World sickle cell day is observed annually on the 19th of june to raise awareness of sickle cell-related diseases. It is observed to increase people's knowledge and the understanding required to face the challenges posed by the disease.


 

What is sickle cell disorder (scd)?

Sickle cell disorders or sickle cell diseases are genetic blood disorders that cause an abnormality in the red blood cells. The rbcs turn into sickle-shaped cells that stick together and block the blood flow in the body.


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Types

There are four major classifications of sickle cell diseases-


	
	Hemoglobin ss disease
	
	
	Hemoglobin sc disease
	
	
	Hemoglobin sb+ thalassemia
	
	
	Hemoglobin sb 0 thalassemia
	



 

Symptoms

One can start noticing symptoms of sickle cell in a patient at around 6 years of age. However, they can differ from person to person. Some of the most typical symptoms are-

 ;


	
	Anemia
	


A shortage of red blood cells occurs due to the excessive early dying in 10-20 days. It leads to an oxygen shortage in the body.


	
	Excessive pain
	


Blockage of blood flow due to the change in shape leads to periodic cycles of pain in the body.


	
	Swelling in the body
	


As the blood circulation becomes irregular, swelling becomes a regular phenomenon.


	
	Infections
	


Sickle cell can be damaging to the spleen. It increases the risk of ailments in the body that can be prevented only by antibiotics.


	
	Delayed puberty
	


Oxygen and nutrients carried by the blood are required for growth. As a reason, irregular blood flow can lead to slow growth or delay in puberty.


	
	Vision issues
	


Infected blood vessels carrying blood to the eyes can cause damage to the retina. It can lead to visual problems.


 

Traits and treatment

As sickle cell is genetic, it is suggested to take a test that can detect any trait of the disease. It can prevent any life-threatening risks to the newborn. However, we don't have a complete cure for sickle cell disorders. There are preventive measures that reduce the adversity of the disease to an extent. Procedures like blood transfusions help greatly in minimizing the effects of the disorder.

World Sickle Cell Day: Know All About Sickle Cell Disease

What are the different types of sickle cell disease?

Sickle cell disease or sickle cell disorder is a term often used to talk about a group of diseases affecting hemoglobin. It is the oxygen-carrying element of blood that makes up 2 alpha globins and 2 beta globins. Sickle cell disease happens due to beta-globin mutation and depending on the abnormality in mutation.

Types-
Sickle cell diseases can be of many types depending on the gene mutation in the blood. Some of the common types are-

Sickle hemoglobin s disease (ss)
Hemoglobin ss disease or sickle cell anemia is the most popular type of scd. It takes place when hemoglobin s gene mutation is inherited from both mother and father. In simple words, it happens when the child inherits one substitution beta-globin gene from each parent. In this type, the body only produces hemoglobin s. It is mostly found in people of african and indian origin.

Sickle hemoglobin- c disease (sc):
Patients with sickle hemoglobin sc disease have a moderately dissimilar swapping in their genes of beta-globin. Here, both hemoglobin c and hemoglobin s are inherited from each parent. It may cause similar symptoms like anemia but remains relatively l. People of west african and mediterranean origin are more prone to this.

Hbs beta-thalassemia
People with this type of scd inherit one sickle cell gene s and one gene for beta-thalassemia from each parent. Zero and plus are the two common types of beta-thalassemia. While beta 0 thalassemia usually takes a severe form, beta + thalassemia is a milder form of the disease.

Sickle beta-zero thalassemia
Beta-zero thalassemia takes form when the child inherits the beta s gene from one parent and beta 0 thalassemia gene mutation from the other. With similar symptoms to anemia, it is a slightly severe form of beta-thalassemia.

Sickle beta-plus thalassemia
Substitutions in both beta-globin genes take place in patients with sickle beta thalassemia (sb) disease. This may even lead to the requirement of blood transfusion if no normal beta globin is produced. Mediterranean and caribbean people are more likely to have this disorder.

Hemoglobin sd, hemoglobin se, and hemoglobin so
These are the few rare and not less common types of sickle cell diseases. They are also less severe. People with these forms of scd inherit one sickle cell gene s and one gene from uncommon hemoglobin (d, e, or o) from each parent.

Sickle cell trait
Hbas
People with sct have one sickle cell gene s and one normal gene a from both mother and father. Ones with this disorder show few to no signs of the disease and usually spend a normal life. However, the risk to their future generations still exists.
 

What Are The Different Types Of Sickle Cell Disease?

Preeclampsia is a condition that affects women during pregnancy. It is characterized by increased blood pressure and high levels of protein in the urine. Women with preeclampsia also experience swelling in the feet, legs, and arms.

Researchers suspect that excessive body fat or poor nutrition are the primary contributors to preeclampsia and eclampsia.

If left undetected, preeclampsia can lead to a more severe complication, known as eclampsia. Eclampsia can put you and your baby at risk, and can even lead to death (in rare cases).

How do preeclampsia and eclampsia affect the mother?

Preeclampsia and eclampsia can cause a host of complications for the mother, such as the following  

Hellp syndrome   hellp syndrome refers to three different conditions   low platelet count, elevated liver enzymes, and haemolysis. This generally occurs late in pregnancy and affects the processing of rbc, functioning of the liver, and blood clotting.

Seizures

Heart and renal failure

Water in the lungs

Bleeding from the liver

Reversible blindness

Effects of preeclampsia and eclampsia on the baby

Preeclampsia can lead to problems with the placenta in the initial stage of pregnancy. This may pose risks, including the following to the baby  

Lack of nutrients and oxygen, which may prevent the foetus to grow properly

Preterm birth

Stillbirth   this happens when the placenta is separated from the uterine wall

Infant death

Stillbirths are more common when the mother has suffered from a severe form of preeclampsia, like hellp syndrome.

Preeclampsia and eclampsia are linked to a myriad of health issues and life-long challenges for prematurely born babies. These may include cerebral palsy, learning disorders, epilepsy, deafness and blindness.

There is no particular cure for preeclampsia and eclampsia. Treatment, however, depends on how close you are to your due date, and how much the foetus has developed. In the case of mild preeclampsia, your doctor may recommend resting, healthy eating   that limits salt intake   and regular prenatal checkups.

Effects Of Preeclampsia And Eclampsia On You And The Baby

Congestive heart failure is a condition when your heart stops pumping blood effectively. By being aware of the risk factors, you can manage your condition in a better way. Also, you must consult your doctor on a regular basis to get yourself checked.

Complications Associated With Congestive Heart Failure

Yoga can cure numerous common ailments like asthma and arthritis if practised frequently. Yoga cannot cure diabetes, yet it is helpful in controlling the glucose in the body to a great level. There are different yoga asanas that are cures for lower back pain and acid reflux. Here is how yoga cures some common ailments:

 

Asthma: the main practical cure for asthma lies in yoga. Inhalers can spare your life when you get an asthma attack; however, for a long-term cure, you need to rehearse pranayam and anulom-vulom.

Diabetes: it is one of the most common illnesses on the planet. You cannot generally cure insulin resistance; however, some yoga asanas like the triangle posture (trikonasana) can control your glucose levels.

Heart disease: bhujangasana or cobra pose stretches the chest, massaging organs inside, including heart, and allowing more blood flow to it, thus stimulating and strengthening the heart muscle. Kapalbhati pranayama is also very good for the heart since it increases the absorption of oxygen in the blood. Yoga is proven to be an excellent heart risk improvement practice according to current research too.

Thyroid disorders: yoga asanas like shoulder stand, inverted pose, plough pose, and the fish pose all help in making the thyroid gland work optimally again. The cobra pose and ujjayi pranayama also work wonders by re-balancing metabolism and working on the throat reflex pathways to cure thyroid imbalance. ;

Headache: migraine and headaches are frequently brought on by insufficient blood supply to the brain. Attempt the yoga postures like shirsasana or a headstand to cure headaches or migraines as opposed to taking medicines.

Back pain or lower back pain: it has turned into a common condition among the working class and individuals even undergo surgery to stop the pain. Attempt yoga postures like tadasana or the tree posture.

Joint inflammation or arthritis: arthritis is an ailment that causes serious joint pain. However, yoga can control the amount of pain brought on because of joint inflammation. Attempt the surya namaskar as a flexible approach to cure arthritis.

Liver problems: liver issues can go from minor ingestion to extreme greasy liver disorder. To keep your liver sound, try some extremely basic yoga postures that may increase the blood circulation in the belly. The stretching posture is a great illustration.

Depression: yoga is one of the best and most powerful cures for depression. If you would prefer not to be reliant on antidepressants and dozing pills, attempt yoga asanas like uttanasana.

Polycystic ovaries syndrome (pcos): it is one of the most common problems that are troubling young women nowadays. The side effects are irregular periods, and it can even lead to infertility. So attempt yoga postures like the body stance to cure ovarian cysts without medications or surgery.

 

10 Diseases You Can Cure With Yoga

C-reactive protein ;is a type of protein produced by the liver in response to an infection ;or inflammation. When your body contracts an infection, the white blood cells produce proteins to fight it. Some of these proteins activate the liver into producing c-reactive protein. For many years, the crp ;blood level has been used to ascertain the level of infection or inflammation.

Assessing the risk of heart disease ;with c-reactive protein

The level of crp is a potential indicator of how likely you are to develop cardiovascular diseases. This is because the development of atherosclerosis is linked with inflammation within the walls of your blood vessel. This results in higher levels of c-reactive protein in atherosclerosis patients than in those without the disorder.

The greater the crp levels, the more chances you have of being affected by cardiovascular disorders. The test also determines the risk of a second attack.

The value of knowing your crp levels depends on whether you come under one of three cardiovascular risk groups.


	
	High risk   not important to know crp because you should be combining lifestyle changes and aggressive treatment to reduce risk
	
	
	Intermediate risk   helpful to find out crp levels, as it can provide vital information crucial in deciding the next line of treatment
	
	
	Low risk   even if your crp levels are high, you will not be at risk   due to negligible risk factors and low cholesterol levels   that should require more than just lifestyle changes
	


To find out crp levels you will have to take a blood test. C-reactive protein is classified into  


	
	High   equal to or greater than 3
	
	
	Intermediate   between 1 and 3
	
	
	Low   below 1
	


If you are having a c-reactive protein test to check for heart diseases, your healthcare provider may recommend a cholesterol test as well. A number of other tests may also be prescribed to evaluate your risk further.

How C-reactive Protein Can Pose A Risk For Heart Disease?

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