Study of the brain has fascinated specialists all over the globe since time immemorial. The brain being the most vital organ for survival and coordination is perhaps the most complex of them all too. This has led to a limited understanding of its working in spite of the available advanced technology. However, with the advent of techniques for diagnosis and treatment, therapeutic strategies are evolving. This is a major step towards rendering Neurosurgery safer than ever in the history of mankind.

Neurosurgery through the 20th Century-

During the beginning of the 20th century, Neurosurgery was considered as a specialty. The clinical-neurologist would draw conclusions related to lesions in the brain through neurological examination and clinical history. It enabled diagnosis of vascular lesions, spinal disorders, and brain tumors. During the second and third decades of the 20th century, vascular pathologies and brain tumors could be diagnosed indirectly through techniques like angiography, ventriculography, and pneumoencephalography. But since the operative techniques were too crude and the lack of skilled professionals were rampant, there were high rates of morbidity and mortality due to neurological conditions. Generally, after diagnosing the nature of brain lesion and its site, surgery was performed with inadequate maintenance and control of intracranial pressure and through not too sophisticated surgical instruments.

During the fifth and sixth decades of the 20th century, chemotherapy and radiation treatment came into the picture for treating malignant brain tumors, thereby reducing mortality to a good extent.

During the seventh decade of the 20th century, Computed Tomography (CT) scan provided a better understanding of the location of lesions in the brain which slightly substantiated the earlier techniques. Then, the procedures for cerebrospinal fluid diversion significantly improved management of intracranial pressure during surgery.

It was only during the last decade of the 20th century that the Neurology saw a giant progressive leap through the introduction of Magnetic Resonance Imaging (MRI) and powerful high magnification microscopes. Combined with Neuroanesthesia and Intracranial Pressure Management, this aided surgeons to work on a relaxed brain. This promoted safe removal of the brain tumor and better management of vascular lesions. Moreover, the understanding of micro-surgical anatomy improved drastically, leading to a boost in confidence levels of the micro-neurosurgeons performing the operation.

Neurosurgery in the 21st Century-

The 21st century is actually a revolutionary era that uses powerful computers in almost all the fields possible. Computer-based applications such as Neuro-imaging, Neuronavigation, Intra-operative Neuro-monitoring, and Neuro-modulation are now used in standard neurosurgical practice as a part of the routine. Extremely powerful CT scans and MRIs are used for diagnosis before surgery. The advent of nanotechnology and its application in Neurosurgery is doing great and has a promising future ahead based on the current study of scenarios. Moreover, there is a possibility of most of the Neurosurgical procedures becoming minimally invasive. Frameless Stereotaxy is another technique that helps in locating the exact position of the tumor, which further helps the neurosurgeon in navigating with great precision the very sensitive, high-risk areas of the brain. Such techniques, to a great extent, have lowered mortality and morbidity, lessened the rate of recovery, and chances of infection related to Neurosurgery.

Take Away-

A number of techniques for diagnosis and precise location of the tumor in the brain have made Neurosurgery much safer today, due to advancement in science and technology, than it ever had been in the history of mankind.

Advancements In Neurosurgery - Know How Safe It Is!

The relationship between intelligence and brain size, both among people and between various species, has never been precisely well defined. People often believe that their outstanding psychological capacities must mean that they are superior to all animals as far as brain size is concerned. However, it is not true since whales and elephants have much bigger brains than humans and humans have the same brain-to-body mass proportion as mice do.

Here are a number of ways by which the brain size can be determined:

Encephalization remainder: Since it would be against human instinct to admit loss and defeat, researchers have created a measure to determine the brain size called the encephalization remainder. It is the proportion of actual brain mass with respect to the anticipated cerebrum mass for the animal s size (based on the suspicion that bigger animals require somewhat less brain matter with respect to their size, compared to little animals). By this metric, human beings prove to be the best, with an EQ of 7.5 outperforming the dolphin's 5.3 and the mouse's 0.5.
IQ testing: Without a solitary and evident method for measuring intelligence, some improved tests like IQ (Intelligence Quotient) are by and large acknowledged as a moderately decent working device. IQ estimations are not without issues, and there is a great deal of criticism about their significance. IQ testing uses government sanctioned tests, for example, the WAIS III (Wechsler Adult Intelligence Scale). The normal IQ is somewhere around 90 and 110. The scores beneath the normal may demonstrate changing degrees of pathology, for example, marginal intellectual function, or mental hindrance of different severity. Over the normal range is regularly connected with knowledge, splendour, talent, or genius. However, as with computers of a few eras, size and intellect do not precisely relate. Present day portable computers weighing around one or two kilogrammes can store more data and perform a greater number of assignments than supercomputers from the 1980s that used to possess expansive structures. This is a contrast amongst quantity and quality. Numerous scientists now hold the view that it is not the whole brain, which is bigger in a human with a higher IQ, yet rather certain zones that are denser and might be bigger. A fascinating late revelation is that these ranges can be expanded in size and enhanced in usefulness during the course of our life.
NeuroplasticityIt refers to the dynamic procedure of repair and maintenance that our brains are continually experiencing. We are conceived with around hundred billion neurones, yet lose around two hundred thousand a day to a procedure called pruning. As we develop and grow, pathways in the brain that are not required are detached, and the neurones pass on. However, in a compensatory procedure, new neurones are delivered and more detailed associations are built up between neurones that are more dynamic. This is the procedure of de-cluttering, in which our brains develop to work at most extreme effectiveness. If you wish to discuss about any specific problem, you can consult a Neurologist.

Brain Size - How It Is Related With Intelligence?

The neurones in the brain are constantly reorganising their connections both functionally and physically according to the environment, your thinking and behaviour. This ability is known as neuroplasticity. Through neuroplasticity the nerve cells of brain can compensate for injury to some parts of the brain and enable a person to recover from stroke, birth abnormalities. It is also beneficial in treating autism, ADD, learning disabilities and helps manage obsessive compulsive disorders.

Here are seven things you should know about neuroplasticity.

Change depends on the attentiveness of the brain: Neuroplasticity changes can only happen if the brain is alert and active. When the brain is active it releases neurochemicals that are necessary for the neurone connections to change. If a person is distracted to inattentive, these changes cannot happen.
The more the effort; the bigger the change: Neuroplasticity changes depend on how motivated the person is to change or learn new tasks. For this reason, when it comes to using neuroplasticity for physiotherapy, it is essential to first deal with any depression or anxiety issues the patient might be having before attempting to rehabilitate them.
It helps strengthen neural connections: Repetition of actions is one of the key elements of neuroplasticity in physiotherapy. Through this, the strength of neurone connections is strengthened to include sensory information, movement and cognitive patterns.
It improves cell to cell connections: This is crucial to a patient s rehabilitation as it increases reliability and makes a person more independent. In turn, this makes behaviour patterns more reliable.
It helps predict actions: A task can usually be broken down into a series of smaller tasks. For example, feeding oneself can be broken down into steps that begin with lifting a spoon and filling it with food to finally putting the spoon into your mouth. Hence, along with completing an action, the brain must also know what to do next. Neuroplasticity helps improve this associative flow and allows the brain to predict the next step.
Changes can be temporary or permanent: Initial changes due to neuroplasticity are temporary ad only if the brain determines the experience to be desired is this change made permanent. This is why when treating mobility issues, patients are not always able to repeat tasks in the same way.
Memory guides the learning: When making new neural connections through neuroplasticity, the brain is taught to discard unsuccessful attempts and only remember the experience of the successful attempts. From here, adjustments are made to improve the connection.

Neuroplasticity - 7 Things You Must Know About it!

Leading a life with peripheral neuropathy is quite similar to riding a roller coaster. Managing the pain can be frustrating at one time and overwhelming on the other as patients can experience alternating symptoms with debilitating pain. So you should learn about the various treatment options as they can help you go a long way in managing the pain.

The peripheral nerves are considered the longest in the body which extend from the hands to feet. When these nerves are damaged, you may feel some sort of pain, tingling in the hands and feet and even numbness, and these symptoms can even get worse and you may experience stabbing pain with increasing weakness. 

There are many things that you should know about peripheral neuropathy as they would help you to manage the condition much more effectively.

Diabetes is the leading cause of neuropathy: More than 70% of diabetics develop symptoms of peripheral neuropathy. So you should keep your blood sugar within optimum levels as a means of reversing diabetic neuropathy.
A melange of causes behind neuropathy: Though diabetes is the number 1 cause of peripheral neuropathy, other causes include deficiency of vitamin B12, alcoholism, traumatic injury, chemotherapy and exposure to toxic substances. Physicians may find it difficult to pin-point the cause and when this happens. This is often termed as  idiopathic neuropathy .
Medications causing neuropathy: If you are suffering from diabetes and being treated with the drug named metformin, you may develop peripheral neuropathy.
Preventing neuropathy is the most recommended way: While it is the fact that some nerves may potentially get damaged from certain surgeries or injury, peripheral neuropathy can be potentially prevented or sometimes stopped from spreading. As diabetes is a major cause of diabetes, being watchful about your diet and exercising regularly can help you go a long way to prevent diabetes as well as neuropathy.
Pain is not simply confined to a tingling sensation: Though pain and a tingling sensation is the commonest and easiest way of recognising the symptoms of peripheral neuropathy, each of your sensory, motor and autonomic nerves can show different set of symptoms that you should be watchful of.
A diet may make the symptoms even worse: You can either help or hurt your nerves with your choice of foods. For improving symptoms, you should avoid food with excessive sugar, refined grains and artificial sweeteners as they may strain your nerves and irritate them further.
Whether you are recently diagnosed with peripheral neuropathy or living with it for many years, understanding a few conditions would help you make informed decisions about your well-being.

Peripheral Neuropathy - 6 Things You Should Know!

Antibiotics are something which have changed are lives for eternity as well as for the better, to say the very least. With each day that passes, there are greater strides of advancement which are made in the field. Of late, it is said that antibiotics also have the potential to stop new cells in the brain from growing, which is quite a risk when it comes to their usage among people are sick.

Research has found that if the brain of the person under treatment is subject to sustained use of antibiotics, it is true that the brain can lose its functionality for a quicker time than what one would consider to be normal. So it can be said, this usually is not the advisable way to go.

Like most testing practices when it comes to medication, antibiotics which were tested on the brains of the subjects i.e. those of mice had an effect of mitigating their high-level memory. How this happened to be is rather interesting, to say the very least.

How dangerous can antibiotics be?
It is often said that eating right does wonder for a person s brain. Well, the mice that were not treated with the antibiotics were seen to lose the healthy bacteria present in their stomachs. In addition to this, they lost new brain cells. This led on to them performing worse in mental tests than their peers who had had some antibiotics administered to them on a consistent basis.

Now a cynic may point out that what is seen to be true for mice may really not hold true when it comes to humans being considered. However, if it is taken into due account that a lot of path-breaking research is carried out on mice, there is quite some credence to the results of the study.

To supplement the evidence even further, it was also seen that for mice which were in possession of low levels of monocytes, which are a type of white blood cells. It was seen that there was a great dependency on monocytes for the generation of white blood cells. The part of the brain which is hindered by generating new cells on account of the sustained use of antibiotics is the hippocampus.

Antibiotics are the proverbial shot in the arm which can aid recovery by destroying the threat to a person s wellness. However, it is to be considered that they are not safe in general as there is collateral damage!

Antibiotics - Can They Stop The Growth Of Brain Cells?

Acoustic vestibular schwannoma or the acoustic neuroma is a kind of tumour. But this tumour is benign which means it is non-cancerous. The vestibular nerve connects your ear to your brain, it is responsible for hearing and balancing. An acoustic neuroma develops on the vestibular nerve. And it can cause hearing impairment.

How does acoustic Vestibular Schwannoma occur? 
The vestibular nerve is lined with Schwann cells. Sometimes, these cells start to develop rapidly. This forms a mound on the nerve, it slowly becomes large enough to prod against the brain, and this adversely affects the actions of the brain.

What are the Symptoms?
In the early phases, the tumour does not trigger any symptoms. They begin to manifest once the tumour starts expanding. Here is a list of the symptoms of acoustic vestibular schwannoma-
  Gradual hearing loss
  Misalignment and losing balance
  Ringing in the ears.
  Regions of numbness in your face
Even though these tumours are benign, sometimes they enlarge to such an extent that they can be harmful to the brain. As soon as you witness the above-mentioned symptoms, book an appointment with a doctor.
With timely treatment and medication, doctors can reverse the growth of an acoustic vestibular schwannoma. 

What triggers this Disease?
The exact cause of this disease is not known. It could be any one of the following-
  A chromosomal anomaly or a malfunctioning gene
  Inhibition in the function of the protein suppressor that regulates the growth of Schwann cells

How is Acoustic Vestibular Schwannoma detected?
Your doctor will recommend these tests-

  Audiometry -
The audiologist will present sounds at different frequencies and you will have to make a gesture whenever you hear a sound. This will reveal the state of your hearing.

  Magnetic Resonance Imaging -
An MRI can detect the presence of a tumour that is 1-2 mms in diameter. If MRI causes pain or discomfort, a CT scan will be done.

Treatment -
If the tumour is tiny, your doctor won t prescribe medicines but your tumour will be monitored and imaged regularly so that the proper action can be taken as soon as it begins to enlarge.

  Surgery -
If the tumour is large, then you might have to undergo surgery. Not only will the tumour be removed, but also care will be taken to preserve the facial nerve so that facial paralysis does not set in.
You will be placed under general anaesthesia. The surgeon will drill a small hole in your skull near the ears and extract the tumour through your inner ears.

  Radiation -
If the tumour is small or if the patient is elderly and surgery can cause complications, doctors suggest radiation therapy. In this therapy, gamma rays are directed towards the tumour to shrink it.
Acoustic vestibular schwannoma can be treated if diagnosed on time. So, if you have noticed any symptoms, talk to a doctor right away.

Acoustic Vestibular Schwannoma - All You Must Know About It!

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