What are the different types of sickle cell disease?

Sickle cell disease or sickle cell disorder is a term often used to talk about a group of diseases affecting hemoglobin. It is the oxygen-carrying element of blood that makes up 2 alpha globins and 2 beta globins. Sickle cell disease happens due to beta-globin mutation and depending on the abnormality in mutation.

Types-
Sickle cell diseases can be of many types depending on the gene mutation in the blood. Some of the common types are-

Sickle hemoglobin s disease (ss)
Hemoglobin ss disease or sickle cell anemia is the most popular type of scd. It takes place when hemoglobin s gene mutation is inherited from both mother and father. In simple words, it happens when the child inherits one substitution beta-globin gene from each parent. In this type, the body only produces hemoglobin s. It is mostly found in people of african and indian origin.

Sickle hemoglobin- c disease (sc):
Patients with sickle hemoglobin sc disease have a moderately dissimilar swapping in their genes of beta-globin. Here, both hemoglobin c and hemoglobin s are inherited from each parent. It may cause similar symptoms like anemia but remains relatively l. People of west african and mediterranean origin are more prone to this.

Hbs beta-thalassemia
People with this type of scd inherit one sickle cell gene s and one gene for beta-thalassemia from each parent. Zero and plus are the two common types of beta-thalassemia. While beta 0 thalassemia usually takes a severe form, beta + thalassemia is a milder form of the disease.

Sickle beta-zero thalassemia
Beta-zero thalassemia takes form when the child inherits the beta s gene from one parent and beta 0 thalassemia gene mutation from the other. With similar symptoms to anemia, it is a slightly severe form of beta-thalassemia.

Sickle beta-plus thalassemia
Substitutions in both beta-globin genes take place in patients with sickle beta thalassemia (sb) disease. This may even lead to the requirement of blood transfusion if no normal beta globin is produced. Mediterranean and caribbean people are more likely to have this disorder.

Hemoglobin sd, hemoglobin se, and hemoglobin so
These are the few rare and not less common types of sickle cell diseases. They are also less severe. People with these forms of scd inherit one sickle cell gene s and one gene from uncommon hemoglobin (d, e, or o) from each parent.

Sickle cell trait
Hbas
People with sct have one sickle cell gene s and one normal gene a from both mother and father. Ones with this disorder show few to no signs of the disease and usually spend a normal life. However, the risk to their future generations still exists.
 

What Are The Different Types Of Sickle Cell Disease?

International yoga day or international day of yoga is celebrated on 21 june annually. It took a shape in the united nations general assembly in 2014 when indian prime minister narendra modi proposed a day for yoga. The mental, physical, and spiritually enticing practice of yoga started being celebrated in 2015.

 

Yoga and its importance

The term'yoga' is derived from sanskrit which means to reunite or join. It is symbolic of the union of mind and body. Yoga originated some 5000 years ago in india. It was developed as a process to interconnect the mind, soul, and body. As it started gaining popularity in the west, it became an exercise and a method to relax. Through yoga, you can easily calm down your nerves, alleviate any physical concerns, get relieved of any chronic pain, and attain bodily well-being.

 ;

Significance of 21 june

June 21 is also called the summer solstice. It is considered the longest day of the year when the sun is out for most parts of the day. From yoga's perspective, the summer solstice allows the transition to dakshinayana. Hence, it was chosen as an ideal day to celebrate a healthy mind and body.

 

Un declaration

After the draft resolution was presented in the un general assembly, it received support from 177 member countries. Pm modi in his statement emphasized yoga's invaluable importance. He also stressed the fact that how yoga connects us to nature.

 ;

Benefits of yoga


	
	Yoga and fitness
	


Yoga ensures that a person is healthy in its true sense. The different postures of yoga encourage overall fitness and balance of the body. In addition, an enhanced mental strength, physical power, stamina, and detoxification of the body.


	
	Yoga and stress relief
	


Some precious moments of yoga each day is a good way to eliminate everyday stress. Be it physical or mental, certain practices like meditation and pranayama are perfect for preventing stress.


	
	Yoga and inner peace
	


There is a serious need for peace in this robust world. Yoga done regularly gives you extensive inner peace. It is vital to calm your disturbed peace. Moreover, breathing exercises in yoga are very helpful against unwanted stress. Immune system enhancement and protection from frequent diseases is another one of yoga s benefits.



 

International Yoga Day: All You Need To Know!

If you have diabetes, many parts of your body are likely to get affected over time. You might observe that your digestion is not the same as it was before you had diabetes. In this case, you are likely to face stomach problems and bowel issues. This is due to the effect of diabetes on your vagus nerve.

The vagus nerve is responsible for managing the complex processes in your digestive system. When the nerve is not functioning properly, your digestion slows down. As a result, the contents of your stomach stay longer than they should. Such a condition is called diabetic ;gastroparesis, which is one of the most common diabetic problems.

What is diabetic gastroparesis?

In gastroparesis, your stomach takes too much time to clear the bowel due to disrupted digestion. Usually, after a meal, the vagus nerve helps to contract the stomach muscles to break down the food into smaller pieces and pass it to the small intestine.

However, if the nerve is damaged, the muscle contraction gets halted and the decomposition of the food is slowed down. This condition is common in patients suffering from type 1 and type 2 diabetes. This is because diabetes causes nerve damage, which in turn damages the vagus nerve.

Symptoms of gastroparesis

The most common symptoms of the condition are  


	
	Heartburn
	
	
	Nausea accompanied by ;vomiting
	
	
	Appetite loss
	
	
	Bloating in the abdomen
	
	
	Acid reflux
	
	
	Weight loss
	
	
	Fluctuations in the blood ;sugar level
	
	
	Feeling full even after consuming a little amount of food
	
	
	Spasms in the stomach
	


What are the treatment options?

The first step to treat diabetic gastroparesis is to manage the levels of blood sugar. In this case, your doctor might ask you to check your blood sugar regularly   that will help him to modify the treatment to cure this condition.

The treatment can include the following steps  


	
	Altering your insulin dosage and the number of times you take it
	
	
	Oral medication may be prescribed to improve the condition
	
	
	Gastric ;electrical stimulation   where a device called gastric neurostimulator is implanted in the lower abdominal region. It sends low energy electrical impulses to your stomach muscles to cure cases of severe vomiting and nausea.
	


The doctors will recommend some dietary changes   avoid fibre-rich foods and include low-fat foods instead. With proper treatment and lifestyle changes, diabetic patients may be able to avoid common digestive problems like gastroparesis.

What Is Gastroparesis- A Diabetes Induced Digestive Problem

A brain tumour is a life-threatening situation. Most of the symptoms of the brain tumour are alike, but not all tumours are malignant. The most common type of brain tumour is meningioma. You may even don t need surgery in this case as they are really not dangerous or life-threatening.

 

Here are some of the facts you should know about meningioma:

 ;

Meningioma can develop in numerous locations

 

Cells in the meninges, the lining of the brain and spinal cord, give rise to these tumours. In fact, they are not brain tumours at all, because they are not caused by the altered brain cells. ;

However, they continue to grow inside your sull, indicating that you should now take immediate steps. Meningioma can produce brain tumour symptoms if it grows or creates swelling that presses against the brain or other tissues in the skull.

 

Meningioma symptoms vary depending on the size and location of the tumour

 ;

Meningioma can cause vision-related issues, headaches or seizures which are all common signs of a brain tumour. A headache, even a strong one, is seldom an indication of meningioma or any other type of brain tumour on its own. 

 ;

Other tumour sites can influence your sense of smell, vision, hearing and even the pituitary gland s function.

 

Meningioma diagnosis usually happens when the doctor is looking for some else

 ;

The discovery of a tumour on a ct scan or mri while investigating the patient for another cause, such as a head injury or another neurological condition, is called an accidental diagnosis. When a doctor identifies a meningioma, you will undergo additional testing to determine how the tumour will behave. A neurosurgeon will decide whether to remove the tumour or just monitor it to see whether it grows based on these findings. 

 ;

Majority of meningioma does not spread

 

Being diagnosed with meningioma, especially a large one, might be shocking, but these tumours are usually non-dangerous. Tumour cells are unlikely to spread to other sections of the body as a result of this. ;

Meningiomas, on the other hand, can grow silently for years without creating any difficulties and they can grow to be enormous.

 

Things You Should Know About Most Common Brain Tumours

People suffering from sickle cell disease (scd) usually start showing symptoms very early. They can appear to show up even during the first year of life. Symptoms of a sickle cell vary from one person to another and can be mild to serious depending on the condition.

 

Sickle cell disease is a health condition that worsens with time. Despite the absence of any full-proof solution, some treatments prevent further complications. These treatments can help patients receive aid for a lifetime. Simply said, sickle cell diseases can be managed medically.

 ;

Treatment

Treatment in a sickle cell patient depends on the severity of the symptoms. Preventing complications and relieving pain is the primary aim of the diagnosis. They can range from medications to blood transfusions.

 

Concerns

Some of the concerns that need to be taken care of during the treatment of scd are-

 ;


	
	Prevent painful scenarios
	


A painful episode or sickle cell crisis can be avoided by consuming sufficient fluids, wearing warm clothing, and staying away from sudden temperature changes.

 


	
	Avoid infections
	


Children with sickle cell anemia are made safe from infections by using penicillin. Adults with anemia might need to take penicillin all their lives. Doctors should ensure that all vaccinations in children and adults are periodically done to avoid any infections. However, during the covid-19 pandemic sickle cell patients should take extra care.

 ;

Medications

While there can be numerous ways to manage sickle cell treatment, medications help in a significant way. Some of the prescribed medicines are-


	
	Hydroxyurea- it reduces the frequency of sickle crises. Pregnant women should stay away from this according to experts.
	
	
	Crizanlizumab- this drug injected into the patient can help reduce the sickle crises in adults and children over the age of 16.
	
	
	Voxelotor- it is an oral drug used in children over 12. It lowers the risk of anemia by improving blood flow.
	
	
	Pain-relievers- narcotics to prevent excessive pain can also be used during the treatment.
	


 

Surgical procedures


	
	Blood transfusion
	


It is used to prevent stroke and other related complications in patients. This can increase the number of red blood cells in the body that can help reduce the symptoms.

 ;


	
	Stem cell transplant
	


It is also called a bone marrow transplant and is used to replace affected bone marrow with a healthy one. This procedure is carried out between matched donor and recipient. Although it is a known cure for sickle cell disease, various risks involved make it a less used practice.

 

Can Sickle Cell Be Cured?

We often forget to take note of things that could cause a spike in blood pressure levels like sleep apnea, ;high sugar intake, among others.

What Are The Things That Could Spike Your Blood Pressure Levels?

Don't wait any longer, manage your Psychopharmacologist online with a Lybrate doctor today

Consult for Psychopharmacologist - Online and Easy!

FilterClear All

COMMON SPECIALITIES

COMMON ISSUES