Genetics is a fascinating subject which has received much attention during present times in the field of medical science as it gives the solutions to many a puzzle. The same applies to the hard to pronounce medical term  schizophrenia  that refers to a mental disorder which disrupts the innate human ability to feel, express, behave, and think clearly.

The condition is a chronic illness, and the disorder may last for years or even a lifetime. Often considered to be the most disabling of mental illnesses, schizophrenia does not refer to multiple or split-personalities. It is more about psychosis where patients become unable to differentiate between reality and fiction.

How does the condition manifest itself?
The symptoms of schizophrenia are rendered into three categories. The positive signs include delusions, hallucination, movement disorders, and dysfunctional, and unusual ways of thought. The negative symptoms include the inability to experience happiness or pleasure in everyday life, reduced talking, and difficulty in sustaining or beginning any activity. While  positive  means exaggerating certain behavior in this context, the term  negative  does not imply bad behavior, but the absence of regular behavior patterns. Then follows the cognitive aspect (the subtlest behavior changes) which includes trouble in paying attention, or problems with using memory, etc.

What could be the possible causes?
There s no specific reason that may cause schizophrenia; however, some factors play an important role in making a person have this mental condition. Various environmental factors are suspected to be responsible for the condition; these may include viral infections, excessive exposure to toxins like marijuana, extreme stress, etc. In some instances, schizophrenia can occur solely due to abnormalities or chemical imbalances in the brain. Experts note that a history of schizophrenia in the family tree can increase the risk of schizophrenia in future generations.

Who can develop schizophrenia?
Schizophrenia can develop at any age. However, it is during the teenage years or the 20s when the condition takes effect. Though rare, it can sometimes invade the minds of children below five years of age.

How can it be treated?
There s no cure available for schizophrenia. However, the periods of recovery from this illness and its symptoms can be reduced through various possible treatments. These include medication and psychosocial therapy, supportive psychotherapy or cognitive behavioral therapy, electroconvulsive therapy, and psychosurgery. The administration of these procedures can reduce the chances of recurrence and relapse. Sometimes hospitalization may become necessary as a part of treatment to stabilize patients that do not have anyone to take care of them at home.

Modern medicine is yet to discover failsafe remedies for schizophrenia. Early diagnosis and treatment can reduce the condition in patients. Hospitalization can reduce the chances of a relapse and can prevent the mental condition from worsening. The moment any sign of schizophrenia is noticed, one is strongly advised to opt for psychological treatment. These actions can help to reduce disruptions in a patient s personal and social life.

Schizophrenia - How Does The Condition Manifests?

Schizophrenia affects over 1% of the world s population and affects the way a person thinks, feels and behaves. In most cases, it is diagnosed when a person is between the ages of 16 to 25. This condition can be hereditary and is said to affect men more often than women. Schizophrenia is characterized by an inability to distinguish between real and imaginary which can lead to delusions, social withdrawal, hallucinations and other forms of social and occupational dysfunction.

Schizophrenia affects different people in different ways. On the basis of the type of symptoms exhibited, this disease has been categorized into 5 sub types. These are:

Paranoid schizophrenia: This type of schizophrenia is characterized by delusions and hallucinations that may make the person exhibit paranoid behaviour. These people often feel like they are being watched or followed and may have delusions of grandeur. They may also get angry quickly on minor issues and show signs of anxiety and hostility.
Disorganized schizophrenia: In such cases, the person may behave in ways that are difficult to understand or speak in broken sentences and have difficulty structuring a sentence. They may also display inappropriate behaviour and react in ways not suitable to the occasion. People suffering from disorganized schizophrenia may also neglect their personal hygiene.
Catatonic schizophrenia: People suffering from catatonic schizophrenia may swing between immobility and periods of rapid movement. They may stay quiet for hours or talk rapidly repeating everything they hear. These people have a high risk of harming themselves as they are usually unable to look after themselves and complete daily activities.
Undifferentiated schizophrenia: People suffering from this type of schizophrenia exhibit behaviour that fits into more than one type of schizophrenia. From time to time they may have hallucinations, suffer from delusions or display catatonic behaviour and disorganized behaviour or speech.
Residual schizophrenia: Even though a person may not be currently showcasing any signs of schizophrenia, they are said to have residual schizophrenia. Such people need to have had at least one schizophrenic episode. These people may exhibit symptoms later or be in complete remission.
With schizophrenia, an early diagnosis can make treatment easier and hence if you notice anyone exhibiting signs of schizophrenia, you must advise them to seek medical help immediately. Schizophrenia cannot be cured but it can be managed with a combination of typical or atypical medication and cognitive therapy. The latter can be in the form of self-help groups, housing and employment programs, counselling and therapy. 

Types Of Schizophrenia - How Can They Be Dealt With?

Chronic health disorders like schizophrenia affect not only the patient, but also the life of their care givers. Though schizophrenia can be treated to improve the patient's quality of life, it cannot be cured. Hence, it falls on the care giver's shoulders to watch out for symptoms of this disease and manage the person and their disorder. What should one do in such a case?

1. Educate yourself: the first step towards looking after a person with schizophrenia is to know the symptoms of the disease. With treatment, these may become better or worse so if you notice any change in the symptoms, bring it to your doctors notice at once.

2. Reduce stress: your goal as a schizophrenic person's caregiver should be to give them a calm environment and boost their confidence. Stress has a negative effect on all people and in schizophrenics this effect is much worse. Hence reduce stress and create an effective support system and structured environment for your loved one.

3. Do not ask the patient to change'his reality: when a person is suffering from schizophrenia, you should not force them to change their behaviour and reality, in order to adjust in the society at large. You should rather support the patient to accept his reality, to be at peace, since there is a very strong genetic component involved in its aetiology. Also, it is important that, both the patient and the family in particular should opt for regular counselling sessions.

4. Regular exercise: schizophrenics need not be cooped up in the house all day. Encourage the patient to go outside and exercise regularly. Exercise reduces stress and produces endorphins that make a person feel energized and happy. This should be complemented by a healthy diet. Minimize the amount of carbs and sugar intake and increase the amounts of omega 3 fatty acids in the patient's diet.

5. Join a support group: joining a support group is a very good idea for both the patient and the caregiver. For the patient, this provides a form of social interaction and for the caregiver is a platform to meet people with similar first hand experiences

6. Encourage treatment: convincing a schizophrenic person to seek treatment can be quite challenging. Suggest treating symptoms of the disorder such as insomnia and lack of energy rather than the disease itself to make the patient feel more comfortable. Give the patient options to choose from to make them feel more in control of the situation.

7. Monitor medication: once the treatment has started, ensure that the patient sticks to the prescription. Maintain a regular schedule by using weekly pill boxes and alarms. Also keep an eye on the possible side effects of these medicines. Ensure that your doctor has a complete list of medicines that the patient takes so that there is no chance of medicines interacting negatively with each other.

8. Prepare for crisis situations: it is always a good idea to have an emergency plan in place. Keep emergency contact details of all the doctors and therapists at hand along with the address and phone number of the closest hospital. Share your situation with friends and family so that in case of an emergency, they can be relied upon to take care of your children and other dependants.

Living with Schizophrenia

Schizophrenia is a debilitating mental and emotional condition that is characterised by a heavily distorted thought process as well as hallucinations and even extreme fear that borders on paranoia. Let us find out more about this debilitating disease:

Causes:
1. Genetics: genetic factors play an important role in the development of schizophrenia.
2. Environment: possible environmental factors include obstetric complications, the mother's exposure to influenza during pregnancy or starvation. It has also been suggested that stress, trauma even migration can lead to the emergence of schizophrenia. 
3. Neurodevelopmental factors: schizophrenia appears to be a neurodevelopmental disorder. That is changes that cause the illness have been occurring from the earliest stages of development even in utero, and may continue to influence the development of the brain over the first 25 years of life. 

Symptoms: 
This disease has a variety of symptoms include cognitive and emotional ones that can vary in the degree and severity. One of the most common symptoms included hallucinations and delusions where the patient may end up imagining things that do not really exist. The patient may also be gripped by sudden and crippling fear like paranoia, which can be debilitating as far as everyday functioning of the person goes. The symptoms can also interfere with the way a person deals with situations and life skills on a cognitive basis. Withdrawal and hopelessness are also a part of this disease.

Treatment: 
The earliest signs and symptoms must be referred to a psychiatrist. The treatment involves the management of the case of an individual basis along with psychological rehabilitation programs and inclusion of the patient in self-help groups. Housing and employment programs must also be availed so as to keep the patient busy. Also, behaviour therapy will be required in such cases. The mode of counselling should usually be on a one on one basis, although many doctors also suggest that group therapy can help in showing examples of progress so as to encourage the patient to change and get a new lease of life.

Schizophrenia: Causes, Symptoms and Treatment

Schizophrenia has been recognized as a mental disorder that combines symptoms like hallucinations with distorted thinking and others like fright and severe paranoia. This condition is one that gets progressively worse over time and leads to delusional thinking. Oversleeping and complaining of fatigue are usually the earliest signs of this condition's onset. Eventually, it becomes a debilitating factor in the life of the patient, who will not be able to function in a normal way due to the severe symptoms.

Read on to know more about the types and causes of this condition:

Genetic Causes: Schizophrenia may be caused due to genetic factors and it may be a learned or inherited disorder. It is known to affect patients who have a parent or a sibling who may have suffered from this condition. Yet, one must also remember that Schizophrenia can only be influenced by genetics, and not determined by the same.
Environmental Causes: When there has been an exposure to a viral infection during the pre natal stage, the patient is susceptible to this condition. Also, it may affect children who have been subject to the loss of a parent or separation at an early age. Physical and emotional abuse in one's childhood may also bring on this condition. Low level of oxygen at the time of birth is one of the causes of this condition in many patients.
Anomalies in Brain Structure: When the brain ventricles of the patient are enlarged, he or she may be prone to this condition. Also, anomalies in the temporal lobes and amygdala have links with the onset of this condition.
Types: A wide variety of mental and medical conditions can manifest with psychotic symptoms that must be considered in the differential diagnosis of schizophreniform disorder. These include psychotic disorder due to another medical condition or its treatment; delirium or major neurocognitive disorder; substance/medication-induced psychotic disorder or delirium; depressive or bipolar disorder with psychotic features; schizoaffective disorder; other specified or unspecified bipolar and related disorder; depressive or bipolar disorder with catatonic features; schizophrenia; brief psychotic disorder; delusional disorder; other specified or unspecified schizophrenia spectrum and other psychotic disorder; schizotypal, schizoid, or paranoid personality disorders; autism spectrum disorder; disorders presenting in childhood with disorganized speech; attention-deficit/hyperactivity disorder; obsessive-compulsive disorder; posttraumatic stress disorder; and traumatic brain injury.
Since the diagnostic criteria for schizophreniform disorder and schizophrenia differ primarily in duration of illness, the discussion of the differential diagnosis of schizophrenia also applies to schizophreniform disorder. 

Brief psychotic disorder. Schizophreniform disorder differs in duration from brief psychotic disorder, which has a duration of less than 1 month.

Residual Schizophrenia is a condition where the patient does not experience the various debilitating symptoms of the condition, and is on the road to recovery. Yet, even in this type of Schizophrenia, the patient will not really show any interest in life and the activities around him or her. Finally, the last type of Schizophrenia is Schizoaffective Disorder which is characterised by the symptoms of Schizophrenia as well as the symptoms of major mood disorders. When combined, this condition can lead to major complications and complex behavior.

A patient suffering from this condition will need to see a mental health specialist like a psychiatrist or a psychologist on an immediate basis. The treatment will be carried out on a long term basis for the results to start appearing.

Schizophrenia - Know the Causes Behind it

Neurological disorders are an enigmatic bunch. There are various ongoing researches to identify the exact cause and how to treat them. While some argue that schizophrenia is a chronic brain disorder, others do not agree with it and debate that the origin is yet to be identified and the factors which produce it are yet to be identified.

Factors supporting it to be a brain disease are listed below.

Scan images (MRI and PET scans) of people who have had schizophrenia are different and have a reduced volume of grey matter, especially in the frontal and temporal lobes. In some people, this loss could be as high as 25%. Serial images have shown that the loss begins in the outer (parietal) region and gradually spreads to the rest of the brain. There is a strong correlation between the extent of this grey matter loss and the severity of the symptoms more the loss, worse the symptoms. Severe symptoms include hearing voices, psychotic thoughts, delusions, hallucinations and severe depression. This grey matter reduction does not depend on whether the person has undergone treatment or not for the condition. 

The counter argument is that grey matter loss is not seen in patients with schizophrenia alone. A number of neurological disorders, including normal ageing, manifest as grey matter loss on the scan images. Also, another consoling news is that this grey matter loss is completely reversible.

The way neurotransmitters respond to stimuli in people with schizophrenia is also slightly different. There are two variations to this debate: that schizophrenia is caused by excessive amounts of dopamine or increased sensitivity to dopamine. There are two proofs for this hypothesis first, dopamine suppressants are useful as antipsychotic drugs and secondly drugs which produce the same effect as dopamine can cause hallucinations similar to those seen in schizophrenics. There could be other neurotransmitters involved too, but the dopamine connection is more strongly established.

The electrical activity of the brain as seen in EEG is very different and abnormal in schizophrenic people. This reduced brain activity is another indication of the fact that schizophrenia is another brain disorder. There is also a strong genetic component to schizophrenia. Family history correlation is also very strong. The correlation extends to the point that where there is a neurologic disorder in the first-degree relatives, the chances of developing schizophrenia is increased.

There are specific genes, mutations of which are also attributed to schizophrenia. While the risk factors are in place (as mentioned above), the environmental conditions (brain infections, head trauma, family/social stressors and toxins can all lead to the manifestation of the symptoms. With medications and support therapy, both prevention and symptom management are possible.

Schizophrenia - Is It Really a Brain Disease?

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