Alzheimer's disease is a neurological problem that is characterised by a cognitive decline and memory loss. It is a type of neurodegenerative dementia. The symptoms of alzheimer's disease include not being able to absorb and retain new information, lack of reasoning and judging, not being able to take on complex tasks, impaired visuospatial abilities, problems in reading, writing and speech, among many others. If a person has at least two of these symptoms in a debilitating manner, then the diagnosis can be made in favour of alzheimer's disease. The main causes of alzheimer's are shrinkage of the brain size and death of the brain cells. The immune system is also said to trigger this neurodegenerative disease. Let us find out what medical science has found so far.

1. Connections: many a times, in alzheimer's disease, the memory and behaviour of the person changes because the brain is unable to make proper neural connections which can lead to memory loss of how a person behaved and the elements that formed the basis of the patient's cognition. Apparently, the immune system behaves in the same way within the brain and blocks the connection. This happens because there is constant communication between the brain and immune system along neurological lines, which is where the disease first emanates.

2. Inflammation: the brain is prone to inflammation or swelling that is not the normal kind. This inflammation happens as a result of the activation of the infection fighting neurotransmitters and the chemical changes that happen in the brain when an infection strikes. The inflammation usually happens in the plaques or clumps which the brain tries to protect. These clumps are made up of a protein called amyloid. The immune system is responsible for creating this inflammation in the brain of the patient.

3. Pattern recognition receptors: many of these receptors work in different manners and cooperate with each other to create a response in the brain. These prrs can be found in the brain plaques, and they develop the signs of danger which further fuels the inflammation in the brain as a matter of protection.

4. Activation of cells linked with the immune system: when the prrs begin to respond, it basically activates the immune system and the cells of the same. This is the basic reaction that causes the changes in brain which then leads to the attachment of the protein to the tissue that is diseased, in which case alzheimer's disease starts. The inflammation that we had spoken about earlier basically happens in the nervous tissue.

It is important to recognise and act on the initial signs of alzheimer's disease before it progresses beyond one's control.

Can the Immune System Trigger Alzheimer's Disease

The skin is an elastic organ (yes, it is an organ!), but only to a certain extent. It has a limit to which it can accommodate the underlying tissues. With the increase in bulk, for example, puberty, pregnancy, muscle mass building or surgical implants, the skin is made to stretch beyond its limits. What happens is this stretch causes the skin to stretch too, and these stretch marks or striae become an unpleasant thing that needs to be hidden. 

Dressing needs to be changed so that they are not showing. Dermatologists see a big demand for getting rid of these marks too. There have been conventional, time-tested methods which help in getting rid of these. However, with newer advancements in dermatology, the platelet rich plasma is being widely used for getting rid of these stretch marks.

Why stretch marks? 

In any of the scenarios above, the stretch marks appear because there is a lack of underlying supportive tissue when it is stretched out. There is a lack of collagen and connective tissue, causing stretch marks. These are most evident in fat collecting areas like breasts, abdomen, thighs, upper arms, etc.

What is platelet-rich plasma or PRP? 

The blood is composed of a liquid portion known as plasma, which contains three main types of cells i.e. white blood cells, red blood cells, and platelets. The white blood cells are the ones responsible for fighting infections. The red cells give blood its color and also are responsible for carrying nutrients to the various organs. The platelets are tiny fragments of cells which help in blood clotting. Platelets are also rich in what are called totipotent cells, which can grow into any type of cells. When the body is affected, due to injury, infection, trauma, etc., these get concentrated in the affected area and are produced in large numbers to help in the recovery of the particular affected area.

Technique: 

The area to be treated is isolated and prepared. Blood is centrifuged to remove other cells and obtain platelet rich plasma. This RPR is injected into the underlying layers of the skin. This induces the release of growth factors into the connective tissue space. Collagen is produced over a period of time, which causes the skin to become taut and lose the stretch marks. The injection can be repeated if required on the topmost layer. It can also be mixed with thrombin to form a gel, which is then used similarly. Using it both in the underlying and superficial layers helps in completely getting rid of the marks.

Studies have shown a reduction in both the depth and size of the stretch marks and some might require two to three repeat injections.


Stretch Marks - How PRP Therapy Can Help You?

Ageing is inevitable, and as much as we want to escape, there is no way out. All organs, whether obvious or not, undergo gradual degeneration and deterioration. The brain is no exception, and memory being one of its main function also begins to decline with age. There are various factors which determine how quickly this ageing sets in and how rapidly it progresses. These are dictated by a person s lifestyle, activity levels, and overall body changes. Dementia also has a strong family history, and if you know someone who has a family history, there are some early signs that you could watch for. This will help in both empathizing with the person, as well as to help in arresting progression. Read on to know the signs that need to be watched out for.

Mood changes: Sudden changes in mood, especially going into short periods of depression without an obvious reason, is one of the first symptoms of dementia. If it is happening repeatedly, this can help identify dementia.
Personality changes: If a shy person suddenly becomes outgoing or vice versa, this could be an early indicator of dementia. They either develop or shed inhibitions, which is a new change for them.
Memory loss: Sudden short-term memory loss for a person who had a very strong memory is a definite indicator of dementia. They might clearly remember the distant events but forget small things like where to find their medicines, where things are in the kitchen or bathroom, etc. Because of this, you might see them repeating what they just did. This could be like washing a glass again, saying or asking the same thing again, etc.
The difficulty with regular tasks: Short-term memory loss causes difficulty with regular tasks like laying out the dinner table, finding regular medicines, paying utility bills, etc. There is also difficulty in learning new tasks, which further complicates things.
Feeling lost: Due to sudden memory loss and difficulty with regular tasks, they suddenly feel lost, which in turns adds to their depression.
Apathy: This also leads to a general lack of interest in things and people around them. They could have had hobbies, which no longer interest them.
Disoriented: They find it difficult to be aligned to time and space. Directions which they clearly know could seem difficult.
Not able to connect the dots: While the elderly people are generally good at telling stories and anecdotes, with dementia setting in, this becomes difficult.
These are some symptoms which can help identify if a near one is slowly developing dementia. Identifying in the early stages can help in arresting progress and extending support.

Dementia - How To Know If Someone Is Suffering From It?

Firstly, what you need to realise is that Alzheimer s is not dementia and the main point you need to remember about the difference between the two is that the former is a disease while the latter is a syndrome. Alzheimer s is a neurodegenerative disease, it breaks down the cognitive functions of the brain and reduces a person s ability to function properly. It s one of the foremost reasons for untimely senility in middle-aged to old-aged persons.

It can be a scary time for the patient themselves as well as for friends and family alike but fear not, there are ways to reduce the chances of suffering from this painful predicament. Here are a few easy hacks to keep in mind to stave off the risk of Alzheimer s:

Fix your diet: Cut down on saturated fats and construct a diet combining lots of healthy vitamin and mineral rich foods, fruits and vegetables. Vitamin E is essential as well as vitamin B12 which can also be taken in the form of supplements. Vitamin E can be found in foods like spinach and even nuts. Rush University Medical Centre in Chicago has, after a lot of research, developed the MIND and DASH diets. The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet collates portions of the DASH (Dietary Approaches to Stop Hypertension) diet to create the perfect combination that has been shown to reduce the risk of Alzheimer s by 53 percent.
Exercise mental and physical: A sedentary lifestyle is one of the major causes of Alzheimer s because it leads to slower brain activity and an overall unhealthy lifestyle. To break out of this you need to regularly exercise and not just physical exercises but also mental exercises such as solving mental maths and crosswords and reading books and newspapers. There are a lot of apps concerning games that help boost brain activity on the market that can help as well. Physical exercise can include swimming, brisk walking, joking and even gardening.
Reduce stress: Stress proves to be a huge issue for the brain contributing to its damage by putting a lot of pressure on it. Try to relax more by improving your sleep cycle, resting as and when required, and not overworking yourself.
Aromatherapy: Essential oils have been shown to work wonders, by reducing stress and relaxing the mind. Lavender, rosemary, lemon and even orange are some great options you can try out. These oils can help rejuvenate damaged brain and nerve cells.
Meditation: Studies have shown that regular meditation helps boost grey matter in the brain, and along with yoga, keeps the minds and bodies of middle-aged people active and better focused contributing to the overall health of the brain.

Life Hacks! How To Beat Alzheimer's

Alzheimer's disease is a neurodegenerative disorder that causes a degradation and eventually death of the brain cells. People with Alzheimer's disease suffer from a memory loss. There is also a progressive decline in the cognitive capacity of the brain.Today, Alzheimer's disease and dementia have become almost synonymous with old age. It is a heartbreaking experience to see aged people with Alzheimer's disease. They have little or no memory of the present time, of their loved people or the things around them. 

The Alzheimer's disease starts off as a mild condition and then gradually progresses through stages. In this article, we will discuss the different stages associated with Alzheimer's disease.

The first stage: This stage shows no significant changes in the affected person. Thus, without any diagnostic tests (such as a PET scan), it will be difficult to detect the condition in the initial stage.
The second stage: This stage brings about some changes in the person. The person might misplace things or may even forget words (something that is often brushed aside as a small problem). However, this seldom interferes with their daily activities. Like the first stage, this stage, in most cases, goes unnoticed.
The third stage: This is the stage that brings about visible changes in the person concerned such as
The person experiences difficulties in trying to organize things.
They forget things they have read, or heard just a few seconds back.
In some cases, the person may not be able to recollect a person's name they have just met.
Some people may end up repeating the same question over and over again.
The fourth stage: This stage marks a further decline in the mental health. The person gets forgetful about himself or herself. They also start mixing up with the dates and months or makes major goof up while cooking (misses out on ingredients).
The fifth stage: The mental deterioration reaches a step further. The person slowly starts forgetting about the present, such as their address, the time of the day, their profession and even phone numbers.
The sixth stage: The problem is getting worse. Hallucination is slowly setting in. The person is starting to forget people and their faces, mixing one identity with another.
The seventh stage: The final and unfortunately, the worst stage. The person stops talking to people, eating, or even walking. They stay confined to their world, oblivious of their immediate surrounding.
Dealing with an Alzheimer patient

In addition to the treatment and medication, a person with Alzheimer's disease needs the love, care, and support of their close and dear ones. Isolating them will only worsen the situation.
It may not be easy to deal with an Alzheimer's patient as the disease progresses, but do not be rude to them. Give them the confidence.
Always keep a paper containing their name, address and emergency contact number in their wallet.
People after the age of 50 should undergo regular health check ups.

Alzheimer's - How The Disease Progresses?

Dementia cannot be singularly regarded as a specific disease, but rather indicates a group of symptoms associated with your memory, cognitive thinking, and social abilities, up to the point where daily functioning gets affected. In most cases, dementia steadily worsens over time (progressive dementias). Dementia is not to be confused with memory loss alone; because it is natural with old people to experience memory loss, but that does not necessarily mean they have dementia. If the reason is dementia, then you may require medical treatment.

Causes

Dementias are generally caused either by damage to or changes in the nerve cells operating in the brain. The causes can be grouped differently based on the type of dementia experienced and the part of the brain affected. While some causes can be reversed with effective treatment, others, unfortunately, cannot.

The most common causes of dementia which cannot be reversed include:

1. Alzheimer's disease
2. Vascular dementia
3. Parkinson's disease
4. Frontotemporal dementia
5. Dementia with Lewy (dementia which is neurodegenerative and progressive in nature) bodies
6. Severe head injuries

Other irreversible causes which are relatively rarer than usual include:

1. Huntington's disease (breakage of the brain's nerve cells)
2. Creutzfeldt-jakob disease (irreversible and fatal brain disease)
3. Multiple sclerosis or amyotrophic lateral sclerosis
4. Infections like syphilis
5. Leukoencephalopathies (diseases affecting the brain's'white' areas)
6. Brain injuries
7. Multiple system atrophy

Causes of dementia which can be treated include:

1. Hypothyroidism
2. Heavy metal poisoning
3. Certain brain tumors
4. Chronic alcoholism
5. Hiv/aids
6. Vitamin b12 deficiency
7. Medicinal side effects or abnormal drug reactions
8. Normal pressure hydrocephalus
9. Certain cases of encephalitis

Symptoms

Symptoms of dementia include:

1. Memory loss
2. Difficulty finding the right words
3. Difficulty exercising judgments, especially during emergencies
4. Inability to recall particular events or to recognize people and places
5. Depression or other mood disorders, in addition to symptoms like uncontrolled aggression or constant agitation.

Causes and Symptoms of Dementia

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