Tuberculosis is an airborne communicable disease that mainly affects the lungs. However, it can attack the other organs as well. A tuberculosis infection may be categorised as latent or clinically active. A person is said to be suffering from latent tuberculosis when he or she has been infected with the tuberculosis bacteria, but is protected from the germs by a strong immune system. People showing symptoms of the disease are said to be suffering from a clinically active form of tuberculosis and must seek medical attention as soon as possible.

The symptoms of tuberculosis may be hard to identify as they can be attributed to other causes as well. In some cases, the symptoms may not appear until the disease has reached an advanced stage. Some of the common symptoms associated with this disease are:

Weight loss
Fever
Dry cough
Excessive sweating at night
Unexplained tiredness
Poor appetite
Chest pain
People with a weakened immune system such as those suffering from HIV or those undergoing chemotherapy have a high risk of suffering from this condition. When the disease is in its active form, tuberculosis causing bacteria multiply rapidly and attack the lungs. From here they may spread to other parts of the body, such as the lymph nodes, kidneys, bones, spine, brain and skin. When it reaches an advanced stage, the symptoms vary according to the organ affected. For example, pain in the bones indicates that the bone tissues have been affected while coughing up blood is a sign of TB of the lungs.

Tuberculosis can be diagnosed through a blood test or with a skin test. An x-ray and a lab analysis of your sputum can also help differentiate between latent and clinically active forms of this disease.
In the case of latent infections, preventive therapy is prescribed to kill the germs before they become active. This typically takes the form of a single tablet that must be taken for six to nine months.

Clinically active tuberculosis can be easily treated and cured as long as the patient undergoes the complete course of treatment. Treatment for this disease usually takes the form of oral medication that must be taken for six to nine months continuously. This is because tuberculosis causing bacteria can take a very long time to die. In some cases, multiple drugs may be prescribed to reduce resistance to the drugs. When it comes to tuberculosis it is important to continue taking medication for its full course, even if the symptoms disappear and you are feeling better. 

7 Signs You Are Suffering From Tuberculosis!

Upper respiratory infection (URI) is a condition, which involves illness, mainly caused by critical infection in the upper respiratory tract. This region includes the pharynx, larynx, nose and sinus. This infection causes diseases, such as tonsillitis (tonsils get inflamed), pharyngitis (causes sore throat) sinusitis (nasal passage becomes inflamed), laryngitis (voice box in your throat gets inflamed) and common cold.

Causes of upper respiratory infection (URI):
1. Both virus and bacteria cause upper respiratory infection (URI). The most common form of virus causing this infection is known as 'rhinovirus.'

2. The immune system of young adults and children are often very vulnerable. Hence, they are more likely to develop upper respiratory tract infection.

3. URI is also contagious and airborne in nature. So if a person comes in contact with an infected person suffering from URI, he/she is likely to develop this infection.

4. Not washing hands before meals can also cause upper respiratory infection because the virus can be transferred easily to the mouth and can travel into your system.

5. If you have any lung problem or heart disease, you are more likely to be susceptible to upper respiratory infection.

6. Those who already have inflamed tonsils can trigger tonsillitis by drinking any cold or spicy beverage like ice-creams or cold milkshakes.

7. Exposure to some flu or cold can cause pharyngitis. It can also be caused by second hand smoking.

8. Birth defects or structural defects in the nasal cavity or nasal polyps can cause sinusitis. Sometimes the inside part of the nose may get swollen due to common cold and block your ducts. This is a common cause for sinusitis.

Symptoms of acute upper respiratory infection:
1. Congestion in the lungs or nasal area.
2. Whooping cough
3. Running nose due to common cold.
4. Feelings of fatigue and lethargy throughout the day.
5. Your body will start aching without engaging in any physical exercise.
6. You can also lose consciousness in severe respiratory tract infections.
7. Difficulty in breathing.
8. Oxygen levels in blood drop down drastically.

Sometimes in worse cases, acute upper respiratory tract infection (URI) can also cause respiratory failure, respiratory arrest and congestive heart failure. Therefore, it is necessary to book an appointment with a doctor as soon as you start experiencing the above symptoms.

Acute Upper Respiratory Infection: Causes and Symptoms

Cystic Fibrosis is a genetic disorder that is known to affect some of the vital organs of the body including the lungs, digestive system to name a few. For long it was believed that cystic fibrosis affects a person in their childhood. However, various research and studies suggest that adults are also susceptible to this inheritable disorder. In this article, we will discuss the cause and symptoms associated with cystic fibrosis.

Cause
The epithelial cells that line the stomach, nasal cavity and lungs, are responsible for the production of the digestive fluids, sweat, tears, mucus. The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene codes for a protein called the CFTR protein. The CFTR protein, a membrane protein plays a pivotal role in transporting the chloride ions of the epithelial cells inside and out of the cell. This regulation of the chloride ions goes a long way in ensuring that the mucus produced is free-flowing and thin.

In the case of Cystic Fibrosis, the CFTR gene that codes for the protein undergoes a mutation. With the CFTR protein unable to perform its function, sticky and thick mucus builds up and clogs some of the major systems of the body including the digestive system, reproductive, and respiratory system. There is also a higher salt content in the sweat of the affected person.

For a person to be affected by cystic fibrosis, he/she must inherit a copy of the mutated CFTR gene from both the parents ( Autosomal Recessive Disorder) at birth.

Symptoms
The symptoms associated with cystic fibrosis depends on the organs and systems affected.

The thick mucus formed can clog the digestive tract resulting in incomplete absorption of the essential nutrients from the food. This may have an impact on the overall growth and development of the body.
- There may be stunted growth or no weight gain.
- The stool may appear greasy and foul smelling. Some may also suffer from constipation.
- Newborns and infants may suffer from an intestinal blockage.
Cystic fibrosis, left unattended can lead to diabetes, intestinal blockage or obstruction.
- The mucus can also block the bile duct triggering a host of problems including liver disorders.
- At times, the obstruction or blockage can occur at the junction where the large and the small intestine meets (Distal intestinal obstruction syndrome).
The thick mucus can also affect the lungs and the respiratory system by blocking the tubes that act as a passage carrying the air inside and out of the lungs. As a result,
- A person may suffer from lung infections frequently.
- There may be difficulty in breathing, stuffy and blocked nose, or wheezing.
- Some people may also suffer from a chronic cough with a thick sputum.
Left untreated the complications can worsen resulting in

Nasal polyps, Chronic infections, Hemoptysis (there is blood while coughing), and Pneumothorax (air fills up in the space bifurcates the chest wall from the lungs).

In severe cases, there may be a respiratory failure.

Cystic fibrosis can also trigger fertility problems (both in males and females).

Cystic Fibrosis- Causes and Symptoms!

If you are having a chronic cough and often pant for breath, it is quite possible that you may be suffering from bronchitis. In addition to this, you may also experience wheezing, fatigue, and pain in the chest. It is triggered when the lining of the airways in the lungs become irritated. To determine, whether or not bronchitis is contagious, it is important to understand what caused the ailment.

Chronic bronchitis: This type of bronchitis happens when the airways get continuously irritated. It may last for months or even years and tend to come back. It is caused by irritants that affect the lungs such as dust, chemicals, smoke, fire, and smoking cigarettes. Even though chronic bronchitis is not considered contagious, it is a serious health issue that requires medical attention.
Acute bronchitis: It generally lasts for about 1 to 3 weeks and stems from cold or flu virus. As these infections are contagious, so is acute bronchitis.
Whether a person having bronchitis can spread the disease depends on the virus that is causing the ailment. In most instances, it is seen that the disease is contagious for a first few weeks of infection. Since there are hundreds of viruses causing bronchitis, it is best to assume that a person is bound to spread the disease when he has symptoms of cold and flu.

What causes transmission of bronchitis?
Acute bronchitis owing to infection is generally transmitted via an airborne droplet containing germs. It is transmitted when someone having infection shakes hand or sneezes or coughs or has any other physical contact. Some virus and bacteria have the power to live outside the body for a prolonged span of time, and therefore, you can get infected by touching any object that is harboring the germs.

It is often seen that acute bronchitis begins as flu and therefore, the best way to prevent it is to get an annual shot of flu. When you come in contact with an infected person, the chances of being affected is high if you have chronic infections or weak immune system. Aged people and young children are most vulnerable to this disease.

How can acute bronchitis be prevented?
Even though acute bronchitis is extremely common and can occur at any time, winter is the most vulnerable season for bronchitis. But there are ways in which you can prevent bronchitis effortlessly. You should avoid close contact and sharing of utensils with an infected person who has flu, cold or bronchitis. You should not touch a used tissue since the virus of bronchitis can easily spread through mucus. Make sure that you get the annual flu shot and wash your hands in warm water.

The disease is very common, and it can make you feel very uncomfortable at times. But there are times when the symptoms subside on their own without any sort of medical attention.

Is Bronchitis Contagious?

Fever in children is a very common phenomenon, but still parents absolutely dread it. It can completely break your heart to suddenly see a happy, healthy child not getting up from the bed. Your first instinct when that thermometer crosses that dreaded 100 degrees F is to rush to the doctor for an immediate cure. That is probably the best remedy as a doctor can often catch additional signs of any disease that you may miss out on. Beyond that, here is how you can understand about fever in children better and how you can help. Technically, your child has fever when the body temperature crosses 100.4 degrees F.
 
Some children manage to stay active even then, but slowly get bogged down with muscle pain or other accompanying symptoms like cold, diarrhea, vomiting etc.
 
Causes: Fever is normally caused by the body's reaction to fighting an infection. (That is why most doctors say it's a sign of a robust immune system). When the body's natural defense system is stimulated, the core inner temperature rises, thereby making it harder for the bacteria and viruses that caused the infection to survive. Most fever subside on their own but that's a tough thing to accept as a parent who only wants to see their child up and running as soon as possible.
 
What you can do: Keep an eye on that temperature obviously. You need to find a doctor the moment the fever crosses the threshold temperature (101+ for less than three months olds, 102+ for 3-6 month olds and over 102 for older children). You should also see a doctor if there are accompanying symptoms or if you've given a dose of Paracetamol but the fever shows no sign of subsiding. It might happen at midnight and beyond, when no regular pediatrician is unavailable. So it is best to find out which hospital has an emergency center capable of handling such eventualities near your home.
 
Fever medications: It is super important for parents to know that fever medications must be given in the correct dose at the right times based on a child's weight, age, and overall health. An overdose can lead you straight to the emergency room. Don't mix a cold/cough medication that also has a fever medication in it.
 
Home remedies: Encourage your child to drink as much fluids as possible to prevent dehydration. Some doctors advise complete body sponging to bring down the temperature and this can be done as long as it doesn't cool the body too suddenly (there are contradictory notes on this practice, so do consult you doctor before your do this).
 
As parent, it is important you equip yourself with the right knowledge before you provide treatment to your child. 

Parenting Tips for Fever in Children

Brain metastases from systemic cancer are the most common type of intracranial neoplasm in adults, being almost 10 times more common than primary malignant brain tumors, which cause a significant burden on the management of patients with advanced cancer (1). The lungs represent one of the most frequent sources of metastases to the brain, with a probability of (36 64%) (3). Symptoms suffered by the patients include headaches, epilepsy, focal weakness, numbness or changes in mental status. The prognosis of patients with brain metastases is not optimistic and the median survival time is  1 2 months if left untreated. The 1-year survival rate has been recorded as 10.4% (4,5). The treatment of metastatic brain tumors is complex; not only due to being able to provide local control and improve neurological function, but also due to factors such as age, performance and systemic disease status and the size, volume, location and number of metastases at presentation

CyberKnife is a robotic radiosurgery system with a linear particle accelerator (linac), which is coupled with real-time imaging to track and compensate for the patient s or target s motion. As a relatively non-invasive treatment modality, CyberKnife demonstrates certain benefits, including a more accurate target localization and improved dose delivery for the management of metastatic brain tumors that allows higher biologically effective dose delivery without increased incidence of toxicity.

In the present case, the results for the treatment of multiple brain metastases after CyberKnife surgery with a 7 8 Gy marginal dose was promising. CyberKnife for metastatic brain tumors is an effective and safe method for reducing the marginal dose prescribed for multiple brain metastases and for minimizing the radiation-related neurotoxicities. In conclusion, CyberKnife, a focused, highly-targeted radiosurgery and fractionated radiotherapy is particularly useful for multiple brain metastases. CyberKnife provides the advantage of the management of local recurrence and a tolerable complication rate. Although the treatment of brain metastases has been performed with CyberKnife, the clinical significance and optimal dose fractionation scheme require further investigation.

In case you have a concern or query you can always consult an expert & get answers to your questions!

CyberKnife Therapy Of 24 Multiple Brain Metastases From Lung Cancer!

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