Cystic Fibrosis is a genetic disorder that is known to affect some of the vital organs of the body including the lungs, digestive system to name a few. For long it was believed that cystic fibrosis affects a person in their childhood. However, various research and studies suggest that adults are also susceptible to this inheritable disorder. In this article, we will discuss the cause and symptoms associated with cystic fibrosis.

Cause
The epithelial cells that line the stomach, nasal cavity and lungs, are responsible for the production of the digestive fluids, sweat, tears, mucus. The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene codes for a protein called the CFTR protein. The CFTR protein, a membrane protein plays a pivotal role in transporting the chloride ions of the epithelial cells inside and out of the cell. This regulation of the chloride ions goes a long way in ensuring that the mucus produced is free-flowing and thin.

In the case of Cystic Fibrosis, the CFTR gene that codes for the protein undergoes a mutation. With the CFTR protein unable to perform its function, sticky and thick mucus builds up and clogs some of the major systems of the body including the digestive system, reproductive, and respiratory system. There is also a higher salt content in the sweat of the affected person.

For a person to be affected by cystic fibrosis, he/she must inherit a copy of the mutated CFTR gene from both the parents ( Autosomal Recessive Disorder) at birth.

Symptoms
The symptoms associated with cystic fibrosis depends on the organs and systems affected.

The thick mucus formed can clog the digestive tract resulting in incomplete absorption of the essential nutrients from the food. This may have an impact on the overall growth and development of the body.
- There may be stunted growth or no weight gain.
- The stool may appear greasy and foul smelling. Some may also suffer from constipation.
- Newborns and infants may suffer from an intestinal blockage.
Cystic fibrosis, left unattended can lead to diabetes, intestinal blockage or obstruction.
- The mucus can also block the bile duct triggering a host of problems including liver disorders.
- At times, the obstruction or blockage can occur at the junction where the large and the small intestine meets (Distal intestinal obstruction syndrome).
The thick mucus can also affect the lungs and the respiratory system by blocking the tubes that act as a passage carrying the air inside and out of the lungs. As a result,
- A person may suffer from lung infections frequently.
- There may be difficulty in breathing, stuffy and blocked nose, or wheezing.
- Some people may also suffer from a chronic cough with a thick sputum.
Left untreated the complications can worsen resulting in

Nasal polyps, Chronic infections, Hemoptysis (there is blood while coughing), and Pneumothorax (air fills up in the space bifurcates the chest wall from the lungs).

In severe cases, there may be a respiratory failure.

Cystic fibrosis can also trigger fertility problems (both in males and females).

Cystic Fibrosis- Causes and Symptoms!

Although your body is already in possession of the bacteria leading to tuberculosis, your immune system is able to prevent you from becoming sick. Doctors have made a distinction between latent and active tuberculosis (TB). In case of latent TB, the bacteria in the body in a passive state and it causes no symptoms, and therefore it is not contagious. But, in the case of active TB, you would become sick and may even spread the disease to others. It can take place in the first few weeks or even after several months of being infected with TB bacteria.

What are the symptoms of active TB?
If you are coughing for over three weeks and sometimes even coughing up blood, it can be a sign of TB. Chest pain and pain while coughing and breathing along with fatigue, fever, chills and night sweat are the common symptoms of TB along with loss of appetite and unintentional weight loss. TB may even affect other organs of your body, including your brain, spine and kidneys. When TB takes place outside the lungs, then the signs of TB can vary as per the organs that are involved. For instance, TB in the spine can cause back pain and that in kidneys may cause blood in the urine.

What are the causes of TB?

TB is stemmed from a bacteria which spreads from individual to individual via the microscopic droplets that are released into the air. This may happen when an affected person is left untreated and he speaks or sneezes or coughs or laughs. Though the disease is contagious, it is not easy to be affected by it. As a result, you are much more likely to get affected with active tuberculosis from a person you live with or come in regular contact with, rather than a stranger. It is important to note here that people who are affected with TB and going through proper medications for over two weeks are no more contagious.

Right from the 1980s, the number of individuals affected with TB has increased dramatically, owing to the spread of HIV, which is the virus known for causing AIDS. A person infected with HIV has a weak immunity system as a result of which it becomes difficult for the body to deal with TB bacteria. So those who have AIDS are more likely to be affected with active TB and sometimes the latent form also progresses to an active one very quickly. Therefore, it is important to seek medical assistance and detect if you have any such health complications concerning TB.

Know The Reasons Behind Tuberculosis!

It is a known and proven fact that eating while consuming alcohol is necessary. One tends to grow hungrier, the more he or she drinks alcohol. This is because alcohol has the attribute to stimulate one s appetite in such a way that one would have you craving for food that is rich in salt and high in fibre. Consuming only alcohol ignoring the hunger would lead to several diseases like pancreatitis and issues with the liver.

Though the appetite of an individual during alcohol consumption tends to incline towards snacks like pizza, french fries, nuts and cheese cubes, it is wise to opt for healthier food choices. Salty food can worsen the dehydration effects of the body. And as the body tends to be dehydrated during drinking, it is better to avoid salty food. High-fibre food items are not good for the health either. It delays the digestion process, which is not a good sign for the body. Also, it is also not advisable to eat food in large portions before going to bed, especially after alcohol intake.

There is a variety of healthy food that one can eat along with alcohol

Soup: A clear soup, like chicken clear soup or vegetable clear soup, which has a broth-like texture, is a healthy choice. Creamy soup with cream of chicken or cream of mushroom should be avoided as it would make one heavy, thus delaying the digestion process.
Rice: Plain rice is said to be one of the best food that is easy to digest, paired up with a light vegetable dish. It is very nutritious as well.
Chicken sandwich: Grilled chicken sandwich without cheese and mayo is a healthy food tip as it contains sodium.
Popcorn: Popcorn does not contain fat, neither is it high-fibre. It is the best low-calorie food to go along with alcohol and it tastes really good too.
Wheat crackers: Wheat crackers contain whole grains. It is full of complex carbohydrates, which help the alcohol to absorb easily. It also consists of Vitamin B, which like potassium, gets reduced with the consumption of alcohol.
Banana: It is rich in potassium. Though an individual would never have a banana along with alcohol, it is healthy as the level of potassium should be taken care of while drinking alcohol.
Wheat bread: Wheat bread toast can be consumed with alcohol without butter or cheese. It is an alternative to wheat crackers for those who do not prefer it.
Oats: Cooked food is easy to digest with alcohol, so a pot of cooked oatmeal can be a healthy accompaniment. It can be spiced up a bit to add flavour.
Salad: Salad is refreshing and healthy at the same time. It can be bland, but it is better to have healthy salad as an accompaniment than having salty food with alcohol.
Milk cereal: Cereal, especially whole grain cooked with low-fat milk, is healthy.
By being aware of the right eatables, the ill effects of alcohol can be mitigated to a large extent.

Alcohol - 10 Healthy Foods that You Can Eat With It!

Sinusitis refers to an extremely painful condition caused due to the inflammation and swelling of sinuses. A host of causes contribute to sinusitis, chief among them being allergies, air pollution or sometimes infection. It causes extreme discomfort, throbbing headache, sore throat and a blocked nose. Though different branches of medicines have tried in their own ways of dealing with this problem, ayurveda with its reliance on natural products as remedial measures have emerged as a clear favorite. Some of the ayurvedic remedies for sinusitis are-

1. Inhalation of steam with tulsi
The benefits of tulsi are widespread and need little introduction. The ambit of its advantages is expansive, making its presence felt even in treating sinusitis. In case of severe bouts of sinusitis, it is highly recommended that you inhale steam with tulsi almost every day in the week.

2. Have ginger along with honey
Another way of treating acute pangs of sinusitis is by making a paste of ginger and honey. Make small tablets of this mixture and for most effective results it is advisable that you have it every day.

3. Avoid certain food
Just how incorporating certain food in the diet help in reducing the pain of sinusitis, eliminating few, often times help you to achieve the same purpose. When you suffer from sinusitis, it is only advisable that you diligently avoid dairy products like milk, yoghurt as well as intoxicants like cigarettes and alcohol.

4. Lemon juice and water
In the initial stages of sinusitis, having a daily concoction of lemon juice and water is considered very beneficial. During this phase maintaining a light diet is advisable.

5. Practice pranayama
The gamut of ayurvedic remedies includes not only the prescription of what to eat and what to avoid but also several exercises that help in expediting the process of recovery. Among them, pranayama with its focus on control and regulation of breath is particularly beneficial in curing sinusitis.

Ayurvedic Remedies for Sinusitis

Brain metastases from systemic cancer are the most common type of intracranial neoplasm in adults, being almost 10 times more common than primary malignant brain tumors, which cause a significant burden on the management of patients with advanced cancer (1). The lungs represent one of the most frequent sources of metastases to the brain, with a probability of (36 64%) (3). Symptoms suffered by the patients include headaches, epilepsy, focal weakness, numbness or changes in mental status. The prognosis of patients with brain metastases is not optimistic and the median survival time is  1 2 months if left untreated. The 1-year survival rate has been recorded as 10.4% (4,5). The treatment of metastatic brain tumors is complex; not only due to being able to provide local control and improve neurological function, but also due to factors such as age, performance and systemic disease status and the size, volume, location and number of metastases at presentation

CyberKnife is a robotic radiosurgery system with a linear particle accelerator (linac), which is coupled with real-time imaging to track and compensate for the patient s or target s motion. As a relatively non-invasive treatment modality, CyberKnife demonstrates certain benefits, including a more accurate target localization and improved dose delivery for the management of metastatic brain tumors that allows higher biologically effective dose delivery without increased incidence of toxicity.

In the present case, the results for the treatment of multiple brain metastases after CyberKnife surgery with a 7 8 Gy marginal dose was promising. CyberKnife for metastatic brain tumors is an effective and safe method for reducing the marginal dose prescribed for multiple brain metastases and for minimizing the radiation-related neurotoxicities. In conclusion, CyberKnife, a focused, highly-targeted radiosurgery and fractionated radiotherapy is particularly useful for multiple brain metastases. CyberKnife provides the advantage of the management of local recurrence and a tolerable complication rate. Although the treatment of brain metastases has been performed with CyberKnife, the clinical significance and optimal dose fractionation scheme require further investigation.

In case you have a concern or query you can always consult an expert & get answers to your questions!

CyberKnife Therapy Of 24 Multiple Brain Metastases From Lung Cancer!

Sputum production and chronic cough for at least three months in a year, consecutively for two years is termed as Chronic Bronchitis. Emphysema and Chronic Bronchitis are different from each other but are covered under the same umbrella COPD, which means Chronic Obstructive Pulmonary disease and that is because both are diseases related to respiration.

How is Chronic Bronchitis different from Emphysema?
Both of them occur when the airways in the lungs get damaged due to the inflammation of the airways. Emphysema is the result of air sacs break down whereas Chronic Bronchitis is the result of excessive mucus formation and inflammation in the Bronchi. Some people show either of the symptoms while some people show combined symptoms.

Symptoms of Chronic Bronchitis:
The following symptoms are seen in people with Chronic Bronchitis:

Long-term cough
Excessive mucus production
Sudden weight gain
Tight chest
Feeling breathlessness even when you are taking rest
Sometimes, these symptoms will be neglected by many people treating them as symptoms of cold weather, or attributing these symptoms to the presence of too much smoke or fumes around them. But it is always good to consult a doctor if the symptoms persist for a long time.

Physiotherapy and Chronic Bronchitis:
The main goal of your physiotherapy involves exercises that improve tolerance, education, mucus clearance, increase lung volume, reduce exacerbations, and reduce hospitalization.

Exercises that improve tolerance:
Upper and lower limb tolerance training have shown tremendous results in preventing, controlling and managing Chronic Bronchitis. This training helps in airway clearance, reduces airflow obstruction, mucus removal, and increased energy levels.

Postural draining:
Usage of different postures for moving the mucus through the throat and removing it through the mouth. There are different postures used for different patients. It is basically done by placing the affected part at a lower height and the unaffected part comparatively higher.

Autogenic draining:
This technique will help in proper and normal airflow through the bronchi. There will not be any blockage of the airway. Retention of carbon dioxide in the lungs will be reduced, the mucus will be removed and airflow through the airways will improve with this technique.

Percussion:
This technique is used by the physiotherapist along with the postural drainage technique. This is also a technique used for clearing the mucus that got stuck in the airways. Many patients find this technique really useful in mucus removal. In Percussion, the physiotherapist claps on the chest of the patient or on the back of the patients. It depends on how the patient prefers. This gives a relaxing and soothing effect on the patients and helps them release out mucus that got stuck in the airways.

Educating:
Finally, educating the patients about its causes and physiotherapy treatments can help them recover faster.

Chronic Bronchitis - What Should You Expect From A Physiotherapist?

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