World sickle cell day is observed annually on the 19th of june to raise awareness of sickle cell-related diseases. It is observed to increase people's knowledge and the understanding required to face the challenges posed by the disease.


 

What is sickle cell disorder (scd)?

Sickle cell disorders or sickle cell diseases are genetic blood disorders that cause an abnormality in the red blood cells. The rbcs turn into sickle-shaped cells that stick together and block the blood flow in the body.


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Types

There are four major classifications of sickle cell diseases-


	
	Hemoglobin ss disease
	
	
	Hemoglobin sc disease
	
	
	Hemoglobin sb+ thalassemia
	
	
	Hemoglobin sb 0 thalassemia
	



 

Symptoms

One can start noticing symptoms of sickle cell in a patient at around 6 years of age. However, they can differ from person to person. Some of the most typical symptoms are-

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	Anemia
	


A shortage of red blood cells occurs due to the excessive early dying in 10-20 days. It leads to an oxygen shortage in the body.


	
	Excessive pain
	


Blockage of blood flow due to the change in shape leads to periodic cycles of pain in the body.


	
	Swelling in the body
	


As the blood circulation becomes irregular, swelling becomes a regular phenomenon.


	
	Infections
	


Sickle cell can be damaging to the spleen. It increases the risk of ailments in the body that can be prevented only by antibiotics.


	
	Delayed puberty
	


Oxygen and nutrients carried by the blood are required for growth. As a reason, irregular blood flow can lead to slow growth or delay in puberty.


	
	Vision issues
	


Infected blood vessels carrying blood to the eyes can cause damage to the retina. It can lead to visual problems.


 

Traits and treatment

As sickle cell is genetic, it is suggested to take a test that can detect any trait of the disease. It can prevent any life-threatening risks to the newborn. However, we don't have a complete cure for sickle cell disorders. There are preventive measures that reduce the adversity of the disease to an extent. Procedures like blood transfusions help greatly in minimizing the effects of the disorder.

World Sickle Cell Day: Know All About Sickle Cell Disease

Type 1 diabetes occurs when your pancreas is unable to produce enough insulin to keep the blood sugar ;levels under control. The condition, if not managed properly, can lead to related health disorders and complications, both long-term and short-term.

Health problems arising from type 1 diabetes

Type 1 diabetes can have severe effects on your eyes, kidney, nervous system, and heart health. The most common ailments associated with type 1 diabetes may include the following-

1. Diabetic retinopathy

Diabetic retinopathy is a disease of the eyes, which occurs when the blood vessels in the retina (tissue present at the back of your eyes) are damaged. The walls of the retina gradually weaken from increasing blood pressure and blood sugar levels, and this leads to leakage of blood or fluid into the nearby tissues.

Early symptoms of diabetic retinopathy include-


	
	Blurred vision
	
	
	Floaters
	
	
	Difficulty perceiving colors
	


2. ;Diabetic neuropathy

Diabetic neuropathy unfolds when the nerves are damaged due to type 1 diabetes. The condition mostly affects your feet and legs. Reduced blood circulation due to high blood glucose impedes normal wound healing in the extremities, hence, even a minor bruise ;can develop into a permanent injury.

Symptoms of diabetic neuropathy are-


	
	Numbness
	
	
	Reduced sensation
	
	
	Severe, debilitating pain in the extremities
	


3. Diabetic nephropathy

Also known as ;diabetic kidney disease, the condition is a slow deterioration of the kidney and its ability to function properly. In severe cases, where the levels of blood glucose are extremely high due to type 1 diabetes, diabetic nephropathy can ultimately result in kidney failure ;or end-stage renal disease (esrd).

The following are the symptoms of diabetic nephropathy-


	
	Dark urine
	
	
	Swollen ankles, feet, eyes, or hands
	
	
	Shortness of breath
	


4. Cardiovascular diseases

Cardiovascular diseases refer to a range of heart conditions including blood clots and diseased blood vessels. High blood glucose levels resulting from type 1 diabetes can contribute to the deposition of fat in the walls of the blood vessel. Over time, this may restrict the flow of blood and put you at risk of cardiovascular disorders such as coronary artery disease, stroke, or even ;heart attack.

Symptoms of cardiovascular diseases widely vary, ranging from palpitations ;to chest pain. Sometimes, such a condition may not exhibit any symptoms at all.

Type 1 diabetes complications are related to poor management of blood glucose. The best way to monitor the condition and control the symptoms is to get in touch with your doctor. A specialist in this field can prescribe the correct treatment and help prevent the onset the related health disorders.

Complications Associated With Type 1 Diabetes

Blood donation is a process that is carried out when a person voluntarily offers for blood to be extracted from his body. There are countless myths about blood donation that need to be squashed and awareness is the only way of doing it.

While blood donation brings multiple health benefits to both the donor and recipient, some facts are known to only a few. These facts will not only open doors to endless possibilities, but will make people feel confident about it.

Facts

Here are some lesser-known facts about blood donation- every person should know-

 


	
	Approximately 112.5 million units of blood are collected from blood donation globally.
	
	
	Around 30 million units are transfused annually.
	
	
	Any person in sound health, at least 18 years old, and weighing at least 45 kilograms can donate blood every 56 days.
	
	
	Your one unit of donated blood can save up to 3 lives.
	
	
	A, b, ab, and o are the primary blood groups. While ab is a universal recipient, o negative is a universal donor.
	
	
	The blood donation process normally takes less than 10-12 minutes.
	
	
	Donating blood does not make you physically weak or decrease your strength.
	
	
	Only 1% of india's population donates blood each year, leading to an annual deficit of two million units.
	
	
	All donated blood units are tested for diseases like hepatitis b, hepatitis c, hiv, and syphilis before transfusion.
	
	
	Red cells, plasma, cryoprecipitate, and platelets are the various types of transfusable elements derived from the blood. The procedure takes place using a method called apheresis.
	
	
	Red blood cells carry oxygen to the organs.
	
	
	Red blood cells survive for about four months in the system of circulation.
	
	
	Platelets encourage blood clotting and provide leukemia patients and other cancer patients with better treatment.
	
	
	Plasma is a pale yellow combination of proteins, salts, and water.
	
	
	Plasma is 55 percent of the volume of blood and 90 percent water.
	
	
	White cells are the chief defense of the body against infections.
	
	
	There is no alternative for blood donation as blood cannot be manufactured.
	
	
	You cannot contract aids or other infectious diseases due to blood donation.
	


Lesser Known Facts About Blood Donation

World brain tumor day is observed on the 8th of june every year. The german brain tumor association initially took this initiative and it is celebrated worldwide to educate people about the brain tumor. 

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What is brain tumor? 

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When abnormal cells grow inside the brain and are in the form of a mass the condition is called a brain tumor. There are various types of brain tumors that exist. Some of the existing brain tumors are malignant or cancerous while others may be non-cancerous.

 

A brain tumor can begin in any part of the brain and spread to other parts of the body or vice-versa. The growth rate of brain tumors is different for each individual suffering from it.

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What are the symptoms of a brain tumor? 

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If a person is suffering from a brain tumor he/she may be exhibiting the following symptoms: 


	
	Headaches in the morning after waking up, while sleeping
	
	
	The headaches will get worse after coughing and sneezing
	
	
	Vomiting
	
	
	Change in the mental functioning
	
	
	Confusion
	
	
	Clumsiness
	
	
	Effect on the memory
	
	
	Loss of balance
	
	
	Numbness or tingling sensation on one side of the body
	
	
	Trouble in speaking
	
	
	Blurred vision
	
	
	A person might have seizures without any previous history of neurological disease
	


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Risk factors of a brain tumor 

There are some risk factors that increase the risk of brain tumors in individuals


	
	The risk of brain tumors increases with age.
	
	
	This condition can also be inherited from the family however, the chances are only 5 to 10 percent.
	
	
	The risk of brain tumors increases in people who have been exposed to ionizing radiation.
	
	
	If a person is exposed to certain chemicals then they have an increased risk of suffering from a brain tumor.
	



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Treatment of brain tumor

 

The treatment of brain tumors depends on the location, size, and type of the tumor. The general health of the patient is also taken into consideration. The treatment which is common for brain tumor is surgery. The objective of the surgery is to remove as much of the tumor as possible without damaging the other parts of the brain. For surgery to take place the tumors must be located within the area of limits of the surgery.

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Doctors may suggest the following treatments according to the type, grade, and position of tumor and the general health of the patient.

 


	
	Surgery
	
	
	Radiation therapy
	
	
	Chemotherapy
	
	
	Anti-seizure medicines
	
	
	Steroids
	
	
	Ventricular peritoneal shunt
	
	
	Combination of treatments
	


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World Brain Tumour Day: All About Brain Tumour- Risk Factors, Symptoms And Treatments

What are the different types of sickle cell disease?

Sickle cell disease or sickle cell disorder is a term often used to talk about a group of diseases affecting hemoglobin. It is the oxygen-carrying element of blood that makes up 2 alpha globins and 2 beta globins. Sickle cell disease happens due to beta-globin mutation and depending on the abnormality in mutation.

Types-
Sickle cell diseases can be of many types depending on the gene mutation in the blood. Some of the common types are-

Sickle hemoglobin s disease (ss)
Hemoglobin ss disease or sickle cell anemia is the most popular type of scd. It takes place when hemoglobin s gene mutation is inherited from both mother and father. In simple words, it happens when the child inherits one substitution beta-globin gene from each parent. In this type, the body only produces hemoglobin s. It is mostly found in people of african and indian origin.

Sickle hemoglobin- c disease (sc):
Patients with sickle hemoglobin sc disease have a moderately dissimilar swapping in their genes of beta-globin. Here, both hemoglobin c and hemoglobin s are inherited from each parent. It may cause similar symptoms like anemia but remains relatively l. People of west african and mediterranean origin are more prone to this.

Hbs beta-thalassemia
People with this type of scd inherit one sickle cell gene s and one gene for beta-thalassemia from each parent. Zero and plus are the two common types of beta-thalassemia. While beta 0 thalassemia usually takes a severe form, beta + thalassemia is a milder form of the disease.

Sickle beta-zero thalassemia
Beta-zero thalassemia takes form when the child inherits the beta s gene from one parent and beta 0 thalassemia gene mutation from the other. With similar symptoms to anemia, it is a slightly severe form of beta-thalassemia.

Sickle beta-plus thalassemia
Substitutions in both beta-globin genes take place in patients with sickle beta thalassemia (sb) disease. This may even lead to the requirement of blood transfusion if no normal beta globin is produced. Mediterranean and caribbean people are more likely to have this disorder.

Hemoglobin sd, hemoglobin se, and hemoglobin so
These are the few rare and not less common types of sickle cell diseases. They are also less severe. People with these forms of scd inherit one sickle cell gene s and one gene from uncommon hemoglobin (d, e, or o) from each parent.

Sickle cell trait
Hbas
People with sct have one sickle cell gene s and one normal gene a from both mother and father. Ones with this disorder show few to no signs of the disease and usually spend a normal life. However, the risk to their future generations still exists.
 

What Are The Different Types Of Sickle Cell Disease?

When abnormal cells grow inside the brain and are in the form of a mass the condition is called a brain tumour. There are various types of brain tumours that exist. Some of the brain tumours which exist are malignant or cancerous while other may be non-cancerous. A brain tumour can begin in any part of the brain and spread to other parts of the body or vice-versa. The growth rate of brain tumours is different for each individual suffering from it. As per studies, every 2 in 1, 00, 000 people are said to be affected by a brain tumour in india. However, it may come as a relief to some as not all brain tumours are cancerous or life-threatening. Some are benign tumours and seldom pose any threat to the affected individual.

 

Types of brain tumor

Brain tumours may be primary or secondary.

Primary brain tumour

In this type of brain tumour, the abnormal mass of cells that originated in the brain does not metastasize to the other organs. Based on their location in the brain, the primary brain tumours may be of the following types.


	
	Gliomas: one of the most common types of primary brain tumours, gliomas can have their origin in the spinal cord or the brain. Some of the common types of gliomas include astrocytomas (originates in the cerebrum of the brain), glioblastomas (these tumours form from the astrocytes which form the supportive tissues of the brain), ependymoma (these develop from the ependymal cells which are present within the cns), oligodendrogliomas (these tumours are found to arise from the oligodendrocytes).
	
	
	Schwannomas: also called acoustic neuromas, these primary brain tumours form on the nerves that play an important role in regulating the balance and hearing from the inner ear to the brain.
	
	
	Meningiomas: these types of tumours are usually benign and have their origin in the meninges (membranes surrounding the spinal cord and the brain).
	
	
	Primitive neuroectodermal tumours (pnets): primitive neuroectodermal tumours (pnets) are rare malignant tumours that originate from the fetal (embryonic) cells in the brain.
	
	
	Pituitary adenomas: as the name suggests, these tumours arise from the pituitary gland located at the base of the brain.
	
	
	Medulloblastomas: common among children, these malignant primary tumours develop in the brain (lower back) and gradually spread via the spinal fluid.
	


Other types of primary brain tumours include craniopharyngiomas and germ cell tumours.

Secondary brain tumours ;

Unlike the primary brain tumours, these tumours have their origin in the other body parts and organs (mostly in the lungs, skin, colon, breast, and kidney) and then gradually metastasize to the brain. Secondary brain tumours are found to be more common.

 

What Are The Different Types Of Brain Tumours?

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