What are the latest advancements in male contraceptions?

The drawback of surgical approaches (such as vasectomy), especially patient compliance and the low success rates with condoms has spurred research on hormonal contraceptive dosage forms. There is a dearth of investigations in the development of pharmaceutical preparations. Evolving technology in the 21st century as well as improvement in living standards further underline the need for new male contraception approaches, especially those that entail new drug delivery methods.

Here are few areas where male contraception is being researched and used in some countries

Hormonal contraception for men is possible, and we are at the threshold of an important breakthrough. Combined testosterone plus progestin administration is more effective and safer than testosterone alone. Combination of testosterone plus an anti-androgenic progestin has several advantages over other formulations. In combined therapy, single injection formulation may have better compliance. 

Conventional male contraception 
Abstinence (doesn't work well)
Masturbation
Male condom
Vasectomy
There are other methods being developed but not sure they are there yet. But for guys? Their options are stuck in a time warp. If a man wants to take pregnancy prevention into his own hands, his choice basically comes down to condoms, a vasectomy, withdrawal, or abstinence. That s why it's so amazing that scientists are finally developing some real advancements when it comes to male contraception.

Researchers writing in the April issue of the Open Access Journal Contraception published a rundown of the top emerging options. A few hold real promise, particularly a daily or weekly pill that would deliver a dose of artificial hormones to a guy s bloodstream, which would then act on reproductive hormones to stop sperm from being produced. Like the female hormonal pill, the male hormonal pill would be reversible. But also like the female hormonal pill, there appear to be side effects, among them acne, weight gain, and even trickier to work around, changes in testosterone levels that trigger a plunge in libido.

Non-hormonal techniques are also being developed, particularly a vaccine that immunizes men with antibodies to halt sperm production. This so-called male birth-control shot is encouraging, because it targets sperm directly (rather than targeting other hormones in the body) and doesn t have the testosterone-lowering side effects of a hormonal pill. Each injection would last for long intervals (experts aren t yet sure how long), but the pregnancy-preventing effects would be reversible, if and when a guy decides he s ready to be a dad.

So when can you expect to see men rushing out to the pharmacy counter to pick up their new birth control Rx?  I think we may see a novel male contraceptive within 10-12 years, That may seem far off, but hey at least it s finally within sight.

Male Contraception - An Insight!

In vitro fertilization (IVF) is a process of fertilization in which eggs (ova) from a woman's ovary are removed. They are combined with sperm outside the body in a laboratory procedure, and then the fertilized egg (zygote) is transferred to the same or another woman s uterus for a successful pregnancy.

IVF is one of the several assisted reproductive techniques (ART) used to help infertile couples to conceive a child.

Causes of Infertility

Blocked fallopian tubes
Hormonal imbalance
Endometriosis
Women with ovulation disorder
Uterine fibroids
In the man, low sperm count or poor quality sperm
Genetic disorder
Procedures
Two procedures are done to gain access to ovaries

It involves inserting the needle through the vagina (transvaginally). With the help of an ultrasound machine, the physician guides the needle to the location of the ovaries
In the other procedure, called laparoscopy, a small thin tube with a viewing lens is inserted through an incision in the navel. This lets physician to see inside the patient, and locate the ovaries.
Method
Without additional techniques, the chances of pregnancy would be extremely small. The additional techniques used in IVF include-

Ovarian hyperstimulation- Stimulation to induce development of multiple follicles of the ovaries.
Final maturation induction- Induction of final oocyte maturation is performed, generally by an injection of human chorionic gonadotropin (HCG), when the ovarian follicles have reached a certain degree of development. This is known as the "trigger shot  
Egg and sperm preparation- Semen is prepared for fertilization by removing inactive cells and seminal fluid in a process called sperm washing. An oocyte selection may be performed prior to fertilization to select eggs with optimal chances of successful pregnancy. 
Co-incubation- Eggs are removed from the woman and placed in one of the fallopian tubes, along with the man's sperm. This allows fertilization to take place inside the woman's body. Therefore, this variation is actually an in vivo fertilization, not in vitro.
Embryo culture- The main durations of embryo culture are until cleavage stage (day two to four after co-incubation) or the blastocyst stage (day five or six after co-incubation)
Embryo transfer- The number to be transferred depends on the number available, the age of the woman and other health and diagnostic factors. Embryos are transferred to the patient's uterus through a thin, plastic catheter, which goes through her vagina and cervix.
Aftercare
After the IVF procedure is performed the woman can resume normal activities. A pregnancy test can be done approximately 12-14 days later to determine if the procedure was successful.

Risks

Multiple pregnancies
Ectopic pregnancy
Ovarian rupture, bleeding
Infections
Complications of anesthesia

In Vitro Fertilization - Quick Facts!

The female reproductive organ is an area of the human body where many microbial organisms inhabit together and it is a necessary requirement for its health. These organisms may include fungi and bacteria and play important roles individually in maintaining the pH levels (the acidic and alkaline balance) levels of the vagina. However, when one of these, especially the fungi go out of balance and begin to propagate, it results in a vaginal yeast infection.

Symptoms
A yeast infection or vaginal candidiasis is a fungal infection that causes extreme itchiness of the vulva (which is the opening of the vagina) and the further insides of the vagina as well. It may result in a white discharge from time to time and causes vaginal inflammation. Some of the other symptoms are:

Pain in the vagina akin to a burning sensation while urinating or when having sex
Rashes in the vagina
General soreness and pain
White odorless discharge, which is thick in consistency
Colorless watery discharges can occur as well
Swelling and redness near the vulva or the vagina in general
Causes
The type of fungi that causes vaginal yeast infections is the  candida fungus . Usually, this fungus is present within the vagina, but is kept in check by the Lactobacillus bacteria. These are bacteria naturally present within the vagina and secrete acids, which keep the fungi in check. However, when the levels of bacteria are reduced, it will cause the levels of fungi to increase causing a yeast infection.

Risk Factors
The below mentioned factors can aggravate the risks of this disease:

Problems brought on by diabetes
A compromised immune system
Pregnancy may also disturb the balance
Starting to use or stopping the use of oral contraceptive pills
Hormone therapy
Usage of antibiotics that may kill off lactobacillus bacteria within the vagina
Generally, yeast infections are not considered to be sexually transmitted, although yeast infection could be spread through sexual contact as well.

The primary treatment includes a course of anti fungal oral medication to lessen the levels of the fungi within your vagina. It could be supplemented with vaginal creams, which may reduce the itching and the inflammation. If you have recurrent infection multiple times within a year, then you may have to go for a longer course of treatment and correct the underlying conditions that may be causing it.

Vaginal Yeast Infection - 6 Signs You are Suffering from it

Disregarding genital tract infections and issues including the symptoms of the same can lead to problems when it comes to fertility. It may also cause problems in your sexual life. Genital problems can also lead to infertility. These days, infertility is a noteworthy and very important occurrence that plagues many couples.

Common Infections: A large portion of these genital tract diseases occurs because of infections. Salpingitis happens in close to 15% of ladies in their reproductive age and 2.5% of all ladies get to be infertile as an aftereffect of salpingitis by age 35. Many times, symptoms of conditions and STDs like Chlamydia trachomatis are usually nonexistent. The real rate of ladies with upper genital tract infections is presumably underestimated.

Infection and Infertility: Infectious agents can hinder different vital human functions, including reproduction. Bacteria, fungi, infections and viruses can meddle with the reproductive capacity in both genders. Diseases of male genito-urinary tract represent around 15% of the instance of male infertility. Diseases can influence distinctive areas of the male regenerative tract, for example, the testis, epididymis and male sex organs and glands. Urogenital diseases at various levels of their advancement, development and transport can affect the sperms themselves in this manner. Among the most widely recognized microorganisms required for sexually transmitted diseases, meddling with male fertility are Chlamydia trachomatis and Neisseria gonorrhea.

Symptoms: If the following symptoms of a genital tract infection are ignored, it can definitely lead to the person being infertile in some stage of life or immediately. These are as follows:

The signs and symptoms in males are

Changes in the way you discharge
Bleeding while urinating or discharge
Thick white, yellow or green release from the tip of the penis along with pain in urethra or pain while urinating
A hard but painless sore on the penis along with swelling of the lymph hubs in the crotch
Pain or uneasiness while urinating or discharge from the urethra
Difficult or irritated red spots and small blisters on the penis
Chestnut bits on the hair around the penis
Gentle delicacy around one of the testicles
Delicate swelling in the scrotum on one or both sides
Extreme pain after injury to your penis
The signs and symptoms in women are as follows:

Irregular vaginal discharge with a pungent smell
Burning sensation while urinating
Tingling or itching in the outer area of vagina
Uneasiness and pain during sex
Sore vagina
Foamy greenish-yellow discharge with a foul smell
Light bleeding after intercourse
Warts in the vagina
Regular check-ups and visits to the gynecologist are very essential. One should always keep the partner updated about their sexual health problems to practice a healthy and honest relationship and to avoid further contagious infections from occurring.

Can Genital Tract Infections Lead to Infertility?

Babies can enter this world in one of two ways: Pregnant women can have either a vaginal birth or a surgical delivery by Cesarean section, but the ultimate goal is to safely give birth to a healthy baby.

C-section or Cesarean section is a surgical procedure to remove baby through an incision in the mother s abdomen and then a second incision in the uterus. It may be a necessity in certain situations, such as delivering a very large baby in a mother with a small pelvis, or if the baby is not in a heads-down position and efforts to turn the baby before a woman gives birth have been unsuccessful.

Sometimes the decision by an obstetrician to perform a C-section is unplanned, and it is done for emergency reasons because the health of the mother, the baby, or both of them is in jeopardy. This may occur because of a problem during pregnancy or after a woman has gone into labor, such as if labor is happening too slowly or if the baby is not getting enough oxygen.

Some C-sections are considered elective, which are planned by the treating doctor for medical reasons. The patient may choose to deliver by CS due to previous unpleasant experience or to avoid the pain of normal labour. In such cases also it is called elective CS.

Reasons for a C-section may include:

Health problems in the mother
The mother carrying more than one baby
The size or position of the baby
The baby s health is in danger
Labor is not moving along as it should
The surgery is relatively safe for mother and baby. Still, it is major surgery and carries risks. It also takes longer to recover from a C-section than from vaginal birth. It can raise the risk of having difficulties with future pregnancies. Some women may have problems attempting a vaginal birth later. Still, many women are able to have a vaginal birth after cesarean (VBAC).

How You Might Feel

You won t feel any pain during the C-section, although you may feel sensations like pulling and pressure. Most women are awake and simply numbed from the waist down using regional anaesthesia during a C-section. That way, they are awake to see and hear their baby being born. A curtain will be over your abdomen during the surgery, but you may be able to take a peek as your baby is being delivered from your belly. However, women who need to have an emergency C-section occasionally require general anesthesia, so they re unconscious during the delivery and won t remember anything or feel any pain.

Recovering from a C-section

After a C-section, a woman may spend two to four days in the hospital, but it may take her up to six weeks to feel more like herself again. Her abdomen will feel sore from the surgery and the skin and nerves in this area will need time to heal. Women will be given narcotic pain medications to take the edge off any post-surgery pain, and most women use them for about two weeks after ward.

A woman may also experience bleeding for about four to six weeks after a surgical birth. She is also advised to not have sex for a few weeks after her C-section and to also avoid strenuous activities, such as lifting heavy objects.

Cesarean Section (C-Section) - Birth and Delivery

Infertility is a very common problem among both men and women and it refers to the inability to conceive even after regular unprotected sex. The causes of this can be varied and some of the most prominent ones are:

Causes in Women:

1. Polycystic ovarian syndrome

PCOS is a medical condition in women in which they do not ovulate. It is a major cause of infertility in most women. It can often result in irregular menstruation and an increase in the release of male hormones in the female body. This causes male symptoms like the growth of a beard, hoarse voice etc. in females. The probable causes of this condition comprise being over or under weight, thyroid imbalance etc. It is possible to treat this condition with medical aid and weight management can also prove to be helpful.

2. Lack of sufficient healthy eggs

As you grow in age, the number and health of your eggs decline significantly. This could be a possible reason for your infertility. In this condition, optimizing egg health by maintaining a healthy weight and quitting alcohol and cigarettes can help you get rid of your infertility.

3. Blockage of the fallopian tubes

Blockage of or damage to the fallopian tubes causes the tubal factor that is responsible for infertility in women. The tubal factor can also be a result of endometriosis or any sexually transmitted disease like Chlamydia etc.

Causes in Men:

1. Ejaculatory disorders

Retrograde ejaculation, premature ejaculation, and other issues associated with ejaculation may cause infertility in men. In retrograde ejaculation, the semen enters the bladder instead of emerging out of the penis during orgasm. In premature ejaculation, the ejaculation occurs before the vagina is prepared to receive the semen.

2. Chromosome defects

Disorders like Klinefelter's syndrome can cause abnormal growth of the male reproductive organs resulting in infertility. Other such syndromes include Kallmann's syndrome, Karatagener's syndrome, cystic fibrosis etc. These conditions are mostly genetic.

3. Hormonal imbalance

Male infertility can also be a result of hormonal imbalances like hypogonadism (low testosterone levels), disorders of the testicles, abnormal functioning of the pituitary, thyroid, adrenal and the other glands as well.

6 Common Causes of Infertility That are also Curable

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