World sickle cell day is observed annually on the 19th of june to raise awareness of sickle cell-related diseases. It is observed to increase people's knowledge and the understanding required to face the challenges posed by the disease.


 

What is sickle cell disorder (scd)?

Sickle cell disorders or sickle cell diseases are genetic blood disorders that cause an abnormality in the red blood cells. The rbcs turn into sickle-shaped cells that stick together and block the blood flow in the body.


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Types

There are four major classifications of sickle cell diseases-


	
	Hemoglobin ss disease
	
	
	Hemoglobin sc disease
	
	
	Hemoglobin sb+ thalassemia
	
	
	Hemoglobin sb 0 thalassemia
	



 

Symptoms

One can start noticing symptoms of sickle cell in a patient at around 6 years of age. However, they can differ from person to person. Some of the most typical symptoms are-

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	Anemia
	


A shortage of red blood cells occurs due to the excessive early dying in 10-20 days. It leads to an oxygen shortage in the body.


	
	Excessive pain
	


Blockage of blood flow due to the change in shape leads to periodic cycles of pain in the body.


	
	Swelling in the body
	


As the blood circulation becomes irregular, swelling becomes a regular phenomenon.


	
	Infections
	


Sickle cell can be damaging to the spleen. It increases the risk of ailments in the body that can be prevented only by antibiotics.


	
	Delayed puberty
	


Oxygen and nutrients carried by the blood are required for growth. As a reason, irregular blood flow can lead to slow growth or delay in puberty.


	
	Vision issues
	


Infected blood vessels carrying blood to the eyes can cause damage to the retina. It can lead to visual problems.


 

Traits and treatment

As sickle cell is genetic, it is suggested to take a test that can detect any trait of the disease. It can prevent any life-threatening risks to the newborn. However, we don't have a complete cure for sickle cell disorders. There are preventive measures that reduce the adversity of the disease to an extent. Procedures like blood transfusions help greatly in minimizing the effects of the disorder.

World Sickle Cell Day: Know All About Sickle Cell Disease

As the name suggests, kidney cancer, also known as renal cancer, starts in the kidneys. It occurs when the healthy kidney cells grow out of control and become malignant to form cancerous tumours. ;Renal cell carcinoma is the most common type of cancer affecting the kidneys  here cancer begins in the lining of the tubes of your kidney.

Risk factors of kidney cancer

The exact cause of kidney cancer is not known. However, studies suggest that certain factors can make you susceptible to renal cancer. These include  


	
	Smoking
	
	
	Overuse of certain medications
	
	
	Excessive body weight
	
	
	Genes/heredity
	
	
	Gender   men rather than women are prone to kidney cancer
	
	
	An underlying health condition, such as ;high blood pressure
	


Early signs of kidney cancer

The symptoms of renal or kidney cancer depend on its types. In most cases, the disease does not exhibit noticeable symptoms in its early stages. This makes the diagnosis of cancer difficult. However, the signs become more apparent and observable as cancer starts to metastasize. You should watch out for these signs of kidney cancer -


	
	Bouts of blood in the urine   a condition commonly known as haematuria
	
	
	Pain on one side of the lower back (near the kidneys)
	
	
	A lump or mass on the lower back or side, where your kidneys are located
	
	
	Loss of appetite
	
	
	Tiredness or ;fatigue
	
	
	Unintentional weight loss
	
	
	Fever ;that does not cure in days
	
	
	Anaemia   low count of the red blood cells
	
	
	In men, a cluster of enlarged veins called varicocele may develop around the testicles (particularly around the right testicle), indicating the presence of a large tumour
	


Often, these symptoms are mistaken for those of other conditions or diseases. Therefore, it is important to consult a specialist.

If you encounter the above symptoms, or if you are concerned about any changes that you have been experiencing lately, talk to your healthcare provider. A doctor will enquire about the symptoms and might ask you questions related to these signs   how long have you been experiencing them, or how severe is the pain etc. This is crucial for early diagnosis and treatment of kidney cancer.

Know How To Detect Kidney Cancer Early

People suffering from sickle cell disease (scd) usually start showing symptoms very early. They can appear to show up even during the first year of life. Symptoms of a sickle cell vary from one person to another and can be mild to serious depending on the condition.

 

Sickle cell disease is a health condition that worsens with time. Despite the absence of any full-proof solution, some treatments prevent further complications. These treatments can help patients receive aid for a lifetime. Simply said, sickle cell diseases can be managed medically.

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Treatment

Treatment in a sickle cell patient depends on the severity of the symptoms. Preventing complications and relieving pain is the primary aim of the diagnosis. They can range from medications to blood transfusions.

 

Concerns

Some of the concerns that need to be taken care of during the treatment of scd are-

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	Prevent painful scenarios
	


A painful episode or sickle cell crisis can be avoided by consuming sufficient fluids, wearing warm clothing, and staying away from sudden temperature changes.

 


	
	Avoid infections
	


Children with sickle cell anemia are made safe from infections by using penicillin. Adults with anemia might need to take penicillin all their lives. Doctors should ensure that all vaccinations in children and adults are periodically done to avoid any infections. However, during the covid-19 pandemic sickle cell patients should take extra care.

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Medications

While there can be numerous ways to manage sickle cell treatment, medications help in a significant way. Some of the prescribed medicines are-


	
	Hydroxyurea- it reduces the frequency of sickle crises. Pregnant women should stay away from this according to experts.
	
	
	Crizanlizumab- this drug injected into the patient can help reduce the sickle crises in adults and children over the age of 16.
	
	
	Voxelotor- it is an oral drug used in children over 12. It lowers the risk of anemia by improving blood flow.
	
	
	Pain-relievers- narcotics to prevent excessive pain can also be used during the treatment.
	


 

Surgical procedures


	
	Blood transfusion
	


It is used to prevent stroke and other related complications in patients. This can increase the number of red blood cells in the body that can help reduce the symptoms.

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	Stem cell transplant
	


It is also called a bone marrow transplant and is used to replace affected bone marrow with a healthy one. This procedure is carried out between matched donor and recipient. Although it is a known cure for sickle cell disease, various risks involved make it a less used practice.

 

Can Sickle Cell Be Cured?

The world celebrates world blood donor day on the 14th of june to raise awareness of the need for safe blood and blood products and to thank voluntary and unpaid blood donors for their life-saving gift of blood. 

Importance of blood donation

The importance of donating blood is not only to save the lives of thousands of people who are deprived of life but also to save the lives of many more who are affected by the various diseases. ;

 

It has also been seen that when people; e have donated their blood, they have gained many health benefits as it helps in weight loss, helps maintain healthy liver and iron levels, it helps reduce the risk of heart attack and cancer. ;

 

A blood donation can save a life of- ;


	
	Victims of natural disasters, including earthquakes
	
	
	Patients with hemophilia, sickle cell disease, or cancer
	
	
	People who suffer traumatic injuries from being in a car accident
	
	
	Surgery patients
	
	
	Shooting or stabbing victims
	
	
	Women who suffer complications during childbirth
	


 

Blood types that are needed most

It s good to donate if you re healthy. However, there s always a need for specific blood and plasma which are universal and can be used when a patient blood type is unknown. For newborn infants or if a patient's particular blood type is unavailable.

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	Type o negative blood is always needed because it can be used in patients regardless of their blood type.
	
	
	Type ab positive plasma can also be transfused to patients with other blood types. 
	


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Donations are constantly needed

Because of their short shelf life of 5 days after being collected, platelet donations are constantly by the blood blank. Red blood cells also have a short shelf life and needed to be used within 42 days after the collection. Cryoprecipitate and plasma can be frozen and stored for up to a year after donation.


 

Some misconceptions about blood donations


	
	The donor will not experience any kind of pain while donating. ;
	
	
	There will be no scarcity of blood in the body after donating the blood as even after the donation the body will have a surplus quantity of blood. 
	
	
	The common misconception everyone has is that they will faint after donating their blood. ;
	
	
	You will be able to resume your everyday activity immediately after donating the blood. 
	
	
	You will not get infected with aids if you donate your blood. ;
	


 

Donating blood is a great way to give back to your community and potentially save a life by only giving up an hour of your time.

World Blood Donor Day: How Can We Save Life By Donating Blood?

Cervical cancer is a ;cancer that affects the cells of the cervix in women. The cancer is believed to be caused by exposure to human papilloma virus (hpv). Also, there are certain factors that are linked to an increased risk of acquiring hpv and developing cervical cancer.

What Are The Major Risk Factors Of Cervical Cancer?

The most common forms of diabetes ;are type 1 and type 2 diabetes. In type 1, your immune system damages the cells inside the pancreas that produce insulin. Therefore, the pancreas are unable to produce an adequate amount of insulin.

In type 2 diabetes, your body does not respond properly to the insulin produced by the pancreas. As a result, your body will have a difficult time removing sugar ;from the blood. The cells may stop insulin production over time that may lead to insulin deficiency. However, there are other forms of diabetes that are lesser-known but can affect you just as bad.

Types of diabetes beyond type 1 and type 2

Gestational diabetes

In gestation diabetes, a condition that affects pregnant women, the blood sugar levels increase to an extent that may hamper the health of the mother and the child.

Symptoms

Usually, there are no symptoms as such. If diabetes worsens, women may observe symptoms such as -


	
	A need to pee more frequently
	
	
	Excessive thirst and hunger
	
	
	Dryness in the mouth
	


Lada (latent autoimmune diabetes in adults)

It is sometimes referred to as type 1.5 diabetes. Here, your immune system kills the insulin-producing cells inside the pancreas. As this condition takes a longer period to develop, you may not need insulin for many months after you have been diagnosed.

Symptoms

You may observe the following symptoms  


	
	Dryness and itchiness
	
	
	Tingling sensation in feet or hands
	
	
	Blurry vision
	
	
	Frequent urination
	


Mody (maturity-onset diabetes of the young)

This condition is observed during adolescence. Here, genetic mutations limit the pancreas from making insulin. So, due to insufficient insulin, your blood sugar level goes up. If any of your parents have mody, you are likely to have the condition.

Symptoms

Symptoms may include  


	
	Yeast and ;skin infections
	
	
	Frequent urination
	
	
	An urge to pee more often
	


Treatment

Primary care for these other forms of diabetes follows the usual course of treatment as with type 1 and type 2.


	
	Diabetic medications
	
	
	Insulin shots or injections
	
	
	Dietary changes
	


The doctor may instruct you to monitor your blood sugar levels frequently to keep it under control. This will be accompanied by a diet ;consisting of adequate calories, but avoid fatty foods, excess sugar and carbohydrates. Mild exercise is also recommended.

The best way to prevent these conditions is to visit your doctor frequently and follow the treatment plan. Do not keep your diabetes untreated.

A Sneak Peek Beyond Type 1 And Type 2 Diabetes

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