Brain metastases from systemic cancer are the most common type of intracranial neoplasm in adults, being almost 10 times more common than primary malignant brain tumors, which cause a significant burden on the management of patients with advanced cancer (1). The lungs represent one of the most frequent sources of metastases to the brain, with a probability of (36 64%) (3). Symptoms suffered by the patients include headaches, epilepsy, focal weakness, numbness or changes in mental status. The prognosis of patients with brain metastases is not optimistic and the median survival time is  1 2 months if left untreated. The 1-year survival rate has been recorded as 10.4% (4,5). The treatment of metastatic brain tumors is complex; not only due to being able to provide local control and improve neurological function, but also due to factors such as age, performance and systemic disease status and the size, volume, location and number of metastases at presentation

CyberKnife is a robotic radiosurgery system with a linear particle accelerator (linac), which is coupled with real-time imaging to track and compensate for the patient s or target s motion. As a relatively non-invasive treatment modality, CyberKnife demonstrates certain benefits, including a more accurate target localization and improved dose delivery for the management of metastatic brain tumors that allows higher biologically effective dose delivery without increased incidence of toxicity.

In the present case, the results for the treatment of multiple brain metastases after CyberKnife surgery with a 7 8 Gy marginal dose was promising. CyberKnife for metastatic brain tumors is an effective and safe method for reducing the marginal dose prescribed for multiple brain metastases and for minimizing the radiation-related neurotoxicities. In conclusion, CyberKnife, a focused, highly-targeted radiosurgery and fractionated radiotherapy is particularly useful for multiple brain metastases. CyberKnife provides the advantage of the management of local recurrence and a tolerable complication rate. Although the treatment of brain metastases has been performed with CyberKnife, the clinical significance and optimal dose fractionation scheme require further investigation.

In case you have a concern or query you can always consult an expert & get answers to your questions!

CyberKnife Therapy Of 24 Multiple Brain Metastases From Lung Cancer!

Lung cancer is the uncontrolled growth of abnormal cells in one or both lungs. These abnormal cells do not carry out the functions of normal lung cells and do not develop into healthy lung tissue. As they grow, the abnormal cells can form tumors and interfere with the functioning of the lung, which provides oxygen to the body via the blood.

Lung cancer is the most common cause of death due to cancer in both men and women throughout the world. According to the U.S. National Cancer Institute, approximately one out of every 14 men and women in the U.S. is diagnosed with cancer of the lung at some point in their lifetime. Lung cancer is predominantly a disease of the elderly; almost 70% of people diagnosed with lung cancer are over 65 years of age, while less than 3% of lung cancers occur in people under 45 years of age.

What Causes Lung Cancer?

The development of lung cancer is strongly associated with cigarette smoking, approximately 90% of lung cancers are attributable to use of tobacco. Pipe and cigar smoking can also cause lung cancer, but the risk is not as high as with cigarette smoking. Tobacco smoke contains more than 4,000 chemical compounds, many of which are cancer causing (carcinogens). Passive smoking, i.e. the inhalation of tobacco smoke by non-smokers who live or work with smokers, is also an established risk factor for the development of lung cancer.

Genetic susceptibility (i.e. family history) may play a role in the development of lung cancer. Other causes of lung cancer include air pollution (from vehicles, industry, and power generation) and inhalation of asbestos fibres (usually in the workplace).

Lung Cancer Symptoms

Early symptoms and signs of lung cancer

There may be no symptoms at the onset of the disease. When present, common symptoms of lung cancer may include:

Coughing: This includes a persistent cough that doesn't go away or changes to a chronic smoker's cough, such as more coughing or pain.
Coughing up blood: Coughing up blood or rust-colored sputum (spit or phlegm) should always be discussed with your doctor.
Breathing Difficulties: Shortness of breath, wheezing or noisy breathing (called stridor) may all be signs of lung cancer.
Loss of Appetite: Many cancers cause changes in appetite, which may lead to unintended weight loss.
Fatigue: It is common to feel weak or excessively tired.
Recurring infections: Recurring infections, like bronchitis or pneumonia, may be one of the signs of lung cancer.
Signs of advanced stages of lung cancer

Advanced stages of lung cancer are often characterized by the spread of cancer to distant sites in the body. This may affect the bones, liver or brain. As other parts of the body are affected, new lung cancer symptoms may develop, including:

Bone pain
Swelling of the face, arms or neck
Headaches, dizziness or limbs that become weak or numb
Jaundice
Lumps in the neck or collar-bone region
Treatment

Treatment for cancer involves a combination of surgery to remove cancer cells, chemotherapy and radiation therapy to kill cancer cells. Lung cancer is incurable unless complete surgical removal of the tumour cells can be achieved. Surgery is the most effective treatment for lung cancer, but only a few percentage of lung cancers are suitable for surgery i.e. Stage I and II NSCLC and cancer that has not spread beyond the lung.

Radiation therapy may be used for both NSCLC and SCLC and is a good option for people who are not suitable for surgery or who refuse surgery. Chemotherapy is used for both NSCLC and SCLC. Chemotherapy drugs may be given alone or in combination with surgery or radiation therapy. Chemotherapy is the treatment of first choice for SCLC since it has usually spread extensively in the body by the time it has been diagnosed.

Also used in the treatment of lung cancer are targeted therapies. These are drugs (gefitinib and erlotinib) or antibodies (cetuximab, bevacizumab) that block the growth and spread of cancer by interfering with specific molecules involved in tumor growth and progression. They are used in some patients with NSCLC that does not respond to standard chemotherapy.

Lung Cancer: Causes, Symptoms and Treatments

Lung cancer is caused by disorderly growth of uncommon cells which line the air passage, usually starting off in a single or both lungs. The irregular cells do not mature into healthy lung tissue but instead divide speedily and result in tumor formation.

Causes behind lung cancer:

Smoking: This is considered as the most significant source of lung cancer. As reported by multiple researches and studies, cigarettes contain over 4,000 chemicals, most of which are cancer causing agents. Active smoking is one of the major causes of lung cancer but what may come to you as a surprise is that extended periods of passive smoking is also a major factor.
Pollution and Exposure: There is high risk of lung cancer development when there is occupational exposure to pollution by chemicals released from industrial factories. Chemical exposure of this kind refers to prolonged exposure over quite few months or years. Some examples of these chemicals are asbestos, diesel exhaust among many others.
Radioactive Gas: Radioactive gases naturally occur in small masses present in all soils and rocks. However, if you breathe in radioactive gases your lungs will damage and may cause the development of abnormal tissue which can cause lung cancer.
Family history: A family history of cancer, especially lung cancer will also put you at high risk of developing lung cancer.
Treatment methods of lung cancer:

Chemotherapy: Chemotherapy is a method in which drugs are injected through veins in your arm (intravenously) or orally or in a combination of both. These drugs kill cancer cells and help to stop it from spreading any further as well.
Clinical Trials: These trials are experimental lung cancer treatment studies. You may have to try out this clinical therapy if other treatment methods aren t working and only if you are accepted into it.
Surgery: A surgeon will help remove affected areas of the lung including cancerous tumors via surgery. The surgeon may need to remove parts of the lung along with the cancerous growth. In certain cases, one side of the lung may also be completely removed to stop the spread of the malignant tissue.
Radiation Therapy: This is a therapy where high energy electromagnetic waves are passed through your body to destroy cancer cells with the help of high-powered energy beams.
Can you prevent lung cancer?

Nutrition -- A  healthy diet with lots of fruits and vegetables may also help reduce your risk of lung cancer. Some evidence suggests that a diet high in fruits and vegetables may help protect against lung cancer in both smokers and non-smokers. But any positive effect of fruits and vegetables on lung cancer risk would be much less than the increased risk from smoking.
Exercise -- Even moderate amounts of exercise can aid in lung cancer prevention. Studies suggest that even something as simple as gardening twice a week is associated with a lower risk of developing lung cancer.
Smoking Habits -- If you stop smoking before a cancer develops, your damaged lung tissue gradually starts to repair itself. No matter what your age or how long you ve smoked, quitting may lower your risk of lung cancer and help you live longer. 
Avoidance of Air Pollution -- Long-term exposure to ambient air pollution and, in particular, particulate matter with absorbed polycyclic aromatic hydrocarbons and other genotoxic chemicals has been suspected to increase the risk for lung cancer. So, avoid air pollution as much as possible.

Lung Cancer - Ways You Can Prevent It!

Cancer indicates the growth of certain unusual cells, generally uncontrolled in nature, in any part of your body. It may also refer to a malignant tumor and it can affect any organ or any part of your body. There are many different cancers accordingly, such as lung cancer, bladder cancer, skin cancer or blood cancer. Ayurveda offers effective measures for preventing cancer. Read on to find more about the tips and get better prepared to fight this killer:

1) According to Ayurveda, having fresh foods can help you to prevent cancer. Consuming more of green leafy vegetables and fresh fruits may prove to be helpful.

2)Avoiding fat based foods or fried foods can be effective in preventing cancer. Strike off hydrogenated fats (such as cookies, peanut butter, crackers etc) or saturated animal fats from your diet.

3) Exercising on a regular basis may be very helpful. Stretching exercises, walking, breathing exercises and aerobics are considered to be useful preventive measures for cancer.

4) Meditation and yoga are also effective ways to prevent cancer. These can help you to reduce stress and remain calm.

5) Drinking green tea regularly can be very useful for killing any growth of cancerous cells in your body and thus help you to prevent cancer.

6) Cutting down on foods with higher quantities of sugar can help you to prevent cancer.

7) Include foods replete in vitamin D and vitamin C or citrus foods as these help to combat many kinds of cancer.

8) Incorporate spices like turmeric in your daily cooking regimen. The 'curcumin' present in turmeric coupled with a few other accompanying properties can help to prevent the growth of cancer cells in your body.

9) Garlic, whether consumed raw or cooked, can help you to fight the killer that cancer is.

9 Ayurvedic Tips to Prevent Cancer

As much as you want to avoid, there are things you have no control over. Lung cancer (Bronchogenic Carcinomas) is one such nemesis that can throw life in shambles. The malignant tumor that originates in the lungs slowly spreads onto the other distinct and vital organs as well. Thought to be mostly affecting men who are chain smokers and into severe tobacco consumption, incidences of lung cancer in women are rising at an alarming rate over the past few years. Non-smokers may also be susceptible (to a lesser extent though) to lung cancer.

Lung cancer can be either

Non-small cell lung cancers: The NSCLC, accounting for ~85% of the lung cancer is one of the most common types of lung cancer affecting people, NSCLC may further be divided into
Adenocarcinoma: This type of NSCLC originates mostly in the peripheral regions of the lungs and may affect (spread) the lymph nodes. Non-smokers and women are mostly at the receiving end (other than the chain smokers).
Squamous Cell Carcinoma: Also known as Epidermoid Carcinoma, often affects men, epidermoid carcinoma may originate in the tissues that line the bronchial tubes. The lymph nodes are often affected by Epidermoid Carcinoma.
Large-cell Undifferentiated Carcinoma: The point of origin of large-cell undifferentiated carcinoma is the surface of the lungs. They have a higher probability of spreading to the lymph nodes.
Bronchioalveolar Carcinoma: Though rare, bronchioalveolar carcinoma originates close to the air sacs.
Small Cell Lung Cancer (SCLC, accounting for ~25% of the lung cancer): As the name suggests, SCLC is marked by the rapid proliferation of small cells into large malignant tumors. SCLC can move throughout the body (affecting vital organs).
Radiotherapy to treat Lung cancer:
Radiotherapy plays a pivotal role in the treatment of lung cancer. The radiation therapy is mainly of two types

External beam radiation therapy (EBRT)
Internal radiation therapy (Brachytherapy)
In external beam radiation therapy, high-energy rays are focused on the cancer cells (thereby resulting in the apoptosis of the cancer cells) externally, from outside the body. EBRT is particularly helpful in case of Non-small cell lung cancers.

The EBRT may be of the following types

3D-CRT (Three-dimensional conformal radiation therapy): An advanced radiation therapy, 3D-CRT accurately marks the position of the cancer cells (using advanced computers). The treatment ensures minimum damage to the other healthy cells and tissues (energy rays are directed at the affected cells from different positions).
SBRT (Stereotactic body radiation therapy): This is a radiation therapy used in the treatment of NSCLC, when it is at a nascent stage.
IMRT (Intensity modulated radiation therapy): As the name suggests, in IMRT, the intensity of the radiation reaching the normal tissues and cells can be modulated. Like 3D-CRT, the radiation in IMRT is directed from different angles (for maximum results).
Internal radiation therapy (Brachytherapy): This type of radiation therapy is generally used to deal with lung cancers that tend to block the airways. In this therapy, the radiation process is carried out through a narrow tube, thereby, shrinking and collapsing the tumor.
The effect, dosage, and duration of radiation therapy depend on the stage and severity of the condition. In some cases, radiation therapy may be given together with chemotherapy.

Radiotherapy - Is It Beneficial For Lung Cancer?


Cancer is the most dangerous disease noticeable throughout the world. The most common type of cancer that affects men is prostate cancer. Prostate is a small exocrine gland situated directly below the bladder and in front of the rectum. This is gland is approximately in size of a walnut and plays an important role in production of a milky fluid during orgasm of sex in which the semen travels. During the climax stage of the prostate gland is forced to push the fluid and remove the semen out of the reproductive structures.

Prostate gland is a slow progressive disease which makes many males left unidentified even the presence of prostate cancer even until they die. 6 out of 100 male over the age of 60 are getting prostate cancer. Though prostate cancer can be cured at a better rate when compared to other type of cancer it is always best to stay protected. Prevention is always better than cure. Here are few tips to keep your prostate healthy.

Signs and symptoms of prostate cancer-
During the early stages of prostate cancer there are usually no symptoms. Most men at this stage find out they have prostate cancer after a routine check up or blood test. When symptoms do exist, they are usually one or more of the following:

The patient urinates more often
The patient gets up at night more often to urinate
He may find it hard to start urinating
He may find it hard to keep urinating once he has started
There may be blood in the urine
Urination might be painful
Ejaculation may be painful (less common)
Achieving or maintaining an erection may be difficult (less common).

If the prostate cancer is advanced the following symptoms are also possible:

Bone pain, often in the spine (vertebrae), pelvis, or ribs
The proximal part of the femur can be painful
Leg weakness 
Urinary incontinence 
Fecal incontinence 

Ways to have a healthy prostate  
Diet and weight   the most important factor is the diet to maintain a healthy weight. Avoid fatty food items and take fats from vegetables than from animals. Avoid dairy products and increase the intake of fresh fruits and vegetables.
Exercise   have a regular practise of doing exercise at least for 30mins a day. This really helps you to keep your body fit.
Be precautious   if you have a family history of prostate cancer or if you feel you are at high risk of getting prostate cancer talk with your doctor about it and take preventive drugs as per the doctor s advice.
Red foods   research shows that men who consume red foods like watermelon, tomato and other red fruits are at lower risk of getting prostate cancer as they contain a powerful antioxidant called lycopene
Caffeine   three to four cups of coffee per day reduces your risk of getting prostate cancer.
Stop smoking   if you are at high risk of getting prostate cancer it is best advised to quit smoking and alcohol. 


Prostate Cancer -  Signs and Symptoms

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