Glomerulonephritis is a disease that is caused due to inflammation of the small filters that are present within the kidneys or glomeruli. Glomeruli eliminate the excess waste, electrolytes and fluids from the blood, discharged through urine. A glomerular disease can be either acute or chronic. If the condition arises without a combination of any other disease, it is termed as primary glomerulonephritis. Secondary glomerulonephritis is characterized by diabetes or lupus (an auto-immune disorder) being at the root of the disease. Prolonged or severe inflammation can take a toll on the kidneys.


Causes-


Nephrotic syndrome can be primary, being a disease specific to the kidneys, or it can be secondary, being a renal manifestation of a systemic general illness. In all cases, injury to glomeruli is an essential feature. Kidney diseases that affect tubules and interstitium, such as interstitial nephritis, will not cause nephrotic syndrome.


Primary causes of nephrotic syndrome include the following, in approximate order of frequency:
Minimal -change nephropathy
Focal glomerulosclerosis
Membranous nephropathy
Hereditary nephropathies


Secondary causes include the following, again in order of approximate frequency:
Diabetes mellitus
Lupus erythematosus
Viral infections (e.g., hepatitis B, hepatitis C, human immunodeficiency virus [HIV] )
Amyloidosis and paraproteinemias
Preeclampsia
Allo-antibodies from enzyme replacement therapy


Nephrotic- range proteinuria may occur in other kidney diseases, such as IgA nephropathy. In that common glomerular disease, one third of patients may have nephrotic- range proteinuria.


Nephrotic syndrome may occur in persons with sickle cell disease and evolve to renal failure. From a therapeutic perspective, nephrotic syndrome may be classified as steroid sensitive, steroid resistant, steroid dependent, or frequently relapsing.


Treatment-
Whether one is suffering from acute or chronic nephrotic glomerular , with symptoms moderate or severe, the treatment lies in treating high blood pressure and other underlying conditions of the disease.
Water pills help control sweating, thus increasing the fluid flushed from the kidneys.
Statins reduce cholesterol level.
Blood thinners such as anticoagulants lower the risk of blood clots.
Corticosteroids regulate the immune system and ease the inflammation that results from kidney disorders.
Incorporating certain lifestyle changes such as opting for lean proteins, cutting on the intake of fat in the diet and consuming lesser amounts of salt can treat inflammation and swelling.
For kidney failure, dialysis can come to the aid in eliminating excess fluids and regulating hypertension.


Nephrotic Syndrome: Causes and Treatment

Blood circulation is one of the most important functions in our body because blood is the medium that carries oxygen and all the significant nutrients to the different organs. When blood circulation takes place, a certain pressure is exerted on the arteries of the heart and the blood vessels. However, when this pressure increases, a condition called high blood pressure develops whereby the systolic and the diastolic pressure escalate above the normal levels. High blood pressure not only leads to the damage of the heart, the brain and the eyes, it also leads to the impairment of the kidneys.

To combat a fast-paced life in an urban setting, we adapt certain lifestyle measures which serve some of the core purposes, like satiating our hunger, quickly. One of these measures includes the intake of canned products. With canned foods, cooking becomes faster and easier. But, one of the major downsides of canned foods is that too much of it can lead to the development of high blood pressure.

The link between BPA and canned foods
BPA or Bisphenol A is an industrial chemical that is present in high concentrations in canned foods and beverages. According to researchers, our body contains the reproductive hormone, estrogen in a particular amount. However, BPA mimics the properties of estrogen and tampers with the cells of the heart and our blood vessels that are otherwise sensitive to estrogen, thereby increasing the chances of high blood pressure. Because of that, same reason BPA can also lead to the development of cardiovascular disorders.

BPA is also the primary chemical used to prepare the food containers or the cans. That is why when people drink or eat from these cans, the body accumulates the chemical as well.

According to medical experts, the systolic pressure rises by 5 mm of Hg after consuming two bottles of canned beverages. To detect this effect better, a medical team conducted a study using 60 men and women, among whom some were asked to drink soy milk from canned bottles and the remaining drank the same product from glass bottles. After this, these 60 men and women underwent a urine test. The test results showed that those who drank from canned bottles had a significant amount of BPA in the urine, which concluded the fact that canned foods are not such a healthy option after all.

What can you do?
So instead of opting for canned foods, another option is basing your diet around fruits and salads. But not the canned variety, but the homemade ones. If you are strapped for time, then you can look for salad bars and cafes. Else simply look for easy to prepare recipes online, prepare the food and store them in your freezer.

How Can Canned Food Products Affect Your Kidneys?

If you notice blood while urinating, you must visit a urologist to get a clear picture of the health issue. Blood in urine is known as hematuria in medical terms. Such a condition can occur in both men and women. It is a common condition and does not require the patient to panic. Rather immediate tests should be conducted to find out the cause of the blood and treated accordingly. Such conditions are very much treatable with a little care and vigilance following of the doctor s advice. Here are some of the common causes of hematuria in individuals: 

Urine Infections: Urine infections are the common cause of blood in your urine. Most commonly these affect urinary bladder and rarely kidneys also. Prompt identification and treatment can easily revert this problem. 
Urinary Stones: Another major cause of hematuria, usually accompanied by pain in the abdomen. 
Enlarged Prostate: With an enlarged prostate, there can be blood flow with the urine. Rarely this may be a sign of cancer in the prostate. 
Exercise: This might come as a surprise for many of the fitness freaks. While exercises are needed for the body and rightly so; but exercises should be done in a certain limit. Heavy exercises, limitless and vigorous exercises can sometimes cause other health problems in the body. One such problem is the passing of blood in the urine. 
Medications: Quite interesting is the fact that long-term consumption of certain medicines might cause hematuria in individuals. Certain medicines like penicillin and aspirin are absorbed by the body to a certain extent. But overdose or the regular dosage might lead to further problems in the human body. 
Kidney Injury: A kidney injury is a form of internal injury which can be felt and manifested through signs and symptoms. Such injuries occur mostly to those who are in the field of sports. At times, a heavy punch, a hard training session, or an exhaustive fall might lead to kidney injuries. This, in turn, would cause hematuria. 
Tumors of Urinary Tract: Bleeding can occur from tumors arising from kidney, ureter, urinary bladder as well as urethra. These require timely detection and management. Early treatment leads to an excellent long-term outcome. 
Thus, these are some of the common reasons for the development of blood in urine. However, it is a condition which can be best analyzed by the medical practitioner. Therefore, on the occasion of blood, you must get it tested and treated immediately.

Blood In Urine - What Does It Mean?

The presence of blood in urine is known as Haematuria. It is categorized under 2 types:

    Macroscopic haematuria, which means the patient has seen blood.
    Microscopic dipstick haematuria, which means blood is identified by urine microscopy or by dipstick testing either in association with other urological symptoms (symptomatic microscopic haematuria) or during a routine medical examination. It has been variably defined as 3 or more , 5 or more or 10 or more Red Blood Cells (RBCs) per high - power field.

Urological and other Causes of Hematuria

    Cancer: Bladder, Kidney and Prostate Cancer
    Stones: Kidney, Ureteric
    Bladder Infections: Bacterial tuberculosis, infective urethritis Inflammation
    Interstitial Cystitis Trauma : Kidney, bladder, urethra, pelvic fracture causing urethral rupture
    Renal cystic disease: (e.g. medullary sponge kidney)
    Other urological causes: Benign prostatic hyperplasia, vascular malformations
    Other medical causes of haematuria: anticoagulation therapy (e.g. asprin, anti platelet therapy) Nephrological Causes: more likely in children and young adults, proteinuria; red blood cell casts.
    Urological investigations: Urine culture, urine cytology, cystoscopy, renal ultrasonography and intravenous Urography and CT Urography.

Management of haematuria depends on the cause as determined by the urologist.

Causes and Treatment for Hematuria

As we all are aware that waste products in the blood are passed through urine. This filtering process is done by the kidneys as it separates the waste products including minerals and salts, which have to be passed out through urine. Many times, these minerals and salts get stuck in your urinary tract and over a long period, this forms kidney stones. They can vary in size from a ping pong ball to the size of a sugar crystal. They are not noticed till the time they cause a blockage. Sometimes, they cause immense pain if they start breaking or are pushed into the ureters (narrow ducts which lead to the bladder).

Symptoms of kidney stones:
1. Immense pain in the groin, belly and back.
2. Pain while urinating and urination occurring frequently.
3. Blood found in the urine (haematuria).
4. Vomiting and nausea.
5. Feeling extremely restless and not being able to lie still.

Kidney stones can also cause a kidney infection. Signs of kidney infection include:
Kidney stones can also cause infection in the kidneys as they block the passage of urine to the bladder by blocking the ureters. This leads to build up of the waste product which can result in an infection. Some of the symptoms of kidney infections could be:
1. Feeling chilly and shivering on your skin.
2. High temperature of 100.4 F (38C) or more.
3. A feeling of fatigue or weakness.
4. Immense diarrhea
5. Bad smelling and cloudy urine.

Types of Kidney stones:
1. Struvite stones: It contains ammonia and magnesium. It is usually quite large and horn- shaped.
2. Uric acid stones: Brown, smooth and softer than other kinds of kidney stones.
3. Cystine stones: They are yellow and don t look like stones. They usually resemble crystal.
4. Calcium stones: It is composed of calcium.

What causes kidney stones?
Kidney stones can occur due to several factors. It usually forms when urine generally contains crystal substances like uric acid, calcium and oxalate. Your urine might not be able to dilute these substances resulting in the perfect environment for the formation of kidney stones. In case you are showing any of the symptoms mentioned above, you should visit you doctor immediately before the problem can worsen.

Common Symptoms of Kidney Stones

Most people would panic on seeing slightly red urine being passed. A common urologic condition, this happens because blood cells are leaking into the urine. There are multiple reasons which can cause it, and not all of them are major causes for concern.

Read on to know more about some common causes, and how to manage this.

Urinary tract infections: There could be an infection of the entire urinary tract including the kidneys, the ureters, the bladder, and the urethra. In addition to blood in the urine, there could also be an urge to urinate, pain with urination, fever, and flank pain.
Enlarged or infected prostate: The prostate naturally enlarges with age and can obstruct the urethra, causing pain and blood in the urine. There is a constant urge to urinate and difficulty initiating the stream. Infection of the prostate also produces similar symptoms along with fever and pain.
Kidney diseases: In addition to infections, other kidney diseases including glomerulonephritis, which can also lead to hematuria. Kidney stones, which are quite common, are also another reason, and this will be characterised by the sudden sharp pain around the flank which is very diagnostic of kidney stones. Injury to the kidneys from trauma or sports is another reason for hematuria.
Cancers/tumours: Cancers in the kidney, bladder, or prostate can cause blood to appear in the urine, but this would happen once cancer has reached some advanced stage, not very early in the process.
Listed below are some risk factors for hematuria.

Age: Men older than 50 are more prone to hematuria
Sex: While men are more likely to have stones or prostate infections, UTIs are quite common in women below 50s.
Family history: though not hereditary, if kidney stones or cancers or infections are in the family, chances of developing hematuria also goes up.
Medications: Aspirin, blood thinners, NSAIDs, and some antibiotics increase the chances of hematuria.
Exercise: Long distance runners are shown to be more prone to developing hematuria.
Diagnosis: In addition to a physical exam, blood tests, imaging (CT scans and/or MRI) and cystoscopy might be required to confirm the diagnosis. Identifying the cause is extremely important as treatment would depend completely on the causative agent. Though hematuria is just one of the symptom, the underlying cause could have severe adverse effects on the whole body system.

Treatment: Whether it is an infection or enlarged prostate or kidney stone or tumour, once the cause is identified treatment is customised accordingly. Antibiotics for the infections, laser treatment for the stones, etc. are recommended.

If you see your urine turning slightly pink in colour, talk to your doctor immediately. Identifying the underlying cause and treating it will help solve the problem of hematuria.

In case you have a concern or query you can always consult an expert & get answers to your questions!


Blood In Urine - Is It Actually Serious?

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