Genetics is a fascinating subject which has received much attention during present times in the field of medical science as it gives the solutions to many a puzzle. The same applies to the hard to pronounce medical term  schizophrenia  that refers to a mental disorder which disrupts the innate human ability to feel, express, behave, and think clearly.

The condition is a chronic illness, and the disorder may last for years or even a lifetime. Often considered to be the most disabling of mental illnesses, schizophrenia does not refer to multiple or split-personalities. It is more about psychosis where patients become unable to differentiate between reality and fiction.

How does the condition manifest itself?
The symptoms of schizophrenia are rendered into three categories. The positive signs include delusions, hallucination, movement disorders, and dysfunctional, and unusual ways of thought. The negative symptoms include the inability to experience happiness or pleasure in everyday life, reduced talking, and difficulty in sustaining or beginning any activity. While  positive  means exaggerating certain behavior in this context, the term  negative  does not imply bad behavior, but the absence of regular behavior patterns. Then follows the cognitive aspect (the subtlest behavior changes) which includes trouble in paying attention, or problems with using memory, etc.

What could be the possible causes?
There s no specific reason that may cause schizophrenia; however, some factors play an important role in making a person have this mental condition. Various environmental factors are suspected to be responsible for the condition; these may include viral infections, excessive exposure to toxins like marijuana, extreme stress, etc. In some instances, schizophrenia can occur solely due to abnormalities or chemical imbalances in the brain. Experts note that a history of schizophrenia in the family tree can increase the risk of schizophrenia in future generations.

Who can develop schizophrenia?
Schizophrenia can develop at any age. However, it is during the teenage years or the 20s when the condition takes effect. Though rare, it can sometimes invade the minds of children below five years of age.

How can it be treated?
There s no cure available for schizophrenia. However, the periods of recovery from this illness and its symptoms can be reduced through various possible treatments. These include medication and psychosocial therapy, supportive psychotherapy or cognitive behavioral therapy, electroconvulsive therapy, and psychosurgery. The administration of these procedures can reduce the chances of recurrence and relapse. Sometimes hospitalization may become necessary as a part of treatment to stabilize patients that do not have anyone to take care of them at home.

Modern medicine is yet to discover failsafe remedies for schizophrenia. Early diagnosis and treatment can reduce the condition in patients. Hospitalization can reduce the chances of a relapse and can prevent the mental condition from worsening. The moment any sign of schizophrenia is noticed, one is strongly advised to opt for psychological treatment. These actions can help to reduce disruptions in a patient s personal and social life.

Schizophrenia - How Does The Condition Manifests?

Both schizophrenia and autism are considered to be neurological disorders resulting from atypical neural development, occurring due to a variety of causes. Both these disorders have a genetic predisposition that may be due to environmental factors. However, there are a few basic differences between the two disease conditions.

Autism is also known as Autism Spectrum Disorder (ASD), is a neurodevelopmental disorder characterized by a spectrum of abnormal behaviour. They include persistent deficits in social communication and interaction, along with restricted and repetitive patterns of behaviour, interests or activities.

Signs of autism in babies

By 6 months - No social smiles or other warm, joyful expressions; limited to no eye contact
By 9 months - No sharing of vocal sounds
By 12 months - No babbling or use of gestures to communicate; not responding to one s name when called
By 16 months - No use of words
By 24 months - No meaningful or two-word phrases
Signs of autism at any age

Avoids eye contact and wants to be alone
Finds it difficult to understand other people s feelings
Speaks very less or has delayed language development
Echolalia - Repeats words or phrases
Cannot accept change in routine or surroundings
Performs repetitive behaviours like flapping or rocking
Has restricted interests and hobbies
Reacts unusually intense to sounds, smells, tastes, lights, colours etc.
Schizophrenia
Schizophrenia is a neuropsychiatric disorder that begins during late adolescence and early adulthood. It is characterized by delusions, hallucinations, disorganized speech and behavioural changes that cause social and occupational dysfunctions.

Signs of Schizophrenia

The symptoms of schizophrenia are usually observed between ages 16 and 30, such as e.g. delusions, hallucinations, thought disorders, movement disorders etc.
Delusions are false beliefs of the patient that may take many forms like delusions of persecution or grandeur. You may feel somebody is controlling you or may think you have extraordinary powers and abilities.
Hallucinations are when the patient hears voices more than seeing, feeling, tasting or smelling random things, which are not actually there.
Thought disorders are when the person jumps from one subject to another for no logical reason.
Some negative symptoms i.e. these are symptoms which are normally present in a healthy individual, but are absent in a schizophrenic patient. E.g. absence of facial expressions, lack of motivation etc.
Cognitive symptoms affect the individual s thought process. They can be positive or negative based on their expression. E.g. poor  executive functioning  which deals with the ability to understand information and make decisions using them, finding it difficult to focus etc.
Although both Autsim spectrum disorder and schizophrenia are interlinked in their causes and neurological background, the symptoms for each disorder are different. 
Consult your physician if you happen to observe any of these symptoms in your loved ones.

Autism & Schizophrenia - What Is The Difference?

Are you aware of the schizophrenia and the adverse effects it inflicts on a person? Schizophrenia is a chronic and extremely severe mental disorder that affects how a person thinks, behaves, and feels. Schizophrenia patients seem like they are not aware of reality. The condition requires lifelong treatment, even after the symptoms leave. There are various types of treatments, which are used for schizophrenic patients. The treatment is usually guided by an experienced psychiatrist. 

The various modes of treatments are as follows:
Medications: Medications are very important for the treatment of schizophrenia, and antipsychotic drugs are most commonly used. They help in managing the symptoms by affecting dopamine. Treatment using antipsychotic drugs aims at managing the symptoms effectively. Antidepressants and anti-anxiety drugs are also used for treatment. Several weeks are required for these medicines to show results. Most of the medications used for schizophrenia treatment are associated with severe side effects and are thus avoided by many people. The patient s cooperation with treatment determines the choice of drug.

First generation antipsychotics: These medicines are associated with adverse neurological side effects, such as the possibility of developing tardive dyskinesia, which is an irreversible movement disorder.
Second generation antipsychotics: These medicines are preferred because of the lower risk of adverse side effects on the body than first generation medicines.
Psychological interventions: When the patient s psychosis decreases, psychological and psychosocial interventions are required. They include the following:

Individual therapy: Psychotherapy is important for normalizing a patient s regular thought patterns. Learning about ways to deal with stress, and identifying warning signs can help patients manage their condition better.
Social skills training: This aims at improving a schizophrenic person s social interactions, communication and his/her ability to take part in daily activities.
Family therapy: Family therapy is important for educating the families of schizophrenic patients about the disorder, and let them know about the ways to deal with it.
Vocational rehabilitation and supported employments: Most people with schizophrenia need some kind of daily living support. Programs are offered by several communities and self-help groups for helping schizophrenic people with housing, jobs, crisis situations. With proper treatment, most schizophrenic people manage to deal with their symptoms and illness.

Hospitalization: During emergency or crisis periods of extreme symptoms, a patient may need to be hospitalized to get proper nutrition, basic hygiene, sufficient sleep, and safety.
Electroconvulsive therapy or ECT is carried out for schizophrenic patients who do not respond to drug treatment. This therapy is also beneficial for patients who have got depression. It is recommended for you to consult a doctor on experiencing any symptom of schizophrenia.


Schizophrenia - Different Modes Of Treatment That Are Followed!

Schizophrenia is a psychiatric disorder in which a person s mood, knowledge, thought and several other characteristics gets disturbed. We can notice most of the adults and old people with few symptoms of schizophrenia, which are most commonly left unidentified. The exact cause of schizophrenia is not yet known. The person feels that they are being constantly watched, they feel the presence of someone or something, which is not actually there. They are always suspicious and think that other people are gossiping and thinking about them.

Possible causes of Schizophrenia
Though the exact cause of schizophrenia is not known there are few factors, which contribute to the cause of schizophrenia.

    Genetic factors: People with a family history of schizophrenia are at higher risk of getting schizophrenia.
    Environmental factors: Environmental factors include excessive stress during pregnancy or later stages of life. Several other factors during pregnancy and childhood are responsible for causing schizophrenia. These factors are:
        Decreased oxygen level during delivery due to premature birth or prolonged labour
        Parental loss or separation in early stages of life
        Parental exposure to virus or during infancy
        Childhood physical or sexual abuse
        Abnormal brain structures and brain chemistry

Sings and symptoms of schizophrenia

    Hallucination: To see, feel or hear anything that really does not exist is known as hallucination.
    Delusion: A thought or belief of a person, which is either false or impossible in reality is known as delusion.
    Thought and speech disturbances: The thought process and speech of a schizophrenic will be disorganized, due to which he or she  will fumble or is distracted as they are unable to align their thoughts.
    Difficulty in concentrating: It is difficult for people suffering from schizophrenia to concentrate on the task at hand.
    Erratic behaviour: People suffering from schizophrenia tend to behave erratically, either they will be too jumpy or will be perfectly still for hours at a stretch. Most people belief that those who are suffering from schizophrenia are often violent in nature, which actually is not the case.

Treatment for schizophrenia
Schizophrenia can be treated, if identified at an early stage. . It is best advised to consult a psychiatrist the moment you spot the symptoms. Anti psychotic drugs, self help behaviour change, counselling and rehabilitation are few treatment modalities available for schizophrenia.

Schizophrenia: Can Genetics be the Reason Behind it?

Schizophrenia is a disease of the mind that is usually degenerative in nature. The complex disorder is generally characterized by symptoms, such as delusions, hallucinations (both auditory and visual) and disturbances in speech and is usually chronic in nature. The symptoms are not regular and can appear at any point of time. So it is highly possible that a person suffering from schizophrenia may sometimes bear resemblance to any other normal person and all of a sudden, might exhibit symptoms typical of Schizophrenia.

The causes of Schizophrenia include:

Brain Dysfunction: Abnormalities in the cerebral cortex (the cerebrum s outer covering that is vital in regulating consciousness) of the brain is the most common cause of this disorder. This is due to the presence of abnormally enlarged ventricles in that region. The decreased brain size owing to the enlarged ventricles is often related to the hallucinations and delusions experienced by schizophrenics.
Genetic Factors: Studies have also stated  genetics  to be an important cause behind this disorder. Closer the family ties, higher the risks of transmitting the disorder.
Biochemical Factors: More than one neurotransmitter is being targeted by recent drugs to control schizophrenia.

Symptoms which most people do not experience normally, but are found in people diagnosed with schizophrenia are said to be positive symptoms. They are:

Hallucinations: These are sensory experiences of things that do not exist outside the mind. Hallucinations usually manifest in the form of auditory or visual images.
Delusions: Delusions on the other hand are false beliefs one has about oneself. Delusions are of 3 major types:
Grandeur: Wherein the person imagines himself to be a famous personality
Persecution: The belief that somebody somewhere is plotting against you and the whole world is going to get you.
Control: The belief that a larger force, let s say a witch, a demon or even a duck for that matter is controlling your actions.
These positive symptoms generally respond well to medications.
In addition to this, schizophrenics think and speak differently than the rest of the society. They jump from idea to idea, lose track of speech mid-way and often speak in fragmented and haphazardly joined sentences. They are, in fact, unable to fix their attention on anything in particular.
Examples of the most common negative symptoms include:

The flat effect: The individual basically shows no facial expression and always has a flat emotionless mask on while staring into space. At times, they have inappropriate reactions to situations. Example - they might laugh at somebody's death and cry ad get angry when something good happens. 
Avolition: This condition occurs when the individual just sit for hours doing nothing as well as behaves in a way lacking any motivation or enthusiasm.

Schizophrenia -  Can Biochemical Factors be the Cause Behind it?

Neurological disorders are an enigmatic bunch. There are various ongoing researches to identify the exact cause and how to treat them. While some argue that schizophrenia is a chronic brain disorder, others do not agree with it and debate that the origin is yet to be identified and the factors which produce it are yet to be identified.

Factors supporting it to be a brain disease are listed below.

Scan images (MRI and PET scans) of people who have had schizophrenia are different and have a reduced volume of grey matter, especially in the frontal and temporal lobes. In some people, this loss could be as high as 25%. Serial images have shown that the loss begins in the outer (parietal) region and gradually spreads to the rest of the brain. There is a strong correlation between the extent of this grey matter loss and the severity of the symptoms more the loss, worse the symptoms. Severe symptoms include hearing voices, psychotic thoughts, delusions, hallucinations and severe depression. This grey matter reduction does not depend on whether the person has undergone treatment or not for the condition. 

The counter argument is that grey matter loss is not seen in patients with schizophrenia alone. A number of neurological disorders, including normal ageing, manifest as grey matter loss on the scan images. Also, another consoling news is that this grey matter loss is completely reversible.

The way neurotransmitters respond to stimuli in people with schizophrenia is also slightly different. There are two variations to this debate: that schizophrenia is caused by excessive amounts of dopamine or increased sensitivity to dopamine. There are two proofs for this hypothesis first, dopamine suppressants are useful as antipsychotic drugs and secondly drugs which produce the same effect as dopamine can cause hallucinations similar to those seen in schizophrenics. There could be other neurotransmitters involved too, but the dopamine connection is more strongly established.

The electrical activity of the brain as seen in EEG is very different and abnormal in schizophrenic people. This reduced brain activity is another indication of the fact that schizophrenia is another brain disorder. There is also a strong genetic component to schizophrenia. Family history correlation is also very strong. The correlation extends to the point that where there is a neurologic disorder in the first-degree relatives, the chances of developing schizophrenia is increased.

There are specific genes, mutations of which are also attributed to schizophrenia. While the risk factors are in place (as mentioned above), the environmental conditions (brain infections, head trauma, family/social stressors and toxins can all lead to the manifestation of the symptoms. With medications and support therapy, both prevention and symptom management are possible.

Schizophrenia - Is It Really a Brain Disease?

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