Chromosomal abnormality happens when a cell has too many or too few chromosomes. The most common form of chromosomal anomaly is Down s syndrome. If a parent has a chromosomal anomaly, she/he will pass it on to the child. PGD or Pre-implantation Genetic Testing aims to select only the embryos with normal chromosomal count and only these embryos are implanted to achieve a healthy pregnancy and bring down the number of children affected with a chromosomal anomaly.

The risk of Aneuploid pregnancy:

The older a woman is when she tries to conceive (aged 35 or more), the higher the risk of Aneuploid pregnancy (carrying a baby with genetic or chromosomal abnormality). Most of these pregnancies end in miscarriages and the few that come to term produce babies with chromosomal abnormalities.

Causes of Chromosomal Abnormality:

Usually, chromosomal abnormalities occur due to an error in the cell division. Meiosis refers to the cell division, which the sperm and the egg undergo during the development procedure. Normally, meiosis breaks the chromosomal material into two equal halves, so that each of the parents contributes 23 chromosomes to the pregnancy. However, when the number of chromosomes in the cell goes up or down than the normal, it results in genetic/chromosomal anomalies.

PGD Procedure for a Chromosomal Anomaly:

If a couple elects to go for Pre-implantation Genetic Diagnosis, they have to undergo ICSI Cycle. ICSI cycle initiates a fertilization cycle to produce embryos. When the embryos reach upto day 5 and blastocyst are formed, they are biopsied and further sent to genetic lab for detecting the chromosomal abnormalities. The embryos are incubated for the entire duration of the genetic screening. Only the embryos that the genetic test clears are implanted. PGD never reveals the gender of the embryo.

PGD can help detect the single genetic disorders that may lead to the following ailments:

  Cystic fibrosis
  Muscular dystrophy
  Tay-Sachs
  Sickle cell anaemia
  Thalassemia
  Turner syndrome

PGD is a revolutionary science that can help root out incurable disorders linked to genetics. It ensures that pregnancy is sustained until term and a healthy baby is born.

Suffering From Genetic & Chromosomal Anomalies - Know About PGD!


Autism is defined as a neurobiological pervasive development disorder that includes lack of social skills and inability to reciprocate to social interactions. The patient may also have intellectual and cognitive deficits and problems in communication (verbal as well as non-verbal).

Ayurveda is the oldest study of medicine and has proved to be very effective when it comes to managing and treating those affected by autism. The earlier an autistic person resorts to ayurveda, the more effective it is.

Ayurvedic drink recipe for treating the symptoms of autism: (should be taken daily)
1.1/3 cup of yogurt
2.3/4 cup of water
3. Cumin
4. Coriander and
5. Ginger
Or
Diluted fresh pomegranate juice

Ayurveda in curbing aggression:
Autism includes heightened aggression and aversion from social interaction due to a neurological condition that impairs the functioning of the brain. Not all autistic patients are violent towards others, but may express their frustration by self-harm and emotional outbursts. One can curb these emotional outbursts by taking herbal supplements. An ayurvedic herb called brahmi (bacopa monnieri) which is known for its, anti-anxiety, neuroprotection and antioxidant properties can help considerably.

Regular massages using sandalwood, rose, lavender and gotu kola oils are also very calming and relieving, because it stimulates the blood flow and neuronal responses. Massage also helps in increasing eye contact and social relatedness, less stereotypical behavior and improved sleep.

Ayurvedic herbs for autism:
1. Brahmi- scientifically known as bacopa monnieri, brahmi is an important herb that delays the process of forgetting and improves memory. Not only does brahmi improve memory, but also increases the grasping power, intellect and speech and also corrects the abnormality of emotions, personality and mood of an autistic individual. It also helps in performing complex tasks such as comprehension, reasoning and learning.

2. Ashwagandha- scientifically known as withania somnifera, ashwagandha has high affinity for gamma aminobutyric acid (gaba) receptors. Low gaba activity is related to cognitive impairment.

3. Shankhapushpi- scientifically known as convolvulus pluricaulis, shankhapushpi is very effective in improving learning and memory and is highly effective in treating insanity and epilepsy. 

4. Centella asiatica- this ayurvedic herb is used as a medication for insanity, speech disorders and epilepsy, making it a very useful drug for treating autism.

Top 5 Ayurvedic Medicine for Autism Treatment

Smith and Mackie (2007) term self-esteem as a set of positive or negative opinions about oneself. Self-esteem is an important predictor of success in career, relationships, marriage and public life. People who are depressed have a very low self-esteem about themselves. They think of themselves as good for nothings and persons having a nil value. There are three states of self-esteem. They are;

Shattered: An example of a person having shattered self-esteem is when he says,  I am old and useless to do this kind of work . This person sees himself as an absolutely useless person.
Vulnerable: In this state, a slight embarrassment or defeat may expose the vulnerable side of the person. Otherwise, such persons have a positive frame of mind.
Strong: People in this state are very strong emotionally. Defeats, embarrassments etc. do not affect them. These people have a very high sense of self-esteem.
Psychologists, however, have prescribed several ways through which one can improve one s self-esteem.

How to improve one s self-esteem

Control your thoughts- Watch out what your inner critic is saying to you. Every time you hear its voice, ask yourself- would this be the way your best friend would speak to you? If your inner critic is being merciless on you all the time, you need to silence it.
Focus on the good things that happen to you- Everyday, write at least 3 good things that happened to you. Avoid the obstructive or harmful things that came your way. Focus on the happier side of the day. Do not dwell upon the negatives.
No need to be perfect- In the quest to be perfect, many people lose control of themselves. It probably must do with the pressures of modern life where achievement is the be all and end all. But, not everyone can be perfect. Rather, focus on the effort or process. This way, you will be better able to appreciate yourself as a person.
Accept mistakes- Often we fail to realise that mistakes come to us masked as opportunities. But, we are too fixated by the mistakes we commit. We are obsessed with the thought,  Why did I commit this mistake?  rather than,  How to avoid this particular mistake? . If we learn how to avoid committing mistakes, we will tremendously improve our self-esteem.
Experiment with new skills- Try out new skills and then improve upon them. For example, you may pick up music and track your achievement levels. If you continually improve yourself in this new skill, you will obviously set new benchmarks. Give credit to yourself after achievement of every new milestone.
Accept your limits- You are no superman. You have your own limits. Once you accept your limitations, you will stop blaming yourself for all the wrongs that are happening to you. 

Self Esteem - How Can You Improve It?

All parents expect their child to start going to school, learn writing and learning and do well in academics. However, children with dyslexia may not be able to progress at school at the same pace as others. The good news is that there are early pointers that can help a parent to identify dyslexia in the early stages. This can be helpful in training and support the child socially to learn and socialise normally.  Dyslexia is a disability that affects both spoken and written language. They have a different learning style and when supported and encouraged, instead of mocked and insulted, they can become avid readers. The following are common 10 indicators of developing dyslexia in children, in general, and at school.

10 Behavioural signs to watch for in general:

The child usually has difficulty concentrating and following instructions
The child is easily distracted, seems to daydream, and tends to forget words.
Poor personal organisation skills and is not very good at time keeping.
May get confused between today, tomorrow, yesterday; east and west; right and left; up and down.
Has difficulty remembering seasons, months and days.
Tends to be doing something to avoid work.
Seems distracted, and  daydream,  does not seem to listen
Requires a lot of effort focusing on things at hand and is constantly tired.
Slow pace of processing in terms of spoken or written language
Often appears withdrawn or lost in his own world.
10 Behaviours to watch for at school:

Poor standard of writing and written work in comparison with oratory skills.
Poor handwriting with badly formed letters.
Confused easily between similar looking letters like m/w, n/u, b/d.
Usually, messes up work by using close but wrong spellings and rewriting the same
Mixes up words by using similar-looking words   quiet and quite, tired and tried.
Same word is spelt differently at different times
Poor motor skills and pencil grip leading to slow, inaccurate writing
Produces a lot of phonetic spelling which does not change with repeated corrections
There is difficulty in blending words together, and struggles a lot when asked to read out loud, can miss out or add words that are familiar in between
Has difficulty connecting the story that is being written or read
As noted, these children have very inconsistent behaviour with very limited understanding of nonverbal communication. If these symptoms go on increasing as they grow, it is advisable to seek professional help so that support can be provided and the condition can be arrested at the early stages.

Dyslexia - 10 Signs Your Child Maybe Suffering From It!

With age, most body organs begin to deteriorate in their function. This happens to the brain also, thereby reducing the overall speed of functioning of most organs. While slowing of bodily movement is visible, the internal organs functioning also slows down, which is not that obvious. Memory loss or dementia is one of the main manifestations of this degeneration of the brain.

Alzheimer s is the most common form of dementia, and the associated symptoms includes reduced reasoning abilities and cognitive defects. Though it is seen only in the elderly, not all elderly people will have Alzheimer s. The overall quality of life of the affected person is reduced with difficulty remembering things that were recently learned. It is a progressive disease and as it gets more severe, a full-time caretaker may be required.

Causes: The brain cells are affected by protein masses known as plaques and tangles. These hamper the way communication between the brain cells happens as well as affect nutrition from reaching all parts of the brain. This leads to shrinking of the brain, eventually leading to memory loss and other problems. There is also a strong genetic linkage, as most people with Alzheimer s have the lipoprotein A gene.

Symptoms: Though memory loss is the most common symptom, there are other symptoms:

Being confused about places, people, and times
Inability to find the right words during conversations
Regular objects are misplaced
Becoming irritable, (in someone who was not so previously)
Mood swings
Personality changes
Inability to organise thoughts
Not able to make the right decisions
Repetitive talks and actions
Forgetfulness (not something the person always does)
Difficulty with numbers (again, not something calculations
Difficulty managing everyday tasks and minor problems
Suspicion of others (like immediate family members and friends)
Risk factors: While age is definitely a risk factor, the fact that not all aged people develop Alzheimer s is to be borne in mind. Other risk factors include the history of stroke, high cholesterol, high blood pressure, diabetes, smoking, obesity, and poor lifestyle choices.

Diagnosis: While there is no definitive way to diagnose Alzheimer s, symptoms along with brain scans and neuropsychological function testing are useful ways to confirm the diagnosis.

Treatment: This is aimed at two things reducing the rate of disease progression and treat (or reverse) symptoms if possible.

Cholinesterase inhibitors improve cellular communication in the brain and also manage depression and agitation. Memantine is used to slow the pace of disease progression.
In people with the disease, small changes are useful to help them with the symptoms. These include keeping essential things like keys and wallet in the same place, keep a daily diary to help them remember things, keep pictures of friends and family within visible distance.

Alzheimer's - An Overview!

Neurology is the branch of science and medicine dealing with the central and peripheral nervous system. The nervous system is made of the brain and spinal cord. The disorders, illness or injuries of the nervous system can become problematic for people suffering from them. One of the worst diseases of the nervous system is Parkinson s disease.

It is a progressive disorder affecting the central nervous system that leads to slowing down of movement and slurring of speech over a period of time. It is a condition where the nerve cells in the brain producing dopamine (a neurotransmitter) are affected.

Some of the early signs of Parkinson s include:

Tremor: If you have noticed a slight shaking of your hands or limbs, then Parkinson s might be the cause. The trembling can range from mild to severe as the disease progresses. The back-and-forth rubbing of your thumb and forefinger is known as pill-rolling tremor. One of the most prominent signs is your hand shaking even when it is rested.
Bradykinesia (slow movement): As the disease progresses, you may find it difficult to move your hands or legs or going from one place to another. Even making the smallest movement will require an increased effort on your part.
Rigid Muscles: The muscles in your body can become stiff causing you pain and making it difficult to perform physical activities.
Masked Face: Your face may experience spasms or become stiff periodically. It can also lead to complete paralysis on one side of the face.
Stooping or improper balance: Having Parkinson s disease can make your body posture imbalanced resulting in stooping or hunching over.
Decreased Automatic Movements: You may experience difficulty in smiling, blinking or swinging your arms while walking.
Alteration in voice or speaking: Your voice can become soft or you may slur while talking. You can also experience a monotonous voice.
Writing may become small: You can experience changes in your handwriting as it becomes small and crowded.
Loss of Smell: The smell of food sitting right in front of you may not register in your olfactory resulting in loss of appetite.
Constipation: Having Parkinson s disease can lead to patients experiencing irritable bowel syndrome.
Have Trouble Sleeping: It might be difficult to fall asleep for people suffering from Parkinson s. Also, there are sudden movements during the sleeping process.
Dizziness: People suffering from Parkinson s may faint from time to time.
These were some of the symptoms and signs by which you can tell whether a person has Parkinson s or not. However, as of now it is not curable and can only be treated with medicines. But, early detection can definitely help in preventing it from affecting the whole body.

Parkinson's Disease - Are You Aware Of These Signs?

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