Factors that determine the success of your IVF procedure

IVF or In Vitro Fertilization is a process wherein an egg is fertilized by a sperm in a laboratory dish to form the embryo (baby's first cell) which after growth in artificial medium in the lab is transferred into the uterus of women, In general, a blood sample is collected to determine whether you're pregnant or not about 10-14 days after the eggs are retrieved.

Coming to the success of the procedure, a number of factors are at play and these are:

The age at which you get pregnant

A factor that plays a role in influencing your chances of experiencing success in your IVF procedure is the age at which you opt for this procedure. The lower your age, the chances that you may get pregnant and deliver a healthy child using your own eggs witness an increase. On the other hand, if you're aged 41 and above, or your egg reserve is very low donor eggs are the most preferred option as they help to increase your prospects of meeting a success.

Lifestyle habits

Certain lifestyle factors can significantly affect your prospects of getting pregnant through this route. Smoking can reduce your prospect of success using this procedure by about 50%. It can cause you to have lesser number of eggs retrieved during the procedure while increasing instances of miscarriages. Likewise, obesity, alcohol use, consumption of excessive caffeine and drugs can adversely affect your chances of getting pregnant using IVF.

Cause of Infertility

If your supply of eggs is normal, success rate using IVF is high. Women who suffer from the problem of endometriosis experience lesser chances of getting pregnant than women who have unexplained fertility.

Reproductive history

IVF success rate chances are higher if you've delivered a baby previously using IVF.

Embryo status

Embryos that are better developed with good grade stand a higher chance of experiencing success than less developed embryos. More importantly, not every embryo is able to survive the development process.



What are the factors that determine the success of your IVF procedure?

What You Must Know About ZIKA VIRUS

Introduction to the ZIKA VIRUS:

After the deadly Yellow Fever and Ebola pandemics, Zika Virus is yet another disease borne out of the African soil and spreading across the world right now. Named after the Zika forest in Uganda, where it originated, this virus spreads through a mosquito bite - that of ‘aedes aegypti’ mosquito. It can also be passed on from mother to child, blood transfusion and sex. 

What’s so deadly about ‘Aedes Aegypti’ Mosquito?

Zika Virus spreads via ‘aedes aegypti’ mosquito, same mosquito that also spreads Dengue and Chikungunya.These mosquitoes typically lay eggs in and near still water found in buckets, bowls, animal dishes, flower pots and vases.  They are aggressive daytime biters, prefer to bite people, and live indoors and outdoors near people.
These mosquitoes become infected when they feed on a person already infected with the virus. Infected mosquitoes can then spread the virus to other people through bites.

Symptoms of Zika Virus Attack
A person bit by an infected mosquito takes about 2-7 days to show symptoms like:
- Mild fever 
- Skin Rash
- Conjunctivitis
- Muscle and joint pain 
- Weakness and Fatigue

However, it lasts no more than a week and is usually milder than its cousins Dengue or Chikungunya. Although it is not a fatal disease, the real reason behind the panic is for the women who are pregnant. Zika is found to be a major cause of microcephaly – a birth defect due to which children are born with visibly smaller heads, severely limiting their mental and physical abilities. 

Should India Worry?

While it originated in the African continent, Zika has already taken South American countries like Brazil, and most others. Although the virus hasn’t reached Indian shores yet, we are very prone to mosquito borne diseases. The Dengue menace since last few years says it all. Since it is from the same family, we need to be all the more cautious. 

Preventions and Precautions:

Since no vaccine exists to prevent Zika virus attack, it’s best to act with caution to prevent the spread.

1. Mosquitoes that spread Zika virus bite mostly during the daytime. Stay in places with air conditioning or that use window and door screens to keep mosquitoes outside.
2. Use Mosquito Repellents during the day when exposed to areas prone to mosquitoes and cover yourself very well.
3. Never allow water to stagnate in or around your habitation. Avoid letting the water stand for long eg: puddles, or water in buckets or potted plants, sewage etc.



What is ZIKA VIRUS? Is it Deadlier than Dengue? Is India Ready To Face the ZIKA 

Egg Freezing, which is also known as mature oocyte cryopreservation, refers to the method through which reproductive potential is restored among women. Eggs get harvested from the ovaries, frozen and in an unfertilized manner and are stored for purpose of using them later on. The egg freezing procedure is recommended for those women, who would like to delay conceiving baby due to various kinds of reasons.

Before the freezing of eggs, it is important to first retrieve the eggs. Let us look at how the eggs are retrieved, followed by the procedure of egg freezing through two different ways.

Retrieval of Egg

Egg Retrieval takes place just like it is done in case of in vitro fertilization (IVF). Women would need to be put under medication for hormones or through injections, which shall lead to the stimulation of ovaries, leading to more eggs getting matured. After this women would receive the necessary medication to stimulate ovulation and then the extraction of eggs takes place through the use of a needle. Specialists perform this whole procedure by putting women under the effect of anesthesia and are also guided by ultrasounds. Once the extraction is completed, the freezing takes place.

There are two different techniques involved in the egg freezing process. They include:

Slow Egg Freezing Method

A substance called cryoprotectant is used in order to protect the biological tissues from getting damaged out of freezing. This slow freezing method of getting eggs freezed relies on low initial concentrations of crytoprotectant. The cryoprotectant in low concentration is introduced when the egg is at a relatively warm temperature and still continues to experience the usual functions of a living cell. Then the cryptoprotectant would spread all throughtout thus fill the egg, hence replacing most of the water inside the egg. The egg is then inserted into a small container made of plastic and ultimately get placed inside a cooling chamber. The lowering of temperature, to around -6 degree centigrade, takes place through injecting very tiny amounts of liquid nitrogen into the cooling chamber. The cooling process is controlled by a computer.

The main purpose of these techniques is to avoid ice crystals from getting formed in the egg. During the spreading of the cryoprotectant, if the ice crystals are still present, they can cause damage to the egg and hence the egg may not survive the process of thawing. Then the temperature is lowered further to around -32 degree centigrade. By this time, the egg s metabolic rate become slow. The container where the egg was placed, is then dipped inside the liquid nitrogen, forming a solid.

Rapid Egg Freezing Method or Vitrification

At the time of rapid freezing method, there is high concentration of initial cryoprotectant whereas the cell remains at room temperature. The egg is unable to stay for long in this temperature and thus gets poured immediately onto the liquid nitrogen. Cryoprotectant spreads at a rapid rate so as to avoid ice-crystal from getting damaged. Vitrification is a very new method for freeing eggs. Recent research has shown that vitrification of eggs largely improves the possibility for survival after thawing and the rates of pregnancy.

Different Techniques That Can Be Used For Egg Freezing!

Frozen Embryo Transfer or FET is an extremely effective method to conceive a pregnancy. Recent studies have proved that there is a increased chance for pregnancy when the embryos, which get used are frozen and get placed inside the uterus at a time right after the ovaries are stimulated. Still, certain issues can arise with the transfer of frozen embryo, such as:

A Thin Lining of the Uterus
Research has shown that there are not many women who get pregnant if the lining in their uterine does not tend to thicken enough. It is not clear exactly why this problem occurs in most women and moreover there is no sure shot treatment to make the lining of the uterine thick. The experts on fertility would try out different methods like increasing the amount of estrogen or change the way how estrogen is given. There are other instances when women might be given supplemental medicines, while for some, the problem will continue to exist.

What Should Be Done In Case The Problem Persists?

In case the problem continues for some women, then there are certain approaches which experts might look to adopt. The first one is to cancel the transfer of embryo and try once again at any later stage, that too with a different treatment method.
The second option which they could think of is to go ahead with the transfer, wherein they might feel that a thin lining does not necessarily mean that it is impossible for a woman to get pregnant but definitely the efficiency would be reduced.
One last option is to make use of the opportunity for undergoing additional tests which would help them to assess the ability of the uterus to allow implantation of the embryos.
Unexpected Ovulation
For enabling the embryos to get implanted into uterus, placing them very precisely and at the appropriate time is important. This is regarded as the window of implantation. The time taken, is based on the time frame since progesterone reaches the lining of the uterine.

Doctor knows the exact time to place the embryos, right from the time he or she instructs a woman to start having progesterone supplements. In case a woman was to ovulate, the production of progesterone would begin earlier than the normal time and would lead to the shift of the window of implantation. As identifying the correct time of ovulation is almost impossible, so that would lead to some sort of uncertainty into the timing.

Due to this reason, there are doctors who would use medication in order to prevent unexpected ovulation from occurring. Generally an injection called Lupron is usually used as medication.

Timing for the Embryo Transfer is Inappropriate
This is a problem related to early ovulation. There are case when the implantation window is shifted, still the timing of the transfer becomes accurate. Recent studies have shown that quite a nominal percentage of women might have a window of implantation, which could be either earlier or later than normal time. A test called the Endometrial Receptivity Array can help determine at what time is the window of implantation open.

Frozen Embryo Transfer - Complications Associated With It!

Miscarriage is termed as the loss of the fetus in or before 20th week of pregnancy. Medically, miscarriage is known as spontaneous abortion, though the word spontaneous is more of a keyword as it is not an abortion.

Symptoms of Miscarriage 
Miscarriage happens due to weakness, back pain, fever, abdominal pain along with severe cramps and bleeding, which starts from slow to heavy.

Cause of Miscarriage 
Common cause of miscarriage is when the fetus is known to have fatal genetic problems and these are not related with the mother. The other causes are infection, medical problems like thyroid and diabetes, immune system rejection, hormonal imbalance, abnormalities of the uterus, and physical problems of the mother. If a woman is over 35 years of age, has thyroid and diabetes and had an miscarriage earlier then that woman is at a high risk of getting a miscarriage.

Sometimes a miscarriage might take place due to the cervical insufficiency. This is due to the weak cervix, also known as the incompetent cervix, which is unable to hold the pregnancy. A miscarriage in this condition usually occurs in the second trimester. Though there are a very few symptoms in this, but there might be a feeling of sudden pressure that the water is going to break and tissues from the placenta and fetus are released without any pain. This can however, be treated by a stitch in the cervix at 12 weeks. This stitch helps to hold the cervix until the full term is completed. If it is first pregnancy and cervical insufficiency is diagnosed, then also a stitch can be applied, thus resulting in full term and avoiding miscarriage.

Diagnosis of Miscarriage: 
-   The doctor does a pelvic test, an ultrasound and blood tests to confirm a miscarriage
-   Blood tests are done to analyze the pregnancy hormone hCG. This is monitored regularly if miscarriage is suspected
-   Genetic tests, blood tests and medication are important in women who have a history of prior miscarriages
-   Pelvic ultrasound and hysterosalpingography are tests, which are done when there are repeated miscarriages
-   Test like hysteroscopy is also done. In this the doctor observes the inside of the uterus with a device, which is thin telescope like device. This is inserted in the vagina and cervix.
-   If the cervix is dilated, then the woman might be diagnosed with an incompetent cervix and this can be corrected by cerclage, a procedure done to close the cervix.
-   If the blood type of the pregnant woman is Rh negative, she is prescribed a blood product called Rh immune globulin (Rhogam). This prevents from forming, antibodies which could turn to be harmful for the baby.

Bleeding in Early Pregnancy: Diagnosing Miscarriage

Daljindar Kaur's inspiring story of motherhood: How IVF became her savior

The success of In vitro fertilization continues in India as a septuagenarian woman gives birth to a baby boy. Even after 46 years of marriage, the couple from Amritsar was childless. Daljinder Kaur, along with her 79-year-old husband, Mohinder Singh Gill, had been visiting National fertility and the Test Tube Baby Centre in Hisar since 2013 and did not give up even after two failed IVF cycles. They had faced ridicule for their inability to have a baby and yet they kept their hopes up.
On the 19th of April, the couple was blessed with a baby boy who is nothing less than a miracle. The groundbreaking achievement of the embryologists from Hisar has been an inspiration and a beacon of hope for couples all across the country. Once again, IVF has proved to be one of the most successful procedures to have babies for couples with fertility issues. Following are some of the advantages of In vitro fertilization, which you should know about-
1. It can be used by anybody
In-vitro fertilization is not necessarily used by the going to be a mother. It can be used by gestational carriers or by a surrogate as well. So it depends on whether the parents want to take the help of a surrogate or themselves want to be involved in the pregnancy. IVF gives an opportunity to single women and same-sex couples to become parents.
2. Use of donated eggs and sperms
There might be circumstances when the doctor can recommend using donated sperms or eggs. In that case, the eggs can be fertilized manually in the lab and the fetus developed can be used for in vitro fertilization. This increases the chance of pregnancy by a fair amount.
3. Control over timing
In vitro fertilization is a solution for couples who have a very engaging professional life, and can be an option for people who want to have babies after a certain point of time. Eggs and embryos can be preserved for future use. It is also helpful for couples who already have a child and plan to have another later.
4. Decreases chances of miscarriage
Genetic abnormality is one of the primary causes of miscarriage. The technique of preimplantation genetic diagnosis (PGD) is used to ensure the viability of the embryo much ahead of time so that the mother can have an uncomplicated pregnancy and carry her baby full term.



Daljindar Kaur's inspiring story of motherhood: How IVF became her savior

Don't wait any longer, manage your Obstetrician online with a Lybrate doctor today

Consult for Obstetrician - Online and Easy!

FilterClear All

COMMON SPECIALITIES

COMMON ISSUES