Hereditary Angioedema is a rare skin related disorder and as the name suggests it is also a genetically inherited condition. This condition mainly afflicts the throat, abdomen and the limbs of the patient, with a certain kind of swelling. This swelling can become fatal if not treated on time. Here is everything you need to know about the condition and its treatment.

Causes: A rare genetic mutation of the SERPING1 gene can cause this condition. Usually, this gene is known to produce C1 esterase inhibitor, which is a kind of blood protein. This blood protein is an important element of one s immune system and is usually involved in the biochemical reactions that control the body s response to inflammation causing elements. This is done when the blood protein produces a hormone known as Bradykinin. If this blood protein does not function in a normal manner, then there is excessive production of this hormone, which leads to swelling and inflammation.

Type One: There are various types of Hereditary Angioedema that can affect various parts of the body. Type one is one of the most common kinds and can be found on the face, hands, abdomen, throat, as well as feet and genitals of the patient. The severity and frequency of attacks cannot really be predicted and the patient may suffer from attacks throughout his or her life. The best way to treat this type of Hereditary Angioedema is with the help of antihistamine drugs and prednisone which can fight allergic attacks.

Type Two: This kind of Hereditary Angioedema has the same symptoms as type one and is caused by a malfunction of the C1 inhibitor, rather than the Bradykinin hormone as one can see in type one. This condition can also be treated with anti-allergy drugs.

Type Three: This is very rare kind of Hereditary Angioedema. In fact, medical science is yet to find a conclusive body of knowledge that can point to the exact causes and symptoms of this condition. Coagulation is one of the main causes recognised so far. This condition is much more common in women than it is in men, and it usually shows up as facial swelling.

Timely Treatment: While there is no cure for this condition, one can prevent a flare up of the symptoms by taking C1 inhibitors and Bradykinin receptors as well as enzyme inhibitors. It is important to get early treatment for the symptoms and to have constant access to a hospital and its emergency unit. One should also keep track of attacks and symptoms and get regular check-ups done by a doctor to detect the earliest signs of the same to avoid fatalities.

What is Hereditary Angioedema and How Can it be Treated?

There are many health benefits of donating blood which include good health, reducing the risk of cancer along with hemochromatosis. Moreover, blood donation is good for the normal functioning of pancreas and liver. With the blood donation, an individual can improve the cardiovascular health as well as reduce the risk of obesity.

Every day blood transfusions take place saving millions of life on earth. And the best part is that blood donation is good for the donor. It is crucial for the blood donation to take place in a medical facility under the supervision of experts. The donors must ensure that they are in optimum health conditions for avoiding any health issues after the transfusion is completed.

Benefits of donating blood:
There are numerous benefits of blood donation, and some of them include-

Hemochromatosis: The health benefits of blood donation reduce the risk of developing hemochromatosis. It is a disorder which arises owing to excessive absorption of iron in the human body. This condition can be inherited through the genes or may also be triggered by uncontrolled alcoholism, chronic anaemia and other health problems. One should take part in blood donation on a regular basis for the reduction of iron overload.
Anti cancer health benefits: Donating blood at regular intervals can also lower the risk of cancer. After donating blood, the iron stored in the body is maintained at healthy levels. The reduction in the iron concentrations in the body is also connected with reduced risk of cancer and thus helps keep cancer at bay.
Good for liver and heart: Blood donation is useful for reducing the risk of heart and liver disorders which are triggered by the iron overload in the body. Only a limited amount of iron can be absorbed by the body, and the rest starts accumulating in the heart, pancreas and lungs. This can pave the way for liver failure and cirrhosis, damage to the pancreas and complications in the heart such as irregular heart rhythms. The blood donation helps in maintaining the optimum iron levels as well as reduces the risk of different ailments.
Helps in weight loss: Regular blood donation also helps in weight of the donors. This is great for those who are overweight and obese. It is advantageous for those who are suffering from cardiovascular and other health disorders.
Production of new cells: After the donation of blood, the body starts working for replenishing the loss of blood. This helps in stimulating the production of new blood cells and in turn aids in the maintenance of good health.
It is imperative to note here that to enjoy the benefits of blood donation, an individual has to wait for eight weeks after a session of whole blood donation. Also, it is crucial to wait for 16 weeks in between the power red blood donation. One should always consult with the doctor to be sure that he or she is fit for donating blood and should avoid it while suffering from any disorders or infections.

World Red Cross Day - Why Donating Blood Is Good For Health?

Bipolar disorder is also known as maniac depression. This usually sets in low and high moods in a person along with change in energy and sleep.
People with bipolar disorder tend to have periodical changes; sometimes they are over happy and other times they might feel sad, depressed and hopeless. Between these changes they are normal. The highs and lows are considered as extreme poles of moods, thus the name bipolar disorder.
Manic term is used when a person with bipolar disorder is highly excited and feels confident. Also, feelings of irritability and recklessness along with irrationality might occur. Some people with mania might have a hallucination that is they see and hear things that are not there, along with delusions. 
The term hypomania is used to describe mild symptoms of mania, in which a person does not have hallucinations and delusions and the symptoms do not interfere with their daily life. Similarly, the term depressive is used to describe a person's time when they feel depressed or sad. 
Symptoms of Bipolar Disorder
The highs and lows in a bipolar disorder do not follow any set pattern. One might feel manic or depressed for hours or days or weeks, months and even years together before they actually switch to a happy mood. The severity depends from person to person and also changes with time by becoming less or more severe.
Symptoms of mania or the high are extreme excitement, change from being happy to angry and irritable along with restlessness, speech is rapid with low concentration, less sleep and increased energy, high se drive, grand plans, alcohol and drug abuse and impulsiveness.
Symptoms of low or depressive phase are lethargy, worthlessness, feeling of sadness and hopelessness, lowered concentration, irritability, loss of sleep or excessive sleeping, loss of appetite and suicidal tendencies.
Diagnosis of Bipolar Disorder:
In case someone exhibits symptoms of bipolar disorder, then talking to a psychiatrist or a doctor helps. Doctors ask questions related to the mental illness and the associated concerns. Diagnosis is basically recognizing the symptoms of the person, whether they are due to some underlying cause or mood swings because of excessive alcohol. The symptoms have to be noted and the duration for which they last along with the severity should all be noted. The most obvious symptoms are that of lows and highs in mood and changes in behavior, energy, sleep and thoughts.
Consulting a doctor or talking to family and friends helps to differentiate the symptoms of bipolar disorder from unipolar disorder.
Treatment:
Medicines which involve mood stabilizers such as lamotrigine, valproate, lithium, carbamazepine and antipsychotics such as olanzapine, quetiapine should be taken. Psychotherapy is also recommended.

Bipolar Disorder - What It Means

An ectopic pregnancy takes place in the case when the completely fertilized egg attaches itself to a place outside the inner side of the uterus. Ectopic pregnancy is also called tubal pregnancy because in most cases, it takes place in the Fallopian tube. Usually, the Fallopian tubes are not responsible for holding an embryo, which keeps on growing. Hence, the egg has no scope to develop in the Fallopian tube. This problem must be treated as soon as possible to avoid further complications. Here are several ways of treating ectopic pregnancy.

1. Expectant management: In case you are not experiencing any symptoms of pregnancy or the pregnancy cannot be found, close observation is required. This is known as expectant management. You should conduct regular blood tests and follow them up in order to detect, whether the hCG level in your blood is ascending or descending. You are likely to have vaginal bleeding. Use pads and towels instead of tampons. Pain in your tummy is also indicated.

2. Proper medication: In case ectopic pregnancy is detected at an early stage and constant monitoring is not suitable for you, a medicine by the name of methotrexate can be used for treatment. The medicine stops this pregnancy from developing. It is usually injected into your buttocks. Regular blood tests must be carried out to know how the treatment is taking shape on your condition. Trusted contraception measures should be taken for three months following the treatment as methotrexate is very harmful for an infant in case you become pregnant. Keep away from alcohol, as the combination of methotrexate with alcohol is harmful to the liver.

3. Surgical means: The most common mode of surgery for removing ectopic pregnancy during an early stage is laparoscopy or keyhole surgery. While a laparoscopy is carried out, you will be in a state of anesthesia. A narrow tube or the laparoscope is inserted through surgical cuts in the tummy. The Fallopian tube, which had the ectopic pregnancy is totally removed in case the other Fallopian tube is functioning well. Else the pregnancy has to be somehow removed without cutting off the Fallopian tube. Removal of the Fallopian tube is the best remedy for treating ectopic pregnancy and getting pregnant again is also possible. It takes a normal woman almost six weeks to recover after the surgery. Laparotomy is another kind of surgery carried out to repair a ruptured Fallopian tube.

Ectopic Pregnancy - How to Treat It?

One of the most common physically transmitted diseases is chlamydia. Chlamydia is a type of infection caused by the bacteria "Chlamydia trachomatis". The symptoms of Chlamydia are similar to the symptoms of Gonorrhoea (a bacterial sexually transmitted infection). Chlamydia infection causes permanent fallopian tube damage in women, leads to future ectopic pregnancy (the fertilised egg attaches itself outside the uterus) and infertility.

Symptoms of Chlamydia 
Men and women afflicted with chlamydia exhibit different symptoms.
The symptoms of chlamydia in women include:
1. Abnormal, sometimes foul-smelling, vaginal discharge
2. Bleeding between menstrual cycles
3. Painful periods
4. Abdominal pain, accompanied with fever
5. Pain during intercourse
6. Burning or itching around or in the vagina
7. Painful urination

Men usually display the following symptoms if they have chlamydia:
1. Minimal amounts of cloudy or clear discharge from the head of the penis
2. Painful urination
3. Itching and burning around the slit of the penis
4. Swollen and painful testicles

Treatment options available
1. Chlamydia is diagnosed by taking a swab from the cervix (in women) or the urethra (in men). These swabs will be sent to the laboratory for analysis. Urine samples can also be taken to check for the appearance of bacteria.

2. Since chlamydia is a bacterial infection, it can be easily treated with antibiotics. Oral antibiotics such as azithromycin or doxycycline are commonly prescribed by doctors. Azithromycin is usually prescribed in a large, single dose. The dose may also be stretched out for five days. Doxycycline is taken two times daily for a week.

3. With the right antibiotic therapy, the infection will clear up in 1 to 2 weeks approximately. It is very important that you finish the medication course if you wish you heal completely without having to suffer from further bouts of this disorder.

4. Women with critical chlamydia may need hospitalisation, pain medicine and IV (intravenous, or directly through the vein) antibiotics. Pregnant women with chlamydia infection can be safely cured with antibiotic such as erythromycin ethylsuccinate, amoxicillin and azithromycin.

Your partner needs testing and treatment as well to avoid further spread and reinfection. It is vital not to engage in any sexual activity while the treatment is ongoing. A further retest should be done three months later to make sure the infection is rectified.

Symptoms of Chlamydia and Ways to Treat the Disease

The diagnosis as well as management of pancreatic cystic lesions is a general problem. Nearly 1% of the patients in the chief medical centers have been observed to have pancreatic cystic lesions on cross sectional imaging. It has also been observed that a quarter of all pancreas scanned in an autopsy series contain pancreatic cysts. Earlier, these cystic lesions were regarded benign but with increasing evidence made available from the cystic lesions, they are regarded as origin of pancreatic malignancies.


Information on asymptomatic neoplastic pancreatic cysts
The most vital medical tools that are used in the diagnosis and management of pancreatic cystic lesions include the endoscopic ultrasound and cross sectional imaging. These are used to distinguish non-mucinous cysts from mucinous cysts. The identification of pancreatic cysts creates a lot of anxiety for the clinicians as well as the patients related to the probable presence of a fatal tumor. The findings of a macro cystic lesion that enclose viscous fluid loaded in cea are helpful in the analysis of a mucinous lesion. 


The most common pancreatic cysts are the non-neoplastic inflammatory pseudo cysts, and they can be detected easily by imaging. The identification of pancreatic irregularity with probable association with malignant cells is a vital source of referral for the specialist. The set of guidelines that have been proposed for the management and diagnosis of patients with asymptomatic neoplastic pancreatic cysts are based specifically on the analysis of the quality of the data. It is also designed to address the most important and frequent clinical scenarios. The diagnostic suggestions are provided based on the clinical problem as well as the risk of malignancy.


Imperative guidelines to follow
To achieve accurate diagnosis of asymptomatic neoplastic pancreatic cysts is indeed a great challenge. It is all the more important to find the reproducible methods that can be used to stratify threat of cancer for the patients. The main guidelines include a two year screening interval of cysts that can be of any size as well as stopping observation after 5 years, in case there is no change. The new guidelines, for the most part, recommend surgery if more than one concerning feature is confirmed on the mri by use of endoscopic ultrasound. The new guidelines even suggest discontinuation of inspection after the surgery if no dysplasia or invasive cancer is identified. The guidelines have mainly been developed by use of grading of recomendations assessment, development and evaluation.

Diagnosis and Management of Asymptomatic Neoplastic Pancreatic Cysts

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