Causes and symptoms of acute tubular necrosis

Damage or destruction to tube-like structures known as tubules in the kidneys can bring about the development of acute tubular necrosis (ATN) and subsequently, acute kidney failure.

What causes acute tubular necrosis (ATN)?

A lack of supply of oxygen to the cells in the kidney is the most common cause of this condition. The reason as to why oxygen may not reach the cells and tissues of this organ could be restriction or blockage of the pathways. When this happens, the kidneys get damaged. Dehydration is the most important cause of ATN which may be because of loose motions, vomitings, heat stroke etc.

Health conditions such as diabetes, heart attack, and stroke can bring about a decrease in blood flow to the organs resulting in ATN and death of cells. Similarly, the presence of toxic substances in the blood can also lead to tubules damage and change the way the cells function in the tubules.

Other causes that may lead you to develop ATN may be medications, radiology dyes, anesthetics and chemicals that cause your body to react adversely.

In addition to these causes, a number of factors can put you at risk of ATN and there are:

- An injury to the body, more specifically your kidneys can cause clotting of the blood vessels
- An adverse response to blood transfusion
- Instances of septic shock can slow down blood flow to the organs
- A major surgery that can interrupt blood supply to the organs

What are the symptoms of the condition?

The symptoms associated with the condition can vary depending on the severity of the problem.

You may experience:

- Troubles in waking up
- Drowsy feeling even during daytime
- Feelings of lethargy
- Feelings of excessive thirstiness
- Problems with urination
- Fluid retention problems
- Instances of confusion
- Feelings of nausea



Can Acute Tubular Necrosis Cause Kidney Failure?

Kidney failure is happening even to 20-year-old Indians now! 4 Reasons why.

Usually more common in the elderly as a consequence of the chronic kidney disease, kidney failure is now increasingly becoming common amongst 20-somethings in the country. 

Why?
Mainly because of their unhealthy lifestyle habits, they are falling prey to a disease that normally strikes later on in life. 

Kidney failure, also known as renal failure, occurs when the kidneys stop functioning properly, that is, they are unable to filter out waste and toxins efficiently from the body. It is the most severe stage of chronic kidney disease. To ensure that toxins don't build up in the body, treatment usually involves dialysis (process for removing excess fluid and waste from the blood) or kidney transplant, among others. It is said that about 1 million people all over the world are on dialysis or are surviving on transplanted kidneys. The condition is permanent and can occur either very suddenly or slowly over time. 

These frightening habits of the young are leading to the rise of the incidence of renal failure:
1. A sedentary lifestyle - A research conducted by the University of Utah School of Medicine suggests that if you spend 80 minutes a day sitting, you see a 20% increase in the risk of developing chronic kidney disease and, in turn, renal failure.Sedentary behaviour can also increase your risk of diabetes, hypertension as well as obesity (causes of chronic kidney disease).India is said to have about 60% of patients who suffer from hypertension and diabetes also suffer from kidney problem. 

2. Poor eating habits - Studies suggest that the right diet consisting of fruits legumes, nuts, and whole grains can help in preventing kidney disease.On the other hand, a diet that is high in processed meats; salt and sugar can worsen the vicious cycle of high blood pressure, high blood sugar, and kidney disease. Furthermore, a BMI of over 30 can increase your risk of developing common kidney ailments by two-fold. With the proliferation of fast food outlets and junk food due to lack of time, Indians are increasingly now at a risk.

3. Smoking - Smoking brings about a decrease in blood flow to the kidneys, rendering the organs inefficient. When you smoke, the arteries of your body harden and the blood vessels become narrow, leading to a worsening of conditions like high blood pressure. A study by the John Hopkins University says that smoking can increase your chances of developing kidney disease by about 60%. Many young Indians view smoking as fashionable and some even take it up to 'look cool', to beat stress or just to blend in with their peers. 

4. Drinking alcohol - Excessive alcohol consumption can bring about significant changes to the way your kidneys may function. Your kidneys end up becoming less efficient at removing alcohol from the blood due to regular drinking. Additionally, more than 2 drinks a day has been found to significantly increase your risk of high blood pressure, a common cause of kidney disease.



20-Year-Old Indians Experiencing Kidney Failure! 4 Killer Reasons.

Often, early stages of kidney diseases do not come with specific signs and symptoms and most people will remain unaware of their condition. However, certain symptoms may be perceived that may indicate that a person is suffering from early stages of kidney failure. When you are diagnosed with kidney failure (also known as renal failure) in the initial stages, certain measures can be taken to retard the progression of the renal disease. This can also help reverse the condition and improve the quality of life of the patient. On the basis of a typical cause, the symptoms of kidney failure are grouped into specific categories that are given below. If you notice any of the specified renal failure symptoms, it is recommended to immediately fix up an appointment with your doctor and get your diagnostic tests done. 

Symptoms of Renal Failure from the accumulation of waste products in the body: 

Metallic taste in mouth 
Nausea and vomiting 
Facing difficulty in concentrating 
Loss of appetite 
Aversion towards meat (protein aversion) 
Itching or pruritus 
Symptoms of Renal Failure from the accumulation of fluid in the body: 

Dyspnoea or shortness of breath (this happens due to the accumulation of fluid in the lungs).
Swelling is seen in the feet, hands or face. 
Symptoms of Kidney Failure from damage to the kidneys: 

The amount of urine production changes, though it is not a reliable sign Haematuria or blood in the urine (usually in microscopic quantity). 
Frothiness or foam in the urine (usually happens when protein is present in the urine). 
Symptoms of Kidney Failure due to decreased blood production (anemia): 

Dyspnoea or shortness of breath. 
Fatigue Weakness. 
Confusion If you happen to feel cold all the time. 
The following diagnostic tests will be performed by your doctor in order to determine whether the symptoms are the manifestation of a kidney failure or not: 

Urine analysis - In this test, a sample of your urine is tested to find traces of blood, white blood cells or proteins which may indicate a problem in kidney function. 
Blood Tests - This includes tests for BUN and creatinine in the blood which are usually removed from the blood if the kidneys function properly. 
Actions must be taken when you show signs and symptoms of kidney failure: 

It is common that the symptoms of early renal failure are not always prominent, but if any of the above symptoms are witnessed, it is recommended to met a physician to determine whether they are caused by a kidney disease. You can pen-down the symptoms that you feel are related and bring it to the doctor when you fix up the next appointment. It is essential to know about your disease at the earliest as it will give you time and the ease of taking measures to retard the damage process and will decrease or delay the probability of undergoing dialysis or kidney transplant.

Kidney Failure - What Should You Know About it?

Most people believe kidneys to be organs solely responsible for the filtration of blood and production of urine. But the truth is that the kidneys perform a host of vital functions in the body which include regulation of blood pressure, blood volume, and blood Ph. Around half of the individuals affected by lupus suffer from kidney problems, and the most affected part is the glomerulus whose function is filtering substances from the blood.

Effects of lupus nephritis on the kidneys
Lupus itself doesn t lead to kidney infection or inflammation. But lupus nephritis, which is the Systemic lupus erythematosus (SLE) that affects the kidneys and the medications used for treating the condition tend to suppress the immune system. It makes the person affected with lupus vulnerable to the infections of various types. It is one of the most severe conditions of that could be encountered by a person wherein the immune system starts attacking various parts of the body as they would tackle a disease.

Lupus nephritis makes the kidney unable to remove the waste materials effectively from the blood. This leads to loss of control over the amounts of fluids regulating in the body. As a result, an abnormal amount of waste can build up in the blood resulting in edema or swelling.

When left untreated, these conditions can cause scarring along with permanent damage to the kidneys and end-stage renal disease. When a person has end stage renal disease, he or she needs regular filtering of the waste products of the body with the help of a machine. In severe cases, a kidney transplant may be required to ensure that at least one kidney is working properly.

Individuals who are susceptible to developing lupus nephritis:
A person with lupus may see the symptoms of lupus nephritis within 5 years and the people aged between 20 and 40 years are most vulnerable to it. In some common instances, it is seen that lupus nephritis is leading to unexplained weight gain along with swelling and puffiness in different parts of the body such as ankles, hands, eyelids, legs, and feet. During the first stages, these symptoms are often ignored which causes worsening of the condition. The urine may also become frothy or foamy with a reddish tinge in it. It is estimated that about 40 percent of children having lupus would develop kidney complications. Lupus nephritis may also cause increased urination, blood in the urine and elevated blood pressure.

If you have lupus, it is imperative to consult with a nephrologist. Testing a sample of the urine can help in showing the problems in the functioning of the kidneys. Your doctor will advise you about the diagnostic tests that can help in determining whether the disease has progressed to severe levels and start with the treatment process accordingly.

How Does Lupus Nephritis Affect Your Kidneys?

You're said to suffer from the problem of acute kidney failure if your kidneys suddenly stop working and lose their ability to eliminate waste materials including excess fluids and salts from the blood. The condition usually develops quickly over a few days or even a few hours. When this happens, waste materials accumulate in your blood, disrupting the chemical balance of your bloodstream.

So, what causes this problem?

Acute kidney failure can occur because of any one of these reasons:

1. A drop or slowdown of blood flow to the kidneys - Adequate blood circulation to the kidneys is of great importance as without it the kidneys may end malfunctioning. If blood flow to the kidney is hampered, a part of or the entire kidney may die. You may suffer from acute kidney failure if blood flow to the kidneys gets impaired due to conditions like

Heavy blood loss
Sepsis (body's inflammatory reaction to an infection, which can bring about organ failure, tissue damage, and death)
Injury
Use of certain drugs
Dehydration
Burns
Heart disease
2. Urinary obstructions - A sudden blockage that hampers your kidney's ability to eliminate urine can also bring about acute kidney failure. When this happens, it leads to a build up of toxins in the body, causing an overload of the kidneys. Conditions that bring about this urinary obstruction include:

Cervical cancer
Colon cancer
Bladder cancer
Kidney stones
Enlarged prostate
Prostate cancer
3. Disease within the kidneys - Even instances of clotting within the blood vessels of the kidneys can lead to acute kidney failure. This is because if the movement of blood cells within the blood vessels gets hampered, kidneys are not able to filter out toxins from the body. The conditions and diseases that may cause clotting, and subsequently damage to the kidneys include:

Scleroderma (an autoimmune disease that affects connective tissues and skin)
Build-up of cholesterol deposits
Glomerulonephritis (an inflammatory condition of the kidney's ball-shaped structures called glomeruli)
Hemolytic uremic syndrome (a condition that occurs due to untimely death of red blood cells)
Lupus (a disorder of the body's immune system that brings about damage to the body's own organs and tissues)

3 Causes of Acute Kidney Failure!

When your kidney function falls below a certain point, it is referred to as a kidney failure or renal failure. Fortunately, you can still continue to lead a normal life with the right treatment for renal failure. Here are the three best treatments that you can choose depending on your condition and lifestyle:

1. Dialysis: Dialysis is the process that takes over the function of your kidneys to filter out the waste from your blood and maintain the proper balance of chemicals in the blood. You may use dialysis for many years or as a short-term treatment while waiting for a kidney transplant. Dialysis is not a cure for kidney disease, rather it helps you deal with renal failure. It is life-saving and without it, the kidneys will no longer function.

There are two types of dialysis treatments that you can choose from:

Hemodialysis   This type uses a machine to remove waste from the blood and sends it back to your body. It can be done at home or at a dialysis center.
Peritoneal Dialysis   This type uses the lining of your belly called the Peritoneum to do the work of your kidneys. A catheter and dialysis solution is used to carry out the function.
There are benefits and complications for each type of dialysis. The treatment decision will largely depend on the patient s illness and their past medical history. Discuss with your doctor to decide the best option for you.

2. Kidney Transplant: Kidney transplants can provide a better quality of life than dialysis and can be seen as a potential cure for kidney failure. A healthy kidney from a live donor or deceased donor is surgically placed in your body as a replacement to the failed kidneys. Although this may be a better option for you, it has certain shortcomings. There is an element of rejection and you may have to wait for a long time to get a donor. Extensive testing and anti-rejection medications are prescribed with this treatment.

3. Palliative Care: Rather than cure, it is the care that people with serious illness need. With so much to deal with, the patients have an array of tough questions and challenges to deal with. Patients need to take into account all medical options and care options based on their condition and severity of the renal failure.

Making the right treatment choice is difficult and that too when you are ill. It is normal to be fearful and worried about the risks involved. Get support from your family and doctor to help you make the right treatment choice. It may also be helpful to visit a dialysis or transplant center to talks to others who have been through these treatments.

3 Best Treatments for Renal Failure!

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