been able to come up with any solution. They are thinking on the lines of aging or hAarmful chemicals in the environment, to be possible causes for this neurological problem. Sometimes researchers even feel that this could be a hereditary problem but there is no concrete evidence to substantiate this statement.

Symptoms Of Parkinson s

As discussed earlier, Parkinson s occur in aged individuals, when nerve cells break down, when the chemical called Dopamine is no longer able to send signals to the brain. You can easily recognize Parkinson s disease in any of your family members, if you come across certain symptoms, which are generally four of them:

Trembling or shaking of limbs and these tremors can affect different body parts like, hands, arms and legs.
Muscles become stiff, due to which it becomes tough for the affected individuals to move their limbs freely.
Due to stiffness of muscles, movement becomes slow and thus each and every activity of theirs takes much more time than usual.
People are unable to keep their balance and walk freely without any hindrance.
Generally, tremor is the first thing you would notice in a person and thus instantly get to know that the person might be suffering from Parkinson s.
Problems of constipation or facing difficult in swallowing tend to happen as the disease goes on to affect all the muscles in one s body. 
During the latter stages, someone who has Parkinson s, might well have a blank expression to the face with problems being faced while trying to speak and other related issues. The symptoms of this disease usually start for people aged between 50 and 60 but at times, it can even crop up at an earlier stage.
Preventive Measures And Treatment

Let s take a look at how you can prevent yourself from getting crippled by Parkinson s Disease.

Unfortunately, as the disease is mostly age related, so after attaining the age of 60, if not from 50, there would be very few individuals who would not be the victims of Parkinson s.

Research has revealed that having less of dairy and red meat and consuming more of fruits, vegetables and high-fibre foods, thus maintaining a healthy diet, can protect people from the dreaded disease.

Parkinson's Disease - Know What's It's All About

Alzheimer s disease is one of the most severe forms of dementia that is, memory loss which also comes with other disorders such as reduced muscle movement. A patient with the Alzheimer s disease practically forgets even the most basic day-to-day activities and hence, the disease interrupts the lives of people suffering from it and the ones who are related to them. A commonly observed pattern in the patients suffering from the Alzheimer s disease is that most of them are aged 60 years and beyond. In simple words, it is the death of the brain cells, that is, the nerve cells which causes the memory loss at first and then the cognitive decline of other bodily functions.

Symptoms:

A patient of the Alzheimer s disease might show one or more of the following mentioned symptoms. Read the symptoms carefully and help identify the symptoms if you see them in anyone in your surroundings. Most people mistake this symptom to be something else which causes a delay in the diagnosis. But if the disorder is diagnosed at an early stage it might help people survive, or at least have a little longer until their memory stays intact. Therefore, it is of utmost importance to know about the symptoms that are given below:

The inability to remembering the information 
Repeating questions or actions
Unable to find the way on a rather regularly visited road
The decrease in decision-making ability
Poor judgment
Unable to solve complex puzzles or do tough activities
Unable to recognize familiar people such as colleagues and relatives
Unable to dress up properly
Inability in speaking mother tongue or word formation
Uncontrollable mood swings
Rude and un-empathetic social behavior such as being outspoken
They will be unable to maintain their own finances unlike before.
Stages of Alzheimer s disease
It is not unknown a fact when someone says that detecting a disease at an early stage is beneficial than at a later stage. The reason being that if a disease is detected earlier, there are more chances of treating it successfully, or in case of the Alzheimer s disease there are more chances of a medication to work on slowing down the adverse effects of the disease since there is no permanent cure available for it. Therefore, it is of utmost importance that one is aware of the early onset of the disease and also, the symptoms to make a quick diagnosis. The disease affects people between the age of 30 and 60, generally, the symptoms begin at the very early age of 30 but they do not become persistent before reaching a later-on stage. The three stages are:

Preclinical when the individual hasn t recorded any symptoms
The beginning with mild symptoms
Complete dementia

Alzheimer's Disease - Know Its Symptoms!

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