Chromosomal abnormality happens when a cell has too many or too few chromosomes. The most common form of chromosomal anomaly is Down s syndrome. If a parent has a chromosomal anomaly, she/he will pass it on to the child. PGD or Pre-implantation Genetic Testing aims to select only the embryos with normal chromosomal count and only these embryos are implanted to achieve a healthy pregnancy and bring down the number of children affected with a chromosomal anomaly.

The risk of Aneuploid pregnancy:

The older a woman is when she tries to conceive (aged 35 or more), the higher the risk of Aneuploid pregnancy (carrying a baby with genetic or chromosomal abnormality). Most of these pregnancies end in miscarriages and the few that come to term produce babies with chromosomal abnormalities.

Causes of Chromosomal Abnormality:

Usually, chromosomal abnormalities occur due to an error in the cell division. Meiosis refers to the cell division, which the sperm and the egg undergo during the development procedure. Normally, meiosis breaks the chromosomal material into two equal halves, so that each of the parents contributes 23 chromosomes to the pregnancy. However, when the number of chromosomes in the cell goes up or down than the normal, it results in genetic/chromosomal anomalies.

PGD Procedure for a Chromosomal Anomaly:

If a couple elects to go for Pre-implantation Genetic Diagnosis, they have to undergo ICSI Cycle. ICSI cycle initiates a fertilization cycle to produce embryos. When the embryos reach upto day 5 and blastocyst are formed, they are biopsied and further sent to genetic lab for detecting the chromosomal abnormalities. The embryos are incubated for the entire duration of the genetic screening. Only the embryos that the genetic test clears are implanted. PGD never reveals the gender of the embryo.

PGD can help detect the single genetic disorders that may lead to the following ailments:

  Cystic fibrosis
  Muscular dystrophy
  Tay-Sachs
  Sickle cell anaemia
  Thalassemia
  Turner syndrome

PGD is a revolutionary science that can help root out incurable disorders linked to genetics. It ensures that pregnancy is sustained until term and a healthy baby is born.

Suffering From Genetic & Chromosomal Anomalies - Know About PGD!

The tooth may look a tiny structure, but is a very complicated one. Structurally, it has very high concentrations of minerals and vitamins, all essential for optimal dental health. Reduced or increased amounts of these substances can lead to obvious defects in the teeth, which may impair aesthetics and sometimes even the functioning of the tooth.
While calcium is one mineral that would immediately come to mind, there are a lot of other vitamins and minerals too which play a significant role both in tooth formation and in optimal dental health. Listed below are some of these, along with their role in dental health.

Vitamins:

Vitamin a: often associated with vision, vitamin a is essential for production of good amount of saliva which maintains healthy mucous membranes. Reduced saliva increases predisposition to decay and gum disease and also increases bad breath.

Vitamin d: needless to say, with the strength of the jaw bones, a good amount of calcium is required to boost bone mineral density.

Vitamin c: the gums have connective tissue fibers which help bind the tooth to the jaw bone. For good strength of the connective tissue, vitamin c is important. Therefore, vitamin c deficiency can lead to tooth mobility and even tooth loss in severe cases.

Vitamin b complex: there are too many people who would have popped a multivitamin to ward off mouth sores. Niacin and riboflavin especially are essential for optimal mucosal health and reduce inflammation.

Vitamin k: this has multiple roles to play. It helps in improving the body's healing process, blocks substances that break down bone, promotes bone strength, and reduces bleeding disorders.

Minerals: there is a long list of minerals that are essential for optimal dental health, as below:
Calcium: from strong enamel to jaw bone, calcium is extremely important for the tooth to be fully formed. Calcium deficiency can result in hypoplastic teeth that are more prone for chipping and decay.

Potassium: needed to improve bone mineral density. It also works in conjunction with magnesium and prevents from the blood turning too acidic. Acidic blood can suck out calcium from teeth and bones.

Fluoride: proven to be the anti-decay magic medicine, fluoride reduces the incidence of tooth decay. Fluoride gels are applied for children to promote remineralization of enamel which may have initial caries.

Phosphorus: provides support to calcium and potassium in bone formation.

Iron: required for keeping red blood cell count at a good level and fighting infections.

Iodine: this trace mineral is required for absorption of calcium and potassium that is essential for tooth formation.

Zinc: naturally found in saliva, it fights against plaque formation and subsequent infections.

For optimal dental function, ensure your diet has these essential nutrients.

The Best Vitamins & Minerals For Your Teeth

Cystic fibrosis is a genetic condition, which primarily affects the lungs and persistence of this condition might lead to severe breathing problems and loss of lung function. If you have inherited two copies of the defective gene from your parents, you are likely to suffer from this disease. Cystic Fibrosis causes a buildup of thick mucus in your lungs and affects other organs such as the kidneys, pancreas and the intestines in your body.

It isn't very uncommon as one out of fifty people in Asia is a carrier of this disease. The disease gets its name from the cysts formed in the pancreas of the sufferer. However, this disease can be detected by testing the quantity of salt present in your sweat. Prenatal testing for Fibrosis is another method to test if your newborn is likely to contract a lung infection.

Complications faced due to cystic fibrosis include:
1. Serious sinus infections
2. Serious damage in lungs due to inflammation and incessant infection
3. Malnutrition
4. Complication in breaking down protein
5. Respiratory tract contamination

If you observe one or more of the following symptoms, you might be suffering from Cystic Fibrosis:
1. Salty-tasting skin
2. Bowel obstruction caused due to meconium ileus (obstruction of the bowels)
3. Mucus amiss in your alveoli
4. Persistent coughing with phlegm discharge
5. Shortness of breath while engaging in a physical task
6. Stunted or measly growth despite healthy lifestyle habits
7. Infertility in males

If you're suffering from cystic fibrosis, there isn't any particular treatment which is recommended due to the varying degrees of it found in people. However, consultation with a medical practitioner and an individualised treatment plan can help you minimise the risks and lead a better life.

Some therapies you can opt for are:
a) Airway clearance: This therapy helps sift the thick layer of mucus around your organs. Some people have also chosen to use the inflatable vest which vibrates around your chest, thereby, thinning and loosening the layer of mucus.

b) Inhaled medicines: Another breakthrough in the field of respiratory medicine, this method requires the patient to sniff a liquid consisting of mist, which is inhaled with the aid of a nebuliser. This method is known to be beneficial for opening airways.

c) Pancreatic enzyme supplements: Along with multivitamins, these specially designed supplements are known to cater to your pancreas with the much-needed nutrients and they need to be consumed with every meal.

Cystic Fibrosis: All You Need to Know

If chewing food and retaining a sparkling smile is not enough for you, avoiding toothaches and a visit to the dentist could be reason enough to maintain healthy teeth. Ignoring your tooth health can lead to many problems. Answer yourself the following question. Would you like your teeth inside your mouth or in a glass tumbler beside your bed at nighttime? 

If you opted for the former, then going through the following tips and advices will go a long way in helping you sustain healthy teeth. They are:

1)  Brush and floss twice a day
Brushing and flossing twice a day, on a regular basis will help you maintain healthy teeth and gums in the long run. The ideal time to brush your teeth is 20 minutes after a meal. Opting for a toothbrush with a small head and soft bristles gives you better access to even the deeper portions of your mouth, thus providing comprehensive cleansing to your teeth. Moreover, softer bristles are generous on your gums as well.

2) Nutrition
Whatever you eat, either protects you or makes you more susceptible to diseases and disorders. This stands true for your oral health as well. As such, choosing the right foods early in your life is of vital importance. Foods such as cold drinks, cakes, candies and other such sugary substances facilitate the growth of germ and bacteria in your mouth, resulting in plaque and cavities. Choosing foods that are low in starch and sugar will reduce the development of germs and help eradicate cavities or plaque in the long run.

3) Smoking
Even the pack of smoke that you buy endorses smoking is injurious to your general health. Smoking causes reduced flow of blood to the mouth, which resultantly leads to increased chances of periodontal disease and mouth cancer. Smoking, moreover causes a decline in the ability of the bones and tissues to revascularize (self-heal). All else apart, just stop smoking.

4) Chewing gums
Chewing gums are highly beneficial especially after a meal. They not only increase the flow of saliva in your mouth, but also improves the flow of blood to your brain, thus enhancing your alertness by close to 10%. In addition, chewing gums help neutralize the acid in your mouth, thus helping you cleanse your mouth.

Tips to Maintain Healthy Teeth

Has your child been coughing frequently? Is the cough chronic in nature, making your child breathe rapidly and does he/she complain about a tightened chest? These symptoms signify that your child is having asthma. Asthma is a medical condition characterized by paroxysmal wheezing respiration dyspnoea. It is common in children and an affected child experiences difficulty in breathing, and a whizzing sound is produced, especially during expiration. Asthma may lead to severe health complications and needs immediate diagnosis and treatment.

Diagnosis: The diagnosis of asthma is based on the symptoms, medical history and a physical examination of the child.

The different modes of asthma diagnosis are as follows:

    Medical history and symptoms: You must tell the doctor about any history of breathing trouble with your child or whether there are chances of other inherited health conditions. You must explain your child's symptoms properly, which may include coughing, wheezing, chest pain or tightness and others if observed.
    Physical examination: A physical exam will be carried out in your child where the doctor will listen to his heart and lungs, and look for eye or nose allergies.
    Medical tests: A chest X-ray of the child has to be carried out, along with a simple lung function test known as spirometry. This test measures the amount of air present in the lungs and determines how fast it can be exhaled. Spirometry enables a doctor to determine the severity of the asthma. Some other tests are also carried out for the identification of asthma triggers. They include allergy skin testing, blood tests and X-rays to know if sinus infections are affecting the asthma. An asthma test determines the amount of nitric oxide in your child's breath.

Treatment: Based on your child's severity of asthma symptoms and his medical history, the doctor will provide you with an action plan to treat the same. This action plan explains all the medications your child requires, the dosage and schedule of the medicines. The plan also includes points on what to do when the asthma worsens and when an emergency treatment is required. Anti-inflammatory drugs are prescribed to children who require bronchodilator medication. All asthma medicines used by adults can be used in case of children but in lower dosages.

You should give the asthma medications to your child using a home nebulizer or a breathing machine. A nebulizer delivers asthma drugs by transforming them from liquid to a mist. The child gets the drug by breathing it via a face mask.

In order to control and manage asthma in children, they must avoid the triggers and should keep away from any source of smoke. A doctor must be consulted to know about the best diagnosis and treatment methods.

Asthma in Children: Diagnosis and Treatment

Children are much more susceptible to tooth decay and gum disorders than grown-ups. This is because the gum and teeth in toddlers are very delicate. Moreover, children are more attracted to sweets and other food items, which cause damage to the teeth.
Here are several ways to protect the teeth of your little one:
1. Have a dental checkup: you should take your child to a dentist on his first birthday. Early prevention is important as any kind of problem in the teeth will be detected and this will save you from a lot of trouble in the future.
2. Teaching healthy habits: brushing is very important and you should teach your child to brush regularly, more than once a day. Before the development of teeth in your baby, you should brush his gums gently by using water on a soft baby toothbrush or with a clean and soft cloth. After developing teeth, brushing must be practiced with delicate toothbrushes and fluoridated toothpaste. If several teeth touch against each other, you should use flossing. Brushing is essential before going to bed, and no food should be taken after brushing.
3. Prevent" baby bottle decay: you should not let your child go to sleep with a bottle of juice or milk. The sugar contained in these liquids sticks to the child's teeth, which activates bacteria and may lead to tooth decay.
4. Avoid giving juice to your child: juice may be healthy for the body, but it leads to tooth decay in little kids. The amount of regular juice intake should never be above four ounces.
5. Avoid excess use of a sippy cup: sippy cups enable children to shift from bottles to a glass. However, all day long usage of sippy cups should be restricted as it may cause decay on the front and back portions of teeth, when the drinks are rich in sugar.
6. Be careful about sweet medicines: many medicines meant for children are sugary and stick to the teeth, increasing the chance of cavities. Several antibiotics cause overgrowth of candida or yeast and cause an oral disease known as oral thrush. This disease causes creamy patches on the tongue. In case your child needs sweet medicines, brushing should be increased.
7. Stop using a pacifier by the age of 2 or 3: pacifiers are good for children, but using pacifiers for a long period of time affects the lining of teeth. The shape of the mouth may also change. Hence, do not let your child use pacifiers after 2 or 3 years of age.
Children are quite prone to teeth disorders and decay in the teeth. Hence, measures must be taken to protect the teeth of children from any kind of disorder.

Ways to Protect the Teeth of Your Little One

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