Hereditary Angioedema is a rare skin related disorder and as the name suggests it is also a genetically inherited condition. This condition mainly afflicts the throat, abdomen and the limbs of the patient, with a certain kind of swelling. This swelling can become fatal if not treated on time. Here is everything you need to know about the condition and its treatment.

Causes: A rare genetic mutation of the SERPING1 gene can cause this condition. Usually, this gene is known to produce C1 esterase inhibitor, which is a kind of blood protein. This blood protein is an important element of one s immune system and is usually involved in the biochemical reactions that control the body s response to inflammation causing elements. This is done when the blood protein produces a hormone known as Bradykinin. If this blood protein does not function in a normal manner, then there is excessive production of this hormone, which leads to swelling and inflammation.

Type One: There are various types of Hereditary Angioedema that can affect various parts of the body. Type one is one of the most common kinds and can be found on the face, hands, abdomen, throat, as well as feet and genitals of the patient. The severity and frequency of attacks cannot really be predicted and the patient may suffer from attacks throughout his or her life. The best way to treat this type of Hereditary Angioedema is with the help of antihistamine drugs and prednisone which can fight allergic attacks.

Type Two: This kind of Hereditary Angioedema has the same symptoms as type one and is caused by a malfunction of the C1 inhibitor, rather than the Bradykinin hormone as one can see in type one. This condition can also be treated with anti-allergy drugs.

Type Three: This is very rare kind of Hereditary Angioedema. In fact, medical science is yet to find a conclusive body of knowledge that can point to the exact causes and symptoms of this condition. Coagulation is one of the main causes recognised so far. This condition is much more common in women than it is in men, and it usually shows up as facial swelling.

Timely Treatment: While there is no cure for this condition, one can prevent a flare up of the symptoms by taking C1 inhibitors and Bradykinin receptors as well as enzyme inhibitors. It is important to get early treatment for the symptoms and to have constant access to a hospital and its emergency unit. One should also keep track of attacks and symptoms and get regular check-ups done by a doctor to detect the earliest signs of the same to avoid fatalities.

What is Hereditary Angioedema and How Can it be Treated?

A bone may break due to several reasons starting from a fall or an injury or a condition like osteoporosis that makes the bones brittle and leaves them susceptible to fractures. The fracture usually takes a few weeks to get fixed as the broken bones grow back together with the help of various forms of treatment including a plaster and sling applied by the orthopaedic specialist or general physician. Find out more about how bones heal with this article.

Types of fracture: Before we get to the subject of how bones heal, it is important to understand the various kinds of fractures recognised by doctors. The first kind is the complete fracture where the bone breaks into two distinct parts. The next kind is the greenstick fracture or hairline fracture where there is simply a crack on one side of the bone due to pressure. Further, there is the single fracture which occurs where there is breakage of the bone only in one place. A bowing fracture may occur when the bones bend instead of breaking completely. This kind of fracture is pretty common for children. The comminuted fracture happens when the bone is crushed or broken in many places. And finally, the open fracture is one where the bone ends up protruding from the skin.

Treatment: Once you have broken a bone, the doctor will conduct an X ray which will help in understanding the type of fracture and the extent of the damage caused. The doctor will then apply a cast and plaster that will help in bringing the bone back to its normal position so that it grows back with the main bone. In case the bone has broken into various parts or there is a complete fracture, then the doctor may even insert metal pins.

Natural healers: Bones are known as natural healers that can heal with the process of new cells and vessel production which rebuilds the bone by covering the broken ends and closing the gap caused due to the damage or the crack.
Clot: Once a bone has broken, a blood clot or a callus forms in the surrounding region, which kind of acts towards sealing the area.
Threads: Once these clots have formed, the new threads of the bone cells begin to grow slowly from the ends of the broken bones. This will grow on both sides of the affected and fractured bones, almost as if drawing a line from one broken end to another.
Absorption: Finally, the callus will be absorbed by the new cell and the gap will close.
See a doctor is you are experiencing any noticeable symptoms that may point towards bone fractures.

Broken Bones - How Do They Heal?

What is paralysis?
Paralysis is a loss of muscle power and function of any part of the body. It is seen in the form of weakness of body parts, loss of sensation, and loss of movement of that part.

What is physiotherapy and why it is used?
Physiotherapy includes massage, therapeutic physical activities, scientific procedures, and education. Physiotherapy should be started as soon as possible, and it needs to be regularly followed, on a daily basis to see its best results. If it is not done under the proper guidance, it may worsen the condition of the patients. It is helpful in the following ways:

Helps to improve blood circulation and relax muscles
Slows down the progress of paralysis
Improves muscle tone
Maintains the respiratory function
Prevents pressure sores and contracture in the bedridden patients
Helps to build up strength in the affected muscles which helps to prevent the limbs from becoming deformed
Helps in building up the motivation and morale of the patient
Helps improve balance and coordination of the muscles
What therapies are included in it?
It includes the following therapies:

Aerobic exercises: It encourages a rapid exchange of oxygen to muscle tissues which increases sensory and motor function.
Method of physical conditioning: It is conducted via active or passive ranges of motion which help improve the muscle strength and also help the patient to adapt or learn how to use the paralyzed limb.
Exercises: Exercises, such as hip rotation exercise and its variation, ankle rotation exercises, and toe rotation exercises are advised in lower limb paralysis.
Electric stimulation therapy: It helps restore the motor function in paralyzed patients where electrical stimulation is done via a low-frequency device.
Mobility aids: Mobility aids, such as a wheelchair, help to move from one place to another place.
Hydrotherapy pool: It helps assist patients to overcome conditions where movement is limited because of paralysis and where muscles are weakened.
Massage therapy: Massage therapy helps regain control of muscles and boost the range of motion by improving blood circulation to the affected part.
Hand muscle exercises: It includes exercise with the balls or any other toy to improve hand grip and muscle power.
Speech therapy: In patients with aphasia, speech therapy is given to improve the speech.
Parallel bars: It helps practice walking and balancing when there is impairment.
Physical training: In physical training, various exercises are taught to improve the muscle strength of the affected part.
Use of teaching transformers (wheelchairs, bed, car, or toilet): It helps improve safety and also promotes independence.

Role Of Physiotherapy In Patients With Paralysis!

Bone Fractures: Causes and Symptoms

'Fracture' is a medical term for a broken bone. According to an estimate, an average person has two fractures within their lifetime. When a force exerted is stronger than the bone itself, it can lead to a fracture. The risk and chance of fracture depend on your age. With age, bones tend to become brittle and, hence, a fall that would have been potentially harmless years ago can lead to a broken bone at a later age.

There are many types of bone fractures, but the main types are:

Closed fracture: A fracture in which the bone breaks but does not tear through the skin

Open fracture: Where the broken bone punctures through the skin and protrudes out. There's a greater chance of bone infection in an open fracture

Displaced fracture: In this type of fracture the bone snaps into more than two parts

Nondisplaced fracture: The bone cracks partly or wholly but it does continue to move

Some of the common signs and symptoms of a fracture are:

- Bruising and swelling of the bones
- Open fractures marked by protruding bones from the skin
- Loss of locomotive and functional ability of the injured area
- Deformity of the injured area
- Pain in the event of movement of the injured area

A fracture can be caused by a number of reasons, and they are:

- Injuries and accidents
- Falls and slips
- Wear and tear through overuse
- Sport injuries
- Fist fights and brawls
- Osteoporosis (a disease which causes bones to weaken in adults)
- Osteomalacia ( a disease caused due to softening of your bones, which is caused by a vitamin D deficiency.) Soft bones are more likely to bow and fracture than are harder, healthy bones.

Note:

Osteomalacia is not the same as osteoporosis. Osteomalacia occurs due to a defect in the bone-building process while osteoporosis develops due to a weakening of existing bones.



Bone Fractures: Causes and Symptoms

The body s reacts to anything suspicious by developing an allergic reaction. Some of the common substances inducing this reaction include certain food substances, pollen, insect bites and certain metals. This body recognises these suspicious substances as antigens and produces what is known as antibodies. These produce various allergic reactions in the body ranging from something as minor as a skin rash to something drastically fatal as respiratory distress and even death.

Features:

Angioedema is one of the most severe forms of allergic reactions.
Translated literally as swelling of the blood vessels, angioedema causes swelling of the blood vessels in the underlying layers and this can lead to the formation of giant hives.
The hives or rashes are extremely itchy, reddish, and can vary in shape (oval or circular). The hives also are warm and painful when touched.
Angioedema usually affects the skin but can have more severe effects like blocking the airway and leading to respiratory distress
Causes: Angioedema is usually caused by one of the following:

Insect bites or stings
People with allergies to foods like peanuts, eggs, milk, shellfish, chocolates, tree nuts, etc.
Pollen, animal dander, latex, poison ivy, and other common allergens
Medicines like penicillin, aspirin, ibuprofen, and some anti-hypertensives
Autoimmune skin disorders like lupus
Reaction to incompatible blood transfusions
Weather conditions like extremes of cold, heat, or pressure
Infections like hepatitis, cytomegalovirus infections, Epstein-Barr infections, etc.
Conditions like leukaemia and thyroid disorders
Extreme emotional stress
Genetic angioedema, inherited from parents by children, which can last forever
Risk factors: Though hives usually develop without any warning signs, the following are some risk factors for developing angioedema.

Previous history of allergies
Predisposition to develop allergic reactions (overactive immune system)
Genetic history of allergies, especially of angioedema
Diagnosis:

In first-time patients, a detailed history with deep dive into similar instances in the past will be done
A physical exam to check for missed hives (like the back) is then done
Allergy testing may also be required to test if a person has a high predisposition to allergies
Blood testing to check for eosinophils, which is usually high in patients with allergies, is done.
Allergy testing to identify the trigger agent may be done if trigger is not known. This will help in preventing further attacks.
If genetic angioedema is suspected, C1 esterase inhibitor test and complement particles are also checked.
Treatment:
Non-medical treatment including loose clothing, cool compresses, and copiously moisturizing to reduce dryness and itching. This is usually sufficient in majority of the cases.
Medical: Antihistamines like cetirizine and loratadine are the next line of treatment. Very severe cases may require steroids like prednisone.


Angioedema - 11 Reasons Why It Can Happen!

Our spinal disk resembles a jelly donut, wherein the softer insides are protected by the hard exterior. Sometimes, as a result of some injury or an accident the jelly slips out, leading to an extremely painful condition which in medical parlance is known as herniated disc. The pain that you are subjected to, during herniated disc, occurs as the nerves nearby are damaged due to the concussion. Apart from pain, herniated disc is preceded by other symptoms, some of them are:

1. Pain in the arm or the leg
Depending on which part of the body you have suffered the herniated disc, in the neck or in your lower back, this condition is succeeded by intense pain either near the buttocks or near the shoulders. It goes without saying that this pain increases sharply with movement.

2. Numbness
That part of the body where the nerves are damaged due to herniated disc often becomes numb and has no sensation whatsoever.

3. Weakness
Due to herniated disc, the muscles become weak that considerably impairs and curbs mobility.

However, there are various ways by which you can prevent a herniated disc. Some of them are-

1. Exercise
Exercise in any form and even for a short while yields several benefits. Your body invariably gains momentum and agility. If you exercise daily, your spine becomes more stable and strong, thereby preventing a possible herniated disc.

2. Maintaining the right and good posture
A lot depends on the way you sit and walk, in fact more than you can imagine. If you sit badly, it exerts a pressure on the spine and the discs. Subsequently, a good posture does the very reverse and curbs chances of a herniated disc in the future.

3. Keep a tab on the weight
It is always healthy to maintain the right weight, the one that keeps you away from the onset of various diseases. If you are overweight, it puts more pressure on the spine disk, thereby increasing the risk of developing a herniated disc.

Tips to Prevent Herniated Discs

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