Parkinson's disease is a neurodegenerative condition that affects your brain cells which produce dopamine and thus hampering all kinds of motor functioning and other emotional responses. After the disease is diagnosed, medication and therapy can help to provide relief from the symptoms to a large extent but a permanent cure is not possible.

Causes:

The disorder does not have a definite set of causes. A small percentage of the cases have been related to hereditary factors and others have a range of environmental causes associated with them.

1. Genetic factors:

Specific gene mutations and gene variations have been proved to cause Parkinson's, such as SNCA, PARK2, PARK7, PINK1 and LRRK2. These make or recycle proteins which are linked to the disease.

Research shows that men are at a 1.75 times greater risk of developing the condition than women are. Also, age plays a role with most cases occurring after the age of 60.

2. Environmental factors:

Regular exposure to inorganic insecticides, pesticides, herbicides and heavy metals or other toxins may cause the disorder. In rare cases, Parkinson's disease occurs in the aftermath of a severe head injury or immune disorders.

Symptoms:

The symptoms can be classified into two broad categories-

1. Motor symptoms:

The hand tremors when in resting position
The grip loosens
Walking slows down
Facial muscles freeze partially
Speech is slurred
Balance is disturbed
Swallowing is painful
Urination is abnormally frequent
Dementia-like symptoms are seen
There is involuntary twitching of the fingers and toes
Repetition of the same movement in quick succession is nearly impossible
2. Non-motor symptoms:

Dental problems
Vision impairment
Skin disorders
Panic attacks
Excessive secretion of saliva
Extreme weight loss or gain
Sexual problems
Loss of sense of smell
Lowering of the pitch of the voice
Fatigue

Causes and Symptoms of Parkinson's Disease

Headaches and migraines can vary drastically depending on their duration, specific symptoms and the person they are affecting. The more you know about your specific type of headache or migraine, the better prepared you will be to treat them and possibly even prevent them. The two types of migraine are- 

Migraine without aura: The majority of migraine sufferers have Migraine without Aura. 
Migraine with aura: Migraine with Aura refers to a range of neurological disturbances that occur before the headache begins, usually lasting about 20-60 minutes.
Symptoms of migraine vary and also depend on the type of migraine. A migraine has four stages: prodrome, aura, headache and postdrome. But it is not necessary that all the migraine sufferers experience all the four stages.

Prodrome: The signs of this begin to appear a day or two days before the headache starts. The signs include depression, constipation, food cravings, irritability, uncontrollable yawning, neck stiffness and hyperactivity.
Migraine Aura: Auras are a range of symptoms of the central nervous system. These might occur much before or during the migraine, but most people get a migraine without an aura. Auras usually begin gradually and increase in intensity. They last for an hour or even longer and are 

Visual: Seeing bright spots, various shapes, experiencing vision loss, and flashes of light
Sensory: Present in the form of touch sensations like feeling of pins and needles in the arms and legs
Motor: Usually related with the movement problems like the limb weakness
Verbal: It is related with the speech problems
Headache: In case of a migraine attack one might experience:

Pain on both sides or one side of the head
Pain is throbbing in nature
Vomiting and nausea
Sensitivity to smells, sound and light
Vision is blurred
Fainting and lightheadedness
Postdrome: This is the final phase of the migraine. During this phase one might feel fatigued, though some people feel euphoric.

Red flags that the patient may be having underlying serious disorder not migraine

Onset of headaches >50 years 
Thunderclap headache - subarachnoid haemorrhage 
Neurological symptoms or signs 
Meningism 
Immunosuppression or malignancy 
Red eye and haloes around lights - acute angle closure glaucoma 
Worsening symptoms 
Symptoms of temporal arteritis
These patients require CT scan / MRI or CSF examination. Most Migraine patients do not need these tests. 

Diagnosis of Migraine: Usually migraines go undiagnosed and thus are untreated. In case you experience the symptoms regularly then talk to the doctor, who evaluates the symptoms and can start a treatment. You can also be referred to a neurologist who is trained to treat the migraines and other conditions. During the appointment the neurologist usually asks about the family history of headaches and migraines along with your symptoms and medical history.

The doctor might advise for some tests like:

Blood Tests: These reveal problems with the blood vessel like an infection in the spinal cord and brain.
CT scan: Used to diagnose the infections, tumors, brain damage, and bleeding that cause the migraines.
MRI: This helps to diagnose the tumors bleeding infections, neurological conditions, and strokes.
Lumbar Puncture: For analyzing infections and neurological damages. In lumbar puncture a thin needle is inserted between the two vertebrae to remove a sample of the cerebrospinal fluid for analysis.
Treatments

Migraine treatments can help stop symptoms and prevent future attacks.

Many medications have been designed to treat migraines. Some drugs often used to treat other conditions also may help relieve or prevent migraines. Medications used to combat migraines fall into two broad categories:

Pain-relieving medications. Also known as acute or abortive treatment, these types of drugs are taken during migraine attacks and are designed to stop symptoms.
Preventive medications. These types of drugs are taken regularly, often on a daily basis, to reduce the severity or frequency of migraines.
Your treatment strategy depends on the frequency and severity of your headaches, the degree of disability your headaches cause, and your other medical conditions.

Some medications aren't recommended if you're pregnant or breast-feeding. Some medications aren't given to children. Your doctor can help find the right medication for you.

Migraine - Identifying the Early Signs!

Parkinson s disease adversely affects the way you move, as it is a neurodegenerative disorder. This happens when there are problems with certain nerve cells in the brain. These nerve cells produce an important chemical called Dopamine, which in turn sends signals to the region of our brain that takes care of the movement. This chemical help muscles to function smoothly and allow in carrying out one s daily activities. When somebody is suffering from Parkinson s disease, the nerve cells break down, thus hampering movements of limbs.

What Causes This Disease?

Over the years, a lot of research has taken place to find out the exact reasons due to which people get affected by Parkinson s disease but till now neither scientists nor doctors have been able to come up with any solution. They are thinking on the lines of aging or hAarmful chemicals in the environment, to be possible causes for this neurological problem. Sometimes researchers even feel that this could be a hereditary problem but there is no concrete evidence to substantiate this statement.

Symptoms Of Parkinson s

As discussed earlier, Parkinson s occur in aged individuals, when nerve cells break down, when the chemical called Dopamine is no longer able to send signals to the brain. You can easily recognize Parkinson s disease in any of your family members, if you come across certain symptoms, which are generally four of them:

Trembling or shaking of limbs and these tremors can affect different body parts like, hands, arms and legs.
Muscles become stiff, due to which it becomes tough for the affected individuals to move their limbs freely.
Due to stiffness of muscles, movement becomes slow and thus each and every activity of theirs takes much more time than usual.
People are unable to keep their balance and walk freely without any hindrance.
Generally, tremor is the first thing you would notice in a person and thus instantly get to know that the person might be suffering from Parkinson s.
Problems of constipation or facing difficult in swallowing tend to happen as the disease goes on to affect all the muscles in one s body. 
During the latter stages, someone who has Parkinson s, might well have a blank expression to the face with problems being faced while trying to speak and other related issues. The symptoms of this disease usually start for people aged between 50 and 60 but at times, it can even crop up at an earlier stage.
Preventive Measures And Treatment

Let s take a look at how you can prevent yourself from getting crippled by Parkinson s Disease.

Unfortunately, as the disease is mostly age related, so after attaining the age of 60, if not from 50, there would be very few individuals who would not be the victims of Parkinson s.

Research has revealed that having less of dairy and red meat and consuming more of fruits, vegetables and high-fibre foods, thus maintaining a healthy diet, can protect people from the dreaded disease.

Parkinson's Disease - Know What's It's All About

Parkinson s disease is a disorder involving the nervous system. It can start with a mere tremor of one hand and advances to slow movement and stiffness. The face might show little no symptoms in the beginning but the speech might become slurred. With every passing day, the condition worsens. This condition has no permanent cure but the symptoms can be improved with proper medication.

What are the symptoms?
Some unmistakable symptoms include the following:

A sudden shaking of the limb. A sudden tremor of the hand is a very common symptom of this disease.
A stiffness of the muscles that can limit the range of motion and sharp pain.
The posture of the body might get compromised. Often balancing problems are witnessed among many patients.
There could be problems with speech leading to soft, slurry or quick speech. The speech in some cases can become monotonous devoid of inflexions.
Parkinson s disease can lead to slow movement and makes performing of simple tasks difficult.
Patients often find writing very difficult
What are the possible causes of Parkinson s disease?

Specific genetic mutation can lead to Parkinson s disease in folks who have a family history of Parkinson s disease. Certain variations of the gene increase the risk of this disease
Exposure to certain environmental factors or certain toxins can trigger Parkinson s disease in an individual.
Certain cells in the brain known as Lewy bodies can trigger Parkinson s disease.
A certain kind of protein cells within the brain known as alpha-synuclein can trigger the Parkinson s disease in an individual
What are the risk factors?

Heredity: Having an immediate family member or a close relative suffering from Parkinson s disease can increase the risk of getting this disease in an individual
Age: Although not a prime risk factor, but an individual over the age of over 60 have an increased risk of getting this disease
Toxins: Exposure to pesticide or certain herbicide increase the risk of Parkinson s
Sex: Men are more likely to get Parkinson s disease than women
What is the medication for Parkinson s disease?

Carbidopa-levodopa: This is a natural chemical that gets passed to the brain and is converted to dopamine by the body. The benefits of this medication might reduce with increased symptoms.
Carbidopa-levodopa infusion: A popular drug in this category is known as the Duopa. It is administered directly into the small intestine in the form of gel through a feeding tube.
MAO-B inhibitors: Drugs from this group include rasagiline and selegiline. This is a powerful medicine. Many patient experiences hallucination during the initial days of consuming these drugs.
Anticholinergics: This medication is mainly used to counter tremors of the limbs in the early stage of the Parkinson s disease.

Parkinson's Disease - What Are The Risk Factors?

Sleep is known to most as a period of rest and relaxation, but there are multiple disorders which are associated with sleep too. Hypersomnolence or hypersomnia is one of the most common sleep disorders. This is characterised by excessive daytime sleepiness and prolonged periods of sleep at night. They wake up fresh in the morning, but can easily go back to sleep any time of the day without feeling strained or tired. There is again no freshness associated upon waking up. Funny as it may sound, they can doze off even during a meal or in the middle of a conversation.

Causes: This condition is most common in men and in the early adolescent days.

There is no underlying cause that has been identified, though there is a genetic predisposition.
People with history of head trauma are more affected
People with anxiety, depression, bipolar disorders, epilepsy, and other mental disorders are also more likely to be affected
People with sleep apnea often are hypersomnolence
Restless legs syndrome, narcolepsy
Neurodegenerative disorders like Parkinson s and Alzheimer s tend to sleep more.
Symptoms:

Sleeping for longer hours at night time
Excessively sleepy during daytime
Able to doze off anytime during the day
Inappropriate and involuntary sleeping pattern
Having difficulty getting out of bed after waking up, even after prolonged sleep
Feeling of disorientation
Feeling agitated, anxious, lethargic, and irritated
Impaired cognition and memory
All these lead to extreme state of drowsiness
Increased tendency for hallucinations
Reduced appetite and even weight loss in some people
There is restlessness, reduced pace of thinking and speaking
Overall reduced energy levels
Social interactions are affected including work life, social functions, etc.
Diagnostic criteria:

If a person happens to sleep more at night or falls asleep during the day easily for more than 3 times a week, it is usually concerning.
The added feature of no tiring physical activity can also lead to suspicion
In acute cases, these symptoms are present for at least a month and in chronic cases, it could be seen for up to 3 months
It cannot be explained by lack of sleep on a regular basis
One or more of the above conditions could be present, which can help in making the diagnosis
Treatment:
Most cases of hypersomnia would need treatment only to improve their energy levels and improve the quality of life. Very often, treating the underlying condition can lead to improvement of hypersomnia. The tired, lethargic, restless feeling affects the overall performance of a person, leaving them with a lowered self-esteem. Brain stimulating drugs like amphetamines are used to improve daytime alertness and also reduce sleepy feeling during the day.


Hypersomnolence - How It Can Be Managed?

A brain stroke can affect anyone at any point of time when the supply of blood to the brain is interrupted. It can threaten major physical functions and can prove to be fatally dangerous at times. The brain stem which is placed right above the spinal cord controls the breathing, heartbeat and levels of blood pressure. It is also in charge of controlling some elementary functions such as swallowing, hearing, speech and eye movements. 

What are the different types of strokes?
There are three main kinds of stroke: ischemic strokes, hemorrhagic strokes and transient ischemic attacks. The most common type of brain stroke is the ischemic stroke is caused by narrowing or blocking of arteries to the brain, which prevents the proper supply of blood to the brain. Sometimes it so happens that the blood clot that has formed elsewhere in the body have travelled via the blood vessels and has been trapped in the blood vessel which provides blood to the brain. When the supply of blood to a part of the brain is hindered, the tissue in that area dies off owing to lack of oxygen. The other variant of brain stroke is termed as hemorrhagic stroke is caused when the blood vessels in and around the brain burst or leak. Strokes need to be diagnosed and treated as quickly as possible in order to minimize brain damage.  Remembering the F.A.S.T. acronym can help with recognizing the onset of stroke (Face, Arms, Speed, Time - explained below). 

What are the common symptoms of a brain stroke?
The symptoms of the brain stroke are largely dependent on the area of the brain that has been affected. It can interfere with normal functioning, such as breathing and talking and other functions which human beings can perform without thinking such as eye movements or swallowing. Since all the signals from the brain as well as other parts of the body traverse through the brain stem, the interruption of blood flow often leads to numbness or paralysis in different parts of the body.

Who is likely to have a stroke?
Anyone is at a risk of developing brain stroke although ageing is directly proportional to the risk of having a stroke. Not only that an individual with a family history of brain stroke or transient ischemic attack is at a higher risk of developing stroke. People who have aged over 65 accounts for about 33 percent of all brain strokes. It is important to point here that individuals with high blood pressure, high blood sugar, cholesterol, cancer, autoimmune diseases and some blood disorders are at a higher risk of developing brain stroke.

There are a few factors which can increase the risk of developing stroke beyond any control. But there are certain lifestyle choices as well which aids in controlling the chances of being affected by stroke. It is crucial to refrain from long-term hormone replacement therapies as well as birth control pills, smoking, lack of physical activity, excessive use of alcohol and drug addiction. A brain stroke is a life-threatening medical condition, and when an individual has symptoms that resemble that of stroke, it is crucial to seek immediate medical help.

Treatment for stroke

Treatment depends on the type of stroke.
Ischemic strokes can be treated with 'clot-busting' drugs.
Hemorrhagic strokes can be treated with surgery to repair or block blood vessel weaknesses.
The most effective way to prevent strokes is through maintaining a healthy lifestyle.
What is TPA?
TPA is a thrombolytic or a  Clot Buster  drug. This clot buster is used to break-up the clot that is causing a blockage or disruption in the flow of blood to the brain and helps restore the blood flow to the area of the brain. It is given by intravenous (IV). This can be given only within 4.5 hrs of the onset of symptoms

Time is brain

Remember Every second Loss means brain cells die.
Rush to the nearest Stroke Centre whenever you experience such symptoms.
U can save the brain cells dying if you reach within 4.5 hrs by the CLOT BUSTER. 
Endovascular procedures 
Another treatment option is an endovascular procedure* called mechanical thrombectomy, strongly recommended, in which trained doctors try  removing a large blood clot by sending a wired-caged device called a stent retriever, to the site of the blocked blood vessel in the brain

Stroke prevention
The good news is that 80 percent of all strokes are preventable. It starts with managing key risk factors, including 

High blood pressure,
Cigarette smoking,
Diabetes
Atrial fibrillation and
Physical inactivity.
More than half of all strokes are caused by uncontrolled hypertension or high blood pressure, making it the most important risk factor to control. 
Rehabilitation
The best way to get better after a stroke is to start stroke rehabilitation ("rehab"). In stroke rehab, a team of health professionals works with you to regain skills you lost as the result of a stroke.

Brain Stroke - Things You Must Know!

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