Chromosomal abnormality happens when a cell has too many or too few chromosomes. The most common form of chromosomal anomaly is Down s syndrome. If a parent has a chromosomal anomaly, she/he will pass it on to the child. PGD or Pre-implantation Genetic Testing aims to select only the embryos with normal chromosomal count and only these embryos are implanted to achieve a healthy pregnancy and bring down the number of children affected with a chromosomal anomaly.

The risk of Aneuploid pregnancy:

The older a woman is when she tries to conceive (aged 35 or more), the higher the risk of Aneuploid pregnancy (carrying a baby with genetic or chromosomal abnormality). Most of these pregnancies end in miscarriages and the few that come to term produce babies with chromosomal abnormalities.

Causes of Chromosomal Abnormality:

Usually, chromosomal abnormalities occur due to an error in the cell division. Meiosis refers to the cell division, which the sperm and the egg undergo during the development procedure. Normally, meiosis breaks the chromosomal material into two equal halves, so that each of the parents contributes 23 chromosomes to the pregnancy. However, when the number of chromosomes in the cell goes up or down than the normal, it results in genetic/chromosomal anomalies.

PGD Procedure for a Chromosomal Anomaly:

If a couple elects to go for Pre-implantation Genetic Diagnosis, they have to undergo ICSI Cycle. ICSI cycle initiates a fertilization cycle to produce embryos. When the embryos reach upto day 5 and blastocyst are formed, they are biopsied and further sent to genetic lab for detecting the chromosomal abnormalities. The embryos are incubated for the entire duration of the genetic screening. Only the embryos that the genetic test clears are implanted. PGD never reveals the gender of the embryo.

PGD can help detect the single genetic disorders that may lead to the following ailments:

  Cystic fibrosis
  Muscular dystrophy
  Tay-Sachs
  Sickle cell anaemia
  Thalassemia
  Turner syndrome

PGD is a revolutionary science that can help root out incurable disorders linked to genetics. It ensures that pregnancy is sustained until term and a healthy baby is born.

Suffering From Genetic & Chromosomal Anomalies - Know About PGD!

Growth hormone or somatropin is responsible for cell growth as well as reproduction. But insufficient somatropin production by the pituitary gland may result in lack in height. It is mostly caused by a serious brain injury, any prevalent medical condition or might occur as a birth defect.

Types
1. Congenital ghd - this form of ghd appears from at the time of birth itself.
2. Acquired ghd- ghd can be acquired during later life as a result of trauma, infection, tumor growth within the brain or radiation therapy.
3. Idiopathic ghd- idiopathic ghd is the third, and comparatively worst kind of ghd since it has no treatment.

Ghd is mostly permanent, but can also be transient. Read on to know how to detect whether you or your child is suffering from growth hormone deficiency (ghd).

Symptoms
Childhood onset
1. Restricted height- compared to other children of your child's age, he/she may be of shorter height, which is a rather conclusive sign to detect somatropin deficiency.
2. Chubby and comparatively younger appearance- your child may have a proportionate body, but if he/she is unnaturally chubby and has a baby-face compared to other children, he/she may be suffering from ghd.
3. Late puberty- your child's puberty maybe later than usual or even not appear at all, depending upon the gravity of the ghd.
4. Hypoglycemia and exaggerated jaundice- low blood sugar is amongst the most primary manifestations of ghd, along with extended duration of jaundice.
5. Micro-penis- micro penis condition is one of the incident signs of ghd, which later escalates to growth deficit as the infant gets older.

Adult onset
1. Fatigue- adults with ghd may experience extreme tiredness throughout the day, with reduced muscle strength.
2. Osteoporosis- osteoporosis, along with bodily deformities, is a common sign in adults with ghd.
3. Lipid abnormalities- a test of your lipid profile may reveal abnormalities in ldl cholesterol, insulin resistance, and impaired cardiac functions.

Tests to determine ghd
1. Physical test- a chart is drawn to determine the proportion of height and weight with respect to your age to detect anomalies.
2. Hand x-ray- a hand x-ray can determine whether the age of bones are at par with your age.
3. Mri-mri scan can determine the health of your brain and pituitary gland.
4. Test for other hormones- growth hormone may not be solely responsible for your health condition, so it is important to determine if other hormone levels are all normal.

Treatment
1. Hormone supplements- hormone supplements like corticosteroids (hydrocortisone or prednisone), levothyroxine (levoxyl, synthroid, etc), and others work to replenish the deficiency of pituitary hormones.
2. Growth hormone injection- gh is injected beneath your skin, to cure gdh. This is a long-term treatment and requires constant monitoring.

All About Growth Hormone Deficiency

Diabetes is something which has become so common over the past few decades and this is said to be a cause of worry as most people don't understand how to prevent and manage it. This has led to some myths, gaining more than their fair share of popularity. So, wouldn t it be a good idea to get to know a little more so as to separate the myths from the facts?

Weight & watch: One of the most common myths when it comes to diabetes is the belief that a person is going to have his or her life adversely affected if he or she is overweight. While it is true that being overweight happens to be one of the risk factors related to diabetes, it is important to keep in mind the fact that there are other risk factors which are responsible, as well. Some of these factors are age and family history, as well as the ethnicity of the person. Taking this into account, it should not come as too much of a surprise to know that there are quite a few people who are not overweight, but are still fighting diabetes.
Packaged tricks: Considering the rise in the number of people who are suffering from diabetes, this has led to food being marketed specifically for their consumption. However, in reality, whatever represents a healthy diet is sufficient for a person who is diabetic. So a diet which does not have a high amount of saturated fats and trans fats and does not go overboard with starch and sugar, but features a fair amount of lean protein works well too. All the fancy diabetic food, which a person buys, is only likely to drive a great hole in the wallet and not have any additional health benefits. Therefore, the extra spending is nowhere close to being worthwhile and should be avoided.
Fruits punch: Many people are of the opinion that it is the processed and sugary food items, which cause diabetes and this is true to a significant extent. However, some people are of the view that since fruit is natural, diabetics can eat as much of it as they like. This is where the thinking gets dangerous. Some fruits are rich in carbohydrates and so it should be consumed in a reasonable quantity, as part of the daily meal plan. After all, too much of any good thing is bad!

Diabetes - 3 Myths Decoded!

Spitting up, refusing to try new foods and occasionally turning up their noses at feeding times, is normal but consistently refusing food and water, vomiting and allergies may indicate an underlying medical condition that requires attention. Common feeding problems that affect infants include sucking, prolonged chewing without swallowing, holding food in their mouth and grabbing food. Infants who are unable to close their mouths in order to keep food inside may also be said to be suffering from feeding problems.

Feeding problems could be triggered by medical conditions like a cleft palate, premature birth, respiratory problems, low birth weight etc. or by non-medical reasons such as the child s feeling of being unloved or stressed. Symptoms of feeding problems vary from infant to infant. However, some of the common symptoms exhibited are:

Problems with chewing

Excessive drooling

Refusing to eat foods or drink liquids

Long feeding times

Coughing or gagging while feeding

Difficulty with breast or bottle feeding

Nasal stuffiness while eating

Poor weight gain

Recurring respiratory infections

Vomiting or excessive spitting up of food

Arching the back while feeding

Disinterest in feeding

Though feeding problems are minor in most cases, it is important to consult a doctor if this behaviour continues over a period of time. This is because the child may be suffering from an underlying medical condition or could be at an increased risk of suffering from dehydration, aspiration and lung problems. It could also lead to delayed physical and mental development, speech problems and cognitive issues.

Feeding problems are addressed in many different ways. The first step to dealing with feeding problems is to change the texture and temperature of food being given to the baby. In addition, try changing the posture of the baby while feeding.

In some cases, mouth exercises may be needed to strengthen the mouth muscles. Chewing exercises and tongue movement may also help reduce feeding problems.

Encourage your infant to try different types of food by including different textures in their daily meals. Alternating food textures and liquids can make it easier for the infant to swallow the food. Do not force your child to eat in a hurry but let him or her take their own time.

In cases where the infant is not gaining weight, the doctor may suggest nutritional changes and a specific diet to help gain weight. In emergency cases, hospitalisation may also be required and your baby may be given a feeding tube to ensure he or she receives adequate nutrition.

12 Signs Your Child Is Not Eating Properly!

The habit of thumb sucking is very common in many toddlers and babies, but often disturbs the parents to a great extent. Before dealing with this habit, it is very imperative for parents to understand the cause of this behavior. The tendency of thumb sucking is quite normal for the babies as it makes them feel comforting.

Problems that occur with thumb sucking
There are certain problems that occur if the baby develops the habit of prolonged thumb sucking. The problem that occurs mainly on sucking the thumb for longer time is with the teeth of the toddlers which may result in speech problems. Some babies get over this habit of thumb sucking on their own without any adverse after affects. However, sometimes prolonged thumb sucking may result in irritation on the skin or lead to peeling off of the skin, causing discomfort and pain to the child. There are chances that even the nails on the fingers grow in a crooked manner because of infection caused by thumb sucking.

How to get your child to leave thumb sucking habit?

Parents must in any case not force their toddlers to stop this habit or get upset with them, as it can cause the toddler to develop this habit all the more.
A child mainly sucks his thumb for comfort, and the habit can be stopped by diverting their mind and offering the child a soft toy or giving them a special blanket.
It is better to give the toddler something to hold which makes him feel secure and comfortable.
It is very important to assess whether it is a problem before stopping the habit of thumb sucking. But if the habit continues, it may affect the alignment of the teeth.
It is always better to make use of ways like positive reinforcement and encouraging behavior change in your child. Parents must set up a reward system and take a note of the days the child does not suck his thumb. It is important that parents praise their child verbally and give them some reward at the end of the month.
The best and simple way to quit the habit of thumb sucking is to cover the thumb with a thumb guard or mittens.
The best way to help your child quit the habit would be to distract him or her and involve them in activities that would require the use of both the hands. Parents can keep their child busy by giving them puzzles or blocks to play.

Thumb-sucking Habit - 7 Things to Keep in Mind!

There is always a sense of anxiety, whenever we tend to start off with something new, as people are resistant to change. It is more so in the case of young children. School refusal refers to the refusal of children to attend school as a result of emotional distress. This school refusal can wreak a kind of havoc on families.

Elaborate on symptoms a little more and causes

Symptoms

There are certain symptoms related to the refusal of children to attend schools. They include:

Often it comes in the form of tantrums
Frequent complaints of stomachaches, vomiting, nausea, exhaustion, headaches or diarrhea
There could be loud meltdowns in an overwhelming manner, which include their refusal to leave the house, running down the street to avoid getting inside the car or on the school bus
Children might even become aggressive and lash out at their parents with physical blows
Child feeling fearful of being alone in a room or dark


Causes

Some of the primary causes include:

It arises out of students having a feeling of separation from their parents and homely atmosphere, hence, leading to anxiety
It comes out of an emotional attachment which children tend to have with their parents, especially mothers
Children tend to feel scared with the thought of getting into an unknown atmosphere all of a sudden.
Consistent fear of criticism, ridiculing, confrontation or punishment by the teacher or any other person in the school
Having learning difficulties
Being afraid of qualifying the tests
Not feeling comfortable with school activities like singing, playing or attending school assembly
Fear of being ridiculed due to appearance, clothes, weight, etc.
Fear of being bullied by a class or schoolmate
How Can Children be Helped to Get Rid of this Problem?

The ideal treatment to help all those children struggling with school refusal includes a team approach. It will be beneficial to have a strong team which includes the class teacher, family and if possible, a mental health professionals. The steps include:

1. Assess: The very first step is to complete medical and psychological examination. Given the fact that school refusal is usually linked to an underlying anxiety or depressive disorder, it is necessary to get to the root of the problem and begin there. This would include both family and teacher questionnaires for interviews.

2. Cognitive Behavioral Therapy: This is a very structured form of therapy, which helps children to identify their maladaptive patterns of thought and also learn replacement behaviours. It would help children to confront and work through their anxiety.

3. Desensitization in a Systematic Manner: Those children who struggle with school refusal, need a graded approach to return to school. They can return for a some increased amount of time and then gradually build upon it.

4. Training for Relaxation: This is extremely essential for all those children who struggle with anxiety. Some of the relaxation strategies include deep breathing, guided imagery and mindfulness, which kids practice at home and also utilize in school.

5. Plan for Re-entry: The treatment team even creates a plan to help children re-enter the classroom. The plan includes contingencies to help the student during anxious moments throughout the day.

6. Routine and Structure: Children who are anxious can even benefit from routines at home that are predictable. Establishing healthy sleeping habits and a regular sleep cycle during holidays and on weekends can yield positive results.

School Refusal - Symptoms, Causes & Treatments Of It!

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