Schnitzler s syndrome is a very rare condition described by a reddish rash that looks like hives (urticaria) and lifted levels of a particular protein in the blood (monoclonal IgM gammopathy). Symptoms connected with the Schnitzler disorder may include increased levels of fever, joint inflammation, joint pain (arthralgia), bone agony, and different discoveries, for example, swollen lymph nodes (lymphadenopathy). It also causes weight reduction, discomfort, exhaustion, and broadened spleen and liver. This condition should be treated in terms of taking care of the symptoms so that they do not become debilitating.

Some of the other symptoms include the following:

Urticaria (hives) depicts red raised patches of the skin. These are once in a while irritated. They may last for about 12 hours to 3 days. This may become severely painful if not treated in time.
80% of such patients suffer from painful or swollen. A few patients experience bone pain as well.
High fever might be there accompanied by chills and night sweating. This can give rise to further uneasiness and is usually caused when the immune system is attacked by the ailment.
One of the main symptoms of the Schnitzler disorder is monoclonal gammopathy. This mostly means a raised level of immunoglobulin M (IgM)
Reasons behind it

The main cause behind the Schnitzler syndrome is unknown. Specialists believe that particular parts of the immune system may not work appropriately in the end because of the Schnitzler syndrome. Individuals with the Schnitzler disorder additionally have monoclonal IgM gammopathy, in which abnormal production of immunoglobins result in elevated levels of immunoglobulin M (IgM) in the body. Immunoglobulins are proteins delivered by the white blood cells. A few analysts believe that IgM antibodies accumulate in the skin (epidermis), setting off a reaction that causes the rash. At the time of diagnosis, IgM levels may just be somewhat raised and may stay stable for quite a long time.

Diagnosis

The diagnosis of the Schnitzler disorder is based upon an intensive clinical assessment, patient history, rejection of different other disorders and proof of fever, joint pain or aggravation, bone pain, discernible lymph nodes, amplification of the liver or spleen, lifted quantities of white platelets (leukocytosis), raised red platelet (erythrocyte) or anomalies, which can uncover expanded bone thickness (osteosclerosis).

Treatment: 
Anakinra is a successful treatment for Schnitzler syndrome. It is also very commonly used to treat rheumatoid joint inflammation. The following medicines and therapies have been proven to be successful for treating the Schnitzler disorder over a period of time. These are as follows:

Antihistamines
Nonsteroidal calming specialists
Systemic steroids (prednisone)
Hydroxychloroquine
Colchicine
Dapsone
Pamidronate
Thalidomide
Pefloxacin
Phototherapy
Immunosuppressive specialists (ciclosporin, methotrexate, cycloposphamide)
Biologic specialists (tocilizumab, rituximab)
The Schnitzler disorder is a long-term infection, so stopping a promising treatment can tend to cause a relapse and may cause the disease to reappear. Also, the medicines mentioned above should not be taken without consulting a doctor as they can have sever side effects, if not administered under the guidance of a physician.

Schnitzler Syndrome - Things You Must Know About It!

The uterine cavity has a tissue base that is known as the endometrium. When this endometrium spills over or spreads to the other parts of the reproductive organ, it begins to punch through the uterine lining. Such a condition creates complications and even infertility, and is known as endometriosis.

Read on to know more about endometriosis and how it can cause infertility.

Endometriosis

When the endometrium tissue spreads to areas like the ovaries, and the abdominal cavity, it can lead to numerous complications. Apart from pain, this may also cause infertility. 5 to 10% of the women worldwide suffer from this condition and have trouble conceiving. Additionally, about 30 to 40% of the infertility cases are due to endometriosis, not all cases. These figures are all confirmed by various medical studies.

How does it cause infertility?

Endometriosis can prevent ovulation, which is the process that occurs every month. During the ovulation process, the ovaries release eggs that may be fertilised in order for the woman to conceive. In this condition, the fimbria of the fallopian tubes also has trouble in capturing the egg, which prevents conception from taking place. This leads to infertility in the long run. Endometriosis also interferes with the proper production of the hormones that are required for normal ovulation and fertilisation of the egg.

Diagnosis: The diagnosis of the condition can be done with the help of lab tests and ultrasounds as well as imaging tests that can create the image of the womb and the endometrium lining. This will help in showing the severity and damage caused by the tissue. A surgical procedure called a laparoscopy may be carried out by the doctor to ascertain whether the patient is suffering from this condition. In this procedure, a small incision will be made and a camera will be inserted to view the insides on a screen, to learn more about the tissue s spread and the kind of treatment that will be required. The doctor will also diagnose the condition on the basis of various symptoms like irregular and heavy bleeding.

Treatment:

Treatment for endometriosis associated with infertility needs to be individualized for each woman. There are no easy answers, and treatment decisions depend on factors such as the age of the woman, the severity of the disease and its location in the pelvis, the length of infertility, and the presence of pain or other symptoms. Some general issues regarding treatment are discussed below.

Treatment for Mild Endometriosis

Medical (drug) treatment can suppress endometriosis and relieve the associated pain in many women. Surgical removal of lesions by laparoscopy might also reduce the pain temporarily.

However, several well-controlled studies have shown that neither medical or surgical treatment for mild endometriosis improve the pregnancy rates for infertile women as compared to expectant management (no treatment).

For treatment of infertility associated with mild to moderate endometriosis, controlled ovarian hyperstimulation with intrauterine insemination - IUI is often attempted and has a reasonable chance to result in pregnancy if other infertility factors are not present.

Details about IUI success rates with endometriosis

IUI and endometriosis

Success rates with IUI for endometriosis have been variable in studies, showing:

A pregnancy rate of 6.5% for women with endometriosis vs. 15.3% per cycle for unexplained infertility
A pregnancy rate of 5.6% for women with advanced endometriosis vs. 22.7% per cycle for mild endometriosis vs. 25.7% for no endometriosis
Pregnancy chances with insemination for natural cycle IUIs (no drugs) with endometriosis are about 2% per cycle vs. 11% with injectables plus IUI for endometriosis
Treatment for severe endometriosis

Several studies have shown that medical treatment for severe endometriosis does not improve pregnancy rates for infertile women.

Unfortunately, the infertility in women with severe endometriosis is usually resistant to treatment with ovarian stimulation plus intrauterine insemination. If the pelvic anatomy is very distorted, artificial insemination is unlikely to be successful. These women often require in vitro fertilization in order to conceive.

Although the studies of in vitro fertilization for women with severe endometriosis do not all show similar results, pregnancy success rates are usually good if the woman is relatively young (under 40) and if she produces enough eggs during the ovarian stimulation.

Endometriosis - How It Results in Infertility?

When you run your hands over the soles of your feet, the surface should be smooth to touch. However, sometimes, the surface may not be so smooth. Piezogenic pedal papules are papules on the medial, posterior or lateral aspects of both heels and result from herniation of fat. These papules are usually asymptomatic and can range from a size of 2mm to 10mm. In some cases, they can be a little painful. This is seen commonly in large lesions. They become apparent when the patient stands with his full weight on his feet and disappear or shrink when the weight is removed. Piezogenic papules can also occur on the wrists. This is a fairly common condition that affects women more than men. Piezogenic pedal papules can occur at any age including infancy.

There is no known cause for the herniation of fat that causes this condition. However, there are a few factors that could increase your risk of suffering from this condition. These factors are:

Obesity
Orthopedic problems
Flat feet
Collagen disorders such as EDS
Jobs which entail standing for long hours
Excessive weight bearing
This condition can also affect newborn babies with no predisposition. The diagnosis of this condition is often confused with infantile pedal papules, xanthoma and tophi. Since they are prominently visible only when pressure is applied, it is essential for a doctor to physically examine the patient while he or she is standing. This condition does not affect the health of a person and is largely only a cosmetic issue. Thus treatment is not usually necessary but some of the things you could do to relieve the discomfort are:

In cases where Ehlers-Danlos syndrome triggers the condition, patients may be recommended betamethasone and bupivacaine injections. These injections need to be administered repeatedly for complete pain relief.
Orthotic soles or custom made inserts for shoes can help relieve the pain and distribute pressure equally.
Heel taping
Compression stockings
Avoid excessive or prolonged weight bearing
Avoid standing for extended periods and try not to run too much
Rest the feet and keep them elevated to help alleviate the symptoms
Lose weight if you are on the heavier side
Electro acupuncture
Piezogenic pedal papules are benign and are no reason to worry. If they begin to affect the quality of your life, you could consult a podiatrist. 

What are Piezogenic Pedal Papules?

Eczema of the scalp, which results in itching, flaking, or crusting of the scalp, is called scalp peeling or is commonly referred to as  dandruff . This condition causes increased shedding of normal scalp skin cells. Dandruff may also be caused by a fungal infection, other than just dehydration of the scalp.

The causes of an extremely dry scalp, thereby causing dandruff or even bigger flakes falling from the head onto shoulders and clothes, may be due to scalp psoriasis, eczema, poor nutrition, generalized dehydration, exposure to too much direct heat, and using too much of shampoo.

The three types of dandruff that need to be treated are those resulting from fungal growth, dry scalp and the one resulting from product build-up.

Fungal growth: This kind of dandruff is a chronic condition, caused by increased oil content on the scalp or an off-balance pH of the scalp. It may also be due to poor cleansing habits, or even an allergic reaction to the hair products one uses. Try switching shampoos, conditioners, or styling products to sulfate-free formulas to cure this condition.
Dry scalp: Sometimes, the skin of the scalp is literally so parched and dry that it is flaky and falls away like snakeskin. People with this kind of dandruff usually have drier hair and notice a tightness in their scalp. To treat dry-scalp dandruff, it is wise to indulge one s hair with moisturizing and hydrating shampoos, cut down on or space out harsh chemical treatments like relaxers, permanents, or dyes, and take in more moisture from the inside - drink at least 8 eight-ounce glasses of water a day, and your skin (including your scalp) will show you results that you want. Eliminating sulfates from your shampoos or other hair care products will also help with dry scalp, since these ingredients help strip away natural oils. Brushing hair or massaging the scalp - either with bare fingertips or a few drops of oil - is another great treatment, since massage helps stimulate circulation and bring blood, nutrients, and oxygen to the scalp and hair.
Product buildup: The most common type of dandruff is due to product buildup. This is what happens when people with otherwise healthy manes and scalps use too many styling products, such as layering gels, hair serum, hairspray, wrap lotions, scalp oils, heat-protecting serum, and so on. Dandruff caused by product buildup usually looks more like small clumps or balls of dirt. It may have a brownish color, since all those products attract and trap plenty of dirt and sweat. Product-buildup dandruff also tends to appear sporadically, only when hair is in need of a wash, whereas other types of dandruff show up more quickly and regularly.
To treat this kind of dandruff, one should wash hair more often or simply aim for using minimum chemical-rich hair products. 

Scalp Peeling - It Can Be Of 3 Different Types?

Eczema refers to any kind of superficial inflammatory process that primarily involves the epidermis, and is characterised by itching, redness, vesicles and sometimes crusting and oozing. Another term for eczema is atopic dermatitis. This kind of skin infection can start during infancy and continue until many years. Though there are some people who outgrow the condition, others may have it all their lives.

Causes:

The factors that play a role in causing eczema are:

Genetics is one of the factors that may affect the proper functioning of your skin as a barrier against harmful substances. Therefore, if either one of the parent or both suffers from the condition, it is very likely that their children too will suffer from it.
Abnormal functioning of your body's immune system can also lead to this skin condition. This is because it's your body's immune system that fights off infections as well as harmful intruders.
Dry skin brings down your skin's ability to fend off irritants as well as allergy causing substances from entering your skin, resulting in an inflammatory condition.
The presence of the bacteria called Staphylococcus aureus, which brings about sweat buildup, inflames the skin considerably, leading to this condition.
Even environmental factors like pollen, cigarette smoke lead to the flaring of eczema.
What are the symptoms of eczema?

Atopic dermatitis is commonly seen as dry patches appearing on the skin and sometimes these patches are extremely itchy and cause discomfort. In the case of infants, the rashes appear on the scalp and cheeks and often bubble up before the liquid oozes out. Rashes commonly appear on the backside of the creases of the elbows and knees in the case of kids above two years, and other places on the body may also be affected. In adults, the rashes can make the skin dry and cover maximum area of the body. It may also lead to further skin infections, skin irritation, and may also cause eye problems.

How can eczema be treated?
Though there is no overall cure for eczema, but the treatments can heal the affected skin as well as prevent flaring of the symptoms. Doctors often suggest a plan of treatment on the basis of the age of the patient, symptoms, and the present state of health. You can opt to take warm baths on a regular basis and apply moisturiser within three minutes. You will have to avoid harsh soaps and instead use the mild soap or non-soap cleansers while washing. It is important to keep your fingernails short so that you don t scratch the affected area which would further aggravate it.
If you are unable to keep eczema under control with all these preventive tips, then it would be best to consult a dermatologist for curing it.

How can you prevent an eczema outbreak?

It is very common for this skin condition to flare-up from time to time. But you can avoid such outbreaks or reduce their severity by following these very simple ways:

Sudden changes in temperature can cause the skin condition to break out. So, when the weather is hot, keep yourself cool but during cold weather, use a humidifier to prevent the skin from drying out.
Keep sweating in check as it can cause an outbreak very easily
Keep your skin well-moisturized so that it doesn't dry out causing further irritation.
Avoid the use of harsh detergents and soaps, woolen materials as well as the consumption of foods that may lead to flare-ups. 

Eczema - Causes, Symptoms and Treatments

Psoriasis is a skin disease, which develops in men and women often during middle age and above. Although tests and researches are being carried out in various laboratories around the world, the exact cause of this condition is yet unknown. Psoriasis is not infectious. In other words, it does not spread by coming in contact with someone suffering from it. In case you see that you are just developing psoriasis or it is in its early stages, then you can opt for some simple and natural methods of curing it. These home remedies fall under Ayurvedic treatments and help you in getting rid of this disease before it spreads further into your body.

Moist skin: Apply lots of moisturizer on your body. This is done to keep the skin moist and supple. The more your skin becomes dry, the chances of it bleeding and causing infections increase. It is often recommended to apply body oil or sesame oil before taking a bath as it softens the skin.
Use natural body soaps: Sometimes the body soaps that you use are made of harsh chemicals. These chemicals come in contact with your body and aggravate the infection furthermore. You can use home made natural soaps, which are made of natural ingredients and are gentle on your skin.
Avoid skin injuries: Skin injuries like a cut, bleeding, blisters etc. can be harmful for psoriasis. They can aggravate the inflammation and cause more damage. In fact, it is recommended that you apply moisturizer and sunscreen every time you step out of the house in order to protect your skin from further damage.
Use medicines after consultation: Certain medicines have the ability to flare up the effects of psoriasis. Thus, when you develop this disease, it is advised that you meet a general physician and discuss your medicines with him/her in order to control the same.
Reduce stress: Stress levels contribute a lot to psoriasis. Thus, you need to relax as much as possible. You can try out yoga and meditation to keep the stress level down and in turn control this disease as well.
Wear cotton clothes: Wear clothes that you are comfortable in and those which do not cause irritation on your skin. Synthetic clothes sometimes cause a lot of irritation and rashes on the skin. It is something that should be avoided.
These are some of the quick and natural remedies to cure yourself of psoriasis as early as possible.

Psoriasis - 6 Ayurvedic Remedies That Can Help!

Don't wait any longer, manage your Immunodermatologist online with a Lybrate doctor today

Consult for Immunodermatologist - Online and Easy!

FilterClear All

COMMON SPECIALITIES

COMMON ISSUES