What are the different types of sickle cell disease?

Sickle cell disease or sickle cell disorder is a term often used to talk about a group of diseases affecting hemoglobin. It is the oxygen-carrying element of blood that makes up 2 alpha globins and 2 beta globins. Sickle cell disease happens due to beta-globin mutation and depending on the abnormality in mutation.

Types-
Sickle cell diseases can be of many types depending on the gene mutation in the blood. Some of the common types are-

Sickle hemoglobin s disease (ss)
Hemoglobin ss disease or sickle cell anemia is the most popular type of scd. It takes place when hemoglobin s gene mutation is inherited from both mother and father. In simple words, it happens when the child inherits one substitution beta-globin gene from each parent. In this type, the body only produces hemoglobin s. It is mostly found in people of african and indian origin.

Sickle hemoglobin- c disease (sc):
Patients with sickle hemoglobin sc disease have a moderately dissimilar swapping in their genes of beta-globin. Here, both hemoglobin c and hemoglobin s are inherited from each parent. It may cause similar symptoms like anemia but remains relatively l. People of west african and mediterranean origin are more prone to this.

Hbs beta-thalassemia
People with this type of scd inherit one sickle cell gene s and one gene for beta-thalassemia from each parent. Zero and plus are the two common types of beta-thalassemia. While beta 0 thalassemia usually takes a severe form, beta + thalassemia is a milder form of the disease.

Sickle beta-zero thalassemia
Beta-zero thalassemia takes form when the child inherits the beta s gene from one parent and beta 0 thalassemia gene mutation from the other. With similar symptoms to anemia, it is a slightly severe form of beta-thalassemia.

Sickle beta-plus thalassemia
Substitutions in both beta-globin genes take place in patients with sickle beta thalassemia (sb) disease. This may even lead to the requirement of blood transfusion if no normal beta globin is produced. Mediterranean and caribbean people are more likely to have this disorder.

Hemoglobin sd, hemoglobin se, and hemoglobin so
These are the few rare and not less common types of sickle cell diseases. They are also less severe. People with these forms of scd inherit one sickle cell gene s and one gene from uncommon hemoglobin (d, e, or o) from each parent.

Sickle cell trait
Hbas
People with sct have one sickle cell gene s and one normal gene a from both mother and father. Ones with this disorder show few to no signs of the disease and usually spend a normal life. However, the risk to their future generations still exists.
 

What Are The Different Types Of Sickle Cell Disease?

When abnormal cells grow inside the brain and are in the form of a mass the condition is called a brain tumour. However, on the other hand, brain cancer is a disease of the brain in which cancer cells (malignant cells) arise in the brain tissue. Cancer cells grow to form a mass of cancer tissue (tumour) that interferes with brain functions such as muscle control, sensation, memory, and other normal body functions. 

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Some brain tumours are cancerous while others fall under the category of non-cancerous ones.

Brain cancer is actually the abnormal growth and uncontrolled growth of the cancer cells in the brain, that forms a tumour in the brain. Tumours can be either benign or malignant.

Benign brain tumours are abnormal collections of cells that reproduce slowly and usually remain separate from the surrounding normal brain.

Malignant tumours reproduce and grow quickly. Their borders are hard to distinguish from the normal brain around them.

 

The underlying cause of primary brain cancer, cancer that begins in the brain, is not known. Secondary brain cancer is caused by a cancer of another organ in the body, such as the breast, prostate, kidney, skin, or bone, that has spread to the brain.

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The brain tumours originate in the brain itself. Tumours start to develop if there are mutations in the dna. It is because of these mutations that cells of the brain increasingly grow and divide. Usually, in adults, the primary brain tumours are uncommon in comparison to the secondary brain tumours.


 

There are few early symptoms of brain cancer, but as the tumour grows within the confines of the skull, it causes increased intracranial pressure and exerts pressure on the brain, causing signs to develop.


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Brain cancer occurs when there is an uncontrolled growth of cancer cells in the brain that form a malignant brain tumour. The underlying cause of primary brain cancer, cancer that begins in the brain, is not known. Secondary brain cancer is caused by a cancer of another organ in the body, such as the breast, prostate, kidney, skin, or bone, that has spread to the brain.


 

What Is The Significant Difference Between Brain Tumour And Brain Cancer?

The moment you are diagnosed with a tumour, the first thing your doctor will do is find out whether the tumour is benign or malignant   this will determine the course of your treatment. In simple words, benign means non-cancerous while malignant means cancerous.

Benign cancer

When tumour cells grow at a normal pace, it is known as benign or non-cancerous growth. In the case of benign cancer, the cells grow slowly and do not spread to other parts of the body or invade the adjacent tissues. Most often, these do not exhibit serious symptoms or pose a threat to your health. So, they are not a cause of concern. However, sometimes a benign tumour can press against nerves, tissues or the blood vessels, causing pain and discomfort.

Some common types of benign cancer are  


	
	Adenomas
	
	
	Fibromas or fibroids
	
	
	Hemangiomas
	
	
	Lipomas
	


Benign tumours, although tend to be harmless, may need to be operated. This is true for tumours that have grown to become large and weigh heavy. When these develop in the brain and cluster around to press against block channels or vital organs, the condition can be potentially dangerous. Moreover, certain types of non-cancerous tumours like intestinal polyps are precancerous   meaning they have the potential to turn cancerous. ;Surgery to remove this type of tumour can help prevent it from becoming malignant.

Malignant cancer

Malignant cancer refers to cancerous tumours that can potentially be fatal. Unlike benign cancer, malignant cancer progresses quickly and metastasizes to invade other organs, tissues or parts of the body.

Here are a few examples of tumours that are cancerous in nature  


	
	Carcinoma
	
	
	Sarcoma
	
	
	Germ cell tumour
	
	
	Blastoma
	


A tumour that has turned malignant, or has spread through the lymphatic system or bloodstream, may require aggressive treatment. Based on the stage of cancer, your ;oncologist will devise a treatment plan that might include immunotherapy, ;radiation therapy, chemotherapy ;or surgery.

Being diagnosed with a tumour can be hard to deal with. To find out if the tumour is benign or malignant, consult a specialist and discuss your concerns.

Benign Cancer Vs Malignant Cancer: Know The Difference!

Yoga is a very important part of everyone s life. Yoga is a time tested and natural way to eliminate various diseases and problems with the body as well as the mind. It is antiquated craftsmanship that strengthens the body as well as relaxes the brain with the right dose of mindfulness as well. Yoga tends to stimulate the nervous system and the endocrine, digestive and circulatory systems and improve the functioning of the same.

 

Below mentioned postures affect at least one of these systems, thereby clearing the path for a strong immune system. ;

Shishuasana (child posture): shishuasana is a phenomenal stance that de-congests the abdomen and constructs a superior and stronger immune system.

Setu bandhasana (bridge posture): setu bandhasana opens the heart and enhances the blood flow. It increases the energy in the body to build a strong resistance against pathogens.

Halasana (plow posture): halasana is a pose that requires a backward bend. It discharges white cells in the body and strengthens the immune system.

Bhujangasana (cobra posture): bhujangasana is a mid-section opening posture which discharges white cells that enhance the body s resistance.

Dhanurasana (bow posture): dhanurasana is yet another posture that enhances the flow of white cells by putting weight on the working of the digestive system.

Matsyasana (fish posture): matsyasana stretches the abdomen and chest and strengthens the thymus. This enhances the body's invulnerability level.

Vinyasa adho mukha svanasana (flowing downward facing dog pose): begin with the plank pose, palms lying on the floor just underneath your shoulder and extend the legs backward. The whole body should form a straight line like a board. Taking a full breath, lift your hips off the floor. Hold yourself on the hands and heels. Your head needs to point towards the ground. Take full breaths, two or three times, as you hold the position. Breathe out a deep breath, relax and return to the plank posture. Gradually bring down your body. Slide your hands backward, allowing your palms to rest alongside the chest. Toes need to be in contact with the mat or the floor.

Ayurveda, yoga and meditation are the perfect variables to carry on with a sound life.

 

Yoga Asanas That Can Boost Your Immune System

Air pollution affects the overall health of a human being. Whether it comes out of exhaust fumes from cars and factories or smoke from burning stubble air pollution, it is a cause of major concern. The effects of this can be seen in the growing number of asthma and other respiratory diseases. These diseases affect adults and children alike, however, it is the younger generation and elderly people who are more susceptible. Hence, it is extremely important to care about the quality of the air you breathe in. 


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What is the significance of the air quality index (aqi)?

The air quality index is a visual representation of pollutant levels in the air around you. A quick glance at this colour coded map can tell you if the air outside your home is likely to harm you or not. The code is broken down into 6 levels ranging from green which signifies minimal impact to red which marks pollution levels that can harm a healthy person and seriously impact those who are already ill. The higher the aqi, the higher the level of air pollution.

 

What are the steps to reduce air pollution?

Simply talking about how there need to be stricter laws about car emissions and the burning of waste will not help you. Here are a few things you can do to protect yourself and your family from the ill-effects of air pollution.


	
	Carpool: exhausts from cars and other vehicles are one of the biggest causes of air pollution. Do your part to reduce air pollution by restricting the amount you use your car. Try taking public transport to work or carpooling with colleagues. Similarly, avoid making individual trips every time you need something from the market. Make a list and when it s long enough, then step out.
	
	
	Limit indoor pollution: do not smoke indoors. When cooking, keep the exhaust fan on so that the smoke produced does not collect indoors. Avoid spraying air fresheners etc. While they may temporarily make the air smell fresh, in the long run, they contribute to air pollution.
	
	
	Use public transport try to use public transport and avoid the use of personal vehicles.
	


How to protect yourself from air pollution


	
	Refrain from morning walks routines to later hours.
	
	
	Use n95/99 face masks whenever you step out.
	
	
	Use air-purifying plants to purify the air around your surroundings.
	
	
	Ventilate your kitchen, and bathroom to keep yourself away from air pollution.
	
	
	Restrict outdoor activities for kids if there is a high level of air pollution
	
	
	Use air-purifiers in your surroundings.
	
	
	Try to take steam with a few drops of eucalyptus oil every day.
	
	
	Keep your car s environment fresh.
	
	
	Ventilate your home, open your windows and doors and allow the air to circulate during mid hours.
	
	
	Eat jaggery (aka gurr) to flush out pollutants from your lungs.
	
	
	Consume a diet rich in vitamin c, omega fatty acids
	


Hence, the other way to cut down this pollution is by bringing significant lifestyle changes in our daily living. Cutting down the number of diesel and petrol vehicles can also prove helpful. People should shift to cng and electric vehicles for daily commuting. These efforts, if practiced on a regular basis, can bring a huge decrease in pollution.

Air purifiers can also be a healthy option for indoor purposes.

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Why Should You Care About Air Quality?

Diabetes is a common chronic condition that results from excessively high blood glucose. In this condition, either the pancreas fail to produce enough insulin, or your body does not utilize insulin produced by pancreas properly. This might lead to cardiovascular problems and neural problems, as well as health problems like ;depression and ;anxiety. Recent studies reveal that diabetes may have an impact on your reproductive health too.

Effects on men

A common problem that affects men s sexual life is erectile dysfunction. Diabetic men face this as they have low testosterone levels and are unable to maintain an erection during sex. For an erection, constant blood flow is necessary inside the penis. However, as diabetes disrupts the blood flow and damages the blood vessels, men are not able to achieve an erection.

Furthermore, diabetes also damages the arteries and nerves, which again, disturbs the blood flow to the penis. This also causes erectile dysfunction. Other factors that can cause sexual complications among men are- ;


	
	Diabetes-induced obesity
	
	
	High blood pressure
	
	
	Retrograde ejaculation ;  refers to a condition where semen is ejaculated to your bladder, but not through your penis
	


Effects on women

For women, during menopause, blood ;sugar levels may drop due to diabetes. Besides, high blood sugar levels damage the nerves of a woman. This may hinder the ability to feel aroused during sex and lowers sexual stimulation. This reduces their capability to achieve orgasm.

Another common issue among women with diabetes is ;vaginal dryness. This causes a lack of lubrication in the vagina that makes sex painful. Damage to the nerves that lubricate the vagina may be the reason for this. During menopause or after menopause, it can be due to low oestrogen.

Diabetes is more likely to cause vaginal infections such as yeast infections and urinary tract infections. Both of these cause pain during sexual intercourse. If the nerves of the bladder are damaged, it can lead to urinary incontinence ;while sex.

There are certain medications and therapy that may help control diabetes. Additionally, changes in lifestyle such as eating healthy, exercising daily etc. Will enhance your well-being that will significantly improve your blood glucose levels   and in turn, your sex life.

Know How Diabetes Impacts Reproductive Health

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