Insulin is the most common treatment prescribed for people affected with diabetes. Diabetes is condition where high amounts of glucose prevail in the blood for an extended period of time. However, there are some drugs that offer an alternative to insulin in treating diabetes, which are:

1. Liraglutide: Liraglutide is a glucagon-like peptide-1 (GLP-1) drug that causes the body to release greater amounts of insulin so as to facilitate the movement of glucose from the blood to the cells. People with type 2 diabetes generally use this treatment. It slows the digestion process and can cause symptoms of headache and nausea. 

2. Pramlintide: It's an artificially produced version of amylin. It is taken by both type 1 and type 2 diabetic patients, facilitates slower digestion of food and therefore, controls release of sugar in the blood. It can cause tiredness and nausea.

3. Dulaglutide:This treatment is for people affected with type 2 diabetes and it is administered once a week. It causes more insulin to be released and pass the glucose to the cells. It can cause loss of appetite, nausea and abdominal cramps as side effects.

4. Albiglutide: This treatment facilitates pancreas to release insulin and limits the glucagon hormone production. It is used by type 2 diabetes patients who have not taken well to other treatments. The side effects are skin reaction, respiratory tract infection and nausea.

5. Exenatide: It is a drug that causes pancreas to release insulin that facilitates movement of glucose to cells. It is a treatment for type 2 diabetes and it restricts release of glucagon in the body. The possible side effects are acidity, constipation and vomiting.

Common Insulin Alternatives

Diabetes might not be the end of the road for you. While it is a chronic disorder, there are a number of steps you can take to minimize its effects. Before that you should know what diabetes is and its various types.

What is diabetes?

Diabetes is a metabolic disorder where the sugar in your blood is not metabolized by the body. This leads to a situation wherein sugar accumulates in your blood; this condition is known as high blood sugar. Now, this can happen in two ways:

Type 1 Diabetes: In this type, the beta cells of the pancreas that produce insulin (the hormone that metabolizes sugar) are destroyed by the immune system of the body. This leads to a reduction in insulin levels, causing blood sugar to shoot up.

Type 2 Diabetes: Type 2 diabetes is a condition wherein the body cannot effectively utilize the insulin to metabolize sugar. This again leads to the accumulation of sugar in the blood.

Apart from these two types, there is a third type that is known as  gestational diabetes . Gestational diabetes occurs during pregnancy wherein the body produces hormones that inhibit insulin.

Now that you know the various types of diabetes, it is time to focus on preventive measures. The various tips for a high blood sugar level are:



Steer Clear of Sugar: Think of sugar as your enemy, as it is something that you have to stay away from. Sugar will only add to the high blood sugar content that you are already diagnosed with.

Welcome whole grains with open arms: Refined grains are a big no; that means no more of those delicious white bread sandwiches. Instead, opt for whole grains such as brown bread, brown rice and oats. Refined grains come under simple carbohydrates that cause your blood sugar levels to shoot up.

Avoid overconsumption of fruits: While fruits are healthy, they do contain fructose which is again, a form of sugar. So, yes eat them but limit their consumption to one serving a day.

High time you realize nothing substitutes exercise: Regular exercise can help you burn calories and also keep your blood sugar levels low. It allows you to maintain healthy weight levels and improves your overall wellbeing.

Take no stress: Stress has been shown to increase blood sugar, so if you are feeling stressed and can t seem to get out of with, take steps to deal with it. Practice relaxation techniques such as meditation that can help you reduce stress and improve focus.

If you wish to discuss about any specific problem, you can consult a doctor and ask a free question.

Diabetes - Types and Tips to Control Your Blood Sugar Level

To understand about hypothyroidism, it is essential to first understand the thyroid gland. Thyroid is an endocrine gland situated in the neck and produces the thyroid hormone. This hormone is then carried through the blood to different cells of the body. It helps the organs to function properly maintain the temperature of the body. The two thyroid hormones are Triiodothyronine (T3) and Thyroxine (T4). They regulate protein, fat, carbohydrates and vitamins in the body along with the metabolism. They are also responsible for the proper differentiation and development of cells.

Hypothyroidism or underactive thyroid or low thyroid
This is a condition where the thyroid gland is underactive and produces a low amount of the thyroid hormone. To help the thyroid gland produce the required amount of T3 and T4 hormones, the pituitary gland will make additional thyroid stimulating hormone called TSH. Due to this additional secretion of TSH, one also develops chance of thyroid gland enlargement and in some cases, it can form a goiter. 

The major cause of the low level of thyroid hormones is considered to be iodine deficiency. Hence the addition of iodine to the common salt has always been considered to be a safe method to prevent goiter. There can be several other causes of hypothyroidism such as weak immune system, radiation, surgery, Hashimoto s disease, hormonal changes etc. It can be caused due to pregnancy and is called postpartum thyroiditis.

Symptoms of Hypothyroidism
Whatever be the cause of hypothyroidism, it can show the following mild symptoms:

Increased sense of fatigue or tiredness
Sudden increase in weight with puffiness on the face
Hoarse voice
Muscle weakness with aches, tenderness and stiffness
Joint pain or stiffness
Increased sensitivity towards cold thus causing dry skin
Constipation due to slow metabolism
Decreased heart rate
Elevated blood cholesterol level
Irregular menstrual periods
Decreased concentration and depression too
However, it is important to understand that you may show no symptoms or show some mild symptoms that can be easily confused with some other condition. Hence, a proper diagnosis is a must to confirm hypothyroidism.

Diagnosis of hypothyroidism
The most common tests to determine if you have hypothyroidism are TSH Testing and T4 Testing. In case the low level of TSH is due to a defect in the pituitary gland, your doctor may request for another test called TRH. Also, Anti-thyroid Microsomal Antibodies Testing or thyroid peroxidase test (TPO) helps in identifying if the thyroid gland is damaged.

Treatment of hypothyroidism
Hormone replacement therapy is the best form of treatment available today. It involves the use of synthetic Levothyroxine (T4) or liothyronine (synthetic T3). Before these synthetic hormones were used for several years, however, prescribing thyroxine tablets is the most common mode of treatment and they are generally given for a really long period of time, although the dosage may vary. It is only in rare cases of severe decompensated hypothyroidism that one requires hospitalization.

Apart from the above treatment options, it is best advised to avoid soy products, sugary processed foods and alcohol to keep a check on hypothyroidism. In case you have a concern or query you can always consult an expert & get answers to your questions!

Hypothyroidism - Signs Your Kid Is Suffering From It!

Female infertility is considered as the inability of conceiving. As per WHO it is described as the inability to be pregnant, maintain and carry forward a pregnancy to its full term. It is often of two types:

    Primary Infertility: This is the inability to give birth to a baby either due to the inability to become pregnant or maintain a pregnancy, which includes stillborn and miscarriage.
    Secondary Infertility: This refers to the inability to give birth when there is already a live birth or the woman was pregnant.

The causes of infertility can vary from being acquired or genetic. However, following factors are largely responsible for infertility:

    Genetic: Some genes can lead to mutation leading to infertility like, in case of BMP15 gene there is a hypergonadotrophic ovarian failure which causes infertility.
    Acquired: This is caused by factors like age, smoking, sexually transmitted diseases, obesity, body weight, eating disorders, diseases like diabetes, thrombophilia and also radiation and chemotherapy.

The treatment for infertility usually depends on the cause, age, duration of time for which a person has been infertile and preference of the patient. Infertility is believed to be a complex disorder and the treatment involves a huge amount of physical, financial and psychological commitments. All this also requires a lot of time. Some women might need just a minimum of two therapies to attain fertility while others might require different treatment before they can conceive.

Treatment is largely aimed to restore the fertility either by means of medication and surgery or help in reproduction with the help of some procedures.

Fertility Restoration through medication

This is the main treatment for women who are infertile because of ovulation disorders. These drugs include:

    Gonadotropins: These are injected to stimulate the ovaries. Drugs like Menopur, Repronex, Follistim AQ, Gonal-F, Bravelle restore the production of eggs, while Ovidrel and Pregnyl are used for maturing the eggs and for their release.
    Clomiphene citrate: This is taken orally and stimulates ovulation by releasing more Follicle Stimulating Hormone and Luteinizing Hormone from the pituitary gland.
    Metformin: This is used in females who have PCOS and also when insulin resistance plays a major role in infertility.
    Bromocriptine: Used when the infertility is caused due to excess prolactin production.
    Letrozole: This also induces ovulation

Fertility Restoration through surgery

Surgical procedures can amend the problem of infertility. However, these treatments are very rare these days owing to the success of other fertility treatments. These include:

    Tubal ligation reversal surgery: In case a tubal ligation has been performed it can be reversed by reconnecting the tubes again through surgery.
    Hysteroscopic surgery: This corrects or removes the abnormalities that cause infertility. This surgery can correct the shape of the uterus, remove endometrial polyps and improve chance of getting pregnant.
    Tubal surgeries: In case of blocked fallopian tubes laproscopic surgery can be performed to dilate the tubes, removed blockages or create a new opening.

Assistance in Reproduction through techniques

The most common used techniques for reproduction assistance are:

    Intrauterine insemination or IUI: In this about million healthy sperms are put in the uterus at the time of ovulation.
    Assisted reproductive technology: In this mature eggs are retrieved from a woman and this is then fertilized with sperms in a dish in the lab. Once the fertilization is done the embryo is placed in the uterus for further development. IVF is the most common and effective assisted reproductive technology. This procedure takes place over weeks with several blood tests and hormone injections.

Dealing with infertility is not easy and can be emotionally and physically draining. To cope with the various tests and treatments of infertility one should be fully prepared, eat a healthy diet, exercise reach out for help and support of family and friends and look for other options like a donor egg, adoption or no children.

Treatments of Infertility

While cold and cough are common, diseases like Addison s disease are rare. It is also known as chronic adrenal insufficiency or hypocortisolism as it is a result of insufficient production of hormones like cortisol and aldosterone by the adrenal glands. This disease can affect men and women of any age.

There are two types of Addison s disease. These are:

    Primary adrenal insufficiency: In this case, the adrenal glands themselves have a problem.
    Secondary adrenal insufficiency: If the hormone production in the adrenal glands is restricted by a problem that has started somewhere else like the pituitary gland, for example, it is known as secondary adrenal insufficiency.

Primary adrenal insufficiency is more common of the two. This could be triggered as a result of autoimmune diseases or a long lasting infection such as HIV, tuberculosis and some fungal infections. Cancer can also cause this type of Addison s disease.

Secondary adrenal insufficiency is usually caused by a problem with the pituitary gland or the hypothalamus as they are responsible for the production of hormones that stimulate the adrenal glands. Damage caused to the pituitary gland by tumors or radiation and surgery can also interfere with hormone production. Prolonged and improper use of steroid hormones can also trigger this condition.

Addison s disease has a very slow progression and its symptoms develop gradually over time. Some of these symptoms are:

    Weight loss and loss of appetite
    Extreme fatigue
    Hyperpigmentation
    Low blood pressure
    Craving for salt
    Nausea and diarrhea
    Pain in the abdomen and joint pains
    Irritability
    Depression
    Loss of body hair and sexual dysfunction in women

Treatment for Addison s disease involves hormone replacement therapy. This aims at correcting the hormone levels in the body. Hormone replacement therapy includes oral corticosteroids and corticosteroid injections. The dosage of these steroids could vary depending on the situation. For example, the doctor may suggest a temporary high dosage when the patient is in a stressful condition. Along with this, sodium is also recommended especially during the summer months and while exercising. This medication must be taken regularly as skipping a single dose can be dangerous.

In some cases this condition can become life threatening. An addisonian crisis causes a drop in blood pressure, sugar and a spike in potassium levels in the body. This requires immediate medical attention and can be treated with intravenous injections of hydrocortisone, saline solution and sugar.

Addison's Disease - What You Should Know About it

There was an era where we had deadly infections like plague and polio causing death of thousands of people. We still have occasional outbreak of swine flu, but by and large, infections are quite controlled. The new killer diseases are caused because of the lifestyle we have adapted and the damage we have done to the environment. High intake of processed foods, artificial chemicals in our foods, sedentary lifestyle with very minimal to no physical activity, couching over the computers; the list is quite long. All these have led to diseases like diabetes and cancer that were not so common about say few decades ago.

Detailed observation has revealed that both these new epidemiologic diseases have a close correlation. There are factors, which induce diabetes and diabetes in turn and in some cases, diabetes inducing agents, can cause cancer also. It has also been observed that mortality is severely increased if diabetic patients are diagnosed with cancer. There are two types of diabetes. While type 1 is mostly hereditary, type 2 is lifestyle induced and the age at which this is being diagnosed is taking a severe plunge. Adolescents and teenagers are being diagnosed for diabetes. Cancer, on the other hand, is of various types (leukaemia, melanoma, etc.) and can affect various organs (lung, breast, prostate, stomach, liver, etc.).

The medical community is yet to decipher the disease pattern of both these conditions. While there is no definite correlation between diabetes and all types of cancer, some types of cancer are definitely correlated with a definite reason identified, pancreatic and liver cancer for instance. The high amounts of insulin that diabetic patients are exposed to causes changes in liver and pancreas including fatty liver and cirrhosis, here the incidence of cancer is higher. The linkage is not very clear in lung and intestinal cancers and also there is no link between prostate cancer and diabetes.

Diabetes is considered as a state of chronic inflammation and leads to conditions like hyperinsulinemia (higher levels of insulin in the blood) hyperglycemia (higher levels of sugar in the blood). These are believed to aggravate the neoplastic process of cancer formation, thereby inducing cancer at a greater pace and also increasing the mortality rates.

The following are risk factors that are applicable to both age, physical activity, diet, obesity, drinking and smoking. It is also possible that onset of one can be followed by the other. As noted earlier, more detailed research is awaited to establish a definite linkage, but the correlation cannot be ignored at all.

Both these new epidemics are here to stay and since they have a common set of factors, we need to work on ways to contain them.

Diabetes and Cancer: The New Epidemic?

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