Hereditary Angioedema is a rare skin related disorder and as the name suggests it is also a genetically inherited condition. This condition mainly afflicts the throat, abdomen and the limbs of the patient, with a certain kind of swelling. This swelling can become fatal if not treated on time. Here is everything you need to know about the condition and its treatment.

Causes: A rare genetic mutation of the SERPING1 gene can cause this condition. Usually, this gene is known to produce C1 esterase inhibitor, which is a kind of blood protein. This blood protein is an important element of one s immune system and is usually involved in the biochemical reactions that control the body s response to inflammation causing elements. This is done when the blood protein produces a hormone known as Bradykinin. If this blood protein does not function in a normal manner, then there is excessive production of this hormone, which leads to swelling and inflammation.

Type One: There are various types of Hereditary Angioedema that can affect various parts of the body. Type one is one of the most common kinds and can be found on the face, hands, abdomen, throat, as well as feet and genitals of the patient. The severity and frequency of attacks cannot really be predicted and the patient may suffer from attacks throughout his or her life. The best way to treat this type of Hereditary Angioedema is with the help of antihistamine drugs and prednisone which can fight allergic attacks.

Type Two: This kind of Hereditary Angioedema has the same symptoms as type one and is caused by a malfunction of the C1 inhibitor, rather than the Bradykinin hormone as one can see in type one. This condition can also be treated with anti-allergy drugs.

Type Three: This is very rare kind of Hereditary Angioedema. In fact, medical science is yet to find a conclusive body of knowledge that can point to the exact causes and symptoms of this condition. Coagulation is one of the main causes recognised so far. This condition is much more common in women than it is in men, and it usually shows up as facial swelling.

Timely Treatment: While there is no cure for this condition, one can prevent a flare up of the symptoms by taking C1 inhibitors and Bradykinin receptors as well as enzyme inhibitors. It is important to get early treatment for the symptoms and to have constant access to a hospital and its emergency unit. One should also keep track of attacks and symptoms and get regular check-ups done by a doctor to detect the earliest signs of the same to avoid fatalities.

What is Hereditary Angioedema and How Can it be Treated?

Cellulitis is a common contagious bacterial skin infection marked by redness and swelling of the skin that feels tender and hot. It usually occurs when bacteria penetrate through a crack or a cut on the skin s surface. Although cellulitis can develop anywhere over the face or the body, it is your lower legs that are affected the most. It damages the tissues beneath the skin, spreading to the bloodstream and the lymph nodes. If left untreated, the infection might get aggravated and turn fatal.  


Prevention:
In case of a recurrence, preventive antibiotics may be recommended by the doctor. Adopting the below mentioned precautionary measures can help: 
1. Gently rinse the wound with soap and water on a daily basis, whenever you go in for a shower.
2. Apply an antibiotic ointment or a cream over the wound to get adequate protection.
3. Use a bandage to dress your wound and change it daily.
4. Watch out for signs of infections such as pain and redness and accordingly go for medical help.
5. People with diabetes often suffer from poor blood circulation. They require extra precautions in order to prevent any skin injury:
Minutely check for signs of injury, failing which you might be even more susceptible to infections. 
Moisturize and lubricate your skin daily to prevent peeling and cracking.
Trim your toenails and fingernails carefully so that they do not injure the ambient skin.
Wear appropriate gloves and footwear to protect your feet and hands.
Treat any infection developing on the skin surface at the right time because they might be contagious.


5 Tips to Prevent Cellulitis

Celiac disease is a condition in which the small intestine becomes sensitive and reactive to gluten, leading to difficulty in digesting food. Gluten is a kind of a protein found in wheat or barley. In reality, if either of the partners is suffering from celiac disease then you are prone to fertility related issues.

Impact of Celiac disease

As compared to men, this disease is more common among women in general. Women suffering from the disease are generally more prone to infertility and other genealogical problems like preterm births and miscarriages. In the case of men, the disease causes the infertility problems including sperm abnormalities such as low count, abnormal shape, reduced function and such others. Additionally, men with the untreated celiac disease might also have reduced levels to testosterone.

Infertility and Celiac disease

Infertility is one of the lesser known effects of the celiac disease, which is relatively uncommon amongst people. The disease causes infertility by affecting the menstrual cycle among women either in a direct or indirect manner. Some of the infertility related problems caused due the disease are listed below.

Delayed occurrence of menstruation
Early menopause
Secondary amenorrhea (a medical condition associated with sudden cessation of menstruation for 6 months or more)
Hormonal disruptions and abnormal changes

Diagnosis

Celiac disease is usually diagnosed by its own set of underlying symptoms such as chronic fatigue syndrome, irritable bowel syndrome (IBS), iron-deficiency anemia, and such others. Additionally, the condition can be diagnosed if a person is having repeated miscarriages or inability to conceive for unidentified causes.

What can you do about it?

If you experience symptoms of Celiac disease, consult your doctor at the earliest and follow the treatments and preventative measures suggested. Additionally, you can also consult a dietician who will help you to move on to a low grain or no grain diet that would help you further to avoid the disease.

Does Celiac Disease Reduce Fertility?

An anorectal condition can be difficult to live with and often remains undiagnosed, due to it being perceived as an embarrassing ailment. Fistulas are conditions where two body parts, that are not meant to be connected, become linked as part of the disorder. Rectal fistulas can be painful and standard treatments are available, which can cure the condition. However, these treatments come with serious side effects.

Most people prefer Ayurvedic fistula treatments over the conventional medications for the lack of side effects as such. Ksar sutra is one such branch of treatment in Ayurveda, which has shown tremendous results against fistulas. Here is a look at all that you need to know about Kshar Sutra.

What does Kshar Sutra mean?
Kshar Sutra is a form of treatment, which uses threads laced with the juices of medicinal herbs to treat rectal fistulas.  Kshar  refers to the herbs and  Sutra  stands for the thread used for the treatment. It is a minimally invasive surgical procedure with almost no side effect or danger. The Kshar Sutra form of treatment was first discovered by Sushruta, Vagbhata and Charak. In recent times, BHU s Shalya Tantra Department has once again proved its efficacy in case of rectal disorders.

How is the treatment done?
Once the thread has been coated with the medicinal herbs, the same thread needs to be inserted into the fistula in ano. The patient is anaesthetized and the thread is inserted into the fistula using a probe. The thread is then taken out from the other side and the two ends of the thread are tied together. This thread is changed after every 7 days. This thread insertion effectively cuts the tract and unhealthy tissue is removed from the region.

Why is Kshar Sutra beneficial?
Benefits for this form of treatment include-

Lower risk of anal incontinence, which may occur in case of conventional medicine and surgery.
Lower risk of the anal canal getting narrower after the treatment is completed.
Minimally invasive treatment, which is why patients can resume normal life after just 3-4 days of recovery.
Apart from the treatment, patients should also follow a diet rich in fibre, fruits and vegetables. Drinking large quantities of water will also result in a better prognosis. Lastly, engaging in daily walks will also help you deal with the condition. 

Ksharsutra in the Treatment of Fistula in Ano, Anorectal Disorders!

Tuberculosis is an opportunistic infection caused by the bacteria Mycobacterium tuberculosis. The infections occurring in people with weak immunity as compared to the people with a healthy immune system are called as opportunistic infections. As, HIV enters the human body, it replicates and weakens the immune system which in turn increases the risk of contracting Tuberculosis in people already suffering from HIV infection.

An HIV and Tuberculosis co-infection occurs when an individual has both, the HIV infection and an either latent or active TB disease simultaneously.  Each disease acts in speeding up the progress of the other, when HIV and TB infection is present together in the body. HIV infection speeds up the progression from latent to active Tuberculosis, Mycobacterium tuberculosis also accelerates the progression of replication and spread of the HIV infection.

HIV infection and Tuberculosis are totally different type of infectious diseases. HIV is a viral infection and TB is a bacterial one. An HIV infected person will not contract TB unless a contact happens with a TB infected person. TB spreads via droplet infection and is communicable. If a person lives in a country with a high prevalence rate of TB, an HIV patient is highly susceptible to contracting the infection. In the similar manner, a person suffering from TB gets infected with the HIV infection only through the blood and bodily fluids borne route, with unprotected sexual intercourse with an HIV infected individual being the most important cause.

Amongst all the other opportunistic infections, TB occurs at an earlier stage in the course of an HIV infection than most other opportunistic infections. Mortality rate in the co-infected patients is more than twice that of HIV infected individuals without a TB infection. Even if a patient is undergoing anti-retroviral therapy, the death rates remain high in co-infected individuals.The natural history and course of TB gets altered in people with an infected immune system. The damage to immunity due to HIV infection causes a drastic reduction in the pathogen killing capacity of the body. In such patients if there is no anti-retroviral treatment prescribed, then the latency period between the infection and progression of disease gets eliminated. 

An active phase of TB is observed in such individuals progressing within a short span of time, ranging from weeks to months, rather than years as it normally should be spanning. Risk of progression from a latent stage to an active stage of TB is around 10-15 times greater in an HIV infected individual as compared to the non-infected person. Such individuals also communicate the disease more rapidly to others.Pulmonary tuberculosis in an HIV infected person can present similar symptoms like that of a classic TB disease. However, a co-infection can sometimes show less presenting TB symptoms, where even the chest X-ray scans can be observed to be normal. A  subclinical  phase of Tb in co-infected patients can cause delay in the diagnosis of the symptoms and subsequently affect the prognosis due to lack of timely treatment.

Social stigma and discrimination has caused an obstacle in provision of adequate treatment for people with HIV. Proper counseling  and initiatives taken to provide indiscriminate care can aid in identification of co-infection and earlier stages. Anti-retroviral treatment teamed up with anti-tubercular drug regimen is prescribed and a successful treatment for drug sensitive cases of TB can be provided with medications for 6-8 months.

How HIV & TB  Are Related?

Acidity or acid efflux refers to a sharp pain and burning sensation in the center of a person s chest. Often referred to as heartburn, this disorder affects millions of people across the world. Even though suffering from acidity once in a while is more or less normal, a frequent case of acid reflux may be indicative of a more severe underlying condition.

Here is a look at some of the common reasons behind your recurring acidity.

Lying down after a meal: A meal requires a bit of time to get digested. Before digestion, the acid is contained in the stomach using the diaphragm. However, if you lie down right after having a meal, the diaphragm may or the lower esophageal sphincter (LES) may open up, causing the stomach acid to spill into the chest. This can alleviate acidity symptoms. Similarly, a particularly heavy meal can also cause acidity.
Obesity: People who are overweight or obese have a greater risk of suffering from acidity compared to those who maintain an ideal body weight. So, start exercising and losing the extra pounds if you have been suffering from acid reflux for quite a while now.
Certain foods: Citrus fruits and vegetables contain citric acid, which help in increasing the overall acidic level in the stomach. Other foods, which should be avoided and can be a cause for acidity include chocolates, garlic, mint, onions, oily and fatty foods. You do not have to stop having these foods completely, but you should try to avoid them as much as possible.
Certain beverages: Alcohol consumption can often lead to acidity. It is best to avoid regular alcohol consumption and even if you choose to have a peg or two, make sure it is only for a limited period of time. Regular or excessive consumption of other artificially sweetened drinks, carbonated drinks and even tea or coffee, can also lead to acid reflux syndrome. If you partake any of these drinks, try to reduce the amount and ingest as little as possible.
Pregnancy: Pregnant women undergo a plethora of changes in their bodies. Some are visible from the exterior, while the others happen inside the body. A range of hormonal changes occur at this point in time which can cause certain problems in the body. One of the major hormones linked to acid reflux during pregnancy is progesterone. This hormone is vital for the proper growth and development of the fetus, but the hormone also slows down the rate of digestion. 

5 Sure Shot Reasons Behind That Acidity 

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