Liver transplantation or hepatic transplantation is the second most carried out transplant procedure in the world. It is a potentially difficult surgery that is performed by a team of two to four surgeons along with the help of anesthesiologists and nurses. It takes around 10 to 12 hours to complete the procedure as there are many anastomoses, sutures, reconnections, and disconnections, which are to be performed under the liver bed which is necessary for the transplant to be a success.

Tests required before a transplant is planned

Computed tomography, or CT scan which employs X-rays and a computer to create pictures of the liver, showing its size and shape. CTs and chest X-rays are also recorded to evaluate your heart and lungs.
Laser Doppler flowmetry: to check if the blood vessels to and from the liver are normal.
Echocardiogram to check the status of heart function.
Pulmonary function test or lung capacity test to study and determine the lungs' ability to exchange oxygen and carbon dioxide.
Blood tests are performed to determine the patient's blood type, clotting ability, and biochemical status of blood, and to determine liver function.
The liver transplant procedure

After an admission at the hospital, an Intravenous line is started in the patient's arm or hand. Other tubes (catheters) are put in their neck and wrist, or their collarbone or the area between the belly and the thigh (the groin). These are used to check heart and blood pressure, and to get blood samples.
The patient is placed on the back, over the operating table.
If there is too much hair at the surgical site, it may be shaved.
A catheter is placed into the bladder to drain urine.
After the patient is sedated, the anesthesiologist will insert a tube into the lungs. This is done so that the breathing can be helped with a ventilator. The anesthesiologist will keep checking the heart rate, blood pressure, breathing, and blood oxygen level during the surgery.
The skin at the surgical site will be cleaned with a sterile (antiseptic) solution.
The doctor will make a cut (incision) just under the ribs on both sides of the belly.
The doctor will carefully separate the diseased or the injured liver from the nearby organs and structures.
The attached arteries and veins are then clamped to stop the blood flow into the diseased liver.
The diseased liver will be cut off from the blood vessels and then removed.
The surgeon will check the donor liver before implanting it into the body.
The donor's liver is placed in the patient's body.
The incision will then be closed with sutures or surgical staples.
In case you have a concern or query you can always consult an expert & get answers to your questions!

Liver Transplant Surgery - Understanding The Procedure!

Ultra sound is commonly known as sonography. It is a process of reproducing ultrasound images of soft tissues of a particular body part and other organs on the computer screen with the help of the echoes of the sound waves produced by the transducer, a high-frequency generating instrument.
Ultra sound is commonly used during the different stages of pregnancy to denote the foetal health, the foetal sex, date of delivery, birth defects etc. However, in recent times, the ultra sound has also been associated with the diagnosis of other body parts such as the eyes, heart, gall bladder, liver, ovary, uterus, kidney, uterus, testicles, and ovaries. Ultra sound has also been useful in conducting biopsies for suspecting cancer patients, although not all of the cancers are detected by this imaging process. 3D & 4D ultrasound imaging are useful for looking at a particular body portion with much more precision and in slow motion respectively.

The advantages of ultra sound are:
1. The process of ultrasound imaging is a painless and a fast one. It does not require any insertion of needles or similar objects to denote the problems of the concerned body part.
2. The process is more convenient as compared to other similar imaging processes like MRI, mammogram and x-rays as they can capture images of the soft tissues, blood flow & cysts more clearly than the other processes.
3. The process is free of any harmful effects as there are no chances of exposure to radiation as compared to similar processes such as CT scans or X-rays.

Ultrasound - How it is Beneficial over Other Imaging Techniques?

Peripheral arterial disease or commonly known as PAD is a common cardiovascular disease. Despite having the power to cause painful symptoms and severe health risks, it is overlooked by many. This particular arterial disease may lead to life-threatening consequences if left untreated for long. Read on to know more about the condition.

What is PAD?
PAD refers to the situation where in the peripheral arteries to the arms, head, stomach, and legs become narrow. Often referred to as the peripheral vascular disease, here, the arteries start to grow narrower due to the slow but constant buildup of fatty deposits on the artery walls. Though it can affect all the arteries in a person s body, except those that supply blood to the heart, in the majority of cases, it affects the arteries in the leg.

What are the threats it poses?
PAD is indeed a life-threatening disease, as the blockages, it creates in the peripheral arteries prevent normal blood circulation to the different organs, legs, and brain. And when the blood flow is restricted, or the vital organs of the body fail to receive necessary blood flow, then the legs, brain and all the vital organs suffer severe damage. And when PAD continues to harm the blood flow for a long time, then it leads to tissue infection or tissue death, which is known as gangrene.

Additional health issues it causes
PAD also creates various other health concerns, such as atherosclerosis. Atherosclerosis is a chronic disease of fatty materials  build up. In the case of atherosclerosis, the entire blood circulatory system gets damaged, including the arteries leading to the heart. The risk of blood clot build ups and vascular inflammation are also common additional threats posed by the fatty deposits.

Probable symptoms
Depending on the part of the body that is affected, the PAD symptoms vary from one to another. However, painful cramping in the muscles of one s legs is the most common symptom of this condition. The pain, originating in the legs often goes up to the muscles in the thighs or hips too. Except this, weakness or numbness in the legs, ulcers or open sores on the feet or legs, skin color changing into bluish or pale are some of the other symptoms of PAD.

Possible treatments
The peripheral arterial disease can be diagnosed easily, painlessly and straightforwardly under proper medical attention. Both prescribed medications and a lifestyle change are considered to be the best treatment for controlling PAD. Including a healthy diet and adopting a healthy lifestyle have often been successful in preventing PAD in its early stage.

The moment any signs or symptoms of PAD is noticed one should not be late in seeking immediate medical attention.

Peripheral Arterial Disease- A Serious Threat To Life Worth Being Concerned About!

A set of cartilage discs present between the vertebrae, ensures that the spinal column can withstand the weight of the upper body. If these discs tear or get injured, the condition is commonly known as slipped disc. In medical terms the same condition is known as prolapsed intervertebral disc. Here is a look at the causes, symptoms and treatment for this painful condition.

Causes for Prolapsed Disc
Intervertebral cartilage discs undergo normal wear and tear with age. However, there are other underlying causes for a slipped disc.

Sitting for prolonged period of time may lead to the disorder
Repeatedly lifting weight in such a manner that all the pressure is exerted on the vertebrae may also lead to a prolapsed intervertebral disc. Example   Exercising with incorrect posture
Alcohol consumption and smoking
Sedentary lifestyle and lack of exercise
Accidental trauma to the spinal region
Diet not consisting of all the essential nutrition
Family history of the same condition
Tweaking one s lifestyle is generally enough to ensure that people are not affected by the condition.

Symptoms of prolapsed intervertebral disc

Patients claim to feel pain radiating from their spinal region to the calves of their feet. This sciatic nerve may get compressed due to the disorder, leading to such a pain.
Tingling sensation in the lower and upper back regions. This sensation may also spread to the arms and legs.
Patients complain of a weakness or numbness in the buttock area, feet and legs.
Treatment for prolapsed intervertebral disc

Limited activity is advised after diagnosis, but complete bed rest is not recommended.
Ice packs should be applied at first. After the pain resides, heat should be applied on the region.
Physical therapy and certain exercises are prescribed by the physician
Anti inflammatory drugs can help control the condition and relieve some of the pain.
Surgery is considered only if the condition does not subside after 4-6 weeks. However, such a surgery is risky and may cause permanent nerve damage.
If you feel that you are at risk of prolapsed intervertebral disc, consult a physician immediately. Follow the recommendations of the doctor, so that you do not have to go through the pain associated with the condition.

Prolapsed Disc - What Causes It?

The human body has 206 bones and bone cancer can affect any of these bones. This condition starts when healthy bone marrow cells mutate and grow out of control to form a tumor. There are many different types of bone cancer. Treatment of bone cancer varies from case to case and depends on factors such as, type of cancer, stage at which it is diagnosed and the patient s overall health amongst other factors.

Surgery, chemotherapy, and radiation are the three most common types of treatments favored for bone cancer. Surgery is usually used for low-grade tumors. This involves the removal of tumor and the surrounding healthy cells and tissues to ensure that that cancer does not recur. For high-grade tumors, surgery may be accompanied by chemotherapy, radiation or a combination of the two. 

Chemotherapy involves the delivery of medication to destroy cancer cells orally or intravenously. Radiation involves the use of high energy X rays to kill cancer cells. This is often used to treat patients with a tumor that cannot be surgically removed.

Apart from these standard forms of treatment, bone cancer patients are often advised to take part in clinical trials for their treatment. This can be described as a research study to test the efficiency of new approaches to the treatment of bone cancer. A clinical trial can be used to treat the safety and efficacy of a new drug, the new dosage of standard drugs or a new combination of treatment types. As a member of a clinical trial, you may be one of the first few people to benefit from treatment even before it is available to the general public. 

Some of the new options available through clinical trials are:

Immunotherapy: This is also known as biologic therapy. It is designed to boost the patient s immune system to fight cancer cells. Mifamurtidesi one of the types of immunotherapy being tested. Immune checkpoint inhibitors such as monoclonal antibodies are also being tested for their ability to block specific molecules.
Targeted therapy: This type of therapy targets the genes and proteins that contribute towards the growth and survival of cancer cells. Targeted therapy limits the damage caused to healthy cells and tissues and only blocks the growth of cancer cells.
Myeloablative therapy: This involves an intense regimen of chemotherapy. High doses of chemotherapy aim at destroying all the cancer cells. Unfortunately, in the process, healthy cells may also be killed. This may be followed by introducing stem cells through a bone marrow transplant to the patient s body to renew blood cells.
Intraoperative radiation therapy: These trials evaluate the use of radiation given inside the patient s body during a surgery. In cases where tumor is in a distant location of the body, stereotactic body radiotherapy and radiofrequency ablation may be used.


Bone Cancer - Understanding The New Approaches For Treatment!

Collectively grouped under the Ewing sarcoma family of tumors, Ewing's sarcoma is the second most common primary bone cancer occurring predominantly in children and in adolescents. Very rarely is it experienced in adults above the age of 30.

Typically forming in the bones of the chest, pelvis, head, back or trunk and in the long bones of the arms and legs, Ewing's sarcoma is believed to originate in certain kinds of primitive cells. When it begins to affect similar kind of cells found outside the bone, it is usually called an extraosseous Ewing's sarcoma.

Causes
1. Similar to all types of Ewing tumors, Ewing's sarcoma is generally caused by an alteration in a certain cell compelling a gene named EWS found on chromosome no. 22 to move over to a DNA section on any one of the surrounding chromosomes resulting in the activation of the EWS gene.
2. While it is not a hereditary condition, it usually occurs after childbirth, but no substantial evidence has been found as to why it happens so.

Symptoms
Symptoms of Ewing's sarcoma may include:
1. Swelling and pain especially in the arms, legs, back, chest or pelvis
2. Swelling accompanied by joint immobility
3. A bone breaks having no apparent cause
4. Swelling which may or may not be accompanied by a warm, tingling sensation
5. Fever resulting from unknown causes
6. Lumps or bumps which do not subside over time
7. Abnormal weight loss
8. High levels of fatigue
9. Tumors which have spread over to the lungs may cause shortness of breath
10.Tumors spread over to the spine may cause weakness or even paralysis.

Because the symptoms of Ewing's sarcoma can hardly be distinguished from symptoms caused by other infections or injuries, an early diagnosis is absolutely necessary for a successive treatment.

Causes and Symptoms of Ewing's Sarcoma

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