Chromosomal abnormality happens when a cell has too many or too few chromosomes. The most common form of chromosomal anomaly is Down s syndrome. If a parent has a chromosomal anomaly, she/he will pass it on to the child. PGD or Pre-implantation Genetic Testing aims to select only the embryos with normal chromosomal count and only these embryos are implanted to achieve a healthy pregnancy and bring down the number of children affected with a chromosomal anomaly.

The risk of Aneuploid pregnancy:

The older a woman is when she tries to conceive (aged 35 or more), the higher the risk of Aneuploid pregnancy (carrying a baby with genetic or chromosomal abnormality). Most of these pregnancies end in miscarriages and the few that come to term produce babies with chromosomal abnormalities.

Causes of Chromosomal Abnormality:

Usually, chromosomal abnormalities occur due to an error in the cell division. Meiosis refers to the cell division, which the sperm and the egg undergo during the development procedure. Normally, meiosis breaks the chromosomal material into two equal halves, so that each of the parents contributes 23 chromosomes to the pregnancy. However, when the number of chromosomes in the cell goes up or down than the normal, it results in genetic/chromosomal anomalies.

PGD Procedure for a Chromosomal Anomaly:

If a couple elects to go for Pre-implantation Genetic Diagnosis, they have to undergo ICSI Cycle. ICSI cycle initiates a fertilization cycle to produce embryos. When the embryos reach upto day 5 and blastocyst are formed, they are biopsied and further sent to genetic lab for detecting the chromosomal abnormalities. The embryos are incubated for the entire duration of the genetic screening. Only the embryos that the genetic test clears are implanted. PGD never reveals the gender of the embryo.

PGD can help detect the single genetic disorders that may lead to the following ailments:

  Cystic fibrosis
  Muscular dystrophy
  Tay-Sachs
  Sickle cell anaemia
  Thalassemia
  Turner syndrome

PGD is a revolutionary science that can help root out incurable disorders linked to genetics. It ensures that pregnancy is sustained until term and a healthy baby is born.

Suffering From Genetic & Chromosomal Anomalies - Know About PGD!

Anxiety is a very normal emotion, which gives rise to feelings of nervousness every now and then. An anxiety disorder is a serious medical condition in which people experience a high degree of distress and mental trauma, which causes difficulties in leading a normal life. People suffering from this medical condition experience high levels of anxiety and nervousness almost all the time. Here are the symptoms that indicate you're suffering from anxiety disorder.

1. Excessive worry - This condition persists if you worry about the day to day activities a bit too much on a regular basis. It is identified when you start taking too much stress about very petty things, which tends to affect you in an adverse manner. A noticeable sign of excessive worry can be too much fatigue.

2. Sleep problems - Problems falling asleep at the right time and problems in maintaining a sound sleep are two signs that indicate you have an anxiety disorder.

3. Irrational fears - This symptom is not generalized; instead, it is specific and subjective in relation to a particular thing or situation. The fears that are experienced under this category are sudden and unexpected in nature and there is no fixed rationale behind these fears.

4. Muscle tension - Muscle discomfort and pain is one of the leading physiological causes of an anxiety disorder. The pain felt is chronic and pervasive, and is very common among people facing situations of anxiety. If you are exposed to constant periods of anxiety, you will experience fatigue, muscle pains and unwillingness to work.

5. Chronic indigestion - Problems related to the digestive system are also a sign of anxiety disorder. In this case, you may face constant digestive problems accompanied by a common disorder called IBS (Irritable Bowel Syndrome). IBS refers to an anxiety situation in the digestive tract, which is characterized by stomach aches, cramping, bloating, gas, constipation, and/or diarrhea.

Apart from the above-mentioned symptoms, other symptoms of an anxiety disorder include stage fright, self- consciousness, panic attacks, memory flashbacks, perfectionism, compulsive behaviors, self- doubt, and such others.



How to know if you have an anxiety disorder?

Personality refers to the enduring and habitual patterns of behaviour, cognition, emotion, motivation and ways of relating to others. In simpler terms, it's the persona we have for the world to see and interact with. If these patterns or ways of relating with others become nonadaptive or pathological, a personality disorder develops.

Borderline Personality Disorder (BPD) is such a disorder of personality that causes mood swings, self-esteem issues, impulsive behavior and recurrent self-harm behaviour. It is very difficult to lead a normal life with these varied psychological issues.

The symptoms begin to appear from early childhood but they take a serious form only when one reaches adulthood. Issues with behavior and emotion are difficult to treat, people suffering from this illness should be willing to spend a lot of time and be dedicated towards his/her recovery. Through treatments and therapies, they do make significant improvements over time.

Causes

The exact cause of borderline personality disorder is not known but various reasons have been hypothesised as possible aetiology. Neuro-chemical disturbance in the brain, genetic vulnerability, some kind of childhood trauma like abandonment, death, neglect and/ or sexual abuse are probable causes of the disease. Prolonged and chronic stress/ anxiety may also lead to triggering of BPD symptomatology in vulnerable individuals later in life.

Symptoms

Prolonged dysthymia/ sadness
Feeling lonely/ misfit
Emotional dysregulation or Frequent mood swings
Significant interpersonal issues
Self-Injurious behaviour like making cuts in skin, burning, pricking etc

These symptoms are warning signs of borderline personality disorder and should be paid attention to:

Abandonment issue - People suffering from BPD have serious abandonment issues. They have an intense fear that they would be left alone and often act out to restrict their love ones from leaving. Sometimes their strategy is to not get too close to protect themselves from being left alone, so they appear aloof.
Disturbed self-image - People have self-esteem issues, they sometimes love or hate themselves or see themselves as evil. They have unclear goals, views, beliefs and often end up changing their friends, lovers, jobs, sexual identity frequently.
Dysfunctional relationships - It is very difficult to maintain a normal relationship for people with personality disorder. They tend to have quick short-lived relationships and get put off very easily which leads to a lot of heartbreak.
Suicidal tendencies and frequent self-harm behaviour like cutting skin using blades/ sharp objects are common.

Drugs and alcohol abuse, eating disorders and sexual promiscuity are other forms of self-destructive behaviour commonly encountered in this population. Extreme aggression, delusions, transitional Psychotic states are other possible symptoms of BPD.

Love and support from family and friends are crucial for patients suffering from this disease. Prolonged counseling sessions, therapies and the effort to break away from the chronic gloomy thoughts will definitely lead one to a better life.

All about Borderline Personality Disorder

Dementia is a dreaded psychological disorder in which the brain cells begin to deteriorate. It is different from regular senility. When the brain cells stop doing their work, it affects the brain function. This leads to a gradual loss of memory. At the same time, the person may also experience changes in personality as well as declining cognitive abilities, all of which are linked to the faculty of memory. Dementia usually affects senior citizens. However, it may happen to the young as well.

What are the Causes of Dementia?
Dementia may be prompted by -
  Alzheimer s Disease
  Huntington Disease, a degenerative disorder
  Vascular dementia
  Atherosclerosis
  HIV
  Multiple Sclerosis
  Pick s Disorder
  Parkinson s Disease
  Encephalitis, both viral and bacterial
  Lewy Body Disease
  Brain Tumour
  Progressive supranuclear palsy
  Chronic Subdural haematoma
  Wilson s Disease
  Neurosyphilis

Dementia in Siddha -
Siddha is an ancient and indigenous branch of medicinal science that was developed in Tamil Nadu. Siddha aims to get to the root of any ailment and eliminate it from the source instead of simply trying to eradicate the symptoms. Siddha believes that the human body primarily consists of three humours- Kapha, pitta and Vata. As long as the right balance is maintained, the human will be healthy. But if the balance goes out of whack or if the quantity of one humour exceeds the others, then that will make a person vulnerable to diseases.
When there is a Vata imbalance in the mind, a person s memory begins to fail him/her.

According to Siddha, a person who has contracted dementia will exhibit the following symptoms -
  Forgetfulness
  Difficulty with recollection and reasoning
  Confusion and disorientation
  Inability to make plans
  Impaired judgement
  Anxiety
  Depression
  Hostile behaviour
  Losing interest in everything around him/her
  Disturbed sleep
  Restlessness
  Hoarding
  Delusion or hallucinations (in advanced stages of dementia)

The approach of Siddha towards neuropsychiatry revolves around the concept of  Kayakarpam    a mode of treatment that can slow down ageing and deterioration of the brain cells. Treatment of dementia consists of -
  Skinned ginger soaked in honey
  Paddy rice mixed with ghee
  Amaranth cooked ghee, salt and pepper
  Aloe Vera
  Black nightshade

Treatment of dementia also includes  thokkanam . Medicinal oils are messaged onto certain parts of the body to activate the Varma points. This will release the  praana vayu - the force of rejuvenation. Siddha also recommends regular meditation top slow down the progression of dementia.

Allopathy has not yet come up with a cure for dementia. But, Siddha can help. Moreover, Siddha medicines are safe and can be consumed without fearing side effects.

Dementia - Getting It Treated With Siddha!

Humans are social animals who thrive on reciprocality. It is in our basic nature to be socially courteous, and the word 'No' feels like a conflict that warns a potential relationship. Many of us tend to comply with every single request that is put forward to us by our peers, family, or at the workplace by our superiors. We choose to take up more jobs than we can efficiently handle and put unnecessary stress on ourselves even at the cost of our time and well-being. Must we always do that? 

Why is it so hard to say 'No'?

People have the notion that saying 'No' can come across as rude or uncaring. You may feel that you are letting someone down by turning down their request or risking a relationship. But, it has mostly to do with your self-confidence than your relationships with people. It may branch from overbearing parents, high expectations set by your peers and mentors or experiencing parenthood yourself and setting unreasonable standards for yourself. Childhood influences are usually the biggest cause of people always saying  yes  all the time.

People who have low self-confidence tend to value their own needs less than the needs of others. Saying 'No' feels rude, and no one wants to be impolite.

Well... saying 'No' does not mean you are being rude or disagreeable.

At the end of the day, it is more about how you say 'no', rather than just saying the word 'No'. Saying 'No' is about valuing and respecting your own time and priorities. 

How to start saying say 'No'?
If you want to take a step back and start saying 'No' to make sure your own needs are valued, here s what you need to do.

Refuse politely, when it seems not possible: Do not overcomplicate responses and try to be as simple in your responses as you can be. If you are asked to do something, and you want to say 'no', try to be polite in your body language and state that it is not convenient for you at the moment and that you would rather get back to it later.
Seek time before committing: The transition from saying  yes  all the time to saying no does take time! Start to give yourself more time and ask people to get back to you later. This way you can begin to build more self-confidence and learn to say no over time. This also allows you to evaluate your response instead of immediately saying yes or no to the person asking the favor or task.
Do not feel guilty: Deep down if you want to do a favor, you can go ahead with it, but you should also understand that it is okay to say no, and there is no need to associate guilt with it. You should set boundaries and allow people around you to understand how much favors they can ask you for instead of presenting you with an endless amount of favors from you.
Set your boundaries: Refusal does not amount to rejection as you have just as much right to say  no  as the person who is asking the favor from you. You are simply turning down a request, and in most situations, there is a middle ground for compromises where both you and the requester can be satisfied. If you have limited time to fulfill a request, let the person know and help out only as much as you can without overstepping your boundaries.
Bringing in these changes can help you be more self-confident, and at the same time enable you to say no when you need to without weighing yourself down with expectations and fear or rejection.

Simple Steps To Help You Say No!

Problems with the arteries and veins present in the hands or legs can lead to vascular disorders. The arteries carry blood from the heart to other parts of the body in order to deliver nutrients and oxygen. The veins carry the blood back to the heart, after the nutrients have been used up. If these blood vessels of the arteries or veins become blocked or narrowed, it can lead to a vascular blockage.

A vascular blockage that occurs in the hands or legs comes under the category of Peripheral Artery Disease or PAD. These type of disorders are less common in the upper extremities of the arms or hands than in the lower extremities of legs. Few of the signs for the same are:

Pain and difficulty in movement due to decreased blood flow
Numbness or weakness of leg or fingertips
Sores on the toes or feet
If the blockage is deep, symptoms of redness, swelling, extreme pain or cramping can be experienced
Abnormal color changes in the fingertips
Ulcers or wounds that don t heal
Skin sensitivity problems when in cold temperatures
How can it be diagnosed?
The blockage can be detected by various methods namely-

Physical Examination   Your doctor may find decreased pulse at armpit, wrist or fingers, full veins, masses, wounds or gangrene.
Doppler or Ultrasound examination to determine the blood flow in the arteries and veins
MRI Scan of the affected area to pay special attention to the blood vessels
Cold Stress Test
Arteriography to show clear blood vessel details
Angiography to map blockages and narrowing of the arteries
What are the Risk Factors for Peripheral Artery Disease?
An individual is at risk for developing vascular blockages in the hands or legs if one or more of the following factors are present:

Smoking
Diabetes
Heredity Factors   A personal or family history of blood vessel disease
High blood pressure
High cholesterol
Aging   People aged above 50 years and older are more prone to vascular blockage
Can it be treated?
Treatments for vascular blockage can vary depending on the age, cause of the blockage, intensity and overall well-being.

Treatments can include:

Self-care   Reducing risk factors and making lifestyle changes to quit smoking, sedentary life or diabetes, blood pressure and cholesterol management can reverse symptoms of vascular disease.
Medications   A variety of drugs can be prescribed to lower the risk and progression of narrowing blood vessels or prevent blood clotting.
Interventional Procedures   Minimally invasive surgery like saloon angioplasty, stenting or removal of artery plaque build-up.
Surgery   If the blockage is severe, surgery may be performed to lessen the vessel narrowing, reconstruct the artery or tie it off, depending on the circumstances.

Pain in the Hands or Legs!

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