Genetics is a fascinating subject which has received much attention during present times in the field of medical science as it gives the solutions to many a puzzle. The same applies to the hard to pronounce medical term  schizophrenia  that refers to a mental disorder which disrupts the innate human ability to feel, express, behave, and think clearly.

The condition is a chronic illness, and the disorder may last for years or even a lifetime. Often considered to be the most disabling of mental illnesses, schizophrenia does not refer to multiple or split-personalities. It is more about psychosis where patients become unable to differentiate between reality and fiction.

How does the condition manifest itself?
The symptoms of schizophrenia are rendered into three categories. The positive signs include delusions, hallucination, movement disorders, and dysfunctional, and unusual ways of thought. The negative symptoms include the inability to experience happiness or pleasure in everyday life, reduced talking, and difficulty in sustaining or beginning any activity. While  positive  means exaggerating certain behavior in this context, the term  negative  does not imply bad behavior, but the absence of regular behavior patterns. Then follows the cognitive aspect (the subtlest behavior changes) which includes trouble in paying attention, or problems with using memory, etc.

What could be the possible causes?
There s no specific reason that may cause schizophrenia; however, some factors play an important role in making a person have this mental condition. Various environmental factors are suspected to be responsible for the condition; these may include viral infections, excessive exposure to toxins like marijuana, extreme stress, etc. In some instances, schizophrenia can occur solely due to abnormalities or chemical imbalances in the brain. Experts note that a history of schizophrenia in the family tree can increase the risk of schizophrenia in future generations.

Who can develop schizophrenia?
Schizophrenia can develop at any age. However, it is during the teenage years or the 20s when the condition takes effect. Though rare, it can sometimes invade the minds of children below five years of age.

How can it be treated?
There s no cure available for schizophrenia. However, the periods of recovery from this illness and its symptoms can be reduced through various possible treatments. These include medication and psychosocial therapy, supportive psychotherapy or cognitive behavioral therapy, electroconvulsive therapy, and psychosurgery. The administration of these procedures can reduce the chances of recurrence and relapse. Sometimes hospitalization may become necessary as a part of treatment to stabilize patients that do not have anyone to take care of them at home.

Modern medicine is yet to discover failsafe remedies for schizophrenia. Early diagnosis and treatment can reduce the condition in patients. Hospitalization can reduce the chances of a relapse and can prevent the mental condition from worsening. The moment any sign of schizophrenia is noticed, one is strongly advised to opt for psychological treatment. These actions can help to reduce disruptions in a patient s personal and social life.

Schizophrenia - How Does The Condition Manifests?

Bipolar disorder:

Also known as manic-depressive disorder, bipolar disorder is the sudden change in mood, which might take a swing from depression to mania. It is a very severe disorder and can bring about unstable and precarious behavior. The risk of having suicidal tendencies is also quite high. Bipolar disorder is usually treated with medicines alongside therapy.

Symptoms:

1. Bipolar mania
2. Hypomania
3. Depression
4. Mood swings

The mood swings do not follow any particular pattern.

Schizophrenia Disorder

Schizophrenia is a chronic mental disorder which affects the general behavior and lifestyle of a person. Schizophrenics might face a difficulty in distinguishing between the real and the imaginary.
Contrary to public belief, schizophrenia is neither split personality nor multiple personalities. It is not an after effect of any previous traumatic experience. It might be genetic or a result of chemical imbalance in the brain chemicals.

Symptoms:

1. Paranoia
2. Senseless talking
3. Feeling apathetic
4. Insomnia
5. Personality change
6. Hallucinations
7. Delusions
8. Withdrawal from society
9. Attention deficit disorder or add

No specific medicine is available for schizophrenia. Usually, rehabilitation is advised to regain confidence and recover skills required for a productive life.

Psychosis

Similar to schizophrenia, psychosis is another mental disorder which is characterized by hallucinations and delusions. Psychosis is extremely dangerous and harmful as it might spur you to cause self-inflicted wounds and pain. It is of utmost importance to consult a doctor immediately after experiencing psychotic symptoms.

Symptoms:

1. Hallucinations
2. Delusions
3. Depression
4. Anxiety
5. Suspicion
6. Insomnia or hypersomnia
7. Withdrawal from society
8. Attention deficit disorder or add
9. Attention deficit hyperactivity disorder or ADHD

The only available diagnosis for psychosis is a psychiatric evaluation. Certain medical tests and x-rays may also be executed along with it to detect the underlying cause. Psychosis may be caused due to Parkinson's disease, Huntington's disease, brain tumors, Alzheimer's disease, epilepsy, etc.

Although there aren't any medical complications in psychosis, it should not be left untreated due to its harmful effects. Medication and therapy are the known cures of psychosis.

Symptoms of Bipolar Disorder, Schizophrenia Disorder and Psychosis

Neurological disorders are an enigmatic bunch. There are various ongoing researches to identify the exact cause and how to treat them. While some argue that schizophrenia is a chronic brain disorder, others do not agree with it and debate that the origin is yet to be identified and the factors which produce it are yet to be identified.

Factors supporting it to be a brain disease are listed below.

Scan images (MRI and PET scans) of people who have had schizophrenia are different and have a reduced volume of grey matter, especially in the frontal and temporal lobes. In some people, this loss could be as high as 25%. Serial images have shown that the loss begins in the outer (parietal) region and gradually spreads to the rest of the brain. There is a strong correlation between the extent of this grey matter loss and the severity of the symptoms more the loss, worse the symptoms. Severe symptoms include hearing voices, psychotic thoughts, delusions, hallucinations and severe depression. This grey matter reduction does not depend on whether the person has undergone treatment or not for the condition. 

The counter argument is that grey matter loss is not seen in patients with schizophrenia alone. A number of neurological disorders, including normal ageing, manifest as grey matter loss on the scan images. Also, another consoling news is that this grey matter loss is completely reversible.

The way neurotransmitters respond to stimuli in people with schizophrenia is also slightly different. There are two variations to this debate: that schizophrenia is caused by excessive amounts of dopamine or increased sensitivity to dopamine. There are two proofs for this hypothesis first, dopamine suppressants are useful as antipsychotic drugs and secondly drugs which produce the same effect as dopamine can cause hallucinations similar to those seen in schizophrenics. There could be other neurotransmitters involved too, but the dopamine connection is more strongly established.

The electrical activity of the brain as seen in EEG is very different and abnormal in schizophrenic people. This reduced brain activity is another indication of the fact that schizophrenia is another brain disorder. There is also a strong genetic component to schizophrenia. Family history correlation is also very strong. The correlation extends to the point that where there is a neurologic disorder in the first-degree relatives, the chances of developing schizophrenia is increased.

There are specific genes, mutations of which are also attributed to schizophrenia. While the risk factors are in place (as mentioned above), the environmental conditions (brain infections, head trauma, family/social stressors and toxins can all lead to the manifestation of the symptoms. With medications and support therapy, both prevention and symptom management are possible.

Schizophrenia - Is It Really a Brain Disease?

Schizophrenia affects over 1% of the world s population and affects the way a person thinks, feels and behaves. In most cases, it is diagnosed when a person is between the ages of 16 to 25. This condition can be hereditary and is said to affect men more often than women. Schizophrenia is characterized by an inability to distinguish between real and imaginary which can lead to delusions, social withdrawal, hallucinations and other forms of social and occupational dysfunction.

Schizophrenia affects different people in different ways. On the basis of the type of symptoms exhibited, this disease has been categorized into 5 sub types. These are:

Paranoid schizophrenia: This type of schizophrenia is characterized by delusions and hallucinations that may make the person exhibit paranoid behaviour. These people often feel like they are being watched or followed and may have delusions of grandeur. They may also get angry quickly on minor issues and show signs of anxiety and hostility.
Disorganized schizophrenia: In such cases, the person may behave in ways that are difficult to understand or speak in broken sentences and have difficulty structuring a sentence. They may also display inappropriate behaviour and react in ways not suitable to the occasion. People suffering from disorganized schizophrenia may also neglect their personal hygiene.
Catatonic schizophrenia: People suffering from catatonic schizophrenia may swing between immobility and periods of rapid movement. They may stay quiet for hours or talk rapidly repeating everything they hear. These people have a high risk of harming themselves as they are usually unable to look after themselves and complete daily activities.
Undifferentiated schizophrenia: People suffering from this type of schizophrenia exhibit behaviour that fits into more than one type of schizophrenia. From time to time they may have hallucinations, suffer from delusions or display catatonic behaviour and disorganized behaviour or speech.
Residual schizophrenia: Even though a person may not be currently showcasing any signs of schizophrenia, they are said to have residual schizophrenia. Such people need to have had at least one schizophrenic episode. These people may exhibit symptoms later or be in complete remission.
With schizophrenia, an early diagnosis can make treatment easier and hence if you notice anyone exhibiting signs of schizophrenia, you must advise them to seek medical help immediately. Schizophrenia cannot be cured but it can be managed with a combination of typical or atypical medication and cognitive therapy. The latter can be in the form of self-help groups, housing and employment programs, counselling and therapy. 

Types Of Schizophrenia - How Can They Be Dealt With?

Are you aware of the schizophrenia and the adverse effects it inflicts on a person? Schizophrenia is a chronic and extremely severe mental disorder that affects how a person thinks, behaves, and feels. Schizophrenia patients seem like they are not aware of reality. The condition requires lifelong treatment, even after the symptoms leave. There are various types of treatments, which are used for schizophrenic patients. The treatment is usually guided by an experienced psychiatrist. 

The various modes of treatments are as follows:
Medications: Medications are very important for the treatment of schizophrenia, and antipsychotic drugs are most commonly used. They help in managing the symptoms by affecting dopamine. Treatment using antipsychotic drugs aims at managing the symptoms effectively. Antidepressants and anti-anxiety drugs are also used for treatment. Several weeks are required for these medicines to show results. Most of the medications used for schizophrenia treatment are associated with severe side effects and are thus avoided by many people. The patient s cooperation with treatment determines the choice of drug.

First generation antipsychotics: These medicines are associated with adverse neurological side effects, such as the possibility of developing tardive dyskinesia, which is an irreversible movement disorder.
Second generation antipsychotics: These medicines are preferred because of the lower risk of adverse side effects on the body than first generation medicines.
Psychological interventions: When the patient s psychosis decreases, psychological and psychosocial interventions are required. They include the following:

Individual therapy: Psychotherapy is important for normalizing a patient s regular thought patterns. Learning about ways to deal with stress, and identifying warning signs can help patients manage their condition better.
Social skills training: This aims at improving a schizophrenic person s social interactions, communication and his/her ability to take part in daily activities.
Family therapy: Family therapy is important for educating the families of schizophrenic patients about the disorder, and let them know about the ways to deal with it.
Vocational rehabilitation and supported employments: Most people with schizophrenia need some kind of daily living support. Programs are offered by several communities and self-help groups for helping schizophrenic people with housing, jobs, crisis situations. With proper treatment, most schizophrenic people manage to deal with their symptoms and illness.

Hospitalization: During emergency or crisis periods of extreme symptoms, a patient may need to be hospitalized to get proper nutrition, basic hygiene, sufficient sleep, and safety.
Electroconvulsive therapy or ECT is carried out for schizophrenic patients who do not respond to drug treatment. This therapy is also beneficial for patients who have got depression. It is recommended for you to consult a doctor on experiencing any symptom of schizophrenia.


Schizophrenia - Different Modes Of Treatment That Are Followed!

Schizophrenia is a disease of the mind that is usually degenerative in nature. The complex disorder is generally characterized by symptoms, such as delusions, hallucinations (both auditory and visual) and disturbances in speech and is usually chronic in nature. The symptoms are not regular and can appear at any point of time. So it is highly possible that a person suffering from schizophrenia may sometimes bear resemblance to any other normal person and all of a sudden, might exhibit symptoms typical of Schizophrenia.

The causes of Schizophrenia include:

Brain Dysfunction: Abnormalities in the cerebral cortex (the cerebrum s outer covering that is vital in regulating consciousness) of the brain is the most common cause of this disorder. This is due to the presence of abnormally enlarged ventricles in that region. The decreased brain size owing to the enlarged ventricles is often related to the hallucinations and delusions experienced by schizophrenics.
Genetic Factors: Studies have also stated  genetics  to be an important cause behind this disorder. Closer the family ties, higher the risks of transmitting the disorder.
Biochemical Factors: More than one neurotransmitter is being targeted by recent drugs to control schizophrenia.

Symptoms which most people do not experience normally, but are found in people diagnosed with schizophrenia are said to be positive symptoms. They are:

Hallucinations: These are sensory experiences of things that do not exist outside the mind. Hallucinations usually manifest in the form of auditory or visual images.
Delusions: Delusions on the other hand are false beliefs one has about oneself. Delusions are of 3 major types:
Grandeur: Wherein the person imagines himself to be a famous personality
Persecution: The belief that somebody somewhere is plotting against you and the whole world is going to get you.
Control: The belief that a larger force, let s say a witch, a demon or even a duck for that matter is controlling your actions.
These positive symptoms generally respond well to medications.
In addition to this, schizophrenics think and speak differently than the rest of the society. They jump from idea to idea, lose track of speech mid-way and often speak in fragmented and haphazardly joined sentences. They are, in fact, unable to fix their attention on anything in particular.
Examples of the most common negative symptoms include:

The flat effect: The individual basically shows no facial expression and always has a flat emotionless mask on while staring into space. At times, they have inappropriate reactions to situations. Example - they might laugh at somebody's death and cry ad get angry when something good happens. 
Avolition: This condition occurs when the individual just sit for hours doing nothing as well as behaves in a way lacking any motivation or enthusiasm.

Schizophrenia -  Can Biochemical Factors be the Cause Behind it?

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