Renal Tubular Acidosis is a medical condition. When the kidney is unable to acidify urine, it leads to the accumulation of acid in the body. Usually, when blood is filtered by the kidney, it passes through the tubules of the nephrons (the functional unit of the kidney).

Before it flows into the bladder from the kidney, the urine undergoes an exchange of salts, acids and other solutes. Renal tubular acidosis results in the formation of excessive amounts of acid because the kidneys cannot drain them. This may happen because the kidneys cannot reabsorb the alkaline bicarbonate ions from the urine in the early segment of the nephron or because of inadequate production of acidic hydrogen ions in the latter half of the nephron.

Renal Tubular Acidosis is simply associated with abnormal urinary acidification. Other functions of the kidneys remain unimpaired.
There are several different types of renal tubular acidosis-

  Distal Renal Tubular Acidosis (RTA)
This is the most fundamental form of RTA. It is characterized when the hydrogen ions are not secreted into the lumen of the nephron by the alpha-intercalated cells of the medullary collective duct of the distal nephron. When this happens the pH of urine cannot be brought down below 5.3. Renal excretion is inhibited and hydrogen ions are not eliminated which leads to academia. At the same time, Potassium ions cannot be absorbed by the cell which leads to hypokalemia. The end result is protein retention and potassium excretion. Distal RTA can lead to the urinary stone formation, calcium deposits in the kidney, rickets and osteomalacia and Sjogren s syndrome.

  Proximal RTA
When proximal tubular cells reabsorb 85% of filtered bicarbonates and 60% of filtered sodium from the urine, then this again leads to academia. The distal intercalated cells, however, function normally and so the academia is not as severe as in case of Distal RTA. The alpha-intercalated cells can acidify urine to a pH of 5.3 or less because they produce hydrogen ions. Proximal RTA is also associated with Fanconi Syndrome which is characterized by aminoaciduria, uricosuria, glucosuria, and tubular proteinuria.

  Combined distal and proximal RTA
Inherited carbonic anhydrase II deficit leads to combined distal and proximal RTA. This is accompanied by osteopetrosis, cerebral calcification, and renal tubular acidosis. Cases of combined distal and proximal RTA are very rare.

How is RTA understood?
The following steps are applied to analyze Renal Tubular Acidosis-
  Determining the anion gap in acidosis. The normal Anion Gap is 8-12 (4-6 mEq/L)
  Separating the renal from the extrarenal causes of normal anion gap acidosis
  Classifying the types of RTA
  If it is distal RTA, further tests will be necessary to support the diagnosis

How is RTA diagnosed?
Three types of tests can reveal if a person is affected by Renal Tubular Acidosis-
  Urine test
  Acid load test
  Physical examination

Treatment of RTA-
Doctors prescribe either or both of the following two types of therapies-

  Alkali therapy- The pH level of urine is restored and electrolytes are balanced
  Vitamin D supplements- If RTA leads to bone deformities or rickets, your doctor will prescribe vitamin supplements to strengthen your bones.

Timely diagnosis can prevent the effects of Renal tubular Acidosis from becoming compounded. With the right medication, a person can lead a healthy normal life.

What Should You Know About Renal Tubular Acidosis?

When dieting and exercising fail to help an obese person in managing his/her weight, bariatric surgery may be suggested. One of the most popular types of bariatric surgery is a gastric sleeve surgery or sleeve gastrectomy. The main aim of this surgery is to reduce the amount of food that can be consumed in one sitting. It does not affect the amount of nutrients and fats absorbed from the food that has been eaten. A majority of the weight loss resulting from this surgery happens within the first 6 months following which there is a slower weight loss over the next 6 months.

A gastric sleeve surgery is a relatively safe and short duration surgery. Prior to the surgery, you would have been given a special diet to be followed, the duration varies between one week to two weeks. It is essential to follow this diet strictly. This surgery may be performed laparoscopically, through tiny keyholes. More than half the outer side of the stomach is removed. The remaining part of the stomach takes the form of a tube. This surgery is not reversible. 

Recovery from a gastric sleeve surgery is quite smooth and varies from person to person. A certain amount of pain and discomfort is normal for the first and second day following the surgery. The patient is put on clear liquids for the first 2 weeks following surgery. Soft foods are introduced in week 3 and 4. You can get back to small amounts of your normal food in week 5. You will notice that you feel fuller much faster and are able to consume a very limited portion of your normal food intake. In some rare cases, your food may also be emptied into the small intestines at a very fast rate. This is known as dumping syndrome. This may cause diarrhea and nausea and leave you feeling weak. It is essential to drink plenty of water to allow for smooth bowel movements and to prevent constipation.

On an average, this surgery can help people lose between 60 to 90% of their excess body weight. However, this requires control over your diet and the amount of exercise you do. At some point in time, your weight loss may plateau. This is normal to overcome this, you must make a change to your diet or exercise schedule. A dietician can also help you address the right number of meals needed by your body. It is very important not to fall back to your earlier unhealthy lifestyle and to maintain a positive attitude.

Gastric Sleeve - Understanding The Course Of It!

What is adrenal gland tumour? Let's answer this question by first knowing the meaning of what a tumour is.

When many tissues grow in the body, some tissues start to grow abnormally and it forms a clot thing in the blood. These clots do not allow the body to function properly and hence, it is called a tumour.

Adrenal gland tumour is the type of tumour when some tissues join together and grow abnormally in the adrenal parts of the endocrine system. It forms a cyst there hence resulting in the swelling of that body part and is called as adrenal gland tumour. This tumour can be cancerous or maybe non-cancerous, depending on the functioning of the cells.

Adrenal glands are an important part of the body. These glands are present on the top of our kidney and are in triangular shape. It releases all kinds of hormones which are important for the metabolism of the human body. These hormones help the human body in many ways.

Causes of Adrenal Gland Tumour:

One of the main causes of adrenal gland tumour is the normal behaviour of any tumour. The tumour grows in the body and does not allow other organs to work properly, which results in many problems inside the body.

The tumour grows and grows and becomes a regular part of metabolism. It suppresses the other glands by not letting them do their work and obviously forming a cyst.

The other reason of these kinds of tumours can be that they release hormones which affect the body and may also result in cancer. These hormones are generally the androgens and estrogens which result in the early growth of many people.

Symptoms of Adrenal Gland Tumour:

People experience many symptoms before they get diagnosed with this tumour. These symptoms are clearly visible and one should take care of all the symptoms. If a person notices any of the symptoms, they should be directly admitted to the hospital.

The symptoms which are visible in a person having adrenal gland tumour are:

They might experience high blood pressure with a low potassium level.

They may experience heart palpitations, anxiety, or panic attacks.

The major signs are that they may experience abdominal pain, weakness, weight loss, or weight gain.

Other symptoms include abdominal stretch marks, excessive hair growth, changes in their genitalia, unusual acne, and also changes in libido.

Treatment for Adrenal Gland Tumour:

The adrenal gland tumour is mainly treated by surgery. The surgery is done by a specialist called endocrine surgeons. The surgery not only consists of many steps performed together by multidisciplinary team. They do the surgery and remove the cyst out of the body and also ensure that it does not return.

The surgery is known as Adrenalectomy, which removes a tumour from the adrenal gland. There is a team of endocrine surgeons who have come together to clear this tumour from the body.

Conclusion:

The adrenal gland tumour should be detected at an early stage so that it can be treated properly and cured at the right time. However, it is always advisable to consult the doctor or specialist before opting for any treatment or medicines.

Adrenal Gland Tumour - What Should You Know?

Cancer is the most dangerous disease noticeable throughout the world. The most common type of cancer that affects men is prostate cancer. Prostate is a small exocrine gland situated directly below the bladder and in front of the rectum. This is gland is approximately in size of a walnut and plays an important role in production of a milky fluid during orgasm of sex in which the semen travels. During the climax stage of the prostate gland is forced to push the fluid and remove the semen out of the reproductive structures.

Prostate gland is a slow progressive disease which makes many males left unidentified even the presence of prostate cancer even until they die. 6 out of 100 male over the age of 60 are getting prostate cancer. Though prostate cancer can be cured at a better rate when compared to other type of cancer it is always best to stay protected. Prevention is always better than cure. Here are few tips to keep your prostate healthy.

Signs and symptoms of prostate cancer-

During the early stages of prostate cancer there are usually no symptoms. Most men at this stage find out they have prostate cancer after a routine check up or blood test. When symptoms do exist, they are usually one or more of the following:

The patient urinates more often

The patient gets up at night more often to urinate

He may find it hard to start urinating

He may find it hard to keep urinating once he has started

There may be blood in the urine

Urination might be painful

Ejaculation may be painful (less common)

Achieving or maintaining an erection may be difficult (less common).

If the prostate cancer is advanced the following symptoms are also possible:

Bone pain, often in the spine (vertebrae), pelvis, or ribs

The proximal part of the femur can be painful

Leg weakness

Urinary incontinence

Fecal incontinence

Ways to have a healthy prostate  

Diet and weight   the most important factor is the diet to maintain a healthy weight. Avoid fatty food items and take fats from vegetables than from animals. Avoid dairy products and increase the intake of fresh fruits and vegetables.

Exercise   have a regular practise of doing exercise at least for 30mins a day. This really helps you to keep your body fit.

Be precautious   if you have a family history of prostate cancer or if you feel you are at high risk of getting prostate cancer talk with your doctor about it and take preventive drugs as per the doctor s advice.

Red foods   research shows that men who consume red foods like watermelon, tomato and other red fruits are at lower risk of getting prostate cancer as they contain a powerful antioxidant called lycopene

Caffeine   three to four cups of coffee per day reduces your risk of getting prostate cancer.

Stop smoking   if you are at high risk of getting prostate cancer it is best advised to quit smoking and alcohol.

Prostate Cancer - What To Expect

Gastric bypass is a kind of bariatric surgery, which helps in weight loss. This surgery aims to make changes so that your stomach becomes smaller than it used to be. This limits the amount of food you consume and effectively helps you to reduce weight.

Are you fit for the surgery?

Not everybody can go in for this surgery. Your doctor will recommend this surgery after careful evaluation. These are the parameters based on which your doctor will make a decision-

  Your medical history - If you suffer from sleep apnoea, heart ailments, liver diseases, kidney stones or if you have blood clots then you might have to undergo the surgery.

  Your psychological status - Sometimes obesity is the outcome of certain psychological ailments. A doctor will first ensure that these conditions are addressed before you go under the knife.

How is the surgery performed?

Gastric bypass operation is performed under general anaesthesia so you will be asleep for the entire duration of the surgery and it will be pain-free. The surgery is done laparoscopically. Tiny incisions are made through which scope and fine surgical instruments are introduced into the abdominal cavity. The camera guides the surgeon by providing live images from inside the body. Laparoscopic gastric surgery is advantageous because the wound heals faster and does not leave any marks.

Sometimes your surgeon might opt for an open surgery where she/he makes a large incision to reach the stomach.

There are two major steps to the surgery-

  The aim of the surgery is to make the stomach smaller so the surgeon divides it into two portions with staples. The food that you eat will go into the upper part (the pouch) of the stomach. The reduced upper stomach can hold at the most 28 grams of food so you are forced to eat less than usual. This will help you lose weight.

  The other step is the bypass surgery. After the pouch is created, the surgeon links it to the small intestine through the small hole in the pouch. This way, food will pass directly from the pouch to the small intestine. The surgery takes around 3-4 hours. You will be kept under observation for a couple of days and you will be released from the hospital in a week.

Gastric bypass operation is an effective and simple surgery that can help you reach your weight goals when you have a very high BMI and most other dietary restrictions have not been successful.

Gastric Bypass Surgery - Everything You Should Know!

A mammogram is an imaging test where an X-ray is taken to recreate the internal imagery of your breasts. This is a screening test that is widely used to find the earliest signs of cancer. There have been instances where the early signs of cancer have been found up to three years before the actual development of the same. There are a number of benefits and risks in this screening method. So let us find out more about getting a mammogram, and whether or not you should get one.

    Procedure: A special X-ray machine is used for conducting a mammogram. There is a clear plastic plate on which the specialist will place the breast while another plate will press on the breast from above. While both the plates serve to flatten the breast and hold it still, the X-ray will be taken. Some pressure will be felt and the same steps will be repeated so as to get the side view of the breasts. The same procedure will be repeated for the other breast. Meanwhile, once it is done, you will need to wait so that the technician can check for clarity, and whether or not the procedure needs to be done again. The results of this procedure cannot be relayed by the technician, and all the images will be different because all breasts are slightly different from each other.
    Preparation: You will need to remember that the process can be a slightly painful one, especially once the pressure gets applied. Many women complain of discomfort and pain. Yet, this discomfort gets over before you know it. The pressure and pain will depend on the size of your breasts and how much they will have to be pressed in order to get a picture. The skill of the technician will also come into play here. One must remember not to get this procedure done a week or so before or after the menstrual cycle, as the breasts tend to be tender around this time, and the pain will be much more.
    Radiologist: Within a few weeks after the procedure, the radiologist will usually deliver the result. This is the professional who does an accurate reading of the X-ray.
    Normal and Abnormal Readings: If your mammogram result has a normal reading, then you can resort to getting one done every once in a while. But an abnormal reading will require further X-ray and tests so as to be able to tell for sure.
    Why should I get one: If you are over 40 and have a family history of such ailments, then you will have to get a mammogram done regularly.

Should You Get a Mammogram?

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